益生菌对肠道营养健康调控作用的研究进展
|
摘要
对近年来国内外有关益生菌对肠道菌群、营养、免疫和代谢的调控研究及应用进展进行了综述,以期为肠道营养健康调控相关研究及应用提供依据和参考。
This paper focuses on the research and application of probiotics on the regulation of intestinal flora,nutrition,immunity and metabolism in recent years,and provides a basis for the research and application of intestinal nutrition health regulation.
This paper focuses on the research and application of probiotics on the regulation of intestinal flora,nutrition,immunity and metabolism in recent years,and provides a basis for the research and application of intestinal nutrition health regulation.
引文
[1]Working group report.Guidelines for the Evaluation of Probiotics in Food[J].Joint Food and Agriculture Organisation of the United Nations and The World Health Organisation,2007.
[2]GLENWRIGHT A,POTHULA K,BHAMIDIMARRI S,et al.Structural basis for nutrient acquisition by dominant members of the human gut microbiota[J].Nature,2017,541:407–411.
[3]宋楠.矢车菊素-3-O-葡萄糖苷对APP~(swe)/PS1~(△E9)转基因阿尔茨海默病模型小鼠神经保护的作用机制及对其肠道菌群的影响[D].北京协和医学院,2016.
[4]RODRIGUEZ S,SANTAMARIA R,FEMAND-ABALOS J,et al.Identification of the sequences involved in the glucose-repressed transcription of the Streptomyces halstedii JM8 xys A promoter[J].Gene,2005,351:1-9.
[5]XU G,JIANG J,WANG M,et al.Lactic Acid Reduces LPS-Induced TNF-and IL-6 m RNA Levels Through Decreasing I B Phosphorylation[J].Journal of Integrative Agriculture,2013,12(6):1073-1078.
[6]ZIMMER J,LANGE B,FRICK J,et al.Avegan or vegetarian diet substantially alters the human co;onic faecal microbiata[J].Eur J Clin Nutri,2012,66(1):53-60.
[7]李胜杰.两歧双歧杆菌WBIN03胞外多糖的抗菌/抗氧化活性及其对小鼠免疫和肠道菌群影响的研究[D].南昌大学,2014.
[8]李超,王春凤,杨桂连.乳酸菌胞外多糖肠道黏附及免疫调节作用研究进展[J].食品科学,2014,(11):314-318.
[9]PARKAR S,TROWER T,STEVENSON D.Fecal microbial metabolism of polyphenols and its effects on human gut microbiota[J].Anaerobe,2013,23:12-19.
[10]SOFI M,GUDI R,KARUMUTHIL-M,ELETHIL S.et al.p H of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence[J].Diabetes,2014,63(2):632-644.
[11]HE Q,KONG X,WU G,et al.Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation[J].Amino acids,2009,37:199-208.
[12]赵宏丽.精氨酸对细毛羊肠道蛋白质合成、氨基酸转运蛋白m RNA表达及肠道健康的影响[D].内蒙古农业大学,2012.
[13]黄强,徐稳,何进田,等日粮补充亮氨酸对超早期断奶宫内发育迟缓仔猪肠道免疫功能的影响[J].食品科学.2017(17),1-8
[14]RIEDIJK M,VAN GOUDOEVER J.Splanchnic metabolism of ingested amino acids inneonates.Curr Opin Clin Nutr Metab Care,2007,10(1):58-62.
[15]KAEWTAPEE C,KRUTTHAI N,BUNCHASAK C.Effects of supplemental liquid DL-methionine hydroxy analog free acid in diet on growth performance and gastrointestinal functions of piglets[J].Asian Australasian Journal of Animal Sciences,2016,29(8):1166-1172.
[16]郑秦文,陈思恋,林欣,等.蛋氨酸羟基类似物异丙酯对福建黄兔屠宰性能、肠道黏膜形态和肠道酶活的影响[J].中国畜牧兽医,2015,(07):1711-1716.
[17]宗恩艳,熊霞,杨焕胜,等.含硫氨基酸对猪生长性能及肠道功能的影响机制[J].生命科学研究,2016,(05):466-470.
[18]黄鑫玮,杨莎莎,刘毅,等.壳寡糖对幼建鲤生长性能、脂肪代谢、非特异性免疫功能和肠道健康的影响[J].动物营养学报,2015,(07):2106-2114.
[19]吴娟娟.肠道菌群对仔鸡肠道黏膜结构、免疫功能及脂肪代谢的影响[D].江西农业大学,2015.
[20]彭墨.饲料脂肪水平和脂肪酸组成对大菱鲆幼鱼脂沉积的影响[D].中国海洋大学,2014.
