LncRNA ATB表达水平与肿瘤患者预后关系Meta分析
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摘要
目的近期研究显示,非编码RNA与肿瘤发生、发展密切相关,可作为预测患者预后的标志物,因此,本研究系统评估长链非编码RNA-ATB(long non-coding RNA-ATB,LncRNA ATB)表达水平与肿瘤患者预后的关系。方法通过计算机全面检索PubMed、Web of science、Embase、The Cochrane Library、Medline、OVID、知网、万方和维普等数据库中,公开发表的关于LncRNA ATB表达与肿瘤患者预后的相关文献,检索截止时间为2018-09,提取相关数据后经Stata12.0软件进行Meta分析。结果最终纳入12篇研究,共1 438例肿瘤患者。Meta分析结果显示,高表达LncRNAATB与肿瘤患者低总生存期相关,HR=1.88,95%CI为1.28～2.76,P=0.001;与低无病生存期(HR=2.20,95%CI为1.18～4.10,P=0.013)及无复发生存期(HR=3.16,95%CI为1.98～5.04,P<0.001)相关。另外高表达LncRNAATB患者具有更高的淋巴结转移可能性(OR=2.19,95%CI为1.02～4.68,P=0.044)及更晚的分期,OR=2.31,95%CI为1.52～3.51,P<0.001。虽然Meta分析的结果存在统计学异质性,I2=83.3%,P<0.001;但是敏感性分析显示,Meta分析的结果是稳定的。结论 LncRNA ATB高表达与肿瘤患者预后不良相关,有可能作为判断肿瘤患者预后的潜在生物标志物。
OBJECTIVE Recent studies have shown that non-coding RNA which is closely related to tumorigenesis and development can be used as a predictor of prognosis.Therefore,this study systematically evaluated the relationship between the expression of long non-coding RNA-ATB and the prognosis of tumor.METHODS Acquiring relative studies about the relationship between the expression of LncRNA ATB and the prognosis of patients with cancer by searching Pubmed,Web of science,Embase,The Cochrane Library,Medline,OVID,CNKI,Wanfang,and Weipu database.The publication time was before September 2018.We analyzed the relevant data which extracted from relative studies by Stata12.0 software.RESULTS A total of 1 438 tumor patients were included in 12 studies.Meta-analysis showed that high expression of LncRNA ATB was associated with low overall survival in patients with cancer(HR=1.88,95%CI:1.28-2.76,P=0.001),with low disease-free survival(HR=2.20,95%CI:1.18-4.10,P=0.013)and recurrence-free survival(HR=3.16,95%CI:1.98-5.04,P<0.001);patients with high expression of LncRNA ATB had higher potential of lymph node metastasis(OR=2.19,95%CI:1.02-4.68,P=0.044)and advanced stage(OR=2.31,95%CI:1.52-3.51,P<0.001).Although the results of the meta-analysis have statistically heterogeneous(I2=83.3%,P<0.001),sensitivity analysis showed that the results of the meta-analysis were stable.CONCLUSION The high expression of LncRNA ATB is associated with poor prognosis in patients with cancer,which means that LncRNA ATB may be a potential biomarker to judge the prognosis of cancer patients.
OBJECTIVE Recent studies have shown that non-coding RNA which is closely related to tumorigenesis and development can be used as a predictor of prognosis.Therefore,this study systematically evaluated the relationship between the expression of long non-coding RNA-ATB and the prognosis of tumor.METHODS Acquiring relative studies about the relationship between the expression of LncRNA ATB and the prognosis of patients with cancer by searching Pubmed,Web of science,Embase,The Cochrane Library,Medline,OVID,CNKI,Wanfang,and Weipu database.The publication time was before September 2018.We analyzed the relevant data which extracted from relative studies by Stata12.0 software.RESULTS A total of 1 438 tumor patients were included in 12 studies.Meta-analysis showed that high expression of LncRNA ATB was associated with low overall survival in patients with cancer(HR=1.88,95%CI:1.28-2.76,P=0.001),with low disease-free survival(HR=2.20,95%CI:1.18-4.10,P=0.013)and recurrence-free survival(HR=3.16,95%CI:1.98-5.04,P<0.001);patients with high expression of LncRNA ATB had higher potential of lymph node metastasis(OR=2.19,95%CI:1.02-4.68,P=0.044)and advanced stage(OR=2.31,95%CI:1.52-3.51,P<0.001).Although the results of the meta-analysis have statistically heterogeneous(I2=83.3%,P<0.001),sensitivity analysis showed that the results of the meta-analysis were stable.CONCLUSION The high expression of LncRNA ATB is associated with poor prognosis in patients with cancer,which means that LncRNA ATB may be a potential biomarker to judge the prognosis of cancer patients.
引文
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[15]Fu XM,Guo W,Li N,et al.The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer[J].Eur Rev Med Pharmacol Sci,2017,21(14):3239-3246.
