近场直写静电纺丝技术及应用的研究进展
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摘要
对近场直写静电纺丝技术的机理、发展、相关参数的控制以及应用方面展开综述,指出该技术亟待解决或改进的问题,包括纺丝机理不甚清晰;接收距离较短、严重限制射流拉伸和溶剂的完全挥发;纺丝纤维在空间第三维的可控性普遍不高;潜在应用有待进一步开发等。提出未来的研究方向主要集中在:近场直写静电纺丝技术理论研究、生产效率的提高、制备3D结构材料以及开发其在生物工程及微纳米技术领域的应用等。
The mechanism, development, control parameters and application of near field directly writing electrospinning is introduced. It is pointed out that the technology needs to be solved or improved, including that the spinning mechanism is not clear, the short receiving distance severely limits jet stretching and complete volatilization of solvents, the controllability of spinning fiber in the third dimension of space is generally not high, potential applications need to be further developed. Therefore, the future research directions should focus on the theoretical research of near field directly writing electrospinning technology, the improvement of production efficiency, the preparation of 3 D structural materials and the further development of its applications in the field of bioengineering and micro-nano technology.
The mechanism, development, control parameters and application of near field directly writing electrospinning is introduced. It is pointed out that the technology needs to be solved or improved, including that the spinning mechanism is not clear, the short receiving distance severely limits jet stretching and complete volatilization of solvents, the controllability of spinning fiber in the third dimension of space is generally not high, potential applications need to be further developed. Therefore, the future research directions should focus on the theoretical research of near field directly writing electrospinning technology, the improvement of production efficiency, the preparation of 3 D structural materials and the further development of its applications in the field of bioengineering and micro-nano technology.
引文
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[2]LI D,XIA Y.Electrospinning of nanofibers:Reinventing the wheel?[J].Advanced Materials,2004,16(14):1151-1170.
[3]GREINER A,WENDORFF J H.Electrospinning:A fascinating method for the preparation of ultrathin fibers[J].Angewandte Chemie International Edition,2007,46(30):5670-5703.
[4]LUO G,TEH K,ZANG X,et al.High aspect-ratio 3D microstructures via near-field electrospinning for energy storage applications,2016[C]//IEEE International Conference on MI-CRO Electro Mechanical Systems(MEMS).Shanghai:IEEE,2016:29-32.
[5]HUANG Y,HUANG Q,LIU H,et al.Preparation,characterization,and applications of electrospun ultrafine fibrous PTFEporous membranes[J].Journal of Membrane Science,2017,523:317-326.
[6]SILL T,VON RECUM H.Electrospinning:Applications in drug delivery and tissue engineering[J].Biomaterials,2008,29(13):1989-2006.
[7]SARKAR S,DEEVI S,TEPPER G.Biased AC electrospinning of aligned polymer nanofibers[J].2010,28(9):1034-1039.
[8]PAN H,LI L,HU L,et al.Continuous aligned polymer fibers produced by a modified electrospinning method[J].Polymer,2006,47(14):4901-4904.
[9]LI D,WANG Y,XIA Y.Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays[J].Nano Letters,2003,3(8):1167-1171.
[10]YANG D,LU B,ZHAO Y,et al.Fabrication of aligned fibrous arrays by magnetic electrospinning[J].Advanced Materials,2007,19(21):3702-3706.
[11]INAI R,KOTAKI M,RAMAKRISHNA S.Structure and properties of electrospun PLLA single fibers[J].Nanotechnology,2005,16(2):208-213.
[12]SHIN Y,HOHMAN M,BRENNER M,et al.Electrospinning:A whipping fluid jet generates submicron polymer fibers[J].Applied Physics Letters,2001,78(8):1149-1151.
[13]SHENOY S,BATES W,FRISCH H,et al.Role of chain entanglements on fiber formation during electrospinning of polymer solutions:Good solvent,non-specific polymer-polymer interaction limit[J].Polymer,2005,46(10):3372-3384.
[14]杨文秀.基于分形原理的静电纺丝技术研究和锂电池隔膜研发[D].天津:天津工业大学,2016.YANG W X.Research on electrospinning technology based on fractal principle and research and development of lithium battery separator[D].Tianjin:Tianjin Polytechnic University,2016(in Chinese).
[15]罗国希.基于近场静电纺丝的聚合物微纳米结构制备及其应用关键技术研究[D].重庆:重庆大学,2016.LUO G X.Research on the preparation of polymer micro-nano structure based on near field electrostatic spinning and application[D].Chongqing:Chongqing University,2016(in Chinese).
