Rab25在肿瘤转移中的研究进展
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摘要
转移是影响肿瘤患者生存和死亡的主要原因,近年来研究发现,Rab25与肿瘤侵袭转移密切相关。Rab25在肿瘤转移中具有双重特性,可作为致癌基因或抑癌基因,在大多数肿瘤类型中,Rab25作为致癌基因,仅在少数肿瘤中,Rab25表现出肿瘤抑制功能,然而Rab25双重作用机制及信号通路尚不明确。文章主要就Rab25在肿瘤转移中作用的相关研究进行综述。
Metastasis is the main reason that affects the survival and death of cancer patients. In recent years,it has been found that Rab25 is closely related to tumor invasion and metastasis. Rab25 has dual role in tumor metastasis,which can be used as oncogene or tumor suppressor gene. In most tumor types,Rab25 is an oncogene,and only in a few tumors,Rab25 shows tumor suppressor function. However,the dual action mechanism and signal pathway of Rab25 are not very clear. This article summarizes the related research on the role of Rab25 in tumor metastasis.
Metastasis is the main reason that affects the survival and death of cancer patients. In recent years,it has been found that Rab25 is closely related to tumor invasion and metastasis. Rab25 has dual role in tumor metastasis,which can be used as oncogene or tumor suppressor gene. In most tumor types,Rab25 is an oncogene,and only in a few tumors,Rab25 shows tumor suppressor function. However,the dual action mechanism and signal pathway of Rab25 are not very clear. This article summarizes the related research on the role of Rab25 in tumor metastasis.
引文
[1]Siegel RL,Miller KD,Jemal A.Cancer statistics,2018[J].CACancer J Clin,2018,68(1):7-30.
[2]朱沙.互联网时代肿瘤学研究生的培养模式思考[J].医学研究生学报,2018,31(5):449-452.
[3]程正武,王子康,何宋兵.Rab1A与肿瘤发生发展的研究进展[J].医学研究生学报,2018,31(1):73-76.
[4]Goldenring JR.A central role for vesicle trafficking in epithelial neoplasia:intracellular highways to carcinogenesis[J].Nat Rev Cancer,2013,13(11):813-820.
[5]Zanotti S,Gibertini S,Bragato C,et al.Fibroblasts from the muscles of Duchenne muscular dystrophy patients are resistant to cell detachment apoptosis[J].Exp Cell Res,2011,317(17):2536-2547.
[6]Wells A,Grahovac J,Wheeler S,et al.Targeting tumor cell motility as a strategy against invasion and metastasis[J].Trends Pharmacol Sci,2013,34(5):283-289.
[7]Alizadeh AM,Shiri S,Farsinejad S.Metastasis review:from bench to bedside[J].Tumour Biol,2014,35(9):8483-8523.
[8]Grzelczyk WL,Szemraj J,Jozefowicz-Korczynska M.The matrix metalloproteinase in larynx cancer[J].Postepy Hig Med Dosw(Online),2016,70:1190-1197.
[9]Hu YY,Zheng MH,Zhang R,et al.Notch signaling pathway and cancer metastasis[J].Adv Exp Med Biol,2012,727:186-198.
[10]Daenen LG,Roodhart JM,van Amersfoort M,et al.Chemotherapy enhances metastasis formation via VEGFR-1-expressing endothelial cells[J].Cancer Res,2011,71(22):6976-6985.
[11]伊日贵,徐晓艳,李时荣.肿瘤侵袭转移机制研究进展[J].中华实用诊断与治疗杂志,2014(10):937-939.
[12]Cernochova R,Nekulova M,Holcakova J.Rab Proteins,Intracellular Transport and Cancer[J].Klin Onkol Fall,2016,29(Suppl 4):31-39.
[13]Bhuin T,Roy JK.Rab proteins:the key regulators of intracellular vesicle transport[J].Exp Cell Res,2014,328(1):1-19.
[14]Cherfils J,Zeghouf M.Regulation of small GTPases by GEFs,GAPs,and GDIs[J].Physiol Rev,2013,93(1):269-309.
[15]Zhen Y,Stenmark H.Cellular functions of Rab GTPases at a glance[J].J Cell Sci,2015,128(17):3171-3176.
[16]Dozynkiewicz MA,Jamieson NB,Macpherson I,et al.Rab25and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression[J].Dev Cell,2012,22(1):131-145.
[17]Wang S,Hu C,Wu F,et al.Rab25 GTPase:Functional roles in cancer[J].Oncotarget,2017,8(38):64591-64599.
