强力定眩片联合氟桂利嗪治疗眩晕症29例
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摘要
目的:观察强力定眩片联合氟桂利嗪治疗眩晕的临床疗效。方法:将59例患者随机分为观察组29例、对照组30例。对照组患者于每天晚上睡前口服氟桂利嗪胶囊,5 mg/次,1次/d;观察组患者在此基础上服用强力定眩片治疗,4~6片/次,3次/d。比较2组临床疗效,临床症状评分,血液动力指标及血浆内皮素1(ET-1)及血脂水平。结果:总有效率观察组为89.65%,对照组为73.33%,2组比较差异有统计学意义(P<0.05)。耳鸣、眩晕、听力障碍、头痛、平衡障碍及植物神经功能紊乱症状评分2组比较,差异有统计学意义(P<0.05)。右椎动脉、左椎动脉及基底动脉血流动力指标治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后组间比较差异也有统计学意义(P<0.05)。ET-1及血脂治疗前后2组组内及组间比较,差异均有统计学意义(P<0.05)。结论:强力定眩片联合氟桂利嗪治疗眩晕症临床疗果明显,可有效改善患者临床症状、血流动力学及血脂水平。
Objective:To observe clinical effects of Qiang Li Ding Xuan tablets and flunarizine in the treatment for vertigo.Methods:All 59 patients were randomized into 29 cases of the observation group and 30 cases of the control group.The control group took flunarizine capsules in the evening each day,5 mg each time,once each day;and the observation group Qiang Li Ding Xuan tablets on the base,four to six tablets each time,three times each day.To compare clinical effects between both groups,the score of clinical symptoms the index of hemodymamics,the levels of ET-1 and blood lipid.Results:Total effective rate of the observation group was 89.65%,higher than 73.33% of the control group,and the difference had statistical meaning(P<0.05).The difference was statistically significant in the comparisons of the scales of the symptoms including tinnitus,dizziness,dysaudia,headache,disequilibrium and vegetative nerve functional disturbance(P<0.05).The difference showed statistical meaning in the comparisons of hemodynamic indexes of right vertebral artery,left vertebral artery and arteriae basilaris between before and after treating within two groups(P<0.05); the difference showed statistical meaning in the comparisons between both groups after treating(P<0.05).The difference was statistically significant in the comparisons of ET-1 and blood lipid within two groups before and after treating(P<0.05); the difference presented statistical meaning in the comparisons between both groups after treating(P<0.05).Conclusion:Qiang Li Ding Xuan tablets and flunarizine are effective in the treatment for vertigo,they could effectively improve clinical symptoms,the levels of hemodynamic indexs and blood lipid of the patients.
Objective:To observe clinical effects of Qiang Li Ding Xuan tablets and flunarizine in the treatment for vertigo.Methods:All 59 patients were randomized into 29 cases of the observation group and 30 cases of the control group.The control group took flunarizine capsules in the evening each day,5 mg each time,once each day;and the observation group Qiang Li Ding Xuan tablets on the base,four to six tablets each time,three times each day.To compare clinical effects between both groups,the score of clinical symptoms the index of hemodymamics,the levels of ET-1 and blood lipid.Results:Total effective rate of the observation group was 89.65%,higher than 73.33% of the control group,and the difference had statistical meaning(P<0.05).The difference was statistically significant in the comparisons of the scales of the symptoms including tinnitus,dizziness,dysaudia,headache,disequilibrium and vegetative nerve functional disturbance(P<0.05).The difference showed statistical meaning in the comparisons of hemodynamic indexes of right vertebral artery,left vertebral artery and arteriae basilaris between before and after treating within two groups(P<0.05); the difference showed statistical meaning in the comparisons between both groups after treating(P<0.05).The difference was statistically significant in the comparisons of ET-1 and blood lipid within two groups before and after treating(P<0.05); the difference presented statistical meaning in the comparisons between both groups after treating(P<0.05).Conclusion:Qiang Li Ding Xuan tablets and flunarizine are effective in the treatment for vertigo,they could effectively improve clinical symptoms,the levels of hemodynamic indexs and blood lipid of the patients.
引文
[1]刘少鸿,袁小霞.点揉推拿治疗颈源性眩晕60例临床观察[J].西部中医药,2013,26(1):102-103.
[2]Hain TC.Cervicogenic causes of vertigo[J].Current Opinion in Neurology,2015,28(1):69-73.
[3]Lahmann C,Henningsen P,Brandt T,et al.Psychiatric comorbidity and psychosocial impairment among patients with vertigo and dizziness[J].J Neurol Neurosurg Psychiatry,2015,86(3):302-308.
[4]刘克卿.硝苯地平控释片联合强力定眩片治疗高血压疗效观察[J].现代药物与临床,2013,28(3):358-360.
[5]王耀山,王德生.神经系统疾病鉴别诊断学[M].北京:军事医学科学出版社,2004:160-166.
[6]周达君,邓特伟,庄义杰,等.方氏头皮针结合体针改善椎动脉型颈椎病的颈痛眩晕状况分析[J].西部中医药,2013,26(4):97-99.
