microRNA(miRNA)对细胞凋亡的调控作用
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摘要
<正>microRNA(miRNA)Lin-4于1993年在线虫中被首次发现~([1]),并且miRNA let-7的功能也在随后得到证实~([2]),因此miRNA开始引起研究人员的注意,成为生物学研究的一个热点和重点领域。miRNAs是一类17～24个核苷酸的单链RNA分子,其在动植物细胞中广泛表达~([3])。miRNA的生物起源始于细胞核,涉及大量的细胞蛋白复合物。miRNA通常在来自"非编码"或"非信使"DNA区域的核中转录作为初级miRNA(pri
引文
[1] AMBROS V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
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[20] WANG X L,DING G Y,LAI W,et al.MicroRNA-383 upregulation protects against propofol-induced hippocampal neuron apoptosis and cognitive impairment[J].Exp Ther Med,2018,15(4):3181-3188.
[21] KANG M,XIA P,HOU T,et al.MicroRNA-190b inhibits tumor cell proliferation and induces apoptosis by regulating Bcl-2 in U2OS osteosarcoma cells[J].Pharmazie,2017,72(5):279-282.
[22] WANG K,CHEN X,ZHAN Y,et al.miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W[J].Tumour Biol,2015,36(9):6875-6882.
[23] BING Z T,YANG G H,XIONG J,et al.Identify signature regulatory network for glioblastoma prognosis by integrative mRNA and miRNA co-expression analysis[J].Iet Syst Biol,2016,10(6):244-251.
[24] SENFTER D,HOLZNER S,KALIPCIYAN M,et al.Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro[J].Hum Mol Genet,2015,24(13):3689-3698.
[25] LIU S,TETZLAFF M T,CUI R,et al.miR-200c Inhibits melanoma progression and drug resistance through down-regulation of Bmi-1[J].Am J Pathol,2012,181(5):1823-1835.
[26] ZHOU X,WU W,ZENG A,et al.MicroRNA-141-3p promotes glioma cell growth and temozolomide resistance by directly targeting p53[J].Oncotarget,2017,8(41):71080-71094.
[27] CAI B,MA M,CHEN B,et al.MiR-16-5p targets SESN1 to regulate the p53 signaling pathway,affecting myoblast proliferation and apoptosis,and is involved in myoblast differentiation[J].Cell Death Dis,2018,9(3):367-381.
[28] PARK M,YOON H J,KANG M C,et al.MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin[J].Sci Rep,2017,7(1):10932-10940.
[29] ZHANG S H,LI Z Y,LIU Z J,et al.MicroRNA15b regulates apoptosis of cutaneous squamous cell carcinoma SCL-1 cell line:a mechanism study[J].Eur Rev Med Pharmacol Sci,2017,21(2):227-233.
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[32] HUANG X,XIE H,XUE G,et al.MiR-3202-Promoted H5V cell apoptosis by directly targeting Fas apoptotic inhibitory molecule 2(FAIM2) in high glucose condition[J].Med Sci Monit,2017,23(1):975-983.
[33] HARITOS A A,GOODALL G J,HORECKER B L.Prothymosin alpha:isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus[J].Proc Natl Acad Sci USA,1984,81(4):1008-1011.
[34] QI X,WANG L,DU F.Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1[J].Biochemistry,2010,49(9):1923-1930.
[35] WU C D,KUO Y S,WU H C,et al.MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells[J].J Biomed Sci,2011,18(1):80-90.
[36] LI S,JIN Z,LU X.MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1[J].Mol Cell Biochem,2017,432(1/2):123-130.
[37] TRIPATHI A,SRIVASTAVA V,SINGH B N.hsa-let-7b-5p facilitates Mycobacterium tuberculosis survival in THP-1 human macrophages by Fas down regulation[J].Fems Microbiol Lett,2018,365(7).doi:10.1093/femsle/fny040.