[18]Fan Y,Wang L,Han X,et al.Rab25 is responsible for phosphoinositide 3-kinase/AKT mediated cisplatin resistance in human epithelial ovarian cancer cells[J].Mol Med Rep,2015,11(3):2173-2178.
[19]Marchand M,Horcajadas JA,Esteban FJ,et al.Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model[J].Biol Reprod,2011,84(6):1258-1271.
[20]Feng ZH,Fang Y,Zhao LY,et al.RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25[J].Cancer Sci,2017,108(8):1620-1627.
[21]Gankhuyag N,Yu KN,Davaadamdin O,et al.Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice[J].JAerosol Med Pulm Drug Deliv,2017,30(2):81-90.
[22]Zhang J,Wei J,Lu J,et al.Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelialmesenchymal transition and activation of Akt/GSK-3beta/Snail signaling[J].Carcinogenesis,2013,34(10):2401-2408.
[23]Geng D,Zhao W,Feng Y,et al.Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion[J].Tumour Biol,2016,37(6):7713-7718.
[24]Ding B,Cui B,Gao M,et al.Knockdown of Ras-Related Protein 25(Rab25)Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells[J].Oncol Res,2017,25(3):331-340.
[25]Jeong BY,Cho KH,Jeong KJ,et al.Rab25 augments cancer cell invasiveness through a beta1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin[J].Exp Mol Med,2018,50(1):e435.
[26]周洁,陈萱,陈钰,等.三阴性乳腺癌的治疗现状及进展[J].医学研究生学报,2018,31(8):853-858.
[27]吴非.人乳腺癌细胞Rab25基因的生物学行为及其与ER,PR,Her-2/neu的相关性研究[D].广西医科大学,2008.
[28]Yin YX,Shen F,Pei H,et al.Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis[J].Tumour Biol,2012,33(5):1581-1587.
[29]Mitra S,Federico L,Zhao W,et al.Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT[J].Oncotarget,2016,7(26):40252-40265.
[30]Ma YF,Yang B,Li J,et al.Expression of Ras-related protein25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer[J].Genet Mol Res,2015,14(4):13998-14008.
[31]Watanabe T,Miura T,Degawa Y,et al.Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR[J].Cancer Cell Int,2010,10:2.
[32]Cao C,Lu C,Xu J,et al.Expression of Rab25 correlates with the invasion and metastasis of gastric cancer[J].Chin J Cancer Res,2013,25(2):192-199.
[33]Li Y,Jia Q,Zhang Q,et al.Rab25 upregulation correlates with the proliferation,migration,and invasion of renal cell carcinoma[J].Biochem Biophys Res Commun,2015,458(4):745-750.
[34]Liu L,Ding G.Rab25 expression predicts poor prognosis in clear cell renal cell carcinoma[J].Exp Ther Med,2014,8(4):1055-1058.
[35]Hu C,Chen B,Zhou Y,et al.High expression of Rab25 contributes to malignant phenotypes and biochemical recurrence in patients with prostate cancer after radical prostatectomy[J].Cancer Cell Int,2017,17:45.
[36]Kessler D,Gruen GC,Heider D,et al.The action of small GT-Pases Rab11 and Rab25 in vesicle trafficking during cell migration[J].Cell Physiol Biochem,2012,29(5-6):647-656.
[37]龚年东,柯昌兴.膀胱癌淋巴结转移评估的生物学研究进展[J].医学研究生学报,2018,31(10):1105-1109.
[38]Zhang J,Wei J,Lu J,et al.Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelialmesenchymal transition and activation of Akt/GSK-3β/Snail signaling[J].Carcinogenesis,2013,34(10):2401-2408.
[39]Fan Y,Xin XY,Chen BL,et al.Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo[J].Pathology,2006,38(6):561-567.
[40]Cheng KW,Lahad JP,Gray JW,et al.Emerging role of RABGTPases in cancer and human disease[J].Cancer Res,2005,65(7):2516-2519.
[41]Cheng KW,Lahad JP,Kuo WL,et al.The RAB25 small GT-Pase determines aggressiveness of ovarian and breast cancers[J].Nat Med,2004,10(11):1251-1256.
[42]Tellez-Gabriel M,Arroyo-Solera I,Leon X,et al.High RAB25expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma[J].Cancer Med,2013,2(6):950-963.
[43]Amornphimoltham P,Rechache K,Thompson J,et al.Rab25regulates invasion and metastasis in head and neck cancer[J].Clin Cancer Res,2013,19(6):1375-1388.
