植物化学物增加肿瘤细胞对化疗药物敏感性的研究进展
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摘要
近年来,癌症的发病率和死亡率一直呈上升趋势,已成为全球范围内严重危害人类健康的公共卫生问题。目前,在肿瘤治疗的三种主要方法中,化学药物治疗占有很重要的地位,极大地提高了癌症患者的生存率。然而,这些药物大多数都有耐药性和毒副作用。为了克服这些缺点,一些天然植物化学物作为化疗增敏剂已被应用到癌症治疗中。这些天然植物化学物不仅能增加肿瘤细胞对化疗药物的敏感性,还可以降低其耐药性和药物的毒副作用。因此,本文对天然植物化学物在化学药物疗法中的增敏作用及其相关机制进行综述。
In recent years,the overall incidence of cancer and mortality have been on an upward trend,cancer becomes a public health problem that seriously endangers human health in the world. Currently,except for radiotherapy and surgery to cancer treatment,chemotherapy plays an important role in greatly improving the survival rate of cancer patients. However,most of chemotherapies have drug-resistance and toxic effects on patients. In order to overcome these shortcomings,some natural phytochemicals have been used as chemosensitizers in chemotherapies. These natural phytochemicals not only increase the sensitivity of tumor cells to therapeutic drugs,but it also reduces their resistance and toxic effects on patients. Therefore,this review summarizes the sensitization of natural phytochemicals to target drug therapies and their possible mechanisms.
In recent years,the overall incidence of cancer and mortality have been on an upward trend,cancer becomes a public health problem that seriously endangers human health in the world. Currently,except for radiotherapy and surgery to cancer treatment,chemotherapy plays an important role in greatly improving the survival rate of cancer patients. However,most of chemotherapies have drug-resistance and toxic effects on patients. In order to overcome these shortcomings,some natural phytochemicals have been used as chemosensitizers in chemotherapies. These natural phytochemicals not only increase the sensitivity of tumor cells to therapeutic drugs,but it also reduces their resistance and toxic effects on patients. Therefore,this review summarizes the sensitization of natural phytochemicals to target drug therapies and their possible mechanisms.
引文
1 Iwamoto T.Clinical application of drug delivery systems in cancer chemotherapy:review of the efficacy and side effects of approved drugs[J].Biol Pharm Bull,2013,36(5):715-718.
2 Kummar S,Chen HX,Wright J,et al.Utilizing targeted cancer therapeutic agents in combination:novel approaches and urgent requirements[J].Nat Rev Drug Discov,2010,9(11):843-856.
3 Liu RH.Potential synergy of phytochemicals in cancer prevention:mechanism of action[J].J Nutr,2004,134(12Suppl):3479-3485.
4 Bolhassani A.Cancer chemoprevention by natural carotenoids as an efficient strategy[J].Anticancer Agents Med Chem,2015,15(8):1026-1031.
5 Pan MH,Ho CT.Chemopreventive effects of natural dietary compounds on cancer development[J].Chem Soc Rev,2008,37(11):2558-2574.
6 Eliassen AH,Liao X,Rosner B,et al.Plasma carotenoids and risk of breast cancer over 20 y of follow-up[J].Am JClin Nutr,2015,101(6):1197-1205.
7 Leoncini E,Edefonti V,Hashibe M,et al.Carotenoid intake and head and neck cancer:a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium[J].Eur J Epidemiol,2016,31(4):369-383.
8 Teng YN,Sheu MJ,Hsieh YW,et al.beta-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function[J].Phytomedicine,2016,23(3):316-323.
9 Tong W,Wang Q,Sun D,et al.Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-kappa B,u PA activator and MMP9[J].Oncol Lett,2016,12(5):4139-4146.
10 Ali NM,Yeap SK,Abu N,et al.Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7breast cancer cells[J].Cancer Cell Int,2017,17:30.
11 Rao CV,Rivenson A,Simi B,et al.Chemoprevention of colon carcinogenesis by dietary curcumin,a naturally occurring plant phenolic compound[J].Cancer Res,1995,55(2):259-266.
12 Sreenivasan S,Krishnakumar S.Synergistic effect of curcumin in combination with anticancer agents in human retinoblastoma cancer cell Lines[J].Curr Eye Res,2015,40(11):1153-1165.