[21]崔成.抗生素、益生菌及银耳孢子发酵物对猪肠道硬壁门菌和拟杆门菌、脂肪沉积和脂肪代谢相关基因表达的影响及其作用机理[D].四川农业大学,2013.
[22]何彦坤,孙晨阳,张帆.结直肠癌术后早期微生态肠内营养对肠道菌群及免疫功能的影响[J].临床医药实践,2017,(03):182-186.
[23]陈静,林源,黄之杰,等.谷氨酰胺对老年胃肠道肿瘤患者术后蛋白质代谢及免疫功能的作用[J].细胞与分子免疫学杂志,2011,(03):322-323.
[24]刘遵莹,刘秋玲,邓燕莉,等.L-茶氨酸对产肠毒素大肠杆菌引起的免疫应激小鼠肠道的保护作用研究[J].茶叶科学,2016,(05):469-476.
[25]茹冬冬.鸟氨酸-α-酮戊二酸对腹腔重症感染大鼠肠道免疫功能的影响[D].山西医科大学,2015.
[26]YATSUNENKO T,REY F,MANARY M.et al Human gut microbiome viewed across age and geography[J].Nature,2012,486(7402):222.
[27]FROST G,SLEETH M,SAHURIARISOYLU M,et al.The shortchain fatty acid acetate reduces appetite via a central homeostatic mechanism[J].Nature Communication,2014,5(3611):3611.
[28]李俊洁,陈庆森.双歧杆菌调理和改善肠道相关疾病作用的研究进展[J].食品科学,2011,32(123):326-332.
[29]CLARKE G,GRENHAM S,SCULLY P,et al.The microbiomegut-brain axis during early life regulates the hippocampal seroton-ergic system in a sex-dependent manner[J].Mol Psychiatry,2013,18(6):666-673.
[30]罗佳,金锋,肠道菌群影响宿主行为的研究进展[J],科学通报,2014,59(22):2169-2190.
[31]SOMMER F,BACKHED F.The gut microbiota--masters of host development and physiology[J].Nat Rev Microbiol.2013,11(4):227-238
[32]叶雷,闫亚丽,陈庆森,等.高通量测序技术在肠道微生物宏基因组学研究中的应用.中国食品学报,2016,16(07):1009-7848..
[33]LE C E,NIELSEN T,QIN J,et al.Richness of human gut microbiome correlates with metabolic markers[J].Nature,2013,500(7464):541-546.
[34]赵立平.食品与肠道微生物组互作对人体代谢表型组的贡献[A].中国食品科学技术学会.乳酸菌与人体健康:第十届乳酸菌与健康国际研讨会摘要汇编[C].中国食品科学技术学会:2015:01.
[35]刘新彩,徐佩茹,李敏,等.新疆哈萨克族肥胖儿童菌群人源化动物模型的建立[J].中国全科医学,2016,19(08):936-940.
[36]李常营.植物乳杆菌K25的益生特性及在干酪中的应用研究[D].长春工业大学,2011.
[37]STEWART D,RUBIANO A,SANTISTEBAN M,et al.Hypertension-linked mechanical changes of rat gut[J]Acta Biomaterialia,2016,45(8):296–302.
[38]张莉.植物乳杆菌的黏附特性研究及其在益生菌干酪中的应用[D].吉林大学,2013.
[39]张健,黄翠姬,刘昭明,等.植物乳杆菌L01对高脂血症大鼠的降胆固醇功效[J].食品科技,2016,41(04):35-39.DOI:10.13684/j.cnki.spkj.2016.04.007.
[40]尹恝,周宏伟.症状性颅内外动脉粥样硬化性狭窄患者肠道菌群特征[A].中华医学会、中华医学会神经病学分会.中华医学会第十八次全国神经病学学术会议论文汇编(上)[C].中华医学会、中华医学会神经病学分会:2015:02.
[41]TANG W,WANG Z,LEVISON B.Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk[J].J of Vas Surgery.2013,58(02):549.
[42]杨笑云.肠道菌群及肠道炎症在OLETF大鼠糖尿病发病中的动态变化[D].天津医科大学,2015.
[43]MCLEAN M,DIEGUEZ D,MILLER L,et al.Does the microbiota play a role in the pathogenesis of autoimmune diseases?[J].Gut,2015,64(2):332-341.
[44]COHN A,SOFIA A,KUPFER S.Type 1 diabetes and celiac disease:clinical overlap and new insights into disease pathogenesis[J].Curr Diab Rep,2014,14(8):517.
[45]KABBANI T,VANGA R,LEFFLER D,et al.Celiac disease or nonceliac gluten sensitivity?An approach to clinical differential diagnosis[J].Am J Gastroenterol,2014,109(5):741-746.