[16]王伟栋,贺晓晓,黄家寅,等.近场静电纺丝制备纳米纤维及应用的研究进展[J].青岛大学学报(自然科学版),2016(1):24-33.WANG W D,HE X X,HUANG J Y,et al.Preparation of nanofibers by near field electrospinning and applications[J].Journal of Qingdao University(Natural Science),2016(1):24-33(in Chinese).
[17]TIAN S,OGATA N,SHIMADA N,et al.Melt electrospinning from poly(L-lactide)rods coated with poly(ethylene-co-vinyl alcohol)[J].Journal of Applied Polymer Science,2010,113(2):1282-1288.
[18]MUERZACASCANTE M,HAYLOCK D,HUTMACHER D,et al.Melt electrospinning and its technologization in tissue engineering[J].Tissue Engineering Part B:Reviews,2015,21(2):187-202.
[19]PONCELET D,DE VOS P,SUTER N,et al.Regenerative medicine:Bio-electrospraying and cell electrospinning:Progress and opportunities for basic biology and clinical sciences[J].Advanced Healthcare Materials,2012(1):27-34.
[20]郭莎莎,王洪,柯勤飞,等.熔体静电纺工艺及研究现状[J].产业用纺织品,2010,28(7):1-5.GUO S S,WANG H,KE Q F,et al.The research status of melt-electrospinning technology[J].Technical Textiles,2010,28(7):1-5(in Chinese).
[21]KAMEOKA J,ORTH R,YANG Y.A scanning tip electrospinning source for deposition of oriented nanofibres[J].Nanotechnology,2003,14(10):1124-1129.
[22]SUN D,CHANG C,LI S,et al.Near-field electrospinning[J].Nano Letters,2006,6(4):839-842.
[23]BISHT G,CANTON G,MIRSEPASSI A,et al.Controlled continuous patterning of polymeric nanofibers on three-dimensional substrates using low-voltage near-field electrospinning[J].Nano Letters,2011,11(4):1831-1837.
[24]徐方远,贺健康,曹毅,等.基于静电纺丝的微纳3D打印工艺研究[C]//第16届全国特种加工学术会议论文集.西安:西安交通大学出版社,2015:291-295.XU F Y,HE J K,CAO Y,et al.Study on micro nano 3Dprinting process based on electrostatic spinning[C]//National Conference on Special Processing.Xi′an:Xi′an Jiaotong University Press,2015:291-295(in Chinese).
[25]林灿然,王晗,曾俊,等.近场直写静电纺丝电场仿真与路径规划分析[J].包装工程,2018(15):146-152.LIN C R,WANG H,ZENG J,et al.Electric field simulation and path planning analysis of near field direct writing electrospinning[J].Packaging Engineering,2018(15):146-152(in Chinese).
[26]WANG C,WANG M.Electrospun multicomponent and multifunctional nanofibrous bone tissue engineering scaffolds[J].Journal of Materials Chemistry B,2017,5(7):1388-1399.
[27]LI G,XUE C,SHI S,et al.Electrospun Fibrous Scaffolds for Cartilage Tissue Regeneration[M].German:Springer International Publishing,2017.
[28]任双双,苗雷英,孙卫斌.近场静电纺丝技术用于生物学领域的研究进展[J].口腔生物医学,2017(4):211-214.REN S S,MIAO L Y,SUN W B.Research progress of near field electrospinning technology in biology field[J].Oral Biomedicine,2017(4):211-214(in Chinese).
[29]FUH Y,WU Y,HE Z,et al.The control of cell orientation using biodegradable alginate fibers fabricated by near-field electrospinning[J].Materials Science&Engineering C,2016(62):879-887.
[30]PHAM Q P,SHARMA U,MIKOS A G.Electrospinning of polymeric nanofibers for tissue engineering applications:A review[J].Tissue Engineering,2006,12(5):1197-1211.
[31]DALTON P,VAQUETTE C,FARRUGIA B,et al.Electrospinning and additive manufacturing converging technologies[J].Biomaterials Science,2003,1(2):171-185.
[32]FUH Yiin-Kuen,CHEN S Z,JANG J.Direct-write,wellaligned chitosan-poly(ethylene oxide)nanofibers deposited via near-field electrospinning[J].Journal of Macromolecular Science:Part A-Chemistry,2012,49(10):845-850.
