注射吸毒人群HIV新发感染研究进展
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摘要
目的了解注射吸毒人群HIV新发感染研究现状。方法查找收集相关文献并综合归纳分析。结果目前注射吸毒人群HIV新发感染的研究方法主要包括前瞻性队列研究、基于横断面调查的实验室检测法和数学模型3种方法;主要影响因素有共用针头或注射器、无保护性行为和毒品的注射频率等。结论艾滋病疫情不容乐观,不同时间和地点存在差异;各地应针对自身情况制定相应的禁毒防制艾滋病策略和措施。
Objective To investigate the current status of new HIV infection in injecting drug users(IDUs). Methods Literatures were collected for comprehensive induction analysis. Results The current research methods of new HIV infection rate in IDUs mainly included prospective cohort study, laboratory test method based on cross-sectional survey, and mathematical model. Main influencing factors were sharing needles or syringes, unprotected sex behavior, frequency of injections of drugs, etc. Conclusions The AIDS epidemic in global IDUs is still not optimistic, there are differences in time and places. Corresponding anti-drug and anti-AIDS strategies and measures should be formulated according to the situations of the locality.
Objective To investigate the current status of new HIV infection in injecting drug users(IDUs). Methods Literatures were collected for comprehensive induction analysis. Results The current research methods of new HIV infection rate in IDUs mainly included prospective cohort study, laboratory test method based on cross-sectional survey, and mathematical model. Main influencing factors were sharing needles or syringes, unprotected sex behavior, frequency of injections of drugs, etc. Conclusions The AIDS epidemic in global IDUs is still not optimistic, there are differences in time and places. Corresponding anti-drug and anti-AIDS strategies and measures should be formulated according to the situations of the locality.
引文
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[2]蓝光华.中国大陆男男性行为人群艾滋病病毒新发感染研究进展[J].应用预防医学,2014,20(3):188-189,193.
[3]倪明健,陈晶,张艺,等.新疆艾滋病流行状况分析[J].疾病预防控制通报,2012,27(2):1-3.
[4]周凯,谢铮,过涛娜,等.将艾滋病防治纳入2015年后千年发展议程的分析与建议[J].中国艾滋病性病,2014,20(3):202-205.
[5]KEITH AHAMAD M,KANNA HAYASHI P,PAULNGUYEN P,et al.Effect of low-threshold methadone maintenance therapy for people who inject drugs on HIVincidence in Vancouver,BC,Canada:An observational cohort study[J].The Lancet HIV,2015,2(10):e445-e50.
[6]ZHENG X,TIAN C,CHOI K H,et al.Injecting drug use and HIV infection in southwest China[J].AIDS,1994,8(8):1141-1148.
[7]中国卫生部,联合国艾滋病规划署,世界卫生组织.2011年中国艾滋病疫情估计[J].中国艾滋病性病,2012,18(1):1-5.
[8]张艳辉,鲍宇刚,厉成梅,等.中国15个大城市艾滋病疫情状况分析[J].实用预防医学,2011,18(5):785-788.
[9]BROOKMEYER R.Should biomarker estimates of HIVincidence be adjusted?[J].AIDS,2009,23(4):485-491.
[10]UNAIDS,WHO.Technical update on HIV incidence assays for surveillance and monitoring purposes[EB/OL].(2015-07-16)[2018-05-15].http://catalogue.safaids.net/sites/default/files/publications/Technical%20Update%20on%20HIV%20Incidence%20Assays%20for%20Surveillance%20and%20Monitoring%20Purposes.pdf.
[11]JANSSEN R S,SATTEN G A,STRAMER S L,et al.New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes[J].JAMA,1998,280(1):42-48.
[12]PAREKH B S,KENNEDY M S,DOBBS T,et al.Quantitative detection of increasing HIV type 1 antibodies after seroconversion:a simple assay for detecting recent HIV infection and estimating incidence[J].AIDS Res Hum Retroviruses,1969,18(4):295-307.
[13]王慜杰,蒋岩,韩梅,等.检测HIV-1新近感染的BED捕获酶免疫实验的重复性和稳定性评价[J].中国艾滋病性病,2007,13(4):305-307.
[14]PAREKH B S,HANSON D L,HARGROVE J,et al.Determination of mean recently period for estimation of HIV type 1 Incidence with the BED-capture EIA in persons infected with diverse subtypes[J].AIDS Res Hum Retroviruses,2011,27(3):265-273.
[15]MARINDA E T,HARGROVE J,PREISER W,et al.Significantly diminished long-term specificity of the BEDcapture enzyme immunoassay among patients with HIV-1with very low CD4 counts and those on antiretroviral therapy[J].JAIDS,2010,53(4):496-499.
[16]HAYASHIDA T,GATANAGA H,TANUMA J,et al.Effects of low HIV type 1 load and antiretroviral treatment on IgG-capture BED-enzyme immunoassay[J].AIDS Res Hum Retroviruses,2008,24(3):495-498.
[17]ANON.UNAIDS Reference Group on estimates,modelling and projections--statement on the use of the BED assay for the estimation of HIV-1 incidence for surveillance or epidemic monitoring[J].Wkly Epidemio Record,2006,81(4):40.
