何首乌中相关蒽醌类化合物抗癌作用的研究进展
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摘要
目的:何首乌是蓼科多年生缠绕藤本植物何首乌Polygonum multiflorum的干燥块根,2015年版《中国药典》根据其加工方法不同分为生何首乌(Polygoni Multiflori Radix)和制何首乌(Polygoni Multiflori Radix Praparata)。该综述总结了何首乌中相关蒽醌类化合物的抗癌作用,为探讨何首乌的抗癌作用活性物质基础和作用机制研究奠定基础。方法:依据网络数据库Pub Med,CNKI,重庆维普等相关文献,对近15年来关于何首乌中相关蒽醌类化学成分及药理作用等研究成果进行汇总分析。结果:何首乌中相关蒽醌类化合物有20种。与其他蓼科植物相比,2015年版《中国药典》规定的何首乌质量标记物大黄素和大黄素甲醚含量较高。在抗癌作用方面,诱导癌细胞凋亡的有大黄素及其大黄素-8-O-β-D-葡萄糖苷、芦荟大黄素、大黄酚、大黄素甲醚及其大黄素甲醚-8-O-β-D-葡萄糖苷、大黄酸;抑制细胞周期的有大黄素、芦荟大黄素、大黄酚、大黄素甲醚、大黄酸;抑制细胞迁移、侵袭和转移的有大黄素、芦荟大黄素、大黄素甲醚及其大黄素甲醚-8-O-β-D-葡萄糖苷;阻断能量代谢者有大黄素、大黄酚、大黄酸;逆转肿瘤多药耐药的有大黄素。结论:何首乌相关蒽醌类化合物具有潜在的抗癌药用价值,其作用机制、成分之间的相互作用等有待深入研究。
Objective: Polygoni Multiflori Radix is the drought root of a perennial vine,Polygonum multiflorum,which is belong to Polygonaceae. According to Chinese Pharmacopeia( edition 2015),its preparations are divided into two types based on the processing: crude Polygoni Multiflori Radix,and processed Polygoni Multiflori Radix Praparata. This study aimed to explore the substantial bases,effect and the mechanisms of anthraquinones in Polygoni Multiflori Radix. Method: Based on the literatures retrieved in PubMed,CNKI and Chongqing VIP in past 15 years, the chemical composition, pharmacological effects and mechanisms of anthraquinones in Polygoni Multiflori were reviewed and summarized. Result: There were 20 anthraquinones in Polygoni Multiflori. Compared with other Polygonaceae plants,there were higher contents of emodin and physcion,both were qualification markers in Polygoni Multiflori. In terms of the anti-cancer effect,emodin,emodin-8-O-β-Dglucoside,aloe-emodin, chrysophanol, physcion, physcion-8-O-β-D-glucoside and rhein induced cancer cell apoptosis. Emodin,aloe-emodin,chrysophanol,physcion and rhein inhibited cancer cell cycles. Emodin,aloeemodin,physcion and emodin-8-O-β-D-glucoside blocked migration, invasion and metastasis. And emodin,chrysophanol and rhein blocked energy metabolism, and emodin reversed multidrug resistance in cancer.Conclusion: Polygoni Multiflori may play a potential anti-cancer value,and its underlying mechanisms and the interaction between components are worth of further studies.
Objective: Polygoni Multiflori Radix is the drought root of a perennial vine,Polygonum multiflorum,which is belong to Polygonaceae. According to Chinese Pharmacopeia( edition 2015),its preparations are divided into two types based on the processing: crude Polygoni Multiflori Radix,and processed Polygoni Multiflori Radix Praparata. This study aimed to explore the substantial bases,effect and the mechanisms of anthraquinones in Polygoni Multiflori Radix. Method: Based on the literatures retrieved in PubMed,CNKI and Chongqing VIP in past 15 years, the chemical composition, pharmacological effects and mechanisms of anthraquinones in Polygoni Multiflori were reviewed and summarized. Result: There were 20 anthraquinones in Polygoni Multiflori. Compared with other Polygonaceae plants,there were higher contents of emodin and physcion,both were qualification markers in Polygoni Multiflori. In terms of the anti-cancer effect,emodin,emodin-8-O-β-Dglucoside,aloe-emodin, chrysophanol, physcion, physcion-8-O-β-D-glucoside and rhein induced cancer cell apoptosis. Emodin,aloe-emodin,chrysophanol,physcion and rhein inhibited cancer cell cycles. Emodin,aloeemodin,physcion and emodin-8-O-β-D-glucoside blocked migration, invasion and metastasis. And emodin,chrysophanol and rhein blocked energy metabolism, and emodin reversed multidrug resistance in cancer.Conclusion: Polygoni Multiflori may play a potential anti-cancer value,and its underlying mechanisms and the interaction between components are worth of further studies.
引文
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