血浆同型半胱氨酸与缺血性脑血管病患者颈动脉粥样硬化斑块的关系研究
|
摘要
目的探讨血浆同型半胱氨酸(Hcy)浓度与缺血性脑血管病患者颈动脉粥样硬化斑块的关系。方法选择2017年1月～2018年6月治疗的缺血性脑血管病患者307例作为研究对象,所有患者均行颈动脉彩色多普勒超声检查,根据超声检查结果分为三组:A组(稳定斑块)、B组(不稳定斑块)、C组(无斑块);对其血浆Hcy浓度进行检测,采用SPSS Pearson相关性分析软件对血浆Hcy浓度与颈动脉粥样硬化斑块的关系进行分析。结果 307例患者中,C组68例(占比22.15%),有颈动脉斑块239例(占比77.85%),其中,B组81例(占比33.89%),A组158例(占比66.11%)。此外,D组112例(占比46.86%),E组127例(占比53.14%);A组与B组的血浆Hcy浓度显著高于C组(P<0.05);B组的血浆Hcy浓度显著高于A组(P<0.05);D组的血浆Hcy浓度显著高于E组(P<0.05);SPSS Pearson相关性分析结果表明:血浆Hcy浓度与颈动脉粥样硬化斑块呈正相关(P<0.05)。结论血浆Hcy浓度与缺血性脑血管病患者颈动脉粥样硬化斑块的形成以及稳定性均存在密切关联,加强血浆Hcy浓度测定可评估患者预后,指导临床治疗。
Objective To investigate the relationship between plasma homocysteine(Hcy) concentration and carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease. Methods A total of 307 patients with ischemic cerebrovascular disease who were treated from January 2017 and June 2018 were enrolled. All patients underwent carotid color Doppler ultrasonography and were divided into three groups according to the results of ultrasound examination, including group A(stable plaque), group B(unstable plaque) and group C(no plaque). The plasma Hcy concentration was detected. The relationship between plasma Hcy concentration and carotid atherosclerotic plaque was analyzed using SPSS Pearson correlation analysis software. Results Of the 307 patients, 68 were in group C(22.15%), and 239 had carotid plaques(77.85%), including 81 in group B(33.89%) and 158 in group A(66.11%). In addition, 112 patients were in group D(46.86%), and 127 patients were in group E(53.14%). Plasma Hcy concentrations in group A and group B were significantly higher than those in group C(P<0.05). The plasma Hcy concentration in group B was significantly higher than that of group A(P<0.05). The plasma Hcy concentration in group D was significantly higher than that of group E(P<0.05). SPSS Pearson correlation analysis showed that plasma Hcy concentration was positively correlated with carotid atherosclerotic plaque(P<0.05). Conclusion Plasma Hcy concentration is closely related to the formation and stability of carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease. Strengthening plasma Hcy concentration detection can evaluate the prognosis of patients and guide clinical treatment.
Objective To investigate the relationship between plasma homocysteine(Hcy) concentration and carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease. Methods A total of 307 patients with ischemic cerebrovascular disease who were treated from January 2017 and June 2018 were enrolled. All patients underwent carotid color Doppler ultrasonography and were divided into three groups according to the results of ultrasound examination, including group A(stable plaque), group B(unstable plaque) and group C(no plaque). The plasma Hcy concentration was detected. The relationship between plasma Hcy concentration and carotid atherosclerotic plaque was analyzed using SPSS Pearson correlation analysis software. Results Of the 307 patients, 68 were in group C(22.15%), and 239 had carotid plaques(77.85%), including 81 in group B(33.89%) and 158 in group A(66.11%). In addition, 112 patients were in group D(46.86%), and 127 patients were in group E(53.14%). Plasma Hcy concentrations in group A and group B were significantly higher than those in group C(P<0.05). The plasma Hcy concentration in group B was significantly higher than that of group A(P<0.05). The plasma Hcy concentration in group D was significantly higher than that of group E(P<0.05). SPSS Pearson correlation analysis showed that plasma Hcy concentration was positively correlated with carotid atherosclerotic plaque(P<0.05). Conclusion Plasma Hcy concentration is closely related to the formation and stability of carotid atherosclerotic plaque in patients with ischemic cerebrovascular disease. Strengthening plasma Hcy concentration detection can evaluate the prognosis of patients and guide clinical treatment.
引文
[1]王赛华,赵志宏,罗俊,等.急性缺血性脑卒中病人Hcy与高血压、颈动脉粥样硬化的相关性分析[J].中西医结合心脑血管病杂志,2016,14(6):586-588.
[2]符明昌,周莲,郑志昂.缺血性脑卒中患者血清Hcy、E-PO、CIMT水平的变化及其意义[J].基因组学与应用生物学,2017,36(8):3291-3296.
[3]谢彦芳,林杰,刘磊,等.缺血性脑血管病患者血浆Hcy水平与颈动脉粥样硬化斑块的关系研究[J].吉林医学,2017,38(3):481-482.
[4]中华医学会神经科专业委员会.脑血管病诊断要点[J]中华神经科杂志,1996,29(6):379-381.