[44]Tong M,Chan KW,Bao JY,et al.Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma[J].Cancer Res,2012,72(22):6024-6035.
[45]Cheng JM,Volk L,Janaki DK,et al.Tumor suppressor function of Rab25 in triple-negative breast cancer[J].Int J Cancer,2010,126(12):2799-2812.
[46]Bhat AA,Pope JL,Smith JJ,et al.Claudin-7 expression induces mesenchymal to epithelial transformation(MET)to inhibit colon tumorigenesis[J].Oncogene,2015,34(35):4570-4580.
[47]Goldenring JR,Nam KT.Rab25 as a tumour suppressor in colon carcinogenesis[J].Br J Cancer,2011,104(1):33-36.
[48]Zhao M,Yin YX,Guo F,et al.Increased Rab25 expression is not correlated with peritoneal metastasis of ovarian cancers[J].Cancer Invest,2012,30(9):683-687.
[2]朱沙.互联网时代肿瘤学研究生的培养模式思考[J].医学研究生学报,2018,31(5):449-452.
[3]程正武,王子康,何宋兵.Rab1A与肿瘤发生发展的研究进展[J].医学研究生学报,2018,31(1):73-76.
[4]Goldenring JR.A central role for vesicle trafficking in epithelial neoplasia:intracellular highways to carcinogenesis[J].Nat Rev Cancer,2013,13(11):813-820.
[5]Zanotti S,Gibertini S,Bragato C,et al.Fibroblasts from the muscles of Duchenne muscular dystrophy patients are resistant to cell detachment apoptosis[J].Exp Cell Res,2011,317(17):2536-2547.
[6]Wells A,Grahovac J,Wheeler S,et al.Targeting tumor cell motility as a strategy against invasion and metastasis[J].Trends Pharmacol Sci,2013,34(5):283-289.
[7]Alizadeh AM,Shiri S,Farsinejad S.Metastasis review:from bench to bedside[J].Tumour Biol,2014,35(9):8483-8523.
[8]Grzelczyk WL,Szemraj J,Jozefowicz-Korczynska M.The matrix metalloproteinase in larynx cancer[J].Postepy Hig Med Dosw(Online),2016,70:1190-1197.
[9]Hu YY,Zheng MH,Zhang R,et al.Notch signaling pathway and cancer metastasis[J].Adv Exp Med Biol,2012,727:186-198.
[10]Daenen LG,Roodhart JM,van Amersfoort M,et al.Chemotherapy enhances metastasis formation via VEGFR-1-expressing endothelial cells[J].Cancer Res,2011,71(22):6976-6985.
[11]伊日贵,徐晓艳,李时荣.肿瘤侵袭转移机制研究进展[J].中华实用诊断与治疗杂志,2014(10):937-939.
[12]Cernochova R,Nekulova M,Holcakova J.Rab Proteins,Intracellular Transport and Cancer[J].Klin Onkol Fall,2016,29(Suppl 4):31-39.
[13]Bhuin T,Roy JK.Rab proteins:the key regulators of intracellular vesicle transport[J].Exp Cell Res,2014,328(1):1-19.
[14]Cherfils J,Zeghouf M.Regulation of small GTPases by GEFs,GAPs,and GDIs[J].Physiol Rev,2013,93(1):269-309.
[15]Zhen Y,Stenmark H.Cellular functions of Rab GTPases at a glance[J].J Cell Sci,2015,128(17):3171-3176.
[16]Dozynkiewicz MA,Jamieson NB,Macpherson I,et al.Rab25and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression[J].Dev Cell,2012,22(1):131-145.
[17]Wang S,Hu C,Wu F,et al.Rab25 GTPase:Functional roles in cancer[J].Oncotarget,2017,8(38):64591-64599.
[18]Fan Y,Wang L,Han X,et al.Rab25 is responsible for phosphoinositide 3-kinase/AKT mediated cisplatin resistance in human epithelial ovarian cancer cells[J].Mol Med Rep,2015,11(3):2173-2178.
[19]Marchand M,Horcajadas JA,Esteban FJ,et al.Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model[J].Biol Reprod,2011,84(6):1258-1271.
[20]Feng ZH,Fang Y,Zhao LY,et al.RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25[J].Cancer Sci,2017,108(8):1620-1627.
[21]Gankhuyag N,Yu KN,Davaadamdin O,et al.Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice[J].JAerosol Med Pulm Drug Deliv,2017,30(2):81-90.
[22]Zhang J,Wei J,Lu J,et al.Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelialmesenchymal transition and activation of Akt/GSK-3beta/Snail signaling[J].Carcinogenesis,2013,34(10):2401-2408.