[46]张弘超,金英朝,李成镇,等.糖尿病患者肠道菌群研究[J].糖尿病新世界,2016,15:113-114.
[47]臧文娟.Ⅱ型糖尿病患者肠道中细菌群落结构研究[D].山西大学,2015.
[48]徐锋,贺超奇,来汉江,等.乙型糖尿病患者与正常人群肠道菌群的比较研究[J].中华全科医学,2015,13(06):996-999.
[49]阿孜尔古丽·阿布都克日木,阿布都哈巴尔·阿布都克日木,马兰英,等.维吾尔族结肠癌患者肠道菌群的分布情况研究[J].现代生物医学进展,2016,16(12):2227-2230.
[50]孟宪红,刘铁夫,刘平,等.结肠癌与结肠腺瘤患者常见肠道菌群数量比较[J].山东医药,2016,56(13):52-54.
[51]王生,黄晓星,余鹏飞,等.肠道菌群失调与结肠癌发生发展之间关系的研究进展[J].中国药理学通报,2014,30(08):1045-1049.
[52]张和平.痛风患者肠道菌群群落结构的研究[A].中国食品科学技术学会.乳酸菌与生物工程:第八届乳酸菌与健康国际研讨会摘要汇编[C].中国食品科学技术学会:2013:1.
[53]玛依娜·卡哈尔,孙玉萍,孜来古丽·米吉提,张蓓.维吾尔族与汉族人群肠道菌群与高尿酸血症关系的研究[J].新疆医科大学学报,2014.37(04):419-422.
[54]王红坡,张冰,林志健,等.菊苣提取物对高甘油三酯并高尿酸血症模型大鼠肠道菌群的影响[J].中医药信息.2015,32(03):3-8.
[55]ALFALEH K,ANABREES J.Probiotics for prevention of necrotizing enterocolitis in preterm infants[J].Evidence-Based Child Health,2014,9(3):584-671.
[56]谢晓平,曾继凤,徐开渝等.益生元对婴儿生长及肠道菌群的影响[J].四川生理科学杂志,2011,33(4):159-161.
[57]李勇超,张波.婴幼儿肠道菌群定殖及对健康的影响研究进展[J].食品科学,2016,37(01):258-262.
[58]BENER A,KIM E,MUTLU F,et al.Burden of diabetes mellitus attributable to demographic levels in Qatar:an emerging public health problem[J].Diabetes Metab Syndr,2014,8(4):216-220.
[59]杨成彬,赵梅珍,杨平常,等.肠道菌群与婴幼儿食物过敏的研究进展[J].实用临床医学,2014,15(08):117-119,124.
[60]KALLIOMAKI M.KIRJAVAINEN P,EEROLA E,et al.Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing[J].J Allergy&Clin Immunol,2001,107(1):129-134.
[61]ABRAHAMSSON T,JAKOBSSON H,ANDERSSON A,et al.Low diversity of the gut microbiota in infants with atopic eczema[J].J Allergy Clinlmmunol,2012,129(2):434-440.
[62]KOENIG J,SPOR A,SCALFONE N,et al.Succession of microbial consortia in the developing infant gut microbiome[J].Proc.Natl.Acad.Sci.USA,2011,108(S1):4578-4585.
[63]刘明颖,李辉,施展.晚孕期孕妇口服益生菌制剂对新生儿肠道菌群及脐血IL-4,IFN-γ水平影响的临床研究[J].中国妇幼保健.2012,27(6):923-925.
[64]KONG F,HUA Y,ZENG B,et al.Gut microbiota signatures of longevity[J].Current Biology,2016,26(18):832-833.
[65]郭飞翔.广西巴马长寿地区不同年龄人群肠道菌群分析[D].扬州大学,2015.
[66]ZHANG C,LI S,YANG L,et al.Structural modulation of gut microbiota in life-long calorie-restricted mice.Nature Communications,2013.
[67]王凯丽,闫西鹏,赵颖颖,等.中医治疗焦虑抑郁症简况[J].实用中医内科杂志,2016,(09):1-4.
[68]FIEDOROWICZ J,ELLINGROD V,KAPLAN M,et al.The development of depressive symptoms during medical internship stress predicts worsening vascular function[J].J Psychosom Res,2015,79(3):243-245.
[69]DINAN T,STANTON C,CRYAN J.Psychobiotics:a novel class of psychotropic.Biological psychiatry 2013?,74(10):720-6.
[70]FOSTER J,NEUFELD K.Gut-brain axis:how the microbiome influences anxiety and depression.Trends in neurosciences 2013:36(5):305-12.
[71]蒋海寅.人类肠道微生物群落菌群多样性变化与抑郁症的相关性研究[D].浙江大学,2015.