[16]Han F,Wang C,Wang Y,et al.Long noncoding RNA ATB promotes osteosarcoma cell proliferation,migration and invasion by suppressing miR-200s[J].Am J Cancer Res,2017,7(4):770-783.
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[18]Saito T,Kurashige J,Nambara S,et al.A long non-coding RNAactivated by transforming growth factor-beta is an independent prognostic marker of gastric cancer[J].Ann Surg Oncol,2015,22(Suppl 3):S915-922.
[19]Yue B,Qiu S,Zhao S,et al.LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis[J].J Gastroenterol Hepatol,2016,31(3):595-603.
[20]Qu S,Yang X,Song W,et al.Downregulation of lncRNA-ATBcorrelates with clinical progression and unfavorable prognosis in pancreatic cancer[J].Tumour Biol,2016,37(3):3933-3938.
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[23]Li Z,Wu X,Gu L,et al.Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2axis[J/CD].Cell Death Dis,2017,8(6):e2888.
[24]Jang SY,Kim G,Park SY,et al.Clinical significance of lncRNA-ATB expression in human hepatocellular carcinoma[J].Oncotarget,2017,8(45):78588-78597.
[25]Qi JJ,Liu YX,Lin L.High expression of long non-coding RNA ATB is associated with poor prognosis in patients with renal cell carcinoma[J].Eur Rev Med Pharmacol Sci,2017,21(12):2835-2839.
[26]姜峰,范庆,魏士博,等.lncRNA-ATB在人肝癌组织中的表达及意义[J].现代肿瘤医学,2017,25(14):2269-2272.
[27]Cao W,Peng T,Zhou Y.Long noncoding RNA activated by transforming growth factor-beta promotes cancer development and is a prognostic marker in cervical cancer[J].J Cancer Res Ther,2017,13(5):801-806.
[28]Xu S,Yi XM,Tang CP,et al.Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma[J].Oncol Rep,2016,36(1):10-22.
[29]Arun G,Diermeier S,Akerman M,et al.Differentiation of mammary tumors and reduction in metastasis upon Malat1lncRNAloss[J].Genes Dev,2016,30(1):34-51.
[30]White NM,Zhao SG,Zhang J,et al.Multi-institutional analysis shows that low PCAT-14expression associates with poor outcomes in prostate cancer[J].Eur Urol,2017,71(2):257-266.
[31]Fan Y,Wang YF,Su HF,et al.Decreased expression of the long noncoding RNA LINC00261indicate poor prognosis in gastric cancer and suppress gastric cancer metastasis by affecting the epithelial-mesenchymal transition[J].J Hematol Oncol,2016,9(1):57.
[32]Shi SJ,Wang LJ,Yu B,et al.LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer[J].Oncotarget,2015,6(13):11652-11663.
[33]Xiong J,Liu Y,Jiang L,et al.High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma[J].Jpn J Clin Oncol,2016,46(4):378-384.
[34]Ma CC,Xiong Z,Zhu GN,et al.Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a[J].J Exp Clin Cancer Res,2016,35(1):90.
[35]Zhai X,Xu W.Long noncoding RNA ATB promotes proliferation,migration and invasion in bladder cancer by suppressing microRNA-126[J].Oncol Res,2018,26(7):1063-1072.
[36]Chen Y,Wei G,Xia H,et al.Long noncoding RNAATB promotes cell proliferation,migration and invasion in gastric cancer[J].Mol Med Rep,2018,17(1):1940-1946.
[2]Allemani C,Weir HK,Carreira H,et al.Global surveillance of cancer survival 1995-2009:analysis of individual data for 25,676,887patients from 279population-based registries in 67countries(CON-CORD-2)[J].Lancet,2015,385(9972):977-1010.
[3]Djebali S,Davis CA,Merkel A,et al.Landscape of transcription in human cells[J].Nature,2012,489(7414):101-108.
[4]Ponting CP,Oliver PL,Reik W.Evolution and functions of long noncoding RNAs[J].Cell,2009,136(4):629-641.
[5]胡洪林,杨兰,邓颖,等.非小细胞肺癌组织LncRNA RP11-164P12.4表达及其临床意义[J].中华肿瘤防治杂志,2017,24(16):1148-1152.
[6]柴松,牛韧,江中太,等.LncRNA AFAP1-AS1对食管鳞癌细胞株EC9706转移潜能影响机制探讨[J].中华肿瘤防治杂志,2016,23(18):1218-1223.
[7]Wapinski O,Chang HY.Long noncoding RNAs and human disease[J].Trends Cell Biol,2011,21(6):354-361.
[8]Shi X,Sun M,Liu H,et al.Long non-coding RNAs:a new frontier in the study of human diseases[J].Cancer Lett,2013,339(2):159-166.
[9]Xia H,Chen Q,Chen Y,et al.The lncRNA MALAT1is a novel biomarker for gastric cancer metastasis[J].Oncotarget,2016,7(35):56209-56218.