[33]LIU Y Y,XIANG K,LI Y,et al.Combining 3D printing and electrospinning for the fabrication of a bioabsorbable poly-pdioxanone stent[C]//The 21st Ispe International Conference on Concurrent Engineering.Beijing:The Authors and IOS Press,2014.
[34]FATTAHI P,DOVER J,BROWN J.3D near-field electrospinning of biomaterial microfibers with potential for blended microfiber-cell-loaded gel composite structures[J].Advanced Healthcare Materials,2017,6(19):2192-2640.
[35]CHEN H,BLITTERSWIJK C,MOTA C,et al.Direct writing electrospinning of scaffolds with multi-dimensional fiber architecture for hierarchical tissue engineering[J].ACS Applied Materials&Interfaces,2017,9(44):38187-38200.
[36]WANG X,ZHENG G,HE G,et al.Electrohydrodynamic direct-writing ZnO nanofibers for device applications[J].Materials Letters,2013,109:58-61.
[37]LIU X,GU L,ZHANG Q,et al.All-printable band-edge modulated ZnO nanowire photodetectors with ultra-high detectivity[J].Nature Communications,2014,5:4007.
[38]VIEU C,CARCENAC F,PEPIN A,et al.Electron beam lithography:Resolution limits and applications[J].Applied Surface Science,2000,164(1/2/3/4):111-117.
[39]MENARD L,RAMSEY J.The fabrication of sub-5-nm nanochannels in insulating substrates using focused ion beam milling[J].Nano Letters,2011,11(2):512-517.
[40]BITYURIN N,AFANASIEV A,BREDIKHIN V,et al.Colloidal particle lens arrays-assisted nano-patterning by harmonics of a femtosecond laser[J].Optics Express,2013,21(18):21485-21490.
[41]WANG X,ZHENG G,XU L,et al.Fabrication of nanochannels via near-field electrospinning[J].Applied Physics A,2012,108(4):825-828.
[42]MIN S,KIM T,KIM B,et al.Largescale organic nanowire lithography and electronics[J].Nat Commun,2013,4(2):1-9.
[43]LUO G,TEH K,LIU Y,et al.Direct-write,self-aligned electrospinning on paper for controllable fabrication of threedimensional structures[J].ACS Applied Materials&Interfaces,2015,7(50):27765-27770.
[44]CHANG C,TRAN V,WANG J,et al.Direct-write piezoelectric polymeric nanogenerator with high energy conversion efficiency[J].Nano Letters,2010,10(2):726-731.
[45]SHEN C,LUO G,KOZINDA A,et al.Solid-state flexible micro supercapacitors by direct-write porous nanofibers[C]//IEEEInternational Conference on Micro Electro Mechanical Systems.[s.l.]:IEEE,2015:1133-1136.
[46]PAN C T,YEN C K,WANG S Y,et al.Near-field electrospinning enhances the energy harvesting of hollow PVDF piezoelectric fibers[J].RSC Advances,2015,5(103):85073-85081.
[2]LI D,XIA Y.Electrospinning of nanofibers:Reinventing the wheel?[J].Advanced Materials,2004,16(14):1151-1170.
[3]GREINER A,WENDORFF J H.Electrospinning:A fascinating method for the preparation of ultrathin fibers[J].Angewandte Chemie International Edition,2007,46(30):5670-5703.
[4]LUO G,TEH K,ZANG X,et al.High aspect-ratio 3D microstructures via near-field electrospinning for energy storage applications,2016[C]//IEEE International Conference on MI-CRO Electro Mechanical Systems(MEMS).Shanghai:IEEE,2016:29-32.
[5]HUANG Y,HUANG Q,LIU H,et al.Preparation,characterization,and applications of electrospun ultrafine fibrous PTFEporous membranes[J].Journal of Membrane Science,2017,523:317-326.
[6]SILL T,VON RECUM H.Electrospinning:Applications in drug delivery and tissue engineering[J].Biomaterials,2008,29(13):1989-2006.
[7]SARKAR S,DEEVI S,TEPPER G.Biased AC electrospinning of aligned polymer nanofibers[J].2010,28(9):1034-1039.
[8]PAN H,LI L,HU L,et al.Continuous aligned polymer fibers produced by a modified electrospinning method[J].Polymer,2006,47(14):4901-4904.