[72]崔心尧,王继中.抑郁症人群肠道微生物群落结构与功能探讨[J].中国微生态学杂志,2015,27(10):1145-1147+1151.
[73]范文涛,闫咏梅,别玉龙,等.脑卒中后抑郁症患者肠道菌群的多样性分析[J].南方医科大学学报,2016,36(10):1305-1311.
[74]王守赟.肠道菌群与类风湿关节炎的发生发展关系[D].大连医科大学,2014.
[75]比力克斯·木合买提.益生菌制剂在溃疡性结肠炎治疗中的作用[J].世界最新医学信息文摘,2015,15(40):16-17.
[76]范文广,王婷婷,霍贵成.婴幼儿肠道微生物的定植特征[J/OL].食品工业科技,2014,35(06):086.DOI:10.13386/j.issn.1002-0306.2014.06.086.
[77]张烨,隋学林,刘成程,等.肥胖孕妇肠道菌群与子代肥胖的相关性[J].中国微生态学杂志,2016,28(09):1107-1109.
[78]张水平,刘黎明,孙晓勉,等,陕西农村0~18个月母乳喂养儿肠道菌群对体格发育的影响.中华预防医学会年会.[A].2009.
[79]任大勇.益生乳酸杆菌的黏附及免疫调节作用研究[D].吉林大学,2013.
[80]刘瑞雪,李勇超,张波.肠道菌群微生态平衡与人体健康的研究进展[J].食品工业科技,2016,37(06):383-387,391.DOI:10.13386/j.issn.1002-0306.2016.06.068.
[81]侯玉洁,侯小辉,张建刚.芽孢杆菌类微生态制剂在动物生产中的应用[J].饲料博览,2012,(3):37-40.
[82]GHOSH K,SEN S,RAY A.Characterization of Bacilli isolated from the gut of rohu,Labeo rohita,fingerlings and its significance in digestion[J].Journal of Applied Aquaculture,2002,(12):33-42.
[83]郭双双.木聚糖酶与益生菌缓解肠道炎症的作用及其机制[D].中国农业大学,2016.
[84]GENG Q,ZHAO X.Influences of exogenous probiotics and tea polyphenols on the production of three acids during the simulated colonic fermentation of maize resistant starch[J]Journal of Food Science and Technology.2014:1-8.
[85]孔璐.6株益生菌对3种膳食纤维模拟肠道发酵产酸的影响[D].东北农业大学,2015.
[86]TABASCO R,PALENCIA P,FONTECHA J,et al.Competition mechanisms of lactic acid bacteria and bifidobacteria:fermentative metabolism and colonization[J].LWT-Food Science and Technology,2014,55(2):680-684.
[87]崔燕丽,徐晓芬,吴正钧,等.乳酸菌胞外多糖对人类肠道菌群的影响[J].中国微生态学杂志,2016,28(07):851-856.
[88]LING Z,LIU X,CHENG Y,et al.Clostridium butyricum combined with Bifidobacterium infantis probiotic mixture restores fecal microbiota and attenuates systemic Inflammation in mice with antibiotic-associated diarrhea[J].Bio M ed Research International.2015:582048.
[89]凌宗欣.女性生殖道微生物群落菌群多样性变化与生殖道感染的相关性研究[D].浙江大学,2012.
[90]丁佳,王慧艳,何秋雯,等.益生菌对雌激素代谢及相关疾病的影响[J].食品科学,2016,37(11):248-254.DOI:10.7506/spkx1002-6630-201611044.
[91]冀建伟.双歧杆菌对应激大鼠肠道菌群及促肾上腺皮质激素释放激素的影响[D].郑州大学,2010.
[92]XIE B,ZHANG S,LIU J,et al.Enhanced estrogenic activity of soy bean isoflavones by coad ministration of Liu wei Di huang Pills in ova eiectomizes rates[J].Phytother Res,2015,19(7):1054-1061.
[93]陈旻远,贾聪慧,洪奇华,等.丁酸梭菌对动物肠道生态的影响及作用机制[J].饲料研究,2016,(06):5-8.DOI:10.13557/j.cnki.issn.1002-2813.2016.06.002.
[94]WEI P,YANG Y,LI T,et al.A engineered Bifidobacterium Long umsecreting a bioactive penetratin-Glucagon-like peptide 1fusion protein enhances Glucagon-like peptide 1 absorption in the intestine[J].J Microbiol Biotechnol,2015,2(12):113-115.
[95]谭婷婷,马丽,朱超,等.双歧杆菌辅助治疗胃癌对于肠道菌群及血清促肾上腺皮质激素表达的影响[J].中国微生态学杂志,2016,28(09):1052-1055
[96]石梦玄.动物双歧杆菌对小鼠肠道黏膜损伤的缓解作用及其机理研究[D].河北工程大学,2016.
