鞭打绣球中苯酚类化合物的研究
|
摘要
利用色谱法从鞭打绣球的95%乙醇提取物的乙酸乙酯部分中分离得到10个苯酚类化合物.根据化合物的理化性质及波谱数据分析,将其确定为:异香草酸(1),5-甲氧基-2-羟基苯甲醛(2),4-羟基-3-甲氧基苯甲醛(3),丁香醛(4),4-羟基苯甲醛(5),3,4-二羟基苯甲酸(6),丁香酸(7),3-甲氧基-5-丙基苯酚(8),阿魏酸(9),阿魏酸甲酯(10).以上所有化合物均为首次从该种植物中分离得到.
Ten phenolic compounds were isolated from 95% ethanol extracts of Hemiphragma heterophyllum by chromatography,spectroscopy technique,and some methods in computational chemistry. The isolates were identified as isovanillic acid( 1),5-methoxy-2-hydroxy benzaldehyde( 2),4-hydroxy-3-methoxy benzaldehyde( 3),syringaldehyde( 4),4-hydroxy-benzaldehyde( 5),3,4-dihydroxy-benzoic acid( 6),syringic acid( 7),3-methoxy-5-propylphenol( 8),4-hydroxy-3-methoxy cinnamic acid( 9) and 4-hydroxy-3-methoxy cinnamic acid methyl ester( 10) based on the detailed spectral analysis. It is very noteworthy that all the compounds were obtained from this plant for the first time.
Ten phenolic compounds were isolated from 95% ethanol extracts of Hemiphragma heterophyllum by chromatography,spectroscopy technique,and some methods in computational chemistry. The isolates were identified as isovanillic acid( 1),5-methoxy-2-hydroxy benzaldehyde( 2),4-hydroxy-3-methoxy benzaldehyde( 3),syringaldehyde( 4),4-hydroxy-benzaldehyde( 5),3,4-dihydroxy-benzoic acid( 6),syringic acid( 7),3-methoxy-5-propylphenol( 8),4-hydroxy-3-methoxy cinnamic acid( 9) and 4-hydroxy-3-methoxy cinnamic acid methyl ester( 10) based on the detailed spectral analysis. It is very noteworthy that all the compounds were obtained from this plant for the first time.
引文
[1]贾敏如,李星炜.中国民族药物志[M].北京:中国医药科技出版社,2005.
[2] YANG M F,LI Y Y,LI B G,et al. A new monoterpene glycoside from Hemiphragma heterophyhum[J]. Acta Botanica Sinica,2004,46(12):1454-1457.
[3]马伟光,李兴从,刘玉青,等.鞭打绣球中的苯丙素甙和环烯醚萜甙[J].云南植物研究,1995,17(1):96-102.
[4] JIN H L,MORI A,TANAKA T,et al. A new phenylethanoid glycoside from Hemiphragma heterophyllum[J]. Japanese Journal of Food Chemistry,2006,13(2):528-531.
[5]何可群,卢文芸,杨琼,等.鞭打绣球总黄酮含量的测定[J].安徽农业科学,2012,40(30):14703-14705.
[6] DING H Y,LIN H C,TENG C M,et al. Phytochemical and pharmacological studies on Chinese Paeonia species[J]. Journal of the Chinese Chemical Society,2000,47(2):381-388.
[7] HOSSEINZADEH M,MOHAMAD J,KHALILZADEH M A,et al. Isolation and characterization of bioactive compounds from the bark of Litsea costalis[J]. Journal of Photochemistry and Photobiology B:Biology,2013,128(128C):85-91.
[8] ITO J K,CHANG F G,WANG H K,et al. Anti-AIDS agents. 48. 1 anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis[J]. Journal of Natural Products,2001,64(10):1278-81.
[9]余小红,李盼盼,耿圆圆,等.小远志化学成分研究[J].林产化学与工业,2017,37(1):149-154.
[10]胡琳,丁智慧,刘吉开.灰黑拟牛肝菌的化学成分[J].植物分类与资源学报,2002,24(5):667-670.
[11]陈亚萍,王娅娟,李玉鹏,等.云南药用植物鼓槌石斛化学成分研究[J].亚太传统医药,2015,11(5):14-15.
[12]刘量,叶静,李萍,等.杜鹃兰假鳞茎化学成分研究[J].中国中药杂志,2014,39(2):250-253.
[13] KODAMA A,SHIBANO H,KAWABATA J. Oxidative dimer produced from a 2,3,4-trihydroxybenzoic ester[J]. Bioscience,Biotechnology,and Biochemistry,2007,71(7):1731-1734.
[14]陈芬,覃宇,丁四海.小分子抗癌新药nutlin-3的合成新法研究[J].武汉职业技术学院学报,2011,10(1):75-78.
[15]王长岱,丁凯,吴玉华,等.羊红膻根的化学成分研究[J].药学学报,1983,18(7):522-524.
[2] YANG M F,LI Y Y,LI B G,et al. A new monoterpene glycoside from Hemiphragma heterophyhum[J]. Acta Botanica Sinica,2004,46(12):1454-1457.
[3]马伟光,李兴从,刘玉青,等.鞭打绣球中的苯丙素甙和环烯醚萜甙[J].云南植物研究,1995,17(1):96-102.
[4] JIN H L,MORI A,TANAKA T,et al. A new phenylethanoid glycoside from Hemiphragma heterophyllum[J]. Japanese Journal of Food Chemistry,2006,13(2):528-531.
[5]何可群,卢文芸,杨琼,等.鞭打绣球总黄酮含量的测定[J].安徽农业科学,2012,40(30):14703-14705.
[6] DING H Y,LIN H C,TENG C M,et al. Phytochemical and pharmacological studies on Chinese Paeonia species[J]. Journal of the Chinese Chemical Society,2000,47(2):381-388.
[7] HOSSEINZADEH M,MOHAMAD J,KHALILZADEH M A,et al. Isolation and characterization of bioactive compounds from the bark of Litsea costalis[J]. Journal of Photochemistry and Photobiology B:Biology,2013,128(128C):85-91.
[8] ITO J K,CHANG F G,WANG H K,et al. Anti-AIDS agents. 48. 1 anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis[J]. Journal of Natural Products,2001,64(10):1278-81.
[9]余小红,李盼盼,耿圆圆,等.小远志化学成分研究[J].林产化学与工业,2017,37(1):149-154.
[10]胡琳,丁智慧,刘吉开.灰黑拟牛肝菌的化学成分[J].植物分类与资源学报,2002,24(5):667-670.
[11]陈亚萍,王娅娟,李玉鹏,等.云南药用植物鼓槌石斛化学成分研究[J].亚太传统医药,2015,11(5):14-15.
[12]刘量,叶静,李萍,等.杜鹃兰假鳞茎化学成分研究[J].中国中药杂志,2014,39(2):250-253.
[13] KODAMA A,SHIBANO H,KAWABATA J. Oxidative dimer produced from a 2,3,4-trihydroxybenzoic ester[J]. Bioscience,Biotechnology,and Biochemistry,2007,71(7):1731-1734.
[14]陈芬,覃宇,丁四海.小分子抗癌新药nutlin-3的合成新法研究[J].武汉职业技术学院学报,2011,10(1):75-78.
[15]王长岱,丁凯,吴玉华,等.羊红膻根的化学成分研究[J].药学学报,1983,18(7):522-524.