猪链球菌病流行病学和病原学研究进展
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摘要
猪链球菌病是由猪链球菌(SS)侵入机体引起的一种人兽共患急性热性传染病。人SS可引起败血症、脑膜炎、心内膜炎、关节炎、肺炎及中毒性休克综合征。SS是引起人细菌性脑膜炎最常见的动物源性病原体之一。该文通过病原学、流行病学、防控技术3方面进行阐述,以引起大家关注猪链球菌病所带来的公共卫生问题与挑战。
The pig streptococcus disease is a acute fever transmitted diseases in a range of animal species and human beings induced by streptococcus suis(SS) invades the body. The human SS can cause sepsis,meningitis,endocarditis,arthritis,pneumonia and toxic shock syndrome. SS is one of the most common animal pathogens which caused bacterial meningitis. In this paper,the three aspects of etiology,epidemiology and prevention and control technology are elaborated to cause the attention of the public health problems and challenges brought by pig streptococcus disease.
The pig streptococcus disease is a acute fever transmitted diseases in a range of animal species and human beings induced by streptococcus suis(SS) invades the body. The human SS can cause sepsis,meningitis,endocarditis,arthritis,pneumonia and toxic shock syndrome. SS is one of the most common animal pathogens which caused bacterial meningitis. In this paper,the three aspects of etiology,epidemiology and prevention and control technology are elaborated to cause the attention of the public health problems and challenges brought by pig streptococcus disease.
引文
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[2]YE CY,ZHU XP,JING HQ,et a1.Streptococcus suis sequence type 7 outbreak,Sichuan,China[J].Emerg Infect Dis,2006,12(8):1203-1208.
[3]董晓静,吕秀芝,柳艳萍,等.天津市2013年人感染猪链球菌病的首次发现与证实[J].中华流行病学杂志,2013,34(11):1154-1155.
[4]彭少静,邓华英,张媛媛,等.重庆地区猪肉样品中猪链球菌病污染、血清型、耐药性及致病性[J],食品科学,2016,37(4):233-237.
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[6]杜德超,于岩飞,马彩凤,等.猪链球菌2型不同mrp基因型与毒力的关系[J].微生物学通报,2016,43(1):147-155.
[7]骈亚亚.我国猪链球菌2型新毒力因子的研究[D].北京:中国人民解放军军事医学科学院,2012.
[8]朱静,王长军.猪链球菌2型89K毒力岛研究进展[J].微生物学通报,2013,40(8):1487-1492.
[9]吴光燕,于岩飞,叶琳璐,等.猪链球菌2型新型毒力因子Rfe A的研究[J].畜牧与兽医,2015,47(4):10-15.
[10]陈恬,李明,赵岩,等.高致病性2型猪链球菌Plc R基因敲除株的构建及其相关生物学特性研究[J].微生物通报,2014,41(4):794-801.
[11]中国疾病预防控制中心.全国人感染猪链球菌病监测方案(2009版)[Z/OL][.2016-7-13]http://www.chinacdc.cn/jkzt/crb/rzzzlqjgr/.
[12]刘海珠,袁晓明.人猪链球菌感染的临床实验室诊断研究进展[J].中国人兽共患病学报,2016,32(5):490-493.
[13]胡玉山,肖丽红,刘巧谊,等.猪链球菌2型感染胶体金诊断方法的研究[J].实用预防医学,2015,22(6):675-678.
[14]谈忠呜,姜仁杰,周伟忠,等.江苏省首例人感染STl型猪链球菌的快速检测及分子特征分析[J].江苏预防医学,2015,26(1):19-22.
[15]GOMER-ZORRILLA S,ARDANUY C,LORA-TAMAYO J,et al.Streptococcus suis infection and malignancy in man,spain[J].Emerg Infect Dis,2014,20(6):1 067-1 068.
[16]汪华,胡晓抒,朱凤才,等.人-猪链球菌感染性综合征的流行病学调查[J].现代预防医学,2000,27(3):312-314.
[17]吕强,吴建林,袁五行,等.四川省人感染猪链球菌病流行病学调查分析[J].预防医学情报杂志,2005,21(4):379-383.
[18]庞为,梁玉红,周伟,等.大连市首例人感染猪链球菌病流行病学调查[J].职业与健康,2015,31(8):封二-封三.
[19]刘伟,高中静,寇增强,等.山东省首例人感染猪链球菌病例流行病学调查[J].中华流行病学杂志,2015,36(2):192.
[20]纪少博,白雪梅,刘凯,等.我国不同地区健康猪猪链球菌检出率调查[J].中国人畜共患病学报,2013,29(5)423-426.
[21]李淼,谢东新,杨东霞,等.广东地区猪链球菌宿主多样性调查[J].中国兽医杂志,2014,50(11):16-18.
[22]朱钱迎,张青,李克诚,等.浙江省瑞安地区人感染猪链球菌病二例[J].中华传染病杂志,2015,33(5):311.
[23]方旭城,黄旭东,刘少漫.猪链球菌感染3例[J].中国感染与化疗杂志,2014,14(16):538-539.