[23]Geng D,Zhao W,Feng Y,et al.Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion[J].Tumour Biol,2016,37(6):7713-7718.
[24]Ding B,Cui B,Gao M,et al.Knockdown of Ras-Related Protein 25(Rab25)Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells[J].Oncol Res,2017,25(3):331-340.
[25]Jeong BY,Cho KH,Jeong KJ,et al.Rab25 augments cancer cell invasiveness through a beta1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin[J].Exp Mol Med,2018,50(1):e435.
[26]周洁,陈萱,陈钰,等.三阴性乳腺癌的治疗现状及进展[J].医学研究生学报,2018,31(8):853-858.
[27]吴非.人乳腺癌细胞Rab25基因的生物学行为及其与ER,PR,Her-2/neu的相关性研究[D].广西医科大学,2008.
[28]Yin YX,Shen F,Pei H,et al.Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis[J].Tumour Biol,2012,33(5):1581-1587.
[29]Mitra S,Federico L,Zhao W,et al.Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT[J].Oncotarget,2016,7(26):40252-40265.
[30]Ma YF,Yang B,Li J,et al.Expression of Ras-related protein25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer[J].Genet Mol Res,2015,14(4):13998-14008.
[31]Watanabe T,Miura T,Degawa Y,et al.Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR[J].Cancer Cell Int,2010,10:2.
[32]Cao C,Lu C,Xu J,et al.Expression of Rab25 correlates with the invasion and metastasis of gastric cancer[J].Chin J Cancer Res,2013,25(2):192-199.
[33]Li Y,Jia Q,Zhang Q,et al.Rab25 upregulation correlates with the proliferation,migration,and invasion of renal cell carcinoma[J].Biochem Biophys Res Commun,2015,458(4):745-750.
[34]Liu L,Ding G.Rab25 expression predicts poor prognosis in clear cell renal cell carcinoma[J].Exp Ther Med,2014,8(4):1055-1058.
[35]Hu C,Chen B,Zhou Y,et al.High expression of Rab25 contributes to malignant phenotypes and biochemical recurrence in patients with prostate cancer after radical prostatectomy[J].Cancer Cell Int,2017,17:45.
[36]Kessler D,Gruen GC,Heider D,et al.The action of small GT-Pases Rab11 and Rab25 in vesicle trafficking during cell migration[J].Cell Physiol Biochem,2012,29(5-6):647-656.
[37]龚年东,柯昌兴.膀胱癌淋巴结转移评估的生物学研究进展[J].医学研究生学报,2018,31(10):1105-1109.
[38]Zhang J,Wei J,Lu J,et al.Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelialmesenchymal transition and activation of Akt/GSK-3β/Snail signaling[J].Carcinogenesis,2013,34(10):2401-2408.
[39]Fan Y,Xin XY,Chen BL,et al.Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo[J].Pathology,2006,38(6):561-567.
[40]Cheng KW,Lahad JP,Gray JW,et al.Emerging role of RABGTPases in cancer and human disease[J].Cancer Res,2005,65(7):2516-2519.
[41]Cheng KW,Lahad JP,Kuo WL,et al.The RAB25 small GT-Pase determines aggressiveness of ovarian and breast cancers[J].Nat Med,2004,10(11):1251-1256.
[42]Tellez-Gabriel M,Arroyo-Solera I,Leon X,et al.High RAB25expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma[J].Cancer Med,2013,2(6):950-963.
[43]Amornphimoltham P,Rechache K,Thompson J,et al.Rab25regulates invasion and metastasis in head and neck cancer[J].Clin Cancer Res,2013,19(6):1375-1388.
[44]Tong M,Chan KW,Bao JY,et al.Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma[J].Cancer Res,2012,72(22):6024-6035.
[45]Cheng JM,Volk L,Janaki DK,et al.Tumor suppressor function of Rab25 in triple-negative breast cancer[J].Int J Cancer,2010,126(12):2799-2812.
[46]Bhat AA,Pope JL,Smith JJ,et al.Claudin-7 expression induces mesenchymal to epithelial transformation(MET)to inhibit colon tumorigenesis[J].Oncogene,2015,34(35):4570-4580.
[47]Goldenring JR,Nam KT.Rab25 as a tumour suppressor in colon carcinogenesis[J].Br J Cancer,2011,104(1):33-36.
[48]Zhao M,Yin YX,Guo F,et al.Increased Rab25 expression is not correlated with peritoneal metastasis of ovarian cancers[J].Cancer Invest,2012,30(9):683-687.