13 Jang M,Cai L,Udeani GO,et al.Cancer chemopreventive activity of resveratrol,a natural product derived from grapes[J].Science,1997,275(5297):218-220.
14 George J,Singh M,Srivastava AK,et al.Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53[J].PLo S One,2011,6(8):e23395.
15 Siddiqui IA,Sanna V,Ahmad N,et al.Resveratrol nanoformulation for cancer prevention and therapy[J].Ann N YAcad Sci,2015,1348(1):20-31.
16 Jiang Q,Yang M,Qu Z,et al.Resveratrol enhances anticancer effects of paclitaxel in Hep G2 human liver cancer cells[J].BMC Complement Altern Med,2017,17(1):477.
17 Rai G,Mishra S,Suman S,et al.Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models:A mechanistic insight[J].Phytomedicine,2016,23(3):233-242.
18 Wu SL,Sun ZJ,Yu L,et al.Effect of resveratrol and in combination with 5-FU on murine liver cancer[J].World J Gastroenterol,2004,10(20):3048-3052.
19 Nair S,Hebbar V,Shen G,et al.Synergistic effects of a combination of dietary factors sulforaphane and(-)epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells[J].Pharm Res,2008,25(2):387-399.
20 Ping SY,Hour TC,Lin SR,et al.Taxol synergizes with antioxidants in inhibiting hormal refractory prostate cancer cell growth[J].Urol Oncol,2010,28(2):170-179.
21 Luo T,Wang J,Yin Y,et al.(-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma[J].Breast Cancer Res,2010,12(1):8.
22 Vinod BS,Maliekal TT,Anto RJ.Phytochemicals as chemosensitizers:from molecular mechanism to clinical significance[J].Antioxid Redox Signal,2013,18(11):1307-1348.
23 Jakubowicz-Gil J,Paduch R,Piersiak T,et al.The effect of quercetin on pro-apoptotic activity of cisplatin in He La cells[J].Biochem Pharmacol,2005,69(9):1343-1350.
24 Du G,Lin H,Wang M,et al.Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1alpha in tumor and normal cells[J].Cancer Chemother Pharmacol,2010,65(2):277-287.
25 Pons DG,Nadal-Serrano M,Torrens-Mas M,et al.The phytoestrogen genistein affects breast cancer cells treatment depending on the ERalpha/ERbeta ratio[J].J Cell Biochem,2016,117(1):218-229.
26 Li Y,Ellis KL,Ali S,et al.Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein,a natural inhibitor of NF-kappa B in Bx PC-3pancreatic cancer cell line[J].Pancreas,2004,28(4):90-95.
27 Liang C,Li H,Shen C,et al.Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-kappa Bpathway[J].Anticancer Agents Med Chem,2012,12(5):554-563.
28 Escarcega RO,Fuentes-Alexandro S,Garcia-Carrasco M,et al.The transcription factor nuclear factor-kappa Band cancer[J].Clin Oncol(R Coll Radiol),2007,19(2):154-161.
29 Li Y,Ahmed F,Ali S,et al.Inactivation of nuclear factor kappa B by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells[J].Cancer Res,2005,65(15):6934-6942.
30 Cover CM,Hsieh SJ,Tran SH,et al.Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling[J].J Biol Chem,1998,273(7):3838-3847.
31 Cover CM,Hsieh SJ,Cram EJ,et al.Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7human breast cancer cells[J].Cancer Res,1999,59(6):1244-1251.
32 Sherr CJ.Cancer cell cycles[J].Science,1996,274(5293):1672-1677.
33 Du Y,Guo H,Lou H.Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes[J].J Agric Food Chem,2007,55(5):1695-1701.
34 Di Domenico F,Foppoli C,Coccia R,et al.Antioxidants in cervical cancer:chemopreventive and chemotherapeutic effects of polyphenols[J].Biochim Biophys Acta,2012,1822(5):737-747.
35 Akcakaya H,Tok S,Dal F,et al.beta-carotene treatment alters the cellular death process in oxidative stress-induced K562 cells[J].Cell Biol Int,2017,41(3):309-319.
36 Lee KS,Lee DH,Chun SY,et al.Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factorkappa B signaling pathway[J].Mol Med Rep,2014,10(2):1007-1012.
