依达拉奉对颅脑损伤急性脑水肿患者氧自由基及脑血流动力学的影响
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摘要
目的:探讨依达拉奉对颅脑损伤急性脑水肿患者氧自由基及脑血流动力学的影响。方法:选取2017年1月—2019年1月我院收治的颅脑损伤急性脑水肿患者80例,按照随机数字表法分成对照组和观察组,各40例。对照组给予常规治疗,观察组在对照组基础上给予依达拉奉注射液(30 mg与100 mL0.9%的氯化钠注射液混合,静脉滴注,bid)治疗,比较两组氧自由基、脑血流动力学指标。结果:观察组治疗后丙二醛(MAD)、脂质过氧化物(LPO)、羟自由基(OH)含量均低于对照组,超氧化物歧化酶(SOD)、颈总动脉平均血流速度(Vmean)、最小血流速度(Vmin)、平均血流量(Qmean)、最小血流量(Qmin)水平均高于对照组,差异有统计学意义(P <0.05)。结论:依达拉奉可有效改善颅脑损伤急性脑水肿患者的氧自由基水平,提高脑血流动力学水平,利于预后。
Objective:To investigate the effect of edaravone on oxygen free radicals and cerebral hemodynamics in patients with acute cerebral edema after craniocerebral injury. Methods:80 patients with acute cerebral edema after craniocerebral injury admitted to our hospital from January 2017 to January 2019 were selected and randomly divided into a control group and an observation group, 40 cases each. The patients in the control group received conventional treatment, and the patients in the observation group were treated with edaravone injection(30 mg injection was mixed with 100 mL 0.9% sodium chloride injection, intravenous drip, bid) on the basis of the control group. The oxygen free radicals and cerebral hemodynamic indexes were compared between the two groups. Results:After treatment, the levels of malondialdehyde(MAD), lipid peroxide(LPO) and hydroxyl radicals(OH) in the observation group were lower than those in the control group, while the levels of superoxide dismutase(SOD), mean carotid artery blood ?ow velocity(Vmean), minimum blood ?ow velocity(Vmin), mean blood ?ow(Qmean) and minimum blood ?ow(Qmin) in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion:Edaravone can effectively improve the level of oxygen free radicals in the patients with acute cerebral edema after craniocerebral injury, improve cerebral hemodynamics and bene?t their prognosis.
Objective:To investigate the effect of edaravone on oxygen free radicals and cerebral hemodynamics in patients with acute cerebral edema after craniocerebral injury. Methods:80 patients with acute cerebral edema after craniocerebral injury admitted to our hospital from January 2017 to January 2019 were selected and randomly divided into a control group and an observation group, 40 cases each. The patients in the control group received conventional treatment, and the patients in the observation group were treated with edaravone injection(30 mg injection was mixed with 100 mL 0.9% sodium chloride injection, intravenous drip, bid) on the basis of the control group. The oxygen free radicals and cerebral hemodynamic indexes were compared between the two groups. Results:After treatment, the levels of malondialdehyde(MAD), lipid peroxide(LPO) and hydroxyl radicals(OH) in the observation group were lower than those in the control group, while the levels of superoxide dismutase(SOD), mean carotid artery blood ?ow velocity(Vmean), minimum blood ?ow velocity(Vmin), mean blood ?ow(Qmean) and minimum blood ?ow(Qmin) in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion:Edaravone can effectively improve the level of oxygen free radicals in the patients with acute cerebral edema after craniocerebral injury, improve cerebral hemodynamics and bene?t their prognosis.
引文
[1]严明科,姚敏学,贡伟一.围术期应用依达拉奉对重型颅脑外伤患者临床疗效及血清NSE、MBP、GFAP水平的影响[J].贵州医药,2017,41(8):826-828.
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[3]王涛,贺中正,朱莽,等.依达拉奉对重型颅脑损伤患者急性期脑水肿及神经功能的影响[J].陕西医学杂志,201746(1):34-36.
[4]邹世斌,张诚.依达拉奉联合脑苷肌肽辅助治疗对重症颅脑损伤患者神经功能损伤程度的影响[J].海南医学院学报,2018,24(5):640-642,646.
[5]孙立谦.复方丹参注射液联合依达拉奉治疗颅脑损伤合并脑水肿41例[J].陕西中医,2014,35(6):660-661.
[6]季志刚,王颖建,周雪东.依达拉奉对颅脑损伤手术患者氧自由基清除能力及脑血流参数的影响[J].西部医学2018,30(6):835-838.
[7]徐猛,赵莘瑜.依达拉奉注射液联合尼莫地平缓释片对高血压脑出血患者脑血肿体积及NIHSS评分的影响[J].中国合理用药探索,2018,15(9):54-56.
[8]朱帅科,赵志强.依达拉奉联合亚低温治疗重型颅脑创伤的疗效及对血清TNF-α、IL-6及神经功能的影响[J].中国合理用药探索,2017,14(7):51-54.
[2]刘朝元.依达拉奉联合亚低温对重型颅脑损伤患者氧化应激水平和神经功能恢复的影响[J].中国药业,201726(17):46-48.
[3]王涛,贺中正,朱莽,等.依达拉奉对重型颅脑损伤患者急性期脑水肿及神经功能的影响[J].陕西医学杂志,201746(1):34-36.
[4]邹世斌,张诚.依达拉奉联合脑苷肌肽辅助治疗对重症颅脑损伤患者神经功能损伤程度的影响[J].海南医学院学报,2018,24(5):640-642,646.
[5]孙立谦.复方丹参注射液联合依达拉奉治疗颅脑损伤合并脑水肿41例[J].陕西中医,2014,35(6):660-661.
[6]季志刚,王颖建,周雪东.依达拉奉对颅脑损伤手术患者氧自由基清除能力及脑血流参数的影响[J].西部医学2018,30(6):835-838.
[7]徐猛,赵莘瑜.依达拉奉注射液联合尼莫地平缓释片对高血压脑出血患者脑血肿体积及NIHSS评分的影响[J].中国合理用药探索,2018,15(9):54-56.
[8]朱帅科,赵志强.依达拉奉联合亚低温治疗重型颅脑创伤的疗效及对血清TNF-α、IL-6及神经功能的影响[J].中国合理用药探索,2017,14(7):51-54.