[9]LI D,WANG Y,XIA Y.Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays[J].Nano Letters,2003,3(8):1167-1171.
[10]YANG D,LU B,ZHAO Y,et al.Fabrication of aligned fibrous arrays by magnetic electrospinning[J].Advanced Materials,2007,19(21):3702-3706.
[11]INAI R,KOTAKI M,RAMAKRISHNA S.Structure and properties of electrospun PLLA single fibers[J].Nanotechnology,2005,16(2):208-213.
[12]SHIN Y,HOHMAN M,BRENNER M,et al.Electrospinning:A whipping fluid jet generates submicron polymer fibers[J].Applied Physics Letters,2001,78(8):1149-1151.
[13]SHENOY S,BATES W,FRISCH H,et al.Role of chain entanglements on fiber formation during electrospinning of polymer solutions:Good solvent,non-specific polymer-polymer interaction limit[J].Polymer,2005,46(10):3372-3384.
[14]杨文秀.基于分形原理的静电纺丝技术研究和锂电池隔膜研发[D].天津:天津工业大学,2016.YANG W X.Research on electrospinning technology based on fractal principle and research and development of lithium battery separator[D].Tianjin:Tianjin Polytechnic University,2016(in Chinese).
[15]罗国希.基于近场静电纺丝的聚合物微纳米结构制备及其应用关键技术研究[D].重庆:重庆大学,2016.LUO G X.Research on the preparation of polymer micro-nano structure based on near field electrostatic spinning and application[D].Chongqing:Chongqing University,2016(in Chinese).
[16]王伟栋,贺晓晓,黄家寅,等.近场静电纺丝制备纳米纤维及应用的研究进展[J].青岛大学学报(自然科学版),2016(1):24-33.WANG W D,HE X X,HUANG J Y,et al.Preparation of nanofibers by near field electrospinning and applications[J].Journal of Qingdao University(Natural Science),2016(1):24-33(in Chinese).
[17]TIAN S,OGATA N,SHIMADA N,et al.Melt electrospinning from poly(L-lactide)rods coated with poly(ethylene-co-vinyl alcohol)[J].Journal of Applied Polymer Science,2010,113(2):1282-1288.
[18]MUERZACASCANTE M,HAYLOCK D,HUTMACHER D,et al.Melt electrospinning and its technologization in tissue engineering[J].Tissue Engineering Part B:Reviews,2015,21(2):187-202.
[19]PONCELET D,DE VOS P,SUTER N,et al.Regenerative medicine:Bio-electrospraying and cell electrospinning:Progress and opportunities for basic biology and clinical sciences[J].Advanced Healthcare Materials,2012(1):27-34.
[20]郭莎莎,王洪,柯勤飞,等.熔体静电纺工艺及研究现状[J].产业用纺织品,2010,28(7):1-5.GUO S S,WANG H,KE Q F,et al.The research status of melt-electrospinning technology[J].Technical Textiles,2010,28(7):1-5(in Chinese).
[21]KAMEOKA J,ORTH R,YANG Y.A scanning tip electrospinning source for deposition of oriented nanofibres[J].Nanotechnology,2003,14(10):1124-1129.
[22]SUN D,CHANG C,LI S,et al.Near-field electrospinning[J].Nano Letters,2006,6(4):839-842.
[23]BISHT G,CANTON G,MIRSEPASSI A,et al.Controlled continuous patterning of polymeric nanofibers on three-dimensional substrates using low-voltage near-field electrospinning[J].Nano Letters,2011,11(4):1831-1837.
[24]徐方远,贺健康,曹毅,等.基于静电纺丝的微纳3D打印工艺研究[C]//第16届全国特种加工学术会议论文集.西安:西安交通大学出版社,2015:291-295.XU F Y,HE J K,CAO Y,et al.Study on micro nano 3Dprinting process based on electrostatic spinning[C]//National Conference on Special Processing.Xi′an:Xi′an Jiaotong University Press,2015:291-295(in Chinese).
[25]林灿然,王晗,曾俊,等.近场直写静电纺丝电场仿真与路径规划分析[J].包装工程,2018(15):146-152.LIN C R,WANG H,ZENG J,et al.Electric field simulation and path planning analysis of near field direct writing electrospinning[J].Packaging Engineering,2018(15):146-152(in Chinese).
[26]WANG C,WANG M.Electrospun multicomponent and multifunctional nanofibrous bone tissue engineering scaffolds[J].Journal of Materials Chemistry B,2017,5(7):1388-1399.
