肺炎链球菌自溶素研究进展
|
摘要
<正>肺炎链球菌(Streptococcus pneumoniae)是一种革兰阳性(G~+)条件致病菌,常定植于人鼻咽部,近一半健康人携带此菌~([1])。当人体免疫力降低,定植的肺炎链球菌可穿透黏膜等防御体系引起多种感染。临床上,肺炎链球菌是导致社区获得性肺炎、脑膜炎、中耳炎等的重要病原之一。易感人群包括儿童、老年人,及伴有其他基础疾病(如肿瘤、红
引文
[1]Varghese R,Jayaraman R,Veeraraghavan B.Current challenges in the accurate identification of Streptococcus pneumoniae and its serogroups/serotypes in the vaccine era.J Microbiol Methods,2017,141:48-54.
[2]Remington LT,Sligl WI.Community-acquired pneumonia.Curr Opin Pulm Med,2014,30(2):215-224.
[3]Xie XF,Luo H.A study of correlation between autolysis and LytA,an autolysin-encoding gene of Streptococcus pneumoniae.J Pathog Bio,2016,11(12):1154-1157.(in Chinese)谢兴凤,罗红.肺炎链球菌自溶素与自溶相关性研究进展.中国病原生物学杂志,2016,11(12):1154-1157.
[4]Kim GL,Luong TT,Park SS,et al.Inhibition of autolysis by lipase LipA in Streptococcus pneumoniae Sepsis.Mol Cells,2017,40(12):935-944.
[5]Magomani V,Wolter N,Tempia S,et al.Challenges of using molecular serotyping for surveillance of pneumococcal disease.J Clin Microbiol,2014,52(9):3271-3276.
[6]Rodríguez-Cerrato V,García P,Del Prado G,et al.In vitro interactions of LytA,the major pneumococcal autolysin,with two bacteriophage lytic enzymes(Cpl-1 and Pal),cefotaxime and moxifloxacin against antibiotic-susceptible and-resistant Streptococcus pneumoniae strains.J Antimicrob Chemother,2007,60(5):1159-1162.
[7]García P,García J,García E,et al.Nucleotide sequence and expression of the pneumococcal autolysin gene from its own promoter in Escherichia coli.Gene,1986,43(3):265-272.
[8]Whatmore AM,Dowson CG.The autolysin-encoding gene(lytA)of Streptococcus pneumoniae displays restricted allelic variation despite localized recombination events with genes of pneumococcal bacteriophage encoding cell wall lytic enzymes.Infect Immun,1999,67(9):4551-4556.
[9]Loeffler JM,Nelson D,Fischetti VA.Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase.Science,2001,294(5549):2170-2172.
[10]Morales M,Martín-Galiano AJ,Domenech M,et al.Insights into the evolutionary relationships of LytA autolysin and Ply pneumolysin-like genes in Streptococcus pneumoniae and related streptococci.Genome Biol Evol,2015,7(9):2747-2761.
[11]Tomasz A,Westphal M.Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition.Proc Natl Acad Sci U S A,1971,68(11):2627-2630.
[12]Li Q,Cheng W,Morlot C,et al.Full-length structure of the major autolysin LytA.Acta Crystallogr D Biol Crystallogr,2015,71(6):1373-1381.
[13]Zhang Z,Li W,Frolet C,et al.Structure of the choline-binding domain of Spr1274 in Streptococcus pneumoniae.Acta Crystallogr Sect F Struct Biol Cryst Commun,2009,65(Pt 8):757-761.
[14]Mellroth P,Sandalova T,Kikhney A,et al.Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.MBio,2014,5(1):e01120-13.
[15]Frolet C,Beniazza M,Roux L,et al.New adhesin functions of surface-exposed pneumococcal proteins.BMC Microbiol,2010,10:190.
[16]Johnston RB Jr.Pathogenesis of pneumococcal pneumonia.Rev Infect Dis,1991,13 Suppl 6:S509-S5017.
[17]Mellroth P,Daniels R,Eberhardt A,et al.LytA,Major autolysin of Streptococcus pneumoniae,requires access to nascent peptidoglycan.J Biol Chem,2012,287(14):11018-11029.
[18]Frias MJ,Melo-Cristino J,Ramirez M.The autolysin LytA contributes to efficient bacteriophage progeny release in Streptococcus pneumoniae.J Bacteriol,2009,191(17):5428-5440.
[19]Maestro B,Sanz JM.Accumulation of partly folded states in the equilibrium unfolding of the pneumococcal choline-binding module C-LytA.Biochem J,2005,387(Pt 2):479-488.
[20]Ramos-Sevillano E,Urzainqui A,Campuzano S,et al.Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.Infect Immun,2015,83(2):591-603.
[21]Kietzman CC,Gao G,Mann B,et al.Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium.Nat Commun,2016,7:10859.
[22]Sanz JC,Ríos E,Rodríguez-Avial I,et al.Identification of Streptococcus pneumoniae lytA,plyA and psaA genes in pleural fluid by multiplex real-time PCR.Enferm Infecc Microbiol Clin,2018,36(7):428-430.