[5]聂颖,冯新恒,陈宝霞,等.老年人血浆同型半胱氨酸水平和颈动脉粥样硬化关系的研究[J].中国医学前沿杂志(电子版),2017,9(9):96-100.
[6]朱美娥,龚道恺.血液学指标与急性缺血性脑卒中颈动脉粥样硬化的关系探讨[J].中西医结合心脑血管病杂志,2016,14(22):2701-2703.
[7]贺亚龙.血浆同型半胱氨酸与缺血性脑血管病患者颈动脉粥样硬化斑块的关系[J].中国实用神经疾病杂志,2015,18(19):18-20.
[8]林宇.血清同型半胱氨酸与C反应蛋白在颈动脉硬化诊断中的应用价值[J].医学综述,2016,22(1):198-199.
[9]吴少璞,祁亚伟,李学,等.血浆同型半胱氨酸与缺血性脑血管病患者颈动脉粥样硬化斑块的相关性[J].中国实用医药,2015,10(26):19-20.
[10]郭艳.血浆同型半胱氨酸和C反应蛋白联合检测在颈动脉粥样硬化诊断中的应用[J].中国当代医药,2017,24(30):145-147.
[11]顾汉沛,葛剑青,王光胜.血浆Lp-PLA2、HCY、尿酸与血脂对稳定大动脉粥样硬化性脑梗死病人颈动脉斑块的临床意义[J].中西医结合心脑血管病杂志,2017,15(5):613-616.
[12]张保珍,薄涛.D-二聚体、同型半胱氨酸检测在缺血性脑血管病患者颈动脉粥样硬化斑块形成中的应用价值[J].吉林医学,2016,37(10):2556-2557.
[13]李丽娜.颈动脉粥样硬化斑块的稳定性与缺血性脑血管疾病危险因素的相关研究[J].中西医结合心血管病电子杂志,2017,5(13):133.
[14]朱荣志,周英,李其英,等.老年脑梗死患者颈动脉粥样硬化的特征及血浆同型半胱氨酸水平的临床观察[J]安徽医药,2015,19(10):1955-1956.
[15]李世敬,金亚娟,赵玉燕.血浆同型半胱氨酸水平与缺血性脑血管病患者颈动脉粥样硬化斑块的相关性研究[J].湖南师范大学学报(医学版),2016,13(1):119-121.
[2]符明昌,周莲,郑志昂.缺血性脑卒中患者血清Hcy、E-PO、CIMT水平的变化及其意义[J].基因组学与应用生物学,2017,36(8):3291-3296.
[3]谢彦芳,林杰,刘磊,等.缺血性脑血管病患者血浆Hcy水平与颈动脉粥样硬化斑块的关系研究[J].吉林医学,2017,38(3):481-482.
[4]中华医学会神经科专业委员会.脑血管病诊断要点[J]中华神经科杂志,1996,29(6):379-381.
[5]聂颖,冯新恒,陈宝霞,等.老年人血浆同型半胱氨酸水平和颈动脉粥样硬化关系的研究[J].中国医学前沿杂志(电子版),2017,9(9):96-100.
[6]朱美娥,龚道恺.血液学指标与急性缺血性脑卒中颈动脉粥样硬化的关系探讨[J].中西医结合心脑血管病杂志,2016,14(22):2701-2703.
[7]贺亚龙.血浆同型半胱氨酸与缺血性脑血管病患者颈动脉粥样硬化斑块的关系[J].中国实用神经疾病杂志,2015,18(19):18-20.
[8]林宇.血清同型半胱氨酸与C反应蛋白在颈动脉硬化诊断中的应用价值[J].医学综述,2016,22(1):198-199.
[9]吴少璞,祁亚伟,李学,等.血浆同型半胱氨酸与缺血性脑血管病患者颈动脉粥样硬化斑块的相关性[J].中国实用医药,2015,10(26):19-20.
[10]郭艳.血浆同型半胱氨酸和C反应蛋白联合检测在颈动脉粥样硬化诊断中的应用[J].中国当代医药,2017,24(30):145-147.
[11]顾汉沛,葛剑青,王光胜.血浆Lp-PLA2、HCY、尿酸与血脂对稳定大动脉粥样硬化性脑梗死病人颈动脉斑块的临床意义[J].中西医结合心脑血管病杂志,2017,15(5):613-616.
[12]张保珍,薄涛.D-二聚体、同型半胱氨酸检测在缺血性脑血管病患者颈动脉粥样硬化斑块形成中的应用价值[J].吉林医学,2016,37(10):2556-2557.
[13]李丽娜.颈动脉粥样硬化斑块的稳定性与缺血性脑血管疾病危险因素的相关研究[J].中西医结合心血管病电子杂志,2017,5(13):133.
[14]朱荣志,周英,李其英,等.老年脑梗死患者颈动脉粥样硬化的特征及血浆同型半胱氨酸水平的临床观察[J]安徽医药,2015,19(10):1955-1956.
[15]李世敬,金亚娟,赵玉燕.血浆同型半胱氨酸水平与缺血性脑血管病患者颈动脉粥样硬化斑块的相关性研究[J].湖南师范大学学报(医学版),2016,13(1):119-121.