天香丹对冠心病稳定型心绞痛病人临床疗效及血清中炎性因子IL-1β和TNF-α的影响
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摘要
目的观察天香丹对冠心病稳定型心绞痛病人临床疗效及血清中炎性因子白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)表达水平的影响,探讨天香丹防治冠心病的可能机制。方法将符合纳入标准的100例冠心病稳定型心绞痛病人随机分为治疗组和对照组,每组50例。治疗组给予天香丹治疗,对照给予阿托伐他汀钙片治疗。结果经治疗后治疗组可明显减轻冠心病病人心绞痛临床症状,两组心绞痛临床疗效总有效率为81.63%与60.42%;改善心电图临床缺血表现,两组心电图总有效率为75.51%与56.25%,两组比较差异有统计学意义(P<0.05)。两组均可降低血清IL-1β和TNF-α表达水平,调节血脂紊乱,两组比较差异无统计学意义。结论天香丹具有抗炎作用,抑制炎症反应是其防治冠心病机制之一。
Objective To observe the effect of Tianxiangdan(TXD)on patients with stable angina pector is coronary heart disease and serum inflammatory factor Interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α),to explore the possible mechanism of TXD the prevention and treatment of coronary heart disease.Methods One hundred patients who met the inclusion criteria with stable angina pectoris were randomly divided into treatment group(n =50),and control group(n =50),The patients in treatment group were given TXD and the patients in control group were given atorvastatin calcium tablets.Results The clinical symptoms of coronary heart disease were reduced,and the clinical manifestations of ECG ischemia were improved in treatment group,compared with that in the control group,the difference was statistically significant.TXD and Atorvastation calcium Tablets Serum IL-1β and TNF-αexpression levels were reduced,blood lipid levels were regulated in two groups,the difference between the 2 groups was not statistically significant.Conclusion TXD has anti-inflammatory effects,inhibition of inflammatory response is one of the mechanisms of its prevention and treatment of stable angina pector is coronary heart disease.
Objective To observe the effect of Tianxiangdan(TXD)on patients with stable angina pector is coronary heart disease and serum inflammatory factor Interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α),to explore the possible mechanism of TXD the prevention and treatment of coronary heart disease.Methods One hundred patients who met the inclusion criteria with stable angina pectoris were randomly divided into treatment group(n =50),and control group(n =50),The patients in treatment group were given TXD and the patients in control group were given atorvastatin calcium tablets.Results The clinical symptoms of coronary heart disease were reduced,and the clinical manifestations of ECG ischemia were improved in treatment group,compared with that in the control group,the difference was statistically significant.TXD and Atorvastation calcium Tablets Serum IL-1β and TNF-αexpression levels were reduced,blood lipid levels were regulated in two groups,the difference between the 2 groups was not statistically significant.Conclusion TXD has anti-inflammatory effects,inhibition of inflammatory response is one of the mechanisms of its prevention and treatment of stable angina pector is coronary heart disease.
引文
[1]中国心血管病报告编写组.《中国心血管病报告2016》概要[J].中国循环杂志,2017,32(6):521-530.
[2]Nomenclatureand criteria for diacnosis of ischemic heart disease.Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature[J].Circulation,1979,59(3):607-609.
[3]安冬青,赵明芬,郑静,等.新疆胸痹秽浊痰阻证探源[J].新疆中医药,2007,25(2):1-2.
[4]安冬青,赵明芬,郑静,等.论胸痹心痛(冠心病)发病“不止于心,亦不离于心”[J].中西医结合心脑血管病杂志,2007,5(6):471-473.
[5]加力肯·吐尔逊,安冬青.天香丹对冠心病稳定型心绞痛病人生活质量的影响及疗效分析[J].新疆医科大学学报,2006,29(11):1053-1055.
[6]安冬青,周铭心,张晓天,等.天香丹对心肌缺血大鼠血栓形成及心肌细胞结构的影响[J].新疆医科大学学报,2007,30(5):434-437.
[7]殷建明,朱江丽,刘琴,等.天香丹颗粒对冠心病心绞痛患者血清中T-SOD、GSH-Px、MDA、LD的影响[J].中国中医药信息杂志,2003,10(7):13-15.
[8]ROSS R.Atherosclerosis is an inflammatory disease[J].Am Heart J,1999,138(5Pt 2):s419-s420.
[9]HANSSON G K.Inflammation,atherosclerosis,and coronary artery disease[J].N Engl J Med,2005,352(16):1685-1695.
