益生菌在肥胖动物模型中的研究进展
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摘要
肥胖已成为严重威胁人类健康的全球性疾病之一,肠道菌群组成的改变与肥胖密切相关。由于益生菌在调节肠道菌群平衡、提高机体免疫力方面具有重要功能,因此益生菌为肥胖治疗带来可能。本文从作用机制、不同动物模型等角度综述近年来益生菌在肥胖模型中的研究现状,为益生菌在临床实验和实际中的应用提供参考。
Obesity has become one of the most prevalent diseases worldwide that seriously threatens human health. Obesity is closely related to variations in the gut microbiota. Probiotics have potential for obesity treatment as they play an important role?in?regulating?the?balance?of?intestinal?flora?and?improving?the?immunity?of?the?body.?This?paper?reviews?the?current?status of research on the mechanisms of action of probiotics in animal models of obesity induced by different factors so as to provide useful information for clinical trials and applications of probiotics.
Obesity has become one of the most prevalent diseases worldwide that seriously threatens human health. Obesity is closely related to variations in the gut microbiota. Probiotics have potential for obesity treatment as they play an important role?in?regulating?the?balance?of?intestinal?flora?and?improving?the?immunity?of?the?body.?This?paper?reviews?the?current?status of research on the mechanisms of action of probiotics in animal models of obesity induced by different factors so as to provide useful information for clinical trials and applications of probiotics.
引文
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[17]何忠梅,李婷婷,赵玉娟,等.植物乳杆菌Sc52对脂多糖诱导小鼠肠道屏障损伤的保护作用[J].食品科学,2018,39(9):134-139.DOI:10.7506/spkx1002-6630-201809021.
[18]王雪,文姝,李华军,等.嗜酸乳杆菌对Ⅱ型糖尿病小鼠预防与治疗的研究[J].中国微生态学杂志,2010,22(12):1069-1073.
[19]LU Yingchen,YIN Lite,CHANG Wenteng,et al.Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats[J].Journal of Bioscience and Bioengineering,2010,110(6):709-715.DOI:10.1016/j.jbiosc.2010.07.006.
[20]EREJUWA O O,SULAIMAN S A,AB WAHAB M S.Modulation of gut microbiota in the management of metabolic disorders:the prospects and challenges[J].International Journal of Molecular Sciences,2014,15(3):4158-4188.DOI:10.3390/ijms15034158.
[21]ELLI M,COLOMBO O,TAGLIABUE A.A common core microbiota between obese individuals and their lean relatives?Evaluation of the predisposition to obesity on the basis of the fecal microflora profile[J]. Medical Hypotheses, 2010, 75(4): 350-352. DOI:10.1016/j.mehy.2010.03.022.
[22]ZHANG Min,WANG Cuiling,WANG Chunhong,et al.Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease[J].Journal of Nutritional Biochemistry,2015,26(4):337-344.DOI:10.1016/j.jnutbio.2014.10.016.
[23]宋晨.乳杆菌对高脂膳食诱导小鼠肥胖形成抑制作用及机制研究[D].哈尔滨:哈尔滨工业大学,2016:43-49.
[24]PATHAK P,CEN X,NICHOLS R G,et al.Intestine farnesoid Xreceptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism[J].Hepatology,2018,68(4):1574-1588.DOI:10.1002/hep.29857.
[25]WATANABE M,HOUTEN S M,MATAKI C,et al.Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation[J].Nature,2006,439:484-489.DOI:10.1038/nature04330.
[26]郭上齐,武华,翟春宝,等.粪菌移植对营养性肥胖大鼠血脂及肠道屏障的影响[J].中国现代医生,2016,54(4):25-27.
[27] CHEVALIER C, STOJANOVI? O, COLIN D J, et al. Gut microbiota orchestrates energy homeostasis during cold[J].Cell,2015,163(6):1360-1374.DOI:10.1016/j.cell.2015.11.004.
[28]EVERARD A,BELZER C,GEURTS L,et al.Cross-talk between Akkermansia muciniphila and intestinal epithelium controls dietinduced obesity[J].PNAS,2013,110(22):9066-9071.DOI:10.1073/pnas.1219451110.
[29]XIE C L,HWANG C E,OH C K,et al.Fermented soy-powder milk with Lactobacillus plantarum P1201 protects against high-fat diet-induced obesity[J].International Journal of Food Science and Technology,2017,52(7):1614-1622.DOI:10.1111/ijfs.13434.
[30]LEE B H,LO Y H,PAN T M.Anti-obesity activity of Lactobacillus fermented soy milk products[J].Journal of Functional Foods,2013,5(2):905-913.DOI:10.1016/j.jff.2013.01.040.
[31]PARK S Y,SEONG K S,LIM S D.Anti-obesity effect of yogurt fermented by Lactobacillus plantarum Q180 in diet-induced obese rats[J].Korean Journal for Food Science of Animal Resources,2016,36(1):77-83.DOI:10.5851/kosfa.2016.36.1.77.