[23]Str?lin K,Herrmann B,Abdeldaim G,et al.Comparison of sputum and nasopharyngeal aspirate samples and of the PCR gene targets lytAand Spn9802 for quantitative PCR for rapid detection of pneumococcal pneumonia.J Clin Microbiol,2014,52(1):83-89.
[24]Ergin A,Eser OK,Sener B,et al.Value of demonstration of pneumococcal surface antigen A and autolysin genes for the identification of Streptococcus pneumoniae clinical isolates.Mikrobiyol Bul,2009,43(1):11-17.
[25]Yuan ZQ,Lv ZY,Gan HQ,et al.Intranasal immunization with autolysin(LytA)in mice model induced protection against five prevalent Streptococcus pneumoniae serotypes in China.Immunol Res,2011,51(1):108-115.
[26]Gan HQ,Xian M,Yuan ZQ,et al.Study on intranasal immunizations with recombinant-pneumococcal autolysin(Re-LytA)in mice.Chin J Microbiol Immunol,2008,28(7):629-633.(in Chinese)甘慧泉,鲜墨,袁竹青,等.肺炎链球菌重组自溶酶(Re-LytA)滴鼻免疫小鼠的实验研究.中华微生物学和免疫学杂志,2008,28(7):629-633.
[27]Zou Q,Yang G,Luo H,et al.Immunological activity of a mini-fragment of Pneumococcal autolysin LytA.J Microbiol,2014,34(3):52-55.(in Chinese)邹琴,杨光,罗红,等.肺炎链球菌自溶素LytA小片段免疫活性的研究.微生物学杂志,2014,34(3):52-55.
[28]Gosink KK,Mann ER,Guglielmo C,et al.Role of novel choline binding proteins in virulence of Streptococcus pneumoniae.Infect Immun,2000,68(10):5690-5695.
[29]Zucchini L,Mercy C,Garcia PS,et al.PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae.Nat Microbiol,2018,3(2):197-209.
[30]Corsini B,Aguinagalde L,Ruiz S,et al.Immunization with LytBprotein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis.Vaccine,2016,34(50):6148-6157.
[31]Moscoso M,López E,García E,et al.Implications of physiological studies based on genomic sequences:Streptococcus pneumoniae TIGR4 synthesizes a functional LytC lysozyme.J Bacteriol,2005,187(17):6238-6241.
[32]Ramos-Sevillano E,Moscoso M,García P,et al.Nasopharyngeal colonization and invasive disease are enhanced by the cell wall hydrolases LytB and LytC of Streptococcus pneumoniae.PLoS One,2011,6(8):e23626.
[33]Domenech M,Ruiz S,Moscoso M,et al.In vitro biofilm development of Streptococcus pneumoniae and formation of choline-binding protein-DNA complexes.Environ Microbiol Rep,2015,7(5):715-727.
[34]Domenech M,García E,Prieto A,et al.Insight into the composition of the intercellular matrix of Streptococcus pneumoniae biofilms.Environ Microbiol,2013,15(2):502-516.
[2]Remington LT,Sligl WI.Community-acquired pneumonia.Curr Opin Pulm Med,2014,30(2):215-224.
[3]Xie XF,Luo H.A study of correlation between autolysis and LytA,an autolysin-encoding gene of Streptococcus pneumoniae.J Pathog Bio,2016,11(12):1154-1157.(in Chinese)谢兴凤,罗红.肺炎链球菌自溶素与自溶相关性研究进展.中国病原生物学杂志,2016,11(12):1154-1157.
[4]Kim GL,Luong TT,Park SS,et al.Inhibition of autolysis by lipase LipA in Streptococcus pneumoniae Sepsis.Mol Cells,2017,40(12):935-944.
[5]Magomani V,Wolter N,Tempia S,et al.Challenges of using molecular serotyping for surveillance of pneumococcal disease.J Clin Microbiol,2014,52(9):3271-3276.
[6]Rodríguez-Cerrato V,García P,Del Prado G,et al.In vitro interactions of LytA,the major pneumococcal autolysin,with two bacteriophage lytic enzymes(Cpl-1 and Pal),cefotaxime and moxifloxacin against antibiotic-susceptible and-resistant Streptococcus pneumoniae strains.J Antimicrob Chemother,2007,60(5):1159-1162.
[7]García P,García J,García E,et al.Nucleotide sequence and expression of the pneumococcal autolysin gene from its own promoter in Escherichia coli.Gene,1986,43(3):265-272.
[8]Whatmore AM,Dowson CG.The autolysin-encoding gene(lytA)of Streptococcus pneumoniae displays restricted allelic variation despite localized recombination events with genes of pneumococcal bacteriophage encoding cell wall lytic enzymes.Infect Immun,1999,67(9):4551-4556.
[9]Loeffler JM,Nelson D,Fischetti VA.Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase.Science,2001,294(5549):2170-2172.
[10]Morales M,Martín-Galiano AJ,Domenech M,et al.Insights into the evolutionary relationships of LytA autolysin and Ply pneumolysin-like genes in Streptococcus pneumoniae and related streptococci.Genome Biol Evol,2015,7(9):2747-2761.