37 Romagnolo DF,Papoutsis AJ,Selmin O.Nutritional targeting of cyclooxygenase-2 for colon cancer prevention[J].Inflamm Allergy Drug Targets,2010,9(3):181-191.
38 Gasparini G,Longo R,Sarmiento R,et al.Inhibitors of cyclo-oxygenase 2:a new class of anticancer agents?[J].Lancet Oncol,2003,4(10):605-615.
39 Lev-Ari S,Strier L,Kazanov D,et al.Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells[J].Clin Cancer Res,2005,11(18):6738-6744.
40 Ferraro C,Quemeneur L,Prigent AF,et al.Anthracyclines trigger apoptosis of both G0-G1 and cycling peripheral blood lymphocytes and induce massive deletion of mature Tand B cells[J].Cancer Res,2000,60(7):1901-1907.
41 Muller MR,Grunebach F,Nencioni A,et al.Transfection of dendritic cells with RNA induces CD4-and CD8-mediated T cell immunity against breast carcinomas and reveals the immunodominance of presented T cell epitopes[J].JImmunol,2003,170(12):5892-5896.
42 Zhang XY,Li WG,Wu YJ,et al.Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism[J].Int Immunopharmacol,2005,5(7/8):1247-1257.
43 Rapozzi V,Zorzet S,Comelli M,et al.Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma[J].Life Sci,1998,63(19):1701-1713.
44 Levine B,Kroemer G.Autophagy in the pathogenesis of disease[J].Cell,2008,132(1):27-42.
45 Onorati AV,Dyczynski M,Ojha R,et al.Targeting autophagy in cancer[J].Cancer,2018,124(16):3307-3318.
46 Liang XH,Jackson S,Seaman M,et al.Induction of autophagy and inhibition of tumorigenesis by beclin 1[J].Nature,1999,402(6762):672-676.
47 Zhang T,Li Y,Park KA,et al.Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis[J].Autophagy,2012,8(4):559-576.
48 Klappan AK,Hones S,Mylonas I,et al.Proteasome inhibition by quercetin triggers macroautophagy and blocks m TOR activity[J].Histochem Cell Biol,2012,137(1):25-36.
49 Wang P,Zhu L,Sun D,et al.Natural products as modulator of autophagy with potential clinical prospects[J].Apoptosis,2017,22(3):325-356.
50 Wang R,Miloso M,Nicolini G,et al.Resveratrol interference with the cell cycle protects human neuroblastoma SH-SY5Y cell from paclitaxel-induced apoptosis[J].Neurochem Int,2005,46(3):205-211.
51 Lau A,Villeneuve NF,Sun Z,et al.Dual roles of Nrf2 in cancer[J].Pharmacol Res,2008,58(5/6):262-70.
52 Lin C J,Lee CC,Shih YL,et al.Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy[J].Free Radic Biol Med,2012,52(2):377-391.
53 Xu X,Chen K,Kobayashi S,et al.Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy[J].J Pharmacol Exp Ther,2012,341(1):183-195.
54 Harhaji L,Mijatovic S,Mijatovic D,et al.Aloe emodin inhibits the cytotoxic action of tumor necrosis factor[J].Eur J Pharmacol,2007,568(1-3):248-259.
2 Kummar S,Chen HX,Wright J,et al.Utilizing targeted cancer therapeutic agents in combination:novel approaches and urgent requirements[J].Nat Rev Drug Discov,2010,9(11):843-856.
3 Liu RH.Potential synergy of phytochemicals in cancer prevention:mechanism of action[J].J Nutr,2004,134(12Suppl):3479-3485.
4 Bolhassani A.Cancer chemoprevention by natural carotenoids as an efficient strategy[J].Anticancer Agents Med Chem,2015,15(8):1026-1031.
5 Pan MH,Ho CT.Chemopreventive effects of natural dietary compounds on cancer development[J].Chem Soc Rev,2008,37(11):2558-2574.
6 Eliassen AH,Liao X,Rosner B,et al.Plasma carotenoids and risk of breast cancer over 20 y of follow-up[J].Am JClin Nutr,2015,101(6):1197-1205.
