白藜芦醇外涂美白功效及安全性的临床观察
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摘要
目的:观察白藜芦醇外涂对人类面部皮肤的美白功效及安全性。方法:招募40名面部光老化女性受试者,随机分为治疗组及对照组,每组20名,分别涂抹白藜芦醇或基质,连续12周。于使用前、后不同时间点,测量皮肤颜色及含水量。结果:白藜芦醇组受试者的黑素指数均值较试验开始前明显下降,黑素指数差值显著低于对照组。红斑指数及角质层含水量在试验前后无明显变化。医师评价约65%的受试者皮肤亮白程度获得了中度至明显的改善,约60%的受试者对疗效满意或非常满意。无不良反应发生。结论:白藜芦醇具有一定程度的美白功效,且安全性好。
Objective To investigate the whitening efficacy and safety of resveratrol on human facial skin.Methods Forty healthy female volunteers were enrolled in this study.They were randomly assigned into treatment group(20 cases) and control group(20 cases).Treatment group and control group were respectively received resveratrol cream and base cream,for 12 consecutive weeks.Before and after treatments,skin color and water content were measured.Results After treatment with resveratrol,the mean melanin index(MI) value decreased obviously compared with pretreatment,and the MI difference value of treatment group was significantly lower than that of control group.The erythema index and water content remained unchanged pre-and post-treatment.The skin pigmentation of about 65% volunteers assessed by a dermatologist obtained moderate to obvious improvement and approximate 60% volunteers rated satisfactory or very satisfactory.There were no side-effects.Conclusion The topical resveratol has whitening effect on skin,without any side effects.
Objective To investigate the whitening efficacy and safety of resveratrol on human facial skin.Methods Forty healthy female volunteers were enrolled in this study.They were randomly assigned into treatment group(20 cases) and control group(20 cases).Treatment group and control group were respectively received resveratrol cream and base cream,for 12 consecutive weeks.Before and after treatments,skin color and water content were measured.Results After treatment with resveratrol,the mean melanin index(MI) value decreased obviously compared with pretreatment,and the MI difference value of treatment group was significantly lower than that of control group.The erythema index and water content remained unchanged pre-and post-treatment.The skin pigmentation of about 65% volunteers assessed by a dermatologist obtained moderate to obvious improvement and approximate 60% volunteers rated satisfactory or very satisfactory.There were no side-effects.Conclusion The topical resveratol has whitening effect on skin,without any side effects.
引文
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[2]杨连春,王峰,刘敏,等.抗蛇毒中草药红背丝绸对内皮素-1的拮抗作用[J].中国新药杂志,2000,9(7):455-458.
[3]Slominski A,Tobin DJ,Shibahara S,et al.Melanin pigmentation inmammalian skin and its hormonal regulation[J].Physiol Rev,2004,84(4):1155-1228.
[4]Monji A,Inoue H,Oshima H,et al.Tyrosinase induction andinactivation in normal cultured human melanocytes by endothelin-1[J].Int J Tissue React,2005,27(2):41-49.
[5]Clarys P,Alewaeters K,Lambrecht R,et a1.Skin color measurements:comparison between three instruments:the Chromameter(R),theDermaSpectrometer(R)and the Mexameter(R)[J].Skin ResTechnol,2000,6(4):230-238.
[6]Fitzpatrick TB.The validity and practicality of sun-reactive skin typesⅠthroughⅥ[J].Arch Dermatol,1988,124:869-871.
[7]贾丽丽,李远宏,吴严,等.白藜芦醇对模拟日光照射所致皮肤损伤的防护作用[J].中国美容医学,2009,18(9):1306-1308.