[38] TASHARROFI N,KOUHKAN F,SOLEIMANI M,et al.Survival improvement in human retinal pigment epithelial cells via Fas receptor targeting by miR-374a[J].J Cell Biochem,2017,118(12):4854-4861.
[39] JEYASEELAN K,LIM K Y,ARMUGAM A.MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion[J].Stroke,2008,39(3):959-966.
[40] ZHANG J F,SHI L L,ZHANG L,et al.MicroRNA-25 negatively regulates cerebral ischemia/reperfusion injury-induced cell apoptosis through Fas/FasL pathway[J].J Mol Neurosci,2016,58(4):507-516.
[41] WANG H,LI J,CHI H,et al.MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells[J].J Cell Mol Med,2015,19(9):2084-2097.
[2] REINHART B J,SLACK F J,BASSON M,et al.The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans[J].Nature,2000,403(6772):901-906.
[3] BARTEL D P.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
[4] LEE Y,KIM M,HAN J,et al.MicroRNA genes are transcribed by RNA polymerase Ⅱ[J].EMBO J,2004,23(20):4051-4060.
[5] YI R,QIN Y,MACARA I G,et al.Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs[J].Genes Dev,2003,17(17):3011-3016.
[6] BERNSTEIN E,CAUDY A A,HAMMOND S M,et al.Role for a bidentate ribonuclease in the initiation step of RNA interference[J].Nature,2001,409(6818):363-366.
[7] ZENG Y.Principles of micro-RNA production and maturation[J].Oncogene,2006,25(46):6156-6162.
[8] ASHKENAZI A,FAIRBROTHER W J,LEVERSON J D,et al.From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors[J].Nat Rev Drug Discov,2017,16(4):273-284.
[9] 崔连鸷,王博,张晓伟,等.胰腺癌细胞外泌体通过激活线粒体凋亡途径促进β细胞凋亡[J].中国病理生理杂志,2017,33(12):2172-2178.
[10] 张晋平,丁艳平,冯汉青.microRNA与动物细胞凋亡的调控[J].动物医学进展,2013,34(6):172-174.
[11] XU P,VERNOOY S Y,GUO M,et al.The drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism[J].Curr Biol,2003,13(9):790-795.
[12] 郭文晋.miR-210在冷应激大鼠肝脏中的靶基因筛选及增殖凋亡研究[D].黑龙江大庆:黑龙江八一农垦大学,2017.
[13] GALLUZZI L,KEPP O,KROEMER G.Mitochondria:master regulators of danger signalling[J].Nat Rev Mol Cell Biol,2012,13(12):780-788.
[14] CHAN S L,MATTSON M P.Caspase and calpain substrates:roles in synaptic plasticity and cell death[J].J Neurosci Res,1999,58(1):167-190.
[15] SLABY O,SVOBODA M,FABIAN P,et al.Altered expression of miR-21,miR-31,miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer[J].Oncology,2007,72(5/6):397-402.
[16] ICHIMI T,ENOKIDA H,OKUNO Y,et al.Identification of novel microRNA targets based on microRNA signatures in bladder cancer[J].Int J Cancer,2009,125(2):345-352.
[17] PAN Y,YE C,TIAN Q,et al.miR-145 suppresses the proliferation,invasion and migration of NSCLC cells by regulating the BAX/BCL-2 ratio and the caspase-3 cascade[J].Oncol Lett,2018,15(4):4337-4343.
[18] ZHANG Y,CHEN N,ZHANG J,et al.Hsa-let-7g miRNA targets caspase-3 and inhibits the apoptosis induced by ox-LDL in endothelial cells[J].Int J Mol Sci,2013,14(11):22708-22720.
[19] 刘丁峰,章圣朋,刘晓平.关于Bcl-2凋亡蛋白家族的研究进展[J].科技视界,2017(1):88-89.
[20] WANG X L,DING G Y,LAI W,et al.MicroRNA-383 upregulation protects against propofol-induced hippocampal neuron apoptosis and cognitive impairment[J].Exp Ther Med,2018,15(4):3181-3188.