[10]孙龙飞,安冬青.炎性信号通路在动脉粥样硬化中的机制与中医药干预作用研究进展[J].中国动脉硬化杂志,2015,23(11):1177-1181.
[11]DUBRAVEC D B,SPRIGGS D R,MANNICK J A,et al.Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha[J].Proc Natl Acad Sci USA,1990,87(17):6758-6761.
[12]POPA C,NETEA M G,VAN-RIEL P L,et al.The role of TNF-αlpha in chronic inflammatory conditions,intermediary metabolism,and cardiovascular risk[J].Journal of Lipid Research,2007,48(4):751-762.
[13]ZHANG H,PARK Y,WU J,et al.Role of TNF-αlpha in vascular dysfunction[J].Clin Sci(Lond),2009,116(3):2119-2130.
[14]江玉娟,张艳慧,王鑫国,等.大黄蛰虫丸对动脉粥样硬化鼠NF-κB通路及炎性因子影响[J].中国实验方剂学杂志,2013,19(7):254-258.
[15]王毅,马志强,黄波,等.粉防己碱对高脂饮食兔血清白细胞介素-1β、肿瘤坏死因子-α及血管壁细胞核因子-κB表达的影响[J].中国临床康复,2004,8(24):5045-5047.
[16]宋蕊,李婉秋,窦健霖,等.白藜芦醇可通过抑制核因子κB和丝裂原活化蛋白激酶信号通路抗兔动脉粥样硬化[J].中华心血管病杂志,2013,41(10):866-869.
[2]Nomenclatureand criteria for diacnosis of ischemic heart disease.Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature[J].Circulation,1979,59(3):607-609.
[3]安冬青,赵明芬,郑静,等.新疆胸痹秽浊痰阻证探源[J].新疆中医药,2007,25(2):1-2.
[4]安冬青,赵明芬,郑静,等.论胸痹心痛(冠心病)发病“不止于心,亦不离于心”[J].中西医结合心脑血管病杂志,2007,5(6):471-473.
[5]加力肯·吐尔逊,安冬青.天香丹对冠心病稳定型心绞痛病人生活质量的影响及疗效分析[J].新疆医科大学学报,2006,29(11):1053-1055.
[6]安冬青,周铭心,张晓天,等.天香丹对心肌缺血大鼠血栓形成及心肌细胞结构的影响[J].新疆医科大学学报,2007,30(5):434-437.
[7]殷建明,朱江丽,刘琴,等.天香丹颗粒对冠心病心绞痛患者血清中T-SOD、GSH-Px、MDA、LD的影响[J].中国中医药信息杂志,2003,10(7):13-15.
[8]ROSS R.Atherosclerosis is an inflammatory disease[J].Am Heart J,1999,138(5Pt 2):s419-s420.
[9]HANSSON G K.Inflammation,atherosclerosis,and coronary artery disease[J].N Engl J Med,2005,352(16):1685-1695.
[10]孙龙飞,安冬青.炎性信号通路在动脉粥样硬化中的机制与中医药干预作用研究进展[J].中国动脉硬化杂志,2015,23(11):1177-1181.
[11]DUBRAVEC D B,SPRIGGS D R,MANNICK J A,et al.Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha[J].Proc Natl Acad Sci USA,1990,87(17):6758-6761.
[12]POPA C,NETEA M G,VAN-RIEL P L,et al.The role of TNF-αlpha in chronic inflammatory conditions,intermediary metabolism,and cardiovascular risk[J].Journal of Lipid Research,2007,48(4):751-762.
[13]ZHANG H,PARK Y,WU J,et al.Role of TNF-αlpha in vascular dysfunction[J].Clin Sci(Lond),2009,116(3):2119-2130.
[14]江玉娟,张艳慧,王鑫国,等.大黄蛰虫丸对动脉粥样硬化鼠NF-κB通路及炎性因子影响[J].中国实验方剂学杂志,2013,19(7):254-258.
[15]王毅,马志强,黄波,等.粉防己碱对高脂饮食兔血清白细胞介素-1β、肿瘤坏死因子-α及血管壁细胞核因子-κB表达的影响[J].中国临床康复,2004,8(24):5045-5047.
[16]宋蕊,李婉秋,窦健霖,等.白藜芦醇可通过抑制核因子κB和丝裂原活化蛋白激酶信号通路抗兔动脉粥样硬化[J].中华心血管病杂志,2013,41(10):866-869.