[10]Li Y,Wan YP,Bai Y.Correlation between long strand non-coding RNA GASS expression and prognosis of cervical cancer patients[J].Eur Rev Med Pharmacol Sci,2018,22(4):943-949.
[11]Serghiou S,Kyriakopoulou A,Ioannidis JPA.Long noncoding RNAs as novel predictors of survival in human cancer:a systematic review and meta-analysis[J].Molecular Cancer,2016,15(1):1-14.
[12]席文娜,宋伟.LncRNA HOTAIR表达水平与肿瘤患者预后关系的Meta分析[J].中南大学学报:医学版,2016,41(12):1352-1357.
[13]Yuan JH,Yang F,Wang F,et al.A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma[J].Cancer Cell,2014,25(5):666-681.
[14]Iguchi T,Uchi R,Nambara S,et al.A long noncoding RNA,lncRNA-ATB,is involved in the progression and prognosis of colorectal cancer[J].Anticancer Res,2015,35(3):1385-1388.
[15]Fu XM,Guo W,Li N,et al.The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer[J].Eur Rev Med Pharmacol Sci,2017,21(14):3239-3246.
[16]Han F,Wang C,Wang Y,et al.Long noncoding RNA ATB promotes osteosarcoma cell proliferation,migration and invasion by suppressing miR-200s[J].Am J Cancer Res,2017,7(4):770-783.
[17]Ke L,Xu SB,Wang J,et al.High expression of long non-coding RNA ATB indicates a poor prognosis and regulates cell proliferation and metastasis in non-small cell lung cancer[J].Clin Transl Oncol,2017,19(5):599-605.
[18]Saito T,Kurashige J,Nambara S,et al.A long non-coding RNAactivated by transforming growth factor-beta is an independent prognostic marker of gastric cancer[J].Ann Surg Oncol,2015,22(Suppl 3):S915-922.
[19]Yue B,Qiu S,Zhao S,et al.LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis[J].J Gastroenterol Hepatol,2016,31(3):595-603.
[20]Qu S,Yang X,Song W,et al.Downregulation of lncRNA-ATBcorrelates with clinical progression and unfavorable prognosis in pancreatic cancer[J].Tumour Biol,2016,37(3):3933-3938.
[21]Tierney JF,Stewart LA,Ghersi D,et al.Practical methods for incorporating summary time-to-event data into meta-analysis[J].Trials,2007,8:16.
[22]Stang A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol,2010,25(9):603-605.
[23]Li Z,Wu X,Gu L,et al.Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2axis[J/CD].Cell Death Dis,2017,8(6):e2888.
[24]Jang SY,Kim G,Park SY,et al.Clinical significance of lncRNA-ATB expression in human hepatocellular carcinoma[J].Oncotarget,2017,8(45):78588-78597.
[25]Qi JJ,Liu YX,Lin L.High expression of long non-coding RNA ATB is associated with poor prognosis in patients with renal cell carcinoma[J].Eur Rev Med Pharmacol Sci,2017,21(12):2835-2839.
[26]姜峰,范庆,魏士博,等.lncRNA-ATB在人肝癌组织中的表达及意义[J].现代肿瘤医学,2017,25(14):2269-2272.
[27]Cao W,Peng T,Zhou Y.Long noncoding RNA activated by transforming growth factor-beta promotes cancer development and is a prognostic marker in cervical cancer[J].J Cancer Res Ther,2017,13(5):801-806.
[28]Xu S,Yi XM,Tang CP,et al.Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma[J].Oncol Rep,2016,36(1):10-22.
[29]Arun G,Diermeier S,Akerman M,et al.Differentiation of mammary tumors and reduction in metastasis upon Malat1lncRNAloss[J].Genes Dev,2016,30(1):34-51.
[30]White NM,Zhao SG,Zhang J,et al.Multi-institutional analysis shows that low PCAT-14expression associates with poor outcomes in prostate cancer[J].Eur Urol,2017,71(2):257-266.
[31]Fan Y,Wang YF,Su HF,et al.Decreased expression of the long noncoding RNA LINC00261indicate poor prognosis in gastric cancer and suppress gastric cancer metastasis by affecting the epithelial-mesenchymal transition[J].J Hematol Oncol,2016,9(1):57.
[32]Shi SJ,Wang LJ,Yu B,et al.LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer[J].Oncotarget,2015,6(13):11652-11663.
[33]Xiong J,Liu Y,Jiang L,et al.High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma[J].Jpn J Clin Oncol,2016,46(4):378-384.
[34]Ma CC,Xiong Z,Zhu GN,et al.Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a[J].J Exp Clin Cancer Res,2016,35(1):90.
[35]Zhai X,Xu W.Long noncoding RNA ATB promotes proliferation,migration and invasion in bladder cancer by suppressing microRNA-126[J].Oncol Res,2018,26(7):1063-1072.
[36]Chen Y,Wei G,Xia H,et al.Long noncoding RNAATB promotes cell proliferation,migration and invasion in gastric cancer[J].Mol Med Rep,2018,17(1):1940-1946.