[97]王然,陈善斌,庞瑞鹏,等.干酪乳杆菌L9对健康人群肠道健康的影响[J].中国食品学报,2016,16(08):38-44.
[98]ELAHI S,ERTELT J,KINDER J,et al.Immunosuppressive CD71+erythroid cells compromise neonatal host defence against infection.Nature,2013,(504):158–162.
[2]GLENWRIGHT A,POTHULA K,BHAMIDIMARRI S,et al.Structural basis for nutrient acquisition by dominant members of the human gut microbiota[J].Nature,2017,541:407–411.
[3]宋楠.矢车菊素-3-O-葡萄糖苷对APP~(swe)/PS1~(△E9)转基因阿尔茨海默病模型小鼠神经保护的作用机制及对其肠道菌群的影响[D].北京协和医学院,2016.
[4]RODRIGUEZ S,SANTAMARIA R,FEMAND-ABALOS J,et al.Identification of the sequences involved in the glucose-repressed transcription of the Streptomyces halstedii JM8 xys A promoter[J].Gene,2005,351:1-9.
[5]XU G,JIANG J,WANG M,et al.Lactic Acid Reduces LPS-Induced TNF-and IL-6 m RNA Levels Through Decreasing I B Phosphorylation[J].Journal of Integrative Agriculture,2013,12(6):1073-1078.
[6]ZIMMER J,LANGE B,FRICK J,et al.Avegan or vegetarian diet substantially alters the human co;onic faecal microbiata[J].Eur J Clin Nutri,2012,66(1):53-60.
[7]李胜杰.两歧双歧杆菌WBIN03胞外多糖的抗菌/抗氧化活性及其对小鼠免疫和肠道菌群影响的研究[D].南昌大学,2014.
[8]李超,王春凤,杨桂连.乳酸菌胞外多糖肠道黏附及免疫调节作用研究进展[J].食品科学,2014,(11):314-318.
[9]PARKAR S,TROWER T,STEVENSON D.Fecal microbial metabolism of polyphenols and its effects on human gut microbiota[J].Anaerobe,2013,23:12-19.
[10]SOFI M,GUDI R,KARUMUTHIL-M,ELETHIL S.et al.p H of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence[J].Diabetes,2014,63(2):632-644.
[11]HE Q,KONG X,WU G,et al.Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation[J].Amino acids,2009,37:199-208.
[12]赵宏丽.精氨酸对细毛羊肠道蛋白质合成、氨基酸转运蛋白m RNA表达及肠道健康的影响[D].内蒙古农业大学,2012.
[13]黄强,徐稳,何进田,等日粮补充亮氨酸对超早期断奶宫内发育迟缓仔猪肠道免疫功能的影响[J].食品科学.2017(17),1-8
[14]RIEDIJK M,VAN GOUDOEVER J.Splanchnic metabolism of ingested amino acids inneonates.Curr Opin Clin Nutr Metab Care,2007,10(1):58-62.
[15]KAEWTAPEE C,KRUTTHAI N,BUNCHASAK C.Effects of supplemental liquid DL-methionine hydroxy analog free acid in diet on growth performance and gastrointestinal functions of piglets[J].Asian Australasian Journal of Animal Sciences,2016,29(8):1166-1172.
[16]郑秦文,陈思恋,林欣,等.蛋氨酸羟基类似物异丙酯对福建黄兔屠宰性能、肠道黏膜形态和肠道酶活的影响[J].中国畜牧兽医,2015,(07):1711-1716.
[17]宗恩艳,熊霞,杨焕胜,等.含硫氨基酸对猪生长性能及肠道功能的影响机制[J].生命科学研究,2016,(05):466-470.
[18]黄鑫玮,杨莎莎,刘毅,等.壳寡糖对幼建鲤生长性能、脂肪代谢、非特异性免疫功能和肠道健康的影响[J].动物营养学报,2015,(07):2106-2114.
[19]吴娟娟.肠道菌群对仔鸡肠道黏膜结构、免疫功能及脂肪代谢的影响[D].江西农业大学,2015.
[20]彭墨.饲料脂肪水平和脂肪酸组成对大菱鲆幼鱼脂沉积的影响[D].中国海洋大学,2014.
[21]崔成.抗生素、益生菌及银耳孢子发酵物对猪肠道硬壁门菌和拟杆门菌、脂肪沉积和脂肪代谢相关基因表达的影响及其作用机理[D].四川农业大学,2013.
[22]何彦坤,孙晨阳,张帆.结直肠癌术后早期微生态肠内营养对肠道菌群及免疫功能的影响[J].临床医药实践,2017,(03):182-186.