[27]LI G,XUE C,SHI S,et al.Electrospun Fibrous Scaffolds for Cartilage Tissue Regeneration[M].German:Springer International Publishing,2017.
[28]任双双,苗雷英,孙卫斌.近场静电纺丝技术用于生物学领域的研究进展[J].口腔生物医学,2017(4):211-214.REN S S,MIAO L Y,SUN W B.Research progress of near field electrospinning technology in biology field[J].Oral Biomedicine,2017(4):211-214(in Chinese).
[29]FUH Y,WU Y,HE Z,et al.The control of cell orientation using biodegradable alginate fibers fabricated by near-field electrospinning[J].Materials Science&Engineering C,2016(62):879-887.
[30]PHAM Q P,SHARMA U,MIKOS A G.Electrospinning of polymeric nanofibers for tissue engineering applications:A review[J].Tissue Engineering,2006,12(5):1197-1211.
[31]DALTON P,VAQUETTE C,FARRUGIA B,et al.Electrospinning and additive manufacturing converging technologies[J].Biomaterials Science,2003,1(2):171-185.
[32]FUH Yiin-Kuen,CHEN S Z,JANG J.Direct-write,wellaligned chitosan-poly(ethylene oxide)nanofibers deposited via near-field electrospinning[J].Journal of Macromolecular Science:Part A-Chemistry,2012,49(10):845-850.
[33]LIU Y Y,XIANG K,LI Y,et al.Combining 3D printing and electrospinning for the fabrication of a bioabsorbable poly-pdioxanone stent[C]//The 21st Ispe International Conference on Concurrent Engineering.Beijing:The Authors and IOS Press,2014.
[34]FATTAHI P,DOVER J,BROWN J.3D near-field electrospinning of biomaterial microfibers with potential for blended microfiber-cell-loaded gel composite structures[J].Advanced Healthcare Materials,2017,6(19):2192-2640.
[35]CHEN H,BLITTERSWIJK C,MOTA C,et al.Direct writing electrospinning of scaffolds with multi-dimensional fiber architecture for hierarchical tissue engineering[J].ACS Applied Materials&Interfaces,2017,9(44):38187-38200.
[36]WANG X,ZHENG G,HE G,et al.Electrohydrodynamic direct-writing ZnO nanofibers for device applications[J].Materials Letters,2013,109:58-61.
[37]LIU X,GU L,ZHANG Q,et al.All-printable band-edge modulated ZnO nanowire photodetectors with ultra-high detectivity[J].Nature Communications,2014,5:4007.
[38]VIEU C,CARCENAC F,PEPIN A,et al.Electron beam lithography:Resolution limits and applications[J].Applied Surface Science,2000,164(1/2/3/4):111-117.
[39]MENARD L,RAMSEY J.The fabrication of sub-5-nm nanochannels in insulating substrates using focused ion beam milling[J].Nano Letters,2011,11(2):512-517.
[40]BITYURIN N,AFANASIEV A,BREDIKHIN V,et al.Colloidal particle lens arrays-assisted nano-patterning by harmonics of a femtosecond laser[J].Optics Express,2013,21(18):21485-21490.
[41]WANG X,ZHENG G,XU L,et al.Fabrication of nanochannels via near-field electrospinning[J].Applied Physics A,2012,108(4):825-828.
[42]MIN S,KIM T,KIM B,et al.Largescale organic nanowire lithography and electronics[J].Nat Commun,2013,4(2):1-9.
[43]LUO G,TEH K,LIU Y,et al.Direct-write,self-aligned electrospinning on paper for controllable fabrication of threedimensional structures[J].ACS Applied Materials&Interfaces,2015,7(50):27765-27770.
[44]CHANG C,TRAN V,WANG J,et al.Direct-write piezoelectric polymeric nanogenerator with high energy conversion efficiency[J].Nano Letters,2010,10(2):726-731.
[45]SHEN C,LUO G,KOZINDA A,et al.Solid-state flexible micro supercapacitors by direct-write porous nanofibers[C]//IEEEInternational Conference on Micro Electro Mechanical Systems.[s.l.]:IEEE,2015:1133-1136.
[46]PAN C T,YEN C K,WANG S Y,et al.Near-field electrospinning enhances the energy harvesting of hollow PVDF piezoelectric fibers[J].RSC Advances,2015,5(103):85073-85081.