[32]ANDERSSON U,BR?NNING C,AHRNéS,et al.Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse[J].Beneficial Microbes,2010,1(2):189-196.DOI:10.3920/BM2009.0036.
[33]BOMHOF M R,SAHA D C,REID D T,et al.Combined effects of oligofructose and Bifidobacterium animalis on gut microbiota and glycemia in obese rats[J].Obesity,2014,22(3):763-771.DOI:10.1002/oby.20632.
[34]李彩娜,沈宁,刘率男,等.MSG肥胖性胰岛素抵抗小鼠特征研究[C]//实验动物与药理学、毒理学研究学术交流会论文汇编.北京:中国实验动物学会,2009.
[35]MARYANA K,NAZARII K,OLEKSANDR V,et al.Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats[J].Current Issues in Pharmacy and Medical Sciences,2014,27(4):243-245.DOI:10.1515/cipms-2015-0025.
[36]SAVCHENIUK O A,VIRCHENKO O V,FALALYEYEVA T M,et al.The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention[J].EPMA Journal,2014,5(1):2-19.DOI:10.1186/1878-5085-5-2.
[37]KOBYLIAK N,FALALYEYEVA T,BEREGOVA T,et al.Probiotics for experimental obesity prevention:focus on strain dependence and viability of composition[J].Endokrynologia Polska,2017,68(6):659-667.DOI:10.5603/EP.a2017.0055.
[2]刘俊,郭毅,刘晴,等.超重、肥胖与2型糖尿病相关性的Meta分析[J].中国循证医学杂志,2013,13(2):190-195.
[3]ANDREOTTI F,CREA F,HENNEKENS C H.Mechanisms,pathophysiology,and management of obesity[J].New England Journal of Medicine,2017,376(15):254-266.DOI:10.1056/NEJMc1701944.
[4]KOBYLIAK N,CONTE C,CAMMAROTA G,et al.Probiotics in prevention and treatment of obesity:a critical view[J].Nutrition and Metabolism,2016,13(1):1-14.DOI:10.1186/s12986-016-0067-0.
[5]张莹,焦怡琳,陆凯,等.中国成年人超重肥胖影响因素Meta分析[J].中国公共卫生,2015,31(2):232-235.
[6]B?CKHED F,DING H,WANG T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proceedings of the National Academy of Sciences,2004,101(44):15718-15723.DOI:10.1073/pnas.0407076101.
[7]SCHROEDER B O,B?CKHED F.Signals from the gut microbiota to distant organs in physiology and disease[J].Nature Medicine,2016,22(10):1079-1089.DOI:10.1038/nm.4185.
[8]FREDRIK B,JILL K M,CLAY F S,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proceedings of the National Academy of Sciences,2007,104(3):979-984.DOI:10.1073/pnas.0605374104.
[9]LIU Ruixin,HONG Jie,XU Xiaoqiang,et al.Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention[J].Nature Medicine,2017,23(7):859-868.DOI:10.1038/nm.4358.
[10]CHEN Yungtsung,YANG Ningsun,LIN Yuchun,et al.A combination of Lactobacillus mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice[J].Scientific Reports,2018,8(1):1-14.DOI:10.1038/s41598-018-23844-y.
[11]RIDAURA V K,FAITH J J,REY F E,et al.Gut microbiota from twins discordant for obesity modulate metabolism in mice[J].Science,2013,341:1-10.DOI:10.1126/science.1241214.
[12]WANG Jingjing,TANG Huang,ZHANG Chenhong,et al.Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice[J].ISME Journal,2015,9(1):1-15.DOI:10.1038/ismej.2014.99.
[13]BUBNOV R V,BABENKO L P,LAZARENKO L M,et al.Comparative study of probiotic effects of Lactobacillus and Bifidobacteria strains on cholesterol levels,liver morphology and the gut microbiota in obese mice[J].EPMA Journal,2017,8(4):357-376.DOI:10.1007/s13167-017-0117-3.
[14]ZHENG Jia,XIAO Xinhua,ZHANG Qian,et al.The programming effects of nutrition-induced catch-up growth on gut microbiota and metabolic diseases in adult mice[J].Microbiologyopen,2016,5(2):296-306.DOI:10.1002/mbo3.328.
[15]CREMONINI E,ZIWEI W,BETTAIEB A,et al.(-)-Epicatechin protects the intestinal barrier from high fatdiet-induced permeabilization:implications for steatosis and insulin resistance[J].Redox Biology,2018,14:588-599.DOI:10.1016/j.redox.2017.11.002.
[16]GRAHAM C,MULLEN A,WHELAN K.Obesity and the gastrointestinal microbiota:a review of associations and mechanisms[J].Nutrition Reviews,2015,73(6):376-385.DOI:10.1093/nutrit/nuv004.
