婴幼儿牛奶蛋白过敏诊治进展
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摘要
回顾婴儿牛奶蛋白过敏的发生机制,症状、辅助检查,诊断及治疗牛奶蛋白过敏的最新进展。牛奶蛋白过敏主要是由IgE和非IgE介导的免疫反应,其症状可表现为消化、呼吸、皮肤等一个或多个系统受损,牛奶回避-双盲激发试验为诊断的金标准,牛奶蛋白回避是治疗牛奶蛋白过敏的主要方法。
To analyze the pathogenesis,symptoms,auxiliary examinations,diagnosis and treatment of milk protein allergy in infants,and the latest progress in the diagnosis and treatment of milk protein allergy.Milk protein allergy is mainly immune response mediated by IgE or non-IgE.Its symptoms can be manifested as digestion,breathing,skin damage,etc.Milk avoidance-double blind provocation test is the golden standard for diagnosis.Milk protein avoidance is the main method to treat milk protein allergy.
To analyze the pathogenesis,symptoms,auxiliary examinations,diagnosis and treatment of milk protein allergy in infants,and the latest progress in the diagnosis and treatment of milk protein allergy.Milk protein allergy is mainly immune response mediated by IgE or non-IgE.Its symptoms can be manifested as digestion,breathing,skin damage,etc.Milk avoidance-double blind provocation test is the golden standard for diagnosis.Milk protein avoidance is the main method to treat milk protein allergy.
引文
[1] World Allergy Organization(WAO).Diagnosis and Rationale for Action against Cow′s Milk Allergy(DRACMA) Guidelines[J].Pediatr Allergy Immunol,2010,21(Suppl21):1-125.
[2] VENTER C,ARSHAD SH.Epidemiology of food allergy[J].Pediatr Clin North Am,2011,58(2):327-349.
[3] 陈静,廖艳,张红忠,等.三城市两岁以下儿童食物过敏现状调查[J].中华儿科杂志,2012,50(1):5-9.
[4] NGAMPHAIBOON J,CHATCHATEE P,THONGKAEW T.Cow′s milk allergy in Thai children[J].Asian Pac J Allergy Immunol,2008,26(4):199-204.
[5] KEMP AS,HILL DJ,ALLEN KJ,et al.Guidelines for the use of infant formulas to treat cows milk protein allergy:an Australian consensus panel opinion[J].Medical J Australia,2008,188(2):109-112.
[6] 黄惠君,余珍珠,杨慧,等.32例新生儿食物过敏性直肠炎临床分析[J].重庆医学,2014,43(26):3523-3525.
[7] 车千红,赵晴,孙灿,等.牛奶蛋白过敏患儿的营养干预[J].实用儿科临床杂志,2011,26(19):1486-1488.
[8] DUPONT C.Food allergy:recent advances in path physiology and diagnosis[J].Ann Nutr Metab,2011,59( Suppl 1):8-18.
[9] 闫俊梅,陈静,黎海芪,等.婴幼儿鸡蛋与牛奶过敏食物皮肤点刺试验的诊断价值[J].中华儿科杂志,2011,49(5):329-332.
[10] 韩煦,景晔,陆光生,等.血清食物不耐受特异性IgG检测方法的研究[J].中国实验诊断学,2015,19(6):951-954.
[11] 拉母卓嘎,皮装,吕欣桐,等.开放性食物激发试验在牛奶蛋白过敏诊治中的应用价值[J].中国免疫学杂志,2016,32(4):567-569.
[12] 唐鲁静,赵泓,陈洁.牛奶蛋白激发试验在消化道牛奶蛋白过敏症中的临床意义[J].中华儿科杂志,2015,53(4):285-289.
[13] 许朝晖,杨敏,耿岚岚,等.饮食回避对6个月以下婴儿儿乳糖不耐受和(或)牛奶蛋白过敏致迁延性慢性腹泻病的效果[J].广东医学,2015,36(19):2990-2991.
[14] SKYPALA I,VLIEG-BOERSTRA B.Food intolerance and allergy:increased incidence or contemporary inadequate diets [J].Curr Opin Clin Nutr Metab Care,2014,17(5):442-447.
[15] 孙灿,娄岩,赵睛,等.260例婴幼儿牛奶蛋白过敏的临床分析[J].国际儿科学杂志,2016,43(4):421-424.
[16] 闫俊梅,陈静,黎海芪,等.三种低敏配方治疗牛奶蛋白过敏效果评价[J].中华儿科杂志,2011,49(7):501-505.
[17] MAVROUDI A,XINIAS I.Dietary interventions for primary allergy prevention in infants[J].Hippokratia,2011,15(3):216-222.
[18] SHOICHI,KANAKO,TETSUYA,et al.Prophylactic probiotics reduce cow′s milk protein intolerance in neonates after small intestine surgery and antibiotic treatment presenting symptoms that mimics postoperative infection[J].Allergology International,2012,61(1):107-113.
[19] WANG JL.Hugh A Sampson,Food allergy:recent advances in pathophysiology and treatment[J].Allergy Asthma Immunol Res,2009,1(1):19-29.
[20] GREER FR,SICHERER SH,BURKS AW.Effects off early nutritional interventions on the development of atopic disease in infants and children:the role of maternal dietary restriction,breastfeeding,timing of complementary foods,and hydrolyzed formulas [J].Pediatrics,2008,121(1):183-191.
[2] VENTER C,ARSHAD SH.Epidemiology of food allergy[J].Pediatr Clin North Am,2011,58(2):327-349.
[3] 陈静,廖艳,张红忠,等.三城市两岁以下儿童食物过敏现状调查[J].中华儿科杂志,2012,50(1):5-9.
[4] NGAMPHAIBOON J,CHATCHATEE P,THONGKAEW T.Cow′s milk allergy in Thai children[J].Asian Pac J Allergy Immunol,2008,26(4):199-204.
[5] KEMP AS,HILL DJ,ALLEN KJ,et al.Guidelines for the use of infant formulas to treat cows milk protein allergy:an Australian consensus panel opinion[J].Medical J Australia,2008,188(2):109-112.
[6] 黄惠君,余珍珠,杨慧,等.32例新生儿食物过敏性直肠炎临床分析[J].重庆医学,2014,43(26):3523-3525.
[7] 车千红,赵晴,孙灿,等.牛奶蛋白过敏患儿的营养干预[J].实用儿科临床杂志,2011,26(19):1486-1488.
[8] DUPONT C.Food allergy:recent advances in path physiology and diagnosis[J].Ann Nutr Metab,2011,59( Suppl 1):8-18.
[9] 闫俊梅,陈静,黎海芪,等.婴幼儿鸡蛋与牛奶过敏食物皮肤点刺试