葛根素注射液联合氟伐他汀治疗老年不稳定型心绞痛临床效果及其对炎性因子的影响
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摘要
目的探讨葛根素注射液联合氟伐他汀治疗老年不稳定型心绞痛的临床效果及其对炎性因子的影响。方法选取2013年1月至2013年12月于本院就诊的168例老年不稳定型心绞痛患者为研究对象,按照随机数表法将其分为对照组和观察组,每组各84例。在常规治疗基础上,对照组患者给予氟伐他汀治疗,观察组患者在对照组基础上联合葛根素注射液治疗。比较两组患者临床疗效,治疗前后不稳定型心绞痛发作频率、持续时间及炎性因子水平。结果观察组患者治疗总有效率明显高于对照组(P<0.05)。两组患者治疗前心绞痛发作频率与持续时间比较差异均无显著性(P>0.05)。治疗后两组患者心绞痛发作频率与持续时间均有不同程度的减少和缩短,观察组显著少于对照组(P<0.05)。治疗前两组患者肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)水平比较差异均无显著性(P>0.05)。治疗后两组患者上述指标均有不同程度降低,观察组各指标均低于对照组(P<0.05)。结论葛根素注射液联合氟伐他汀治疗老年不稳定型心绞痛效果显著,减少不稳定型心绞痛发作频率,缩短发作持续时间,并明显减轻机体炎性反应,临床值得进一步研究。
Objective To investigate the clinical effect of puerarin injection combined with fluvastatin in the treatment of elderly patients with unstable angina pectoris and its effects on inflammatory factors. Method Selected from January 2013 to December 2013 in our hospital for treatment of 168 cases of elderly patients with unstable angina pectoris as the research objects, according to the random number table method, they were divided into observation group and control group, 84 cases in each group. On the basis of conventional treatment, control group were treated with fluvastatin, observation group were treated with puerarin injection on the basis of control group. The clinical efficacy, duration and occurrence frequency of unstable angina puerarin before and after treatment, levels of inflammatory factors between the two groups were compared. Result The total effective rate in observation group was significantly higher than control group(P < 0.05). Before the treatment, angina frequency and duration of two groups of patients had no significant differences(P > 0.05). After treatment, the frequency and duration of angina pectoris in the two groups were decreased and shortened, and observation group was significantly less than control group(P < 0.05). Before treatment, tumor necrosis factor-α(TNF-α), interleukin(IL)-6, high-sensitivity C-reactive protein(hs-CRP) levels between the two groups had no significant difference(P > 0.05). After treatment, these indicators of the two groups were decreased with different degrees and observation group were lower than control group(P < 0.05). Conclusion Puerarin injection combined with fluvastatin in the treatment of elderly patients with unstable angina pectoris has curative effect, reduce the incidence of unstable angina frequency, shorten the duration of episodes, and significantly reduce the inflammatory response, worthy of further study.
Objective To investigate the clinical effect of puerarin injection combined with fluvastatin in the treatment of elderly patients with unstable angina pectoris and its effects on inflammatory factors. Method Selected from January 2013 to December 2013 in our hospital for treatment of 168 cases of elderly patients with unstable angina pectoris as the research objects, according to the random number table method, they were divided into observation group and control group, 84 cases in each group. On the basis of conventional treatment, control group were treated with fluvastatin, observation group were treated with puerarin injection on the basis of control group. The clinical efficacy, duration and occurrence frequency of unstable angina puerarin before and after treatment, levels of inflammatory factors between the two groups were compared. Result The total effective rate in observation group was significantly higher than control group(P < 0.05). Before the treatment, angina frequency and duration of two groups of patients had no significant differences(P > 0.05). After treatment, the frequency and duration of angina pectoris in the two groups were decreased and shortened, and observation group was significantly less than control group(P < 0.05). Before treatment, tumor necrosis factor-α(TNF-α), interleukin(IL)-6, high-sensitivity C-reactive protein(hs-CRP) levels between the two groups had no significant difference(P > 0.05). After treatment, these indicators of the two groups were decreased with different degrees and observation group were lower than control group(P < 0.05). Conclusion Puerarin injection combined with fluvastatin in the treatment of elderly patients with unstable angina pectoris has curative effect, reduce the incidence of unstable angina frequency, shorten the duration of episodes, and significantly reduce the inflammatory response, worthy of further study.
引文
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[12]屈敦涛,周于禄.法舒地尔对不稳定性心绞痛患者心功能及IL-6、IL-8和TNF-α表达的影响[J].医学临床研究,2011,28(9):1753-1755.
[13]朱洪权,徐传和,李琳,等.hs-CRP测定在心绞痛患者中的应用[J].中国实验诊断学,2011,15(7):1129-1130.
[14]邢聪慧,管军,王旭,等.心绞痛病人血清炎性因子的变化及其临床意义[J].齐鲁医学杂志,2010,25(4):324-326.
[2]牟华明,邵江,牟一丹,等.不稳定性心绞痛患者近期预后评估相关因素分析[J].重庆医学,2014,(35):4796-4797,4798.
[3]杜寻辉,何昆仑,唐发宽,等.丹红注射液对老年心绞痛患者炎性因子的影响[J].中华保健医学杂志,2012,14(2):137-139.
[4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304.
[5]王杨,关德明,田野.不稳定性心绞痛患者心电图改变的实验室检查指标特征[J].哈尔滨医科大学学报,2014,(4):338-341.
[6]马骏,刘旭正.氟伐他汀联合依折麦布用于伴高胆固醇血症的老年不稳定心绞痛患者的有效性和安全性[J].中华老年医学杂志,2014,33(6):643-644.
[7]袁平年.阿托伐他汀治疗不稳定性心绞痛的疗效和安全性[J].实用临床医药杂志,2014,(17):107-108,111.
[8]Nakamura M,Yamashita T,Yajima J,et al.Impact of early statin initiation on secondary prevention in Japanese patients with coronary artery disease[J].J Cardiol,2011,57(2):172-180.
[9]张德明.氟伐他汀联合曲美他嗪治疗不稳定性心绞痛临床观察[J].临床合理用药杂志,2014,(20):49-50.
[10]容林,杨旭东,陈理军,等.葛根素药理作用及其作用机制研究新进展[J].大众科技,2014,(6):138-142.
[11]寇建会,任慧雅,吴欣,等.通心络胶囊短期大剂量应用对不稳定性心绞痛血清炎性因子的影响[J].河北中医,2011,33(6):904-906.
[12]屈敦涛,周于禄.法舒地尔对不稳定性心绞痛患者心功能及IL-6、IL-8和TNF-α表达的影响[J].医学临床研究,2011,28(9):1753-1755.
[13]朱洪权,徐传和,李琳,等.hs-CRP测定在心绞痛患者中的应用[J].中国实验诊断学,2011,15(7):1129-1130.
[14]邢聪慧,管军,王旭,等.心绞痛病人血清炎性因子的变化及其临床意义[J].齐鲁医学杂志,2010,25(4):324-326.