大三阳和小三阳患者自身抗体的检测结果分析
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摘要
目的分析比较大三阳和小三阳慢性乙型肝炎患者的自身抗体的检测结果。方法 2016年5月至2018年4月,根据430例慢性乙型肝炎患者的乙肝两对半检测结果,将其分为大三阳和小三阳两组。采集患者清晨空腹静脉血4 ml,分离血清后,对自身抗体加以检测,检测内容包括ANA、SMA、LC-1、AMA、LKM、SLA和ENA等。结果大三阳组患者ANA、AMA、LKM和LC-1的阳性率分别为90.23%、88.72%、51.13%和81.95%,小三阳组患者以上4项自身抗体的阳性率分别为51.18%、46.80%、18.52%和44.78%。大三阳组ANA等4项自身抗体的阳性率均高于小三阳组,两组比较差异均有统计学意义(P<0.05)。结论大三阳慢性乙型肝炎患者ANA、AMA、LKM和LC-1的阳性率高于小三阳组。
Objective To analyze and compare the detection results of autoantibodies in patients with chronic hepatitis b in dasanyang and xiaosanyang. Methods From May 2016 to April 2018, 430 patients with chronic hepatitis b were divided into two groups according to the HBV two-half test results. 4 ml of the patients' fasting venous blood was collected in the morning. After the serum was separated, the autoantibodies were tested, including ANA, SMA, lc-1, AMA, LKM, SLA and ENA, etc. Results The positive rates of ANA, AMA, LKM and lc-1 in the three positive groups were 90.23%, 88.72%, 51.13% and 81.95%, respectively. The positive rates of the above four autoantibodies in the three positive groups were51.18%, 46.80%, 18.52% and 44.78%, respectively. The positive rate of ANA and other four autoantibodies in the big three positive group was higher than that in the small three positive group, and the difference between the two groups was statistically significant(P<0.05). Conclusion The positive rates of ANA, AMA, LKM and lc-1 in patients with chronic hepatitis b were higher than those in patients with minor hepatitis b.
Objective To analyze and compare the detection results of autoantibodies in patients with chronic hepatitis b in dasanyang and xiaosanyang. Methods From May 2016 to April 2018, 430 patients with chronic hepatitis b were divided into two groups according to the HBV two-half test results. 4 ml of the patients' fasting venous blood was collected in the morning. After the serum was separated, the autoantibodies were tested, including ANA, SMA, lc-1, AMA, LKM, SLA and ENA, etc. Results The positive rates of ANA, AMA, LKM and lc-1 in the three positive groups were 90.23%, 88.72%, 51.13% and 81.95%, respectively. The positive rates of the above four autoantibodies in the three positive groups were51.18%, 46.80%, 18.52% and 44.78%, respectively. The positive rate of ANA and other four autoantibodies in the big three positive group was higher than that in the small three positive group, and the difference between the two groups was statistically significant(P<0.05). Conclusion The positive rates of ANA, AMA, LKM and lc-1 in patients with chronic hepatitis b were higher than those in patients with minor hepatitis b.
引文
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[2]陆正贤,倪沈珏,曹利华.电化学发光免疫法定量检测乙肝病毒的临床应用[J].当代医学,2018,24(29):107-108.
[3]罗晓丹,陈小苹,陈仁,等.聚乙二醇干扰素α-2a治疗HBeAg阳性慢性乙型肝炎24周应答不佳患者序贯替比夫定及恩替卡韦104周疗效观察[J].中华肝脏病杂志,2016,24(4):241-245.
[4]崔峻,高传华.替诺福韦酯对慢性乙肝患者的免疫应答及肾脏的影响[J].当代医学,2018,24(7):57-59.
[5]刘文恩,谭德明,范学工.丙型病毒性肝炎发病机制中自身免疫反应的作用[J].世界华人消化杂志,1999,36(7):32.
[6]王云萍,张琳,赵华明.慢性乙型肝炎患者相关自身抗体与血清乙型肝炎病毒DNA含量的相关性研究[J].山西医药杂志,2011,40(5):506-507.
[7]唐名红,蒋春燕.慢性乙型肝炎病人血清“两对半”检验结果模式与肝炎相关自身抗体的相关性研究[J].内蒙古医科大学学报,2015,12(3):251-254.
[8]牛志立,张平安.抗核抗体与慢性乙型肝炎病程及肝功能和血脂关系的研究[J].执业与健康,2018,34(11):1495-1496.
[9]陈韧刚,鲁艳,魏三舟.慢性乙型肝炎患者自身抗体与HBV基因分型及耐药突变相关因素研究[J].检验医学与临床,2018,15(8):1095-1096.
[10]孙丽娜,孙剑,刘学恩,等.乙型肝炎病毒耐药相关位点变异模式与基因型的相关性[J].中国病毒病杂志,2012,2(2):102-106.