[11]Tomasz A,Westphal M.Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition.Proc Natl Acad Sci U S A,1971,68(11):2627-2630.
[12]Li Q,Cheng W,Morlot C,et al.Full-length structure of the major autolysin LytA.Acta Crystallogr D Biol Crystallogr,2015,71(6):1373-1381.
[13]Zhang Z,Li W,Frolet C,et al.Structure of the choline-binding domain of Spr1274 in Streptococcus pneumoniae.Acta Crystallogr Sect F Struct Biol Cryst Commun,2009,65(Pt 8):757-761.
[14]Mellroth P,Sandalova T,Kikhney A,et al.Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.MBio,2014,5(1):e01120-13.
[15]Frolet C,Beniazza M,Roux L,et al.New adhesin functions of surface-exposed pneumococcal proteins.BMC Microbiol,2010,10:190.
[16]Johnston RB Jr.Pathogenesis of pneumococcal pneumonia.Rev Infect Dis,1991,13 Suppl 6:S509-S5017.
[17]Mellroth P,Daniels R,Eberhardt A,et al.LytA,Major autolysin of Streptococcus pneumoniae,requires access to nascent peptidoglycan.J Biol Chem,2012,287(14):11018-11029.
[18]Frias MJ,Melo-Cristino J,Ramirez M.The autolysin LytA contributes to efficient bacteriophage progeny release in Streptococcus pneumoniae.J Bacteriol,2009,191(17):5428-5440.
[19]Maestro B,Sanz JM.Accumulation of partly folded states in the equilibrium unfolding of the pneumococcal choline-binding module C-LytA.Biochem J,2005,387(Pt 2):479-488.
[20]Ramos-Sevillano E,Urzainqui A,Campuzano S,et al.Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.Infect Immun,2015,83(2):591-603.
[21]Kietzman CC,Gao G,Mann B,et al.Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium.Nat Commun,2016,7:10859.
[22]Sanz JC,Ríos E,Rodríguez-Avial I,et al.Identification of Streptococcus pneumoniae lytA,plyA and psaA genes in pleural fluid by multiplex real-time PCR.Enferm Infecc Microbiol Clin,2018,36(7):428-430.
[23]Str?lin K,Herrmann B,Abdeldaim G,et al.Comparison of sputum and nasopharyngeal aspirate samples and of the PCR gene targets lytAand Spn9802 for quantitative PCR for rapid detection of pneumococcal pneumonia.J Clin Microbiol,2014,52(1):83-89.
[24]Ergin A,Eser OK,Sener B,et al.Value of demonstration of pneumococcal surface antigen A and autolysin genes for the identification of Streptococcus pneumoniae clinical isolates.Mikrobiyol Bul,2009,43(1):11-17.
[25]Yuan ZQ,Lv ZY,Gan HQ,et al.Intranasal immunization with autolysin(LytA)in mice model induced protection against five prevalent Streptococcus pneumoniae serotypes in China.Immunol Res,2011,51(1):108-115.
[26]Gan HQ,Xian M,Yuan ZQ,et al.Study on intranasal immunizations with recombinant-pneumococcal autolysin(Re-LytA)in mice.Chin J Microbiol Immunol,2008,28(7):629-633.(in Chinese)甘慧泉,鲜墨,袁竹青,等.肺炎链球菌重组自溶酶(Re-LytA)滴鼻免疫小鼠的实验研究.中华微生物学和免疫学杂志,2008,28(7):629-633.
[27]Zou Q,Yang G,Luo H,et al.Immunological activity of a mini-fragment of Pneumococcal autolysin LytA.J Microbiol,2014,34(3):52-55.(in Chinese)邹琴,杨光,罗红,等.肺炎链球菌自溶素LytA小片段免疫活性的研究.微生物学杂志,2014,34(3):52-55.
[28]Gosink KK,Mann ER,Guglielmo C,et al.Role of novel choline binding proteins in virulence of Streptococcus pneumoniae.Infect Immun,2000,68(10):5690-5695.
[29]Zucchini L,Mercy C,Garcia PS,et al.PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae.Nat Microbiol,2018,3(2):197-209.
[30]Corsini B,Aguinagalde L,Ruiz S,et al.Immunization with LytBprotein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis.Vaccine,2016,34(50):6148-6157.
[31]Moscoso M,López E,García E,et al.Implications of physiological studies based on genomic sequences:Streptococcus pneumoniae TIGR4 synthesizes a functional LytC lysozyme.J Bacteriol,2005,187(17):6238-6241.
[32]Ramos-Sevillano E,Moscoso M,García P,et al.Nasopharyngeal colonization and invasive disease are enhanced by the cell wall hydrolases LytB and LytC of Streptococcus pneumoniae.PLoS One,2011,6(8):e23626.
[33]Domenech M,Ruiz S,Moscoso M,et al.In vitro biofilm development of Streptococcus pneumoniae and formation of choline-binding protein-DNA complexes.Environ Microbiol Rep,2015,7(5):715-727.
[34]Domenech M,García E,Prieto A,et al.Insight into the composition of the intercellular matrix of Streptococcus pneumoniae biofilms.Environ Microbiol,2013,15(2):502-516.