醒脑静联合盐酸纳洛酮治疗脑出血后昏迷患者的疗效分析
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摘要
目的分析醒脑静联合盐酸纳洛酮治疗脑出血后昏迷患者治疗效果。方法选取我院2015年1月～2017年10月中收治脑出血后昏迷患者68例作为研究对象,随机分为参照组和联合组,每组34例。参照组在常规治疗上加盐酸纳洛酮,联合组在参照组的基础上加用醒脑静配合治疗,将两组GCS分值与脑血肿量变化及NIHSS评分情况进行比较。结果治疗后联合组的GCS分值(14.24±2.05)分与脑血肿量(17.41±2.44)ml明显优于参照组的(9.87±1.62)分和(25.50±2.42)ml,差异有统计学意义(P<0.05);联合组在出院后3个月的NIHSS评分情况(10.01±1.95)分优于参照组(12.50±2.31)分,差异有统计学意义(P<0.05)。结论采用醒脑静联合盐酸纳洛酮治疗脑出血后昏迷患者可显著改善脑出血患者的意识障碍,促进神经功能恢复,减轻脑部水肿情况,改善患者临床疗效。
Objective To analyze the therapeutic effect of Xingnaojing combined with naloxone hydrochloride in the treatment of coma patients with cerebral hemorrhage. Methods A total of 68 patients with coma after cerebral hemorrhage were enrolled in our hospital from January 2015 to October2017. They were randomly divided into reference group and combined group, with 34 cases in each group. In the reference group, naloxone hydrochloride was added to the conventional treatment, and the combined group was treated with Xingnaojing on the basis of the reference group. The GCS scores of the two groups were compared with the changes of cerebral hematoma volume and NIHSS score. Results After treatment, the GCS score(14.24±2.05) and cerebral hematoma volume(17.41±2.44) ml were significantly better than the reference group(9.87±1.62) and(25.50±2.42) ml,the difference was statistically significant(P<0.05); The NIHSS score(10.01±1.95) in the combined group was better than the reference group(12.50±2.31) at 3 months after discharge,the difference was statistically significant(P<0.05). Conclusion The treatment of coma after cerebral hemorrhage with Xingnaojing combined with naloxone hydrochloride can significantly improve the disturbance of consciousness in patients with cerebral hemorrhage, promote the recovery of nerve function, reduce the edema of the brain and improve the clinical efficacy of patients.
Objective To analyze the therapeutic effect of Xingnaojing combined with naloxone hydrochloride in the treatment of coma patients with cerebral hemorrhage. Methods A total of 68 patients with coma after cerebral hemorrhage were enrolled in our hospital from January 2015 to October2017. They were randomly divided into reference group and combined group, with 34 cases in each group. In the reference group, naloxone hydrochloride was added to the conventional treatment, and the combined group was treated with Xingnaojing on the basis of the reference group. The GCS scores of the two groups were compared with the changes of cerebral hematoma volume and NIHSS score. Results After treatment, the GCS score(14.24±2.05) and cerebral hematoma volume(17.41±2.44) ml were significantly better than the reference group(9.87±1.62) and(25.50±2.42) ml,the difference was statistically significant(P<0.05); The NIHSS score(10.01±1.95) in the combined group was better than the reference group(12.50±2.31) at 3 months after discharge,the difference was statistically significant(P<0.05). Conclusion The treatment of coma after cerebral hemorrhage with Xingnaojing combined with naloxone hydrochloride can significantly improve the disturbance of consciousness in patients with cerebral hemorrhage, promote the recovery of nerve function, reduce the edema of the brain and improve the clinical efficacy of patients.
引文
[1]傅国萍,鲁国建,董芬.醒脑静与盐酸纳洛酮治疗处于昏迷状态的脑出血患者的临床效果对比[J].中华中医药学刊,2015,33(6):1387-1389.
[2]吕囡囡.醒脑静联合盐酸纳洛酮对急诊内科昏迷患者神经功能、生化指标的影响及临床安全性研究[J].陕西中医,2018,39(6):695-698.
[3]朱沈辉.盐酸纳洛酮联合醒脑静注射液治疗急性酒精中毒的临床疗效及其对血清β-内啡肽、丙二醛水平的影响[J].实用心脑肺血管病杂志,2017,25(10):92-94.
[4]陈爱男,张志明,祝兆林,等.醒脑静联合纳洛酮对脑出血意识障碍患者的促醒作用[J].中国中西医结合急救杂志,2016,23(6):649-650.
[5]黎志迪,魏建功,王士强,等.盐酸纳洛酮联合正中神经电刺激对脑出血昏迷患者脑血流及电生理变化的影响[J].中国临床药理学杂志,2016,32(17):1549-1552.
[2]吕囡囡.醒脑静联合盐酸纳洛酮对急诊内科昏迷患者神经功能、生化指标的影响及临床安全性研究[J].陕西中医,2018,39(6):695-698.
[3]朱沈辉.盐酸纳洛酮联合醒脑静注射液治疗急性酒精中毒的临床疗效及其对血清β-内啡肽、丙二醛水平的影响[J].实用心脑肺血管病杂志,2017,25(10):92-94.
[4]陈爱男,张志明,祝兆林,等.醒脑静联合纳洛酮对脑出血意识障碍患者的促醒作用[J].中国中西医结合急救杂志,2016,23(6):649-650.
[5]黎志迪,魏建功,王士强,等.盐酸纳洛酮联合正中神经电刺激对脑出血昏迷患者脑血流及电生理变化的影响[J].中国临床药理学杂志,2016,32(17):1549-1552.