[23]陈静,林源,黄之杰,等.谷氨酰胺对老年胃肠道肿瘤患者术后蛋白质代谢及免疫功能的作用[J].细胞与分子免疫学杂志,2011,(03):322-323.
[24]刘遵莹,刘秋玲,邓燕莉,等.L-茶氨酸对产肠毒素大肠杆菌引起的免疫应激小鼠肠道的保护作用研究[J].茶叶科学,2016,(05):469-476.
[25]茹冬冬.鸟氨酸-α-酮戊二酸对腹腔重症感染大鼠肠道免疫功能的影响[D].山西医科大学,2015.
[26]YATSUNENKO T,REY F,MANARY M.et al Human gut microbiome viewed across age and geography[J].Nature,2012,486(7402):222.
[27]FROST G,SLEETH M,SAHURIARISOYLU M,et al.The shortchain fatty acid acetate reduces appetite via a central homeostatic mechanism[J].Nature Communication,2014,5(3611):3611.
[28]李俊洁,陈庆森.双歧杆菌调理和改善肠道相关疾病作用的研究进展[J].食品科学,2011,32(123):326-332.
[29]CLARKE G,GRENHAM S,SCULLY P,et al.The microbiomegut-brain axis during early life regulates the hippocampal seroton-ergic system in a sex-dependent manner[J].Mol Psychiatry,2013,18(6):666-673.
[30]罗佳,金锋,肠道菌群影响宿主行为的研究进展[J],科学通报,2014,59(22):2169-2190.
[31]SOMMER F,BACKHED F.The gut microbiota--masters of host development and physiology[J].Nat Rev Microbiol.2013,11(4):227-238
[32]叶雷,闫亚丽,陈庆森,等.高通量测序技术在肠道微生物宏基因组学研究中的应用.中国食品学报,2016,16(07):1009-7848..
[33]LE C E,NIELSEN T,QIN J,et al.Richness of human gut microbiome correlates with metabolic markers[J].Nature,2013,500(7464):541-546.
[34]赵立平.食品与肠道微生物组互作对人体代谢表型组的贡献[A].中国食品科学技术学会.乳酸菌与人体健康:第十届乳酸菌与健康国际研讨会摘要汇编[C].中国食品科学技术学会:2015:01.
[35]刘新彩,徐佩茹,李敏,等.新疆哈萨克族肥胖儿童菌群人源化动物模型的建立[J].中国全科医学,2016,19(08):936-940.
[36]李常营.植物乳杆菌K25的益生特性及在干酪中的应用研究[D].长春工业大学,2011.
[37]STEWART D,RUBIANO A,SANTISTEBAN M,et al.Hypertension-linked mechanical changes of rat gut[J]Acta Biomaterialia,2016,45(8):296–302.
[38]张莉.植物乳杆菌的黏附特性研究及其在益生菌干酪中的应用[D].吉林大学,2013.
[39]张健,黄翠姬,刘昭明,等.植物乳杆菌L01对高脂血症大鼠的降胆固醇功效[J].食品科技,2016,41(04):35-39.DOI:10.13684/j.cnki.spkj.2016.04.007.
[40]尹恝,周宏伟.症状性颅内外动脉粥样硬化性狭窄患者肠道菌群特征[A].中华医学会、中华医学会神经病学分会.中华医学会第十八次全国神经病学学术会议论文汇编(上)[C].中华医学会、中华医学会神经病学分会:2015:02.
[41]TANG W,WANG Z,LEVISON B.Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk[J].J of Vas Surgery.2013,58(02):549.
[42]杨笑云.肠道菌群及肠道炎症在OLETF大鼠糖尿病发病中的动态变化[D].天津医科大学,2015.
[43]MCLEAN M,DIEGUEZ D,MILLER L,et al.Does the microbiota play a role in the pathogenesis of autoimmune diseases?[J].Gut,2015,64(2):332-341.
[44]COHN A,SOFIA A,KUPFER S.Type 1 diabetes and celiac disease:clinical overlap and new insights into disease pathogenesis[J].Curr Diab Rep,2014,14(8):517.
[45]KABBANI T,VANGA R,LEFFLER D,et al.Celiac disease or nonceliac gluten sensitivity?An approach to clinical differential diagnosis[J].Am J Gastroenterol,2014,109(5):741-746.
[46]张弘超,金英朝,李成镇,等.糖尿病患者肠道菌群研究[J].糖尿病新世界,2016,15:113-114.
[47]臧文娟.Ⅱ型糖尿病患者肠道中细菌群落结构研究[D].山西大学,2015.
[48]徐锋,贺超奇,来汉江,等.乙型糖尿病患者与正常人群肠道菌群的比较研究[J].中华全科医学,2015,13(06):996-999.