[17]何忠梅,李婷婷,赵玉娟,等.植物乳杆菌Sc52对脂多糖诱导小鼠肠道屏障损伤的保护作用[J].食品科学,2018,39(9):134-139.DOI:10.7506/spkx1002-6630-201809021.
[18]王雪,文姝,李华军,等.嗜酸乳杆菌对Ⅱ型糖尿病小鼠预防与治疗的研究[J].中国微生态学杂志,2010,22(12):1069-1073.
[19]LU Yingchen,YIN Lite,CHANG Wenteng,et al.Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats[J].Journal of Bioscience and Bioengineering,2010,110(6):709-715.DOI:10.1016/j.jbiosc.2010.07.006.
[20]EREJUWA O O,SULAIMAN S A,AB WAHAB M S.Modulation of gut microbiota in the management of metabolic disorders:the prospects and challenges[J].International Journal of Molecular Sciences,2014,15(3):4158-4188.DOI:10.3390/ijms15034158.
[21]ELLI M,COLOMBO O,TAGLIABUE A.A common core microbiota between obese individuals and their lean relatives?Evaluation of the predisposition to obesity on the basis of the fecal microflora profile[J]. Medical Hypotheses, 2010, 75(4): 350-352. DOI:10.1016/j.mehy.2010.03.022.
[22]ZHANG Min,WANG Cuiling,WANG Chunhong,et al.Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease[J].Journal of Nutritional Biochemistry,2015,26(4):337-344.DOI:10.1016/j.jnutbio.2014.10.016.
[23]宋晨.乳杆菌对高脂膳食诱导小鼠肥胖形成抑制作用及机制研究[D].哈尔滨:哈尔滨工业大学,2016:43-49.
[24]PATHAK P,CEN X,NICHOLS R G,et al.Intestine farnesoid Xreceptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism[J].Hepatology,2018,68(4):1574-1588.DOI:10.1002/hep.29857.
[25]WATANABE M,HOUTEN S M,MATAKI C,et al.Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation[J].Nature,2006,439:484-489.DOI:10.1038/nature04330.
[26]郭上齐,武华,翟春宝,等.粪菌移植对营养性肥胖大鼠血脂及肠道屏障的影响[J].中国现代医生,2016,54(4):25-27.
[27] CHEVALIER C, STOJANOVI? O, COLIN D J, et al. Gut microbiota orchestrates energy homeostasis during cold[J].Cell,2015,163(6):1360-1374.DOI:10.1016/j.cell.2015.11.004.
[28]EVERARD A,BELZER C,GEURTS L,et al.Cross-talk between Akkermansia muciniphila and intestinal epithelium controls dietinduced obesity[J].PNAS,2013,110(22):9066-9071.DOI:10.1073/pnas.1219451110.
[29]XIE C L,HWANG C E,OH C K,et al.Fermented soy-powder milk with Lactobacillus plantarum P1201 protects against high-fat diet-induced obesity[J].International Journal of Food Science and Technology,2017,52(7):1614-1622.DOI:10.1111/ijfs.13434.
[30]LEE B H,LO Y H,PAN T M.Anti-obesity activity of Lactobacillus fermented soy milk products[J].Journal of Functional Foods,2013,5(2):905-913.DOI:10.1016/j.jff.2013.01.040.
[31]PARK S Y,SEONG K S,LIM S D.Anti-obesity effect of yogurt fermented by Lactobacillus plantarum Q180 in diet-induced obese rats[J].Korean Journal for Food Science of Animal Resources,2016,36(1):77-83.DOI:10.5851/kosfa.2016.36.1.77.
[32]ANDERSSON U,BR?NNING C,AHRNéS,et al.Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse[J].Beneficial Microbes,2010,1(2):189-196.DOI:10.3920/BM2009.0036.
[33]BOMHOF M R,SAHA D C,REID D T,et al.Combined effects of oligofructose and Bifidobacterium animalis on gut microbiota and glycemia in obese rats[J].Obesity,2014,22(3):763-771.DOI:10.1002/oby.20632.
[34]李彩娜,沈宁,刘率男,等.MSG肥胖性胰岛素抵抗小鼠特征研究[C]//实验动物与药理学、毒理学研究学术交流会论文汇编.北京:中国实验动物学会,2009.
[35]MARYANA K,NAZARII K,OLEKSANDR V,et al.Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats[J].Current Issues in Pharmacy and Medical Sciences,2014,27(4):243-245.DOI:10.1515/cipms-2015-0025.
[36]SAVCHENIUK O A,VIRCHENKO O V,FALALYEYEVA T M,et al.The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention[J].EPMA Journal,2014,5(1):2-19.DOI:10.1186/1878-5085-5-2.
[37]KOBYLIAK N,FALALYEYEVA T,BEREGOVA T,et al.Probiotics for experimental obesity prevention:focus on strain dependence and viability of composition[J].Endokrynologia Polska,2017,68(6):659-667.DOI:10.5603/EP.a2017.0055.