狗牙花生物碱成分的研究
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摘要
狗牙花(Ervatamia divaricata(L.)Burk.'Gouyahua')枝叶用丙酮提取,利用硅胶柱层析、Sephadex LH-20柱层析和反相柱层析进行化学成分分离纯化,从中分离得到6个吲哚生物碱。根据波谱技术和理化性质对化合物结构进行鉴定,鉴定结构为:coronaridine(1)、19-epi-heyneanine(2)、isovoacangine(3)、ibogamine(4)、19(S)-hydroxyibogamine(5)和apparicine(6),其中化合物2、3和5为首次从该植物中分离得到。
Six indole alkaloids were extracted from the acetone extract of the twigs and leaves of Ervatamia divaricata(L.)Burk. 'Gouyahua' and isolated and purified by silica gel chromatography, Sephadex LH-20 chromatography and reversedphase chromatography. With spectroscopic analysis combined with their physicochemical data, the structures of these indole alkaloids were identified as coronaridine(1), 19-epi-heyneanine(2), isovoacangine(3), ibogamine(4), 19(S)-hydroxyibogamine(5), apparicine(6). Among these compounds, compound 2, 3 and 5 were obtained from Ervatamia divaricata(L.)Burk. 'Gouyahua' for the first time.
Six indole alkaloids were extracted from the acetone extract of the twigs and leaves of Ervatamia divaricata(L.)Burk. 'Gouyahua' and isolated and purified by silica gel chromatography, Sephadex LH-20 chromatography and reversedphase chromatography. With spectroscopic analysis combined with their physicochemical data, the structures of these indole alkaloids were identified as coronaridine(1), 19-epi-heyneanine(2), isovoacangine(3), ibogamine(4), 19(S)-hydroxyibogamine(5), apparicine(6). Among these compounds, compound 2, 3 and 5 were obtained from Ervatamia divaricata(L.)Burk. 'Gouyahua' for the first time.
引文
[1]金丽,卢嘉,金永生,等.海南狗牙花化学成分研究[J].中国天然药物,2008,6(4):271-274.
[2]中国科学院中国植物志编辑委员会.中国植物志(第77卷)[M].北京:科学出版社,1977.
[3] ZHANG H,WANG X N,LIN L P,et al. Indole alkaloids from three species of the Ervatamia genus:E. officinalis, E. divaricata, and E. divaricata Gouyahua[J]. Journal of Natural Products,2007,70(1):54-59.
[4] GORMAN M,NEUSS N,CONE N J,et al. Alkaloids from Apocynaceae. III. alkaloids of Tabernaemontana and Ervatamia. The structure of coronaridine, a new alkaloid related to ibogamine[J]. Journal of the American Chemical Society,1960,82(5):1142-1145.
[5] KAM T S,SIM K M. Five new iboga alkaloids from Tabernaemontana corymbosa[J]. Journal of Natural Products,2002,65(5):669-672.
[6] DAMAK M,POUPAT C,AHOND A. Bis[hydroxy-11 coronaridinyl]-12,nouvel alcalo?de dimere de type ibogane:elucidation de La structure par RM13C[J]. Tetrahedron Letters,1976,17(39):3531-3534.
[7] JOULE J A,MONTEIRO H,DURHAM L J,et al. Alkaloid studies. Part XLVIII. The structure of apparicine, a novel Aspidosperma alkaloid[J]. Journal of the Chemical Society(Resumed),1965:4773.
[2]中国科学院中国植物志编辑委员会.中国植物志(第77卷)[M].北京:科学出版社,1977.
[3] ZHANG H,WANG X N,LIN L P,et al. Indole alkaloids from three species of the Ervatamia genus:E. officinalis, E. divaricata, and E. divaricata Gouyahua[J]. Journal of Natural Products,2007,70(1):54-59.
[4] GORMAN M,NEUSS N,CONE N J,et al. Alkaloids from Apocynaceae. III. alkaloids of Tabernaemontana and Ervatamia. The structure of coronaridine, a new alkaloid related to ibogamine[J]. Journal of the American Chemical Society,1960,82(5):1142-1145.
[5] KAM T S,SIM K M. Five new iboga alkaloids from Tabernaemontana corymbosa[J]. Journal of Natural Products,2002,65(5):669-672.
[6] DAMAK M,POUPAT C,AHOND A. Bis[hydroxy-11 coronaridinyl]-12,nouvel alcalo?de dimere de type ibogane:elucidation de La structure par RM13C[J]. Tetrahedron Letters,1976,17(39):3531-3534.
[7] JOULE J A,MONTEIRO H,DURHAM L J,et al. Alkaloid studies. Part XLVIII. The structure of apparicine, a novel Aspidosperma alkaloid[J]. Journal of the Chemical Society(Resumed),1965:4773.