[49]阿孜尔古丽·阿布都克日木,阿布都哈巴尔·阿布都克日木,马兰英,等.维吾尔族结肠癌患者肠道菌群的分布情况研究[J].现代生物医学进展,2016,16(12):2227-2230.
[50]孟宪红,刘铁夫,刘平,等.结肠癌与结肠腺瘤患者常见肠道菌群数量比较[J].山东医药,2016,56(13):52-54.
[51]王生,黄晓星,余鹏飞,等.肠道菌群失调与结肠癌发生发展之间关系的研究进展[J].中国药理学通报,2014,30(08):1045-1049.
[52]张和平.痛风患者肠道菌群群落结构的研究[A].中国食品科学技术学会.乳酸菌与生物工程:第八届乳酸菌与健康国际研讨会摘要汇编[C].中国食品科学技术学会:2013:1.
[53]玛依娜·卡哈尔,孙玉萍,孜来古丽·米吉提,张蓓.维吾尔族与汉族人群肠道菌群与高尿酸血症关系的研究[J].新疆医科大学学报,2014.37(04):419-422.
[54]王红坡,张冰,林志健,等.菊苣提取物对高甘油三酯并高尿酸血症模型大鼠肠道菌群的影响[J].中医药信息.2015,32(03):3-8.
[55]ALFALEH K,ANABREES J.Probiotics for prevention of necrotizing enterocolitis in preterm infants[J].Evidence-Based Child Health,2014,9(3):584-671.
[56]谢晓平,曾继凤,徐开渝等.益生元对婴儿生长及肠道菌群的影响[J].四川生理科学杂志,2011,33(4):159-161.
[57]李勇超,张波.婴幼儿肠道菌群定殖及对健康的影响研究进展[J].食品科学,2016,37(01):258-262.
[58]BENER A,KIM E,MUTLU F,et al.Burden of diabetes mellitus attributable to demographic levels in Qatar:an emerging public health problem[J].Diabetes Metab Syndr,2014,8(4):216-220.
[59]杨成彬,赵梅珍,杨平常,等.肠道菌群与婴幼儿食物过敏的研究进展[J].实用临床医学,2014,15(08):117-119,124.
[60]KALLIOMAKI M.KIRJAVAINEN P,EEROLA E,et al.Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing[J].J Allergy&Clin Immunol,2001,107(1):129-134.
[61]ABRAHAMSSON T,JAKOBSSON H,ANDERSSON A,et al.Low diversity of the gut microbiota in infants with atopic eczema[J].J Allergy Clinlmmunol,2012,129(2):434-440.
[62]KOENIG J,SPOR A,SCALFONE N,et al.Succession of microbial consortia in the developing infant gut microbiome[J].Proc.Natl.Acad.Sci.USA,2011,108(S1):4578-4585.
[63]刘明颖,李辉,施展.晚孕期孕妇口服益生菌制剂对新生儿肠道菌群及脐血IL-4,IFN-γ水平影响的临床研究[J].中国妇幼保健.2012,27(6):923-925.
[64]KONG F,HUA Y,ZENG B,et al.Gut microbiota signatures of longevity[J].Current Biology,2016,26(18):832-833.
[65]郭飞翔.广西巴马长寿地区不同年龄人群肠道菌群分析[D].扬州大学,2015.
[66]ZHANG C,LI S,YANG L,et al.Structural modulation of gut microbiota in life-long calorie-restricted mice.Nature Communications,2013.
[67]王凯丽,闫西鹏,赵颖颖,等.中医治疗焦虑抑郁症简况[J].实用中医内科杂志,2016,(09):1-4.
[68]FIEDOROWICZ J,ELLINGROD V,KAPLAN M,et al.The development of depressive symptoms during medical internship stress predicts worsening vascular function[J].J Psychosom Res,2015,79(3):243-245.
[69]DINAN T,STANTON C,CRYAN J.Psychobiotics:a novel class of psychotropic.Biological psychiatry 2013?,74(10):720-6.
[70]FOSTER J,NEUFELD K.Gut-brain axis:how the microbiome influences anxiety and depression.Trends in neurosciences 2013:36(5):305-12.
[71]蒋海寅.人类肠道微生物群落菌群多样性变化与抑郁症的相关性研究[D].浙江大学,2015.
[72]崔心尧,王继中.抑郁症人群肠道微生物群落结构与功能探讨[J].中国微生态学杂志,2015,27(10):1145-1147+1151.
[73]范文涛,闫咏梅,别玉龙,等.脑卒中后抑郁症患者肠道菌群的多样性分析[J].南方医科大学学报,2016,36(10):1305-1311.
[74]王守赟.肠道菌群与类风湿关节炎的发生发展关系[D].大连医科大学,2014.
