他汀类药物所致不良反应及其相关影响因素的研究进展
摘要
在临床上,他汀类药物目前主要应用在动脉粥样硬化的治疗及改善预后方面,但在实际应用中发现在使用这类药物的过程中会出现不良反应,从而影响临床效果。近年来,相关领域对于他汀类药物导致的不良反应及其耐受性进行了越来越深入的研究,为他汀类药物在临床上的使用提供了重要的参考,但需要注意的是他汀类药物在肌肉、肝脏功能、神经系统损伤以及新发肿瘤等疾病的治疗中出现的不良反应尚未明确。本文对他汀类药物引起的不良反应及影响因素的研究进展进行总结。
引文
[1]王鹏,严妍,于文君,等.他汀类药物不良反应的研究进展[J].中国医院药学杂志,2016,36(22):2035-2039.
[2]Mancano M A. ISMP Adverse Drug Reactions:LevofloxacinInduced Neuroexcitation and Hallucinations; Statin-Induced Muscle Rupture; Mefloquine-Induced Rhabdomyolysis; MethimazoleInduced Cholestatic Hepatitis; Decitabine-Induced Hand and Foot Syndrome.[J]. Hosp Pharm,2017,52(5):330-333.
[3]岳媛.他汀类药物在心血管病中的不良反应研究进展[J].中西医结合心血管病电子杂志,2016,4(9):12-13.
[4]Aida O A,Camilla S,Isabel L M,et al. Case Characterization,Clinical Features and Risk Factors in Drug-Induced Liver Injury[J]. International Journal of Molecular Sciences,2016,17(5):714.
[5]刘学伟.他汀类药物不良反应的研究进展[J].大家健康(学术版),2016,10(7):130-133.
[6]Pedro-Botet J,Millán N J,Chillarón J J,et al. Severity of statin-induced adverse effects on muscle and associated conditions:data from the DAMA study[J]. Expert Opinion on Drug Safety,2016,15(12):1-5.
[7]陈爱荣.浅论他汀类药物所致不良反应的特点和预防措施[J].当代医药论丛,2017,15(16):130-131.
[8]孙静,陈铁龙,陈启兰.他汀类药物对糖尿病影响的研究进展[J].中国现代医生,2016,54(26):162-164.
[9]Sadighara M,Joktaji J P,Hajhashemi V,et al. Protective effects of coenzyme Q10 and L-carnitine against statin-induced pancreatic mitochondrial toxicity in rats[J]. Research in Pharmaceutical Sciences,2017,12(6):434.
[10]肖青兰,王友清.他汀类药物不良反应与临床合理应用[J].临床合理用药杂志,2016,9(23):78.
[11]赵璇,邹红,彭毅.他汀类药物临床不良反应分析及其应对措施[J].当代医学,2017,23(9):69-70.
[12]Vevera J,Fi a Z,Nekov T,et al. Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia[J]. Physiological Research,2016,65(5):777-788.
[13]Nishtala P S,Chyou T‐. Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions[J]. Journal of Clinical Pharmacy&Therapeutics,2017,42(2):189-194.
[2]Mancano M A. ISMP Adverse Drug Reactions:LevofloxacinInduced Neuroexcitation and Hallucinations; Statin-Induced Muscle Rupture; Mefloquine-Induced Rhabdomyolysis; MethimazoleInduced Cholestatic Hepatitis; Decitabine-Induced Hand and Foot Syndrome.[J]. Hosp Pharm,2017,52(5):330-333.
[3]岳媛.他汀类药物在心血管病中的不良反应研究进展[J].中西医结合心血管病电子杂志,2016,4(9):12-13.
[4]Aida O A,Camilla S,Isabel L M,et al. Case Characterization,Clinical Features and Risk Factors in Drug-Induced Liver Injury[J]. International Journal of Molecular Sciences,2016,17(5):714.
[5]刘学伟.他汀类药物不良反应的研究进展[J].大家健康(学术版),2016,10(7):130-133.
[6]Pedro-Botet J,Millán N J,Chillarón J J,et al. Severity of statin-induced adverse effects on muscle and associated conditions:data from the DAMA study[J]. Expert Opinion on Drug Safety,2016,15(12):1-5.
[7]陈爱荣.浅论他汀类药物所致不良反应的特点和预防措施[J].当代医药论丛,2017,15(16):130-131.
[8]孙静,陈铁龙,陈启兰.他汀类药物对糖尿病影响的研究进展[J].中国现代医生,2016,54(26):162-164.
[9]Sadighara M,Joktaji J P,Hajhashemi V,et al. Protective effects of coenzyme Q10 and L-carnitine against statin-induced pancreatic mitochondrial toxicity in rats[J]. Research in Pharmaceutical Sciences,2017,12(6):434.
[10]肖青兰,王友清.他汀类药物不良反应与临床合理应用[J].临床合理用药杂志,2016,9(23):78.
[11]赵璇,邹红,彭毅.他汀类药物临床不良反应分析及其应对措施[J].当代医学,2017,23(9):69-70.
[12]Vevera J,Fi a Z,Nekov T,et al. Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia[J]. Physiological Research,2016,65(5):777-788.
[13]Nishtala P S,Chyou T‐. Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions[J]. Journal of Clinical Pharmacy&Therapeutics,2017,42(2):189-194.