7 Leoncini E,Edefonti V,Hashibe M,et al.Carotenoid intake and head and neck cancer:a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium[J].Eur J Epidemiol,2016,31(4):369-383.
8 Teng YN,Sheu MJ,Hsieh YW,et al.beta-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function[J].Phytomedicine,2016,23(3):316-323.
9 Tong W,Wang Q,Sun D,et al.Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-kappa B,u PA activator and MMP9[J].Oncol Lett,2016,12(5):4139-4146.
10 Ali NM,Yeap SK,Abu N,et al.Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7breast cancer cells[J].Cancer Cell Int,2017,17:30.
11 Rao CV,Rivenson A,Simi B,et al.Chemoprevention of colon carcinogenesis by dietary curcumin,a naturally occurring plant phenolic compound[J].Cancer Res,1995,55(2):259-266.
12 Sreenivasan S,Krishnakumar S.Synergistic effect of curcumin in combination with anticancer agents in human retinoblastoma cancer cell Lines[J].Curr Eye Res,2015,40(11):1153-1165.
13 Jang M,Cai L,Udeani GO,et al.Cancer chemopreventive activity of resveratrol,a natural product derived from grapes[J].Science,1997,275(5297):218-220.
14 George J,Singh M,Srivastava AK,et al.Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53[J].PLo S One,2011,6(8):e23395.
15 Siddiqui IA,Sanna V,Ahmad N,et al.Resveratrol nanoformulation for cancer prevention and therapy[J].Ann N YAcad Sci,2015,1348(1):20-31.
16 Jiang Q,Yang M,Qu Z,et al.Resveratrol enhances anticancer effects of paclitaxel in Hep G2 human liver cancer cells[J].BMC Complement Altern Med,2017,17(1):477.
17 Rai G,Mishra S,Suman S,et al.Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models:A mechanistic insight[J].Phytomedicine,2016,23(3):233-242.
18 Wu SL,Sun ZJ,Yu L,et al.Effect of resveratrol and in combination with 5-FU on murine liver cancer[J].World J Gastroenterol,2004,10(20):3048-3052.
19 Nair S,Hebbar V,Shen G,et al.Synergistic effects of a combination of dietary factors sulforaphane and(-)epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells[J].Pharm Res,2008,25(2):387-399.
20 Ping SY,Hour TC,Lin SR,et al.Taxol synergizes with antioxidants in inhibiting hormal refractory prostate cancer cell growth[J].Urol Oncol,2010,28(2):170-179.
21 Luo T,Wang J,Yin Y,et al.(-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma[J].Breast Cancer Res,2010,12(1):8.
22 Vinod BS,Maliekal TT,Anto RJ.Phytochemicals as chemosensitizers:from molecular mechanism to clinical significance[J].Antioxid Redox Signal,2013,18(11):1307-1348.
23 Jakubowicz-Gil J,Paduch R,Piersiak T,et al.The effect of quercetin on pro-apoptotic activity of cisplatin in He La cells[J].Biochem Pharmacol,2005,69(9):1343-1350.
24 Du G,Lin H,Wang M,et al.Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1alpha in tumor and normal cells[J].Cancer Chemother Pharmacol,2010,65(2):277-287.
25 Pons DG,Nadal-Serrano M,Torrens-Mas M,et al.The phytoestrogen genistein affects breast cancer cells treatment depending on the ERalpha/ERbeta ratio[J].J Cell Biochem,2016,117(1):218-229.
26 Li Y,Ellis KL,Ali S,et al.Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein,a natural inhibitor of NF-kappa B in Bx PC-3pancreatic cancer cell line[J].Pancreas,2004,28(4):90-95.
27 Liang C,Li H,Shen C,et al.Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-kappa Bpathway[J].Anticancer Agents Med Chem,2012,12(5):554-563.
28 Escarcega RO,Fuentes-Alexandro S,Garcia-Carrasco M,et al.The transcription factor nuclear factor-kappa Band cancer[J].Clin Oncol(R Coll Radiol),2007,19(2):154-161.
29 Li Y,Ahmed F,Ali S,et al.Inactivation of nuclear factor kappa B by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells[J].Cancer Res,2005,65(15):6934-6942.
30 Cover CM,Hsieh SJ,Tran SH,et al.Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling[J].J Biol Chem,1998,273(7):3838-3847.
