摘要
目的观察天香丹对冠心病稳定型心绞痛病人临床疗效及血清中炎性因子白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)表达水平的影响,探讨天香丹防治冠心病的可能机制。方法将符合纳入标准的100例冠心病稳定型心绞痛病人随机分为治疗组和对照组,每组50例。治疗组给予天香丹治疗,对照给予阿托伐他汀钙片治疗。结果经治疗后治疗组可明显减轻冠心病病人心绞痛临床症状,两组心绞痛临床疗效总有效率为81.63%与60.42%;改善心电图临床缺血表现,两组心电图总有效率为75.51%与56.25%,两组比较差异有统计学意义(P<0.05)。两组均可降低血清IL-1β和TNF-α表达水平,调节血脂紊乱,两组比较差异无统计学意义。结论天香丹具有抗炎作用,抑制炎症反应是其防治冠心病机制之一。
Objective To observe the effect of Tianxiangdan(TXD)on patients with stable angina pector is coronary heart disease and serum inflammatory factor Interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α),to explore the possible mechanism of TXD the prevention and treatment of coronary heart disease.Methods One hundred patients who met the inclusion criteria with stable angina pectoris were randomly divided into treatment group(n =50),and control group(n =50),The patients in treatment group were given TXD and the patients in control group were given atorvastatin calcium tablets.Results The clinical symptoms of coronary heart disease were reduced,and the clinical manifestations of ECG ischemia were improved in treatment group,compared with that in the control group,the difference was statistically significant.TXD and Atorvastation calcium Tablets Serum IL-1β and TNF-αexpression levels were reduced,blood lipid levels were regulated in two groups,the difference between the 2 groups was not statistically significant.Conclusion TXD has anti-inflammatory effects,inhibition of inflammatory response is one of the mechanisms of its prevention and treatment of stable angina pector is coronary heart disease.
引文
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