[7]Yang TH,Oh SY.Otolith dysfunction in benign paroxysmal positional vertigo:bilateral abnormalities of ocular and cervical VEMPs persist after successful repositioning maneuvers[J].Radiologic Technology,2015,87(2):592-599.
[8]秦小东,秦德怀,罗英豪,等.羊藿三七胶囊联合阿托伐他汀治疗后循环缺血性眩晕症疗效观察[J].中西医结合心脑血管病杂志,2017,15(13):4636-4637.
[9]Kahraman ss,Arlic.Re:″Symptom resolution rates of posttraumatic versus nontraumatic benign paroxysmal positional vertigo:a systematic review″[J].Otolaryngology-head and neck surgery:official journal of American Academy of Otolaryngology-Head and Neck Surgery,2015,15(35):896-907.
[10]王浩.眩复宁加减结合氟桂利嗪治疗眩晕症效果观察[J].现代中西医结合杂志,2015,24(12):1324-1326.
[11]李夏莲.眩晕的辨证施护[J].西部中医药,2014,27(12):110-111.
[12]顾超,沈婷,袁灿兴.利舒康胶囊治疗腔隙性脑梗死伴眩晕症的效果观察[J].解放军医药杂志,2017,29(4):58-61.
[13]张玮,李腊梅.中医技术耳穴压豆治疗290例眩晕患者的疗效及安全性[J].中国组织工程研究,2015,19(5):137-141.
[14]邵义泽,王会民,赵文莉.中西医结合优化治疗眩晕症的临床观察[J].中草药,2014,45(7):982-984.
[15]韩振强.天麻素联合舒血宁治疗眩晕症[J].长春中医药大学学报,2014,30(1):103-104.
[16]Tarnutzer AA,Lee SH,Robinson KA,et al.Clinical and electrographic findings in epileptic vertigo and dizziness:A systematic review[J].Neurology,2015,84(15):159-163.
[17]张安富,游艳华,冉利,等.眩晕症85例的分型论治观察[J].中国中医急症,2015,24(2):257-259.
[18]王润山,张俊峰.中西医结合治疗眩晕症150例[J].中西医结合心脑血管病杂志,2017,15(5):636-638.
[2]Hain TC.Cervicogenic causes of vertigo[J].Current Opinion in Neurology,2015,28(1):69-73.
[3]Lahmann C,Henningsen P,Brandt T,et al.Psychiatric comorbidity and psychosocial impairment among patients with vertigo and dizziness[J].J Neurol Neurosurg Psychiatry,2015,86(3):302-308.
[4]刘克卿.硝苯地平控释片联合强力定眩片治疗高血压疗效观察[J].现代药物与临床,2013,28(3):358-360.
[5]王耀山,王德生.神经系统疾病鉴别诊断学[M].北京:军事医学科学出版社,2004:160-166.
[6]周达君,邓特伟,庄义杰,等.方氏头皮针结合体针改善椎动脉型颈椎病的颈痛眩晕状况分析[J].西部中医药,2013,26(4):97-99.
[7]Yang TH,Oh SY.Otolith dysfunction in benign paroxysmal positional vertigo:bilateral abnormalities of ocular and cervical VEMPs persist after successful repositioning maneuvers[J].Radiologic Technology,2015,87(2):592-599.
[8]秦小东,秦德怀,罗英豪,等.羊藿三七胶囊联合阿托伐他汀治疗后循环缺血性眩晕症疗效观察[J].中西医结合心脑血管病杂志,2017,15(13):4636-4637.
[9]Kahraman ss,Arlic.Re:″Symptom resolution rates of posttraumatic versus nontraumatic benign paroxysmal positional vertigo:a systematic review″[J].Otolaryngology-head and neck surgery:official journal of American Academy of Otolaryngology-Head and Neck Surgery,2015,15(35):896-907.
[10]王浩.眩复宁加减结合氟桂利嗪治疗眩晕症效果观察[J].现代中西医结合杂志,2015,24(12):1324-1326.
[11]李夏莲.眩晕的辨证施护[J].西部中医药,2014,27(12):110-111.
[12]顾超,沈婷,袁灿兴.利舒康胶囊治疗腔隙性脑梗死伴眩晕症的效果观察[J].解放军医药杂志,2017,29(4):58-61.
[13]张玮,李腊梅.中医技术耳穴压豆治疗290例眩晕患者的疗效及安全性[J].中国组织工程研究,2015,19(5):137-141.
[14]邵义泽,王会民,赵文莉.中西医结合优化治疗眩晕症的临床观察[J].中草药,2014,45(7):982-984.
[15]韩振强.天麻素联合舒血宁治疗眩晕症[J].长春中医药大学学报,2014,30(1):103-104.
[16]Tarnutzer AA,Lee SH,Robinson KA,et al.Clinical and electrographic findings in epileptic vertigo and dizziness:A systematic review[J].Neurology,2015,84(15):159-163.
[17]张安富,游艳华,冉利,等.眩晕症85例的分型论治观察[J].中国中医急症,2015,24(2):257-259.
[18]王润山,张俊峰.中西医结合治疗眩晕症150例[J].中西医结合心脑血管病杂志,2017,15(5):636-638.