血栓烷A_2在临床中的应用进展
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摘要
血栓烷A_2是花生四烯酸代谢过程中的重要产物,主要由活化的血小板释放。TXA_2主要具有两大活性:一是有强烈的血小板聚集作用,能促使血小板聚集形成血栓;二是可使血管、支气管和平滑肌收缩,对血管张力具有调节作用。TXA_2与心血管及相关疾病的发生有密切的关系,并越来越受到重视,现就近年来TXA_2在临床中的应用作一综述。
Thrombane A_2 is an important product in the metabolism of arachidonic acid, which is mainly released by activated platelets. TXA_2 mainly has two acitivities: one is that there is strong platelet aggregation, which causes platelet aggregation to form thrombus. The second is to make the blood vessels, bronchus and smooth muscle contract, which can regulate the angiotasis. TXA_2 is closely related to the occurrence of cardioascular and related diseases, and has been paid more and more attention, This article will be revising the clinical application of TXA_2 of late years.
Thrombane A_2 is an important product in the metabolism of arachidonic acid, which is mainly released by activated platelets. TXA_2 mainly has two acitivities: one is that there is strong platelet aggregation, which causes platelet aggregation to form thrombus. The second is to make the blood vessels, bronchus and smooth muscle contract, which can regulate the angiotasis. TXA_2 is closely related to the occurrence of cardioascular and related diseases, and has been paid more and more attention, This article will be revising the clinical application of TXA_2 of late years.
引文
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[12]郭玲,王金华,黄振.不同剂量葛根素对2型糖尿病患者血栓前状态分子标志物的影响分析[J].中国处方药,2015,13(11):12-13.
[13]王赞鑫.个体炎症反应、凝血功能状态与冠心病外科治疗预后关系的临床研究[D].天津医科大学,2014.
[14]陈卫.动脉粥样硬化高危人群中阿司匹林抵抗调查[J].中国误诊学杂志,2011,11(9):2268.
[15]张连英,傅珂,何英杰,等.妊娠期高血压患者血管内皮细胞功能和氧化应激水平的变化[J].疑难病杂志,2014,13(8):852-854.
[16]胡赛,黄艳,吴小宁.自拟热哮宁汤对支气管哮喘急性发作期患者血清TXB2和6-ket-PGF-1α水平的影响[J].现代医药卫生,2015,31(10):1448-1449,1452.
[17]王武明,陈家玲.恶性淋巴瘤外周血TXB2、PAgT和FIB检测的临床意义[J].临床肿瘤学杂志,2010,15(12):1116-1118.
[18]田燕,谭兰,郁金泰.血浆血栓烷B2水平与血管性痴呆的相关性研究[J].青岛大学医学院学报,2010,46(1):65-66,69.
[2]杨文,于欣,杨震,等.心绞痛患者PAF、GMP140和TXB2检测的临床意义[J].宁夏医科大学学报,2012,34(9):884-886.
[3]王峥,高枫,郝洪军,等.急性脑梗死血浆血栓烷B2、氧化型低密度脂蛋白、脂蛋白(a)、同型半胱氨酸相关性分析[J].中国康复理论与实践,2010,16(5):457-459.
[4]袁昌文,谈友芬.川芎茶调散对偏头痛患者血小板功能及血液流变学的影响[J].辽宁中医杂志,2012,39(2):297-298.
[5]曹磊,罗红.小剂量多巴胺联合前列地尔治疗慢性肾功能不全临床研究[J].淮海医药,2012,30(1):31-33.
[6]王辉,董万利,方琪,等.高尿酸症合并高脂血症患者血小板活化功能的研究[J].中风与神经疾病杂志,2014,31(7):633-635.
[7]钟广芝,胡鹏飞.百令胶囊联合环磷酰胺和醋酸泼尼松治疗肾病综合征的临床研究[J].现代药物与临床,2016,33(7):1028-1031.
[8]陈建梅,刘姣,秦翠梅,等.莪术水煎液、配方颗粒及莪术油抗痛经作用的比较研究[J].中药药理与临床,2016,32(4):60-63.
[9]马新骏,张爱华,李小亮,等.血小板活化和内皮细胞损害对系统性红斑狼疮影响的临床研究[J].血栓与止血学,2013,19(1):9-11.
[10]唐念中,陈少萍,王君,等.不同剂量ASA对PCI术后患者血浆TXB2和P选择素水平的影响[J].现代生物医学进展,2014,14(25):4869-4872.
[11]宋昨非,李幕军.子痫前期与正常妊娠血小板相关血栓前状态标志物对比观察[J].人民军医,2013,56(2):191-193.
[12]郭玲,王金华,黄振.不同剂量葛根素对2型糖尿病患者血栓前状态分子标志物的影响分析[J].中国处方药,2015,13(11):12-13.
[13]王赞鑫.个体炎症反应、凝血功能状态与冠心病外科治疗预后关系的临床研究[D].天津医科大学,2014.
[14]陈卫.动脉粥样硬化高危人群中阿司匹林抵抗调查[J].中国误诊学杂志,2011,11(9):2268.
[15]张连英,傅珂,何英杰,等.妊娠期高血压患者血管内皮细胞功能和氧化应激水平的变化[J].疑难病杂志,2014,13(8):852-854.
[16]胡赛,黄艳,吴小宁.自拟热哮宁汤对支气管哮喘急性发作期患者血清TXB2和6-ket-PGF-1α水平的影响[J].现代医药卫生,2015,31(10):1448-1449,1452.
[17]王武明,陈家玲.恶性淋巴瘤外周血TXB2、PAgT和FIB检测的临床意义[J].临床肿瘤学杂志,2010,15(12):1116-1118.
[18]田燕,谭兰,郁金泰.血浆血栓烷B2水平与血管性痴呆的相关性研究[J].青岛大学医学院学报,2010,46(1):65-66,69.