[24]刘伦光,张丽杰,雷凤英,等.人感染猪链球菌宰杀过程危险因素病例对照调查[J].预防医学情报杂志,2007,23(5):537-539.
[25]WHO.Stimulating the development of national Streptococcus suis guidelines in Viet Nam through a strategic research partnership[Z/OL].[2016-7-13].http://www.who.int/bulletin/volumes/88/6/09-067959-ab/en/.
[26]王宇,刘沛.人感染猪链球菌病[J].中国实用乡村医生杂志.2014,21(5):10-11.
[2]YE CY,ZHU XP,JING HQ,et a1.Streptococcus suis sequence type 7 outbreak,Sichuan,China[J].Emerg Infect Dis,2006,12(8):1203-1208.
[3]董晓静,吕秀芝,柳艳萍,等.天津市2013年人感染猪链球菌病的首次发现与证实[J].中华流行病学杂志,2013,34(11):1154-1155.
[4]彭少静,邓华英,张媛媛,等.重庆地区猪肉样品中猪链球菌病污染、血清型、耐药性及致病性[J],食品科学,2016,37(4):233-237.
[5]NUTRAVONG T,ANGKIT S,JIWAKANON N,et a1.Identification of major Streptococcus suis serotypes 2,7,8 and 9 isolated from pigs and humans in upper northeastern Thailand[J].Southeast Asian J Trop Med Public Health,2014,45(5):1173-1181.
[6]杜德超,于岩飞,马彩凤,等.猪链球菌2型不同mrp基因型与毒力的关系[J].微生物学通报,2016,43(1):147-155.
[7]骈亚亚.我国猪链球菌2型新毒力因子的研究[D].北京:中国人民解放军军事医学科学院,2012.
[8]朱静,王长军.猪链球菌2型89K毒力岛研究进展[J].微生物学通报,2013,40(8):1487-1492.
[9]吴光燕,于岩飞,叶琳璐,等.猪链球菌2型新型毒力因子Rfe A的研究[J].畜牧与兽医,2015,47(4):10-15.
[10]陈恬,李明,赵岩,等.高致病性2型猪链球菌Plc R基因敲除株的构建及其相关生物学特性研究[J].微生物通报,2014,41(4):794-801.
[11]中国疾病预防控制中心.全国人感染猪链球菌病监测方案(2009版)[Z/OL][.2016-7-13]http://www.chinacdc.cn/jkzt/crb/rzzzlqjgr/.
[12]刘海珠,袁晓明.人猪链球菌感染的临床实验室诊断研究进展[J].中国人兽共患病学报,2016,32(5):490-493.
[13]胡玉山,肖丽红,刘巧谊,等.猪链球菌2型感染胶体金诊断方法的研究[J].实用预防医学,2015,22(6):675-678.
[14]谈忠呜,姜仁杰,周伟忠,等.江苏省首例人感染STl型猪链球菌的快速检测及分子特征分析[J].江苏预防医学,2015,26(1):19-22.
[15]GOMER-ZORRILLA S,ARDANUY C,LORA-TAMAYO J,et al.Streptococcus suis infection and malignancy in man,spain[J].Emerg Infect Dis,2014,20(6):1 067-1 068.
[16]汪华,胡晓抒,朱凤才,等.人-猪链球菌感染性综合征的流行病学调查[J].现代预防医学,2000,27(3):312-314.
[17]吕强,吴建林,袁五行,等.四川省人感染猪链球菌病流行病学调查分析[J].预防医学情报杂志,2005,21(4):379-383.
[18]庞为,梁玉红,周伟,等.大连市首例人感染猪链球菌病流行病学调查[J].职业与健康,2015,31(8):封二-封三.
[19]刘伟,高中静,寇增强,等.山东省首例人感染猪链球菌病例流行病学调查[J].中华流行病学杂志,2015,36(2):192.
[20]纪少博,白雪梅,刘凯,等.我国不同地区健康猪猪链球菌检出率调查[J].中国人畜共患病学报,2013,29(5)423-426.
[21]李淼,谢东新,杨东霞,等.广东地区猪链球菌宿主多样性调查[J].中国兽医杂志,2014,50(11):16-18.
[22]朱钱迎,张青,李克诚,等.浙江省瑞安地区人感染猪链球菌病二例[J].中华传染病杂志,2015,33(5):311.
[23]方旭城,黄旭东,刘少漫.猪链球菌感染3例[J].中国感染与化疗杂志,2014,14(16):538-539.
[24]刘伦光,张丽杰,雷凤英,等.人感染猪链球菌宰杀过程危险因素病例对照调查[J].预防医学情报杂志,2007,23(5):537-539.
[25]WHO.Stimulating the development of national Streptococcus suis guidelines in Viet Nam through a strategic research partnership[Z/OL].[2016-7-13].http://www.who.int/bulletin/volumes/88/6/09-067959-ab/en/.
[26]王宇,刘沛.人感染猪链球菌病[J].中国实用乡村医生杂志.2014,21(5):10-11.