[75]比力克斯·木合买提.益生菌制剂在溃疡性结肠炎治疗中的作用[J].世界最新医学信息文摘,2015,15(40):16-17.
[76]范文广,王婷婷,霍贵成.婴幼儿肠道微生物的定植特征[J/OL].食品工业科技,2014,35(06):086.DOI:10.13386/j.issn.1002-0306.2014.06.086.
[77]张烨,隋学林,刘成程,等.肥胖孕妇肠道菌群与子代肥胖的相关性[J].中国微生态学杂志,2016,28(09):1107-1109.
[78]张水平,刘黎明,孙晓勉,等,陕西农村0~18个月母乳喂养儿肠道菌群对体格发育的影响.中华预防医学会年会.[A].2009.
[79]任大勇.益生乳酸杆菌的黏附及免疫调节作用研究[D].吉林大学,2013.
[80]刘瑞雪,李勇超,张波.肠道菌群微生态平衡与人体健康的研究进展[J].食品工业科技,2016,37(06):383-387,391.DOI:10.13386/j.issn.1002-0306.2016.06.068.
[81]侯玉洁,侯小辉,张建刚.芽孢杆菌类微生态制剂在动物生产中的应用[J].饲料博览,2012,(3):37-40.
[82]GHOSH K,SEN S,RAY A.Characterization of Bacilli isolated from the gut of rohu,Labeo rohita,fingerlings and its significance in digestion[J].Journal of Applied Aquaculture,2002,(12):33-42.
[83]郭双双.木聚糖酶与益生菌缓解肠道炎症的作用及其机制[D].中国农业大学,2016.
[84]GENG Q,ZHAO X.Influences of exogenous probiotics and tea polyphenols on the production of three acids during the simulated colonic fermentation of maize resistant starch[J]Journal of Food Science and Technology.2014:1-8.
[85]孔璐.6株益生菌对3种膳食纤维模拟肠道发酵产酸的影响[D].东北农业大学,2015.
[86]TABASCO R,PALENCIA P,FONTECHA J,et al.Competition mechanisms of lactic acid bacteria and bifidobacteria:fermentative metabolism and colonization[J].LWT-Food Science and Technology,2014,55(2):680-684.
[87]崔燕丽,徐晓芬,吴正钧,等.乳酸菌胞外多糖对人类肠道菌群的影响[J].中国微生态学杂志,2016,28(07):851-856.
[88]LING Z,LIU X,CHENG Y,et al.Clostridium butyricum combined with Bifidobacterium infantis probiotic mixture restores fecal microbiota and attenuates systemic Inflammation in mice with antibiotic-associated diarrhea[J].Bio M ed Research International.2015:582048.
[89]凌宗欣.女性生殖道微生物群落菌群多样性变化与生殖道感染的相关性研究[D].浙江大学,2012.
[90]丁佳,王慧艳,何秋雯,等.益生菌对雌激素代谢及相关疾病的影响[J].食品科学,2016,37(11):248-254.DOI:10.7506/spkx1002-6630-201611044.
[91]冀建伟.双歧杆菌对应激大鼠肠道菌群及促肾上腺皮质激素释放激素的影响[D].郑州大学,2010.
[92]XIE B,ZHANG S,LIU J,et al.Enhanced estrogenic activity of soy bean isoflavones by coad ministration of Liu wei Di huang Pills in ova eiectomizes rates[J].Phytother Res,2015,19(7):1054-1061.
[93]陈旻远,贾聪慧,洪奇华,等.丁酸梭菌对动物肠道生态的影响及作用机制[J].饲料研究,2016,(06):5-8.DOI:10.13557/j.cnki.issn.1002-2813.2016.06.002.
[94]WEI P,YANG Y,LI T,et al.A engineered Bifidobacterium Long umsecreting a bioactive penetratin-Glucagon-like peptide 1fusion protein enhances Glucagon-like peptide 1 absorption in the intestine[J].J Microbiol Biotechnol,2015,2(12):113-115.
[95]谭婷婷,马丽,朱超,等.双歧杆菌辅助治疗胃癌对于肠道菌群及血清促肾上腺皮质激素表达的影响[J].中国微生态学杂志,2016,28(09):1052-1055
[96]石梦玄.动物双歧杆菌对小鼠肠道黏膜损伤的缓解作用及其机理研究[D].河北工程大学,2016.
[97]王然,陈善斌,庞瑞鹏,等.干酪乳杆菌L9对健康人群肠道健康的影响[J].中国食品学报,2016,16(08):38-44.
[98]ELAHI S,ERTELT J,KINDER J,et al.Immunosuppressive CD71+erythroid cells compromise neonatal host defence against infection.Nature,2013,(504):158–162.