[18]YAN H,YU H,XING W,et al.Development of a proficien‐cy testing program for the HIV-1 BED incidence assay in China[J].Scientific Reports,2014,4(3):4512.
[19]谭四军,曹健荣,张誌.HIV新发感染检测方法研究[C].银川:第五次全国免疫诊断暨疫苗学术研讨会论文集,2011:75-76.
[20]于海英,蒋岩,王宇.用于HIV新发感染检测的亲和力方法的研究进展[J].中国艾滋病性病,2012,18(8):575-578.
[21]REMIS R S.Reaching for the STARHS[J].Sexually Transmitted Infections,2010,86(7):486.
[22]WILSON K M,JOHNSON E I,CROOM H A,et al.Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations[J].AIDS,2004,18(17):2253-2259.
[23]SCHUPBACH J,GEBHARDT M D,TOMASIK Z,et al.Assessment of recent HIV-1 infection by a line immunoassay for HIV-1/2 confirmation[J].PLoS Med,2007,4(12):e343.
[24]赵金扣,欧阳琳,李建军,等.用小年龄组HIV感染率估计男男性行为人群的HIV新发感染率[J].中国预防医学杂志,2010,11(6):643-644.
[25]陈颖,周颖,吴春霖,等.亚洲流行模型在凉山州艾滋病疫情估计及干预效果预测中的应用[J].中国艾滋病性病,2012,18(2):73-75,85.
[26]马知恩.传染病动力学的数学建模与研究[M].北京:科学出版社,2017.
[27]KERMACK W O,MCKENDRICK A G.Contributions to the mathematical theory of epidemics--I[J].Bull Math Biol,1991,53(1-2):33-55.
[28]KERMACK W O,MCKENDRICK A G.Contributions to the mathematical theory of epidemics--II.The problem of endemicity[J].Bull Math Biol,1991,53(1-2):57-87.
[29]KERMACK W O,MCKENDRICK A G.Contributions to the mathematical theory of epidemics--III.Further studies of the problem of endemicity[J].Bull Math Biol,1991,53(1-2):89-118.
[30]KERMACK W O,MCKENDRICK A G.Contributions to the mathematical theory of epidemics IV.Analysis of experimental epidemics of the virus disease mouse ectromelia[J].Journal of Hygiene,1937,37(2):172-187.
[31]KERMACK W O,MCKENDRICK A G.Contributions to the mathematical theory of epidemics:V.Analysis of experimental epidemics of mouse-typhoid;a bacterial disease conferring incomplete immunity[J].Epidemiology&Infection,1939,39(3):271-288.
[32]BROWN T,SALOMON J A,ALKEMA L,et al.Progress and challenges in modeling country-level HIV/AIDSepidemics:the UNAIDS estimation and projection package2007[J].Sexually Transmitted Infections,2008,84(1):i5-i10.
[33]KIM A A,HALLETT T,STOVER J,et al.Estimating HIVincidence among adults in Kenya and Uganda:A systematic comparison of multiple methods[J].PloS One,2011,6(3):e17535-.
[34]陶钧,孟令章,肖瑶.HIV-1发病率研究方法及其比较[J].中国艾滋病性病,2011,17(2):191-195.
[35]吴静,汪宁.传染病动力学模型在我国艾滋病研究领域中的应用[J].中华流行病学杂志,2014,35(4):466-470.
[36]LINDENBURG C E,KROL A,SMIT C,et al.Decline in HIV incidence and injecting,but not in sexual risk behaviour,seen in drug users in Amsterdam:A 19-year prospective cohort study[J].AIDS,2006,20(13):1771-1775.
[37]VANICHSENI S,KITAYAPORN D,MASTRO T D,et al.Continued high HIV-1 incidence in a vaccine trial preparatory cohort of injection drug users in Bangkok,Thailand[J].AIDS,2001,15(3):397-405.
[38]XIRIDOU M,VAN GRIENSVEN F,TAPPERO J W,et al.The spread of HIV-1 subtypes B and CRF01_AE among injecting drug users in Bangkok,Thailand[J].J AIDS,2007,45(4):468-475.
[39]WOOD E,KERR T,MARSHALL B D L,et al.Longitudinal community plasma HIV-1 RNAconcentrations and incidence of HIV-1 among injecting drug users:Prospective cohort study[J].BMJ,2009,338:b1649.
[40]JUDD A,HICKMAN M,JONES S,et al.Incidence of hepatitis C virus and HIV among new injecting drug users in London:prospective cohort study[J].BMJ,2005,330(7481):24-25.
[41]SARNA A,SARASWATI L R,SEBASTIAN M,et al.High HIV incidence in a cohort of male injection drug users in Delhi,India[J].Drug and Alcohol Depend,2014,139:106-114.
[42]郑锡文,张家鹏,曲书泉,等.1993年云南省瑞丽等地吸毒者艾滋病病毒感染定群研究[J].中华流行病学杂志,1994,15(1):3-5.
[43]姜正清,胡薇,张莉,等.静脉吸毒人群HIV阳转率与队列保持影响因素[J].中国公共卫生,2005,21(11):1289-1291.
[44]尹潞,秦光明,阮玉华,等.四川省吸毒人群艾滋病病毒和梅毒新发感染的队列研究[J].中华流行病学杂志,2006,27(4):293-297.
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