31 Cover CM,Hsieh SJ,Cram EJ,et al.Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7human breast cancer cells[J].Cancer Res,1999,59(6):1244-1251.
32 Sherr CJ.Cancer cell cycles[J].Science,1996,274(5293):1672-1677.
33 Du Y,Guo H,Lou H.Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes[J].J Agric Food Chem,2007,55(5):1695-1701.
34 Di Domenico F,Foppoli C,Coccia R,et al.Antioxidants in cervical cancer:chemopreventive and chemotherapeutic effects of polyphenols[J].Biochim Biophys Acta,2012,1822(5):737-747.
35 Akcakaya H,Tok S,Dal F,et al.beta-carotene treatment alters the cellular death process in oxidative stress-induced K562 cells[J].Cell Biol Int,2017,41(3):309-319.
36 Lee KS,Lee DH,Chun SY,et al.Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factorkappa B signaling pathway[J].Mol Med Rep,2014,10(2):1007-1012.
37 Romagnolo DF,Papoutsis AJ,Selmin O.Nutritional targeting of cyclooxygenase-2 for colon cancer prevention[J].Inflamm Allergy Drug Targets,2010,9(3):181-191.
38 Gasparini G,Longo R,Sarmiento R,et al.Inhibitors of cyclo-oxygenase 2:a new class of anticancer agents?[J].Lancet Oncol,2003,4(10):605-615.
39 Lev-Ari S,Strier L,Kazanov D,et al.Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells[J].Clin Cancer Res,2005,11(18):6738-6744.
40 Ferraro C,Quemeneur L,Prigent AF,et al.Anthracyclines trigger apoptosis of both G0-G1 and cycling peripheral blood lymphocytes and induce massive deletion of mature Tand B cells[J].Cancer Res,2000,60(7):1901-1907.
41 Muller MR,Grunebach F,Nencioni A,et al.Transfection of dendritic cells with RNA induces CD4-and CD8-mediated T cell immunity against breast carcinomas and reveals the immunodominance of presented T cell epitopes[J].JImmunol,2003,170(12):5892-5896.
42 Zhang XY,Li WG,Wu YJ,et al.Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism[J].Int Immunopharmacol,2005,5(7/8):1247-1257.
43 Rapozzi V,Zorzet S,Comelli M,et al.Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma[J].Life Sci,1998,63(19):1701-1713.
44 Levine B,Kroemer G.Autophagy in the pathogenesis of disease[J].Cell,2008,132(1):27-42.
45 Onorati AV,Dyczynski M,Ojha R,et al.Targeting autophagy in cancer[J].Cancer,2018,124(16):3307-3318.
46 Liang XH,Jackson S,Seaman M,et al.Induction of autophagy and inhibition of tumorigenesis by beclin 1[J].Nature,1999,402(6762):672-676.
47 Zhang T,Li Y,Park KA,et al.Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis[J].Autophagy,2012,8(4):559-576.
48 Klappan AK,Hones S,Mylonas I,et al.Proteasome inhibition by quercetin triggers macroautophagy and blocks m TOR activity[J].Histochem Cell Biol,2012,137(1):25-36.
49 Wang P,Zhu L,Sun D,et al.Natural products as modulator of autophagy with potential clinical prospects[J].Apoptosis,2017,22(3):325-356.
50 Wang R,Miloso M,Nicolini G,et al.Resveratrol interference with the cell cycle protects human neuroblastoma SH-SY5Y cell from paclitaxel-induced apoptosis[J].Neurochem Int,2005,46(3):205-211.
51 Lau A,Villeneuve NF,Sun Z,et al.Dual roles of Nrf2 in cancer[J].Pharmacol Res,2008,58(5/6):262-70.
52 Lin C J,Lee CC,Shih YL,et al.Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy[J].Free Radic Biol Med,2012,52(2):377-391.
53 Xu X,Chen K,Kobayashi S,et al.Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy[J].J Pharmacol Exp Ther,2012,341(1):183-195.
54 Harhaji L,Mijatovic S,Mijatovic D,et al.Aloe emodin inhibits the cytotoxic action of tumor necrosis factor[J].Eur J Pharmacol,2007,568(1-3):248-259.