[21] KANG M,XIA P,HOU T,et al.MicroRNA-190b inhibits tumor cell proliferation and induces apoptosis by regulating Bcl-2 in U2OS osteosarcoma cells[J].Pharmazie,2017,72(5):279-282.
[22] WANG K,CHEN X,ZHAN Y,et al.miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W[J].Tumour Biol,2015,36(9):6875-6882.
[23] BING Z T,YANG G H,XIONG J,et al.Identify signature regulatory network for glioblastoma prognosis by integrative mRNA and miRNA co-expression analysis[J].Iet Syst Biol,2016,10(6):244-251.
[24] SENFTER D,HOLZNER S,KALIPCIYAN M,et al.Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro[J].Hum Mol Genet,2015,24(13):3689-3698.
[25] LIU S,TETZLAFF M T,CUI R,et al.miR-200c Inhibits melanoma progression and drug resistance through down-regulation of Bmi-1[J].Am J Pathol,2012,181(5):1823-1835.
[26] ZHOU X,WU W,ZENG A,et al.MicroRNA-141-3p promotes glioma cell growth and temozolomide resistance by directly targeting p53[J].Oncotarget,2017,8(41):71080-71094.
[27] CAI B,MA M,CHEN B,et al.MiR-16-5p targets SESN1 to regulate the p53 signaling pathway,affecting myoblast proliferation and apoptosis,and is involved in myoblast differentiation[J].Cell Death Dis,2018,9(3):367-381.
[28] PARK M,YOON H J,KANG M C,et al.MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin[J].Sci Rep,2017,7(1):10932-10940.
[29] ZHANG S H,LI Z Y,LIU Z J,et al.MicroRNA15b regulates apoptosis of cutaneous squamous cell carcinoma SCL-1 cell line:a mechanism study[J].Eur Rev Med Pharmacol Sci,2017,21(2):227-233.
[30] MAK C S,YUNG M M,HUI L M,et al.MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis[J].Mol Cancer,2017,16(1):11-27.
[31] WANG M,SU P.The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis:An update[J].Syst Biol Reprod Med,2018,64(2):93-102.
[32] HUANG X,XIE H,XUE G,et al.MiR-3202-Promoted H5V cell apoptosis by directly targeting Fas apoptotic inhibitory molecule 2(FAIM2) in high glucose condition[J].Med Sci Monit,2017,23(1):975-983.
[33] HARITOS A A,GOODALL G J,HORECKER B L.Prothymosin alpha:isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus[J].Proc Natl Acad Sci USA,1984,81(4):1008-1011.
[34] QI X,WANG L,DU F.Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1[J].Biochemistry,2010,49(9):1923-1930.
[35] WU C D,KUO Y S,WU H C,et al.MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells[J].J Biomed Sci,2011,18(1):80-90.
[36] LI S,JIN Z,LU X.MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1[J].Mol Cell Biochem,2017,432(1/2):123-130.
[37] TRIPATHI A,SRIVASTAVA V,SINGH B N.hsa-let-7b-5p facilitates Mycobacterium tuberculosis survival in THP-1 human macrophages by Fas down regulation[J].Fems Microbiol Lett,2018,365(7).doi:10.1093/femsle/fny040.
[38] TASHARROFI N,KOUHKAN F,SOLEIMANI M,et al.Survival improvement in human retinal pigment epithelial cells via Fas receptor targeting by miR-374a[J].J Cell Biochem,2017,118(12):4854-4861.
[39] JEYASEELAN K,LIM K Y,ARMUGAM A.MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion[J].Stroke,2008,39(3):959-966.
[40] ZHANG J F,SHI L L,ZHANG L,et al.MicroRNA-25 negatively regulates cerebral ischemia/reperfusion injury-induced cell apoptosis through Fas/FasL pathway[J].J Mol Neurosci,2016,58(4):507-516.
[41] WANG H,LI J,CHI H,et al.MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells[J].J Cell Mol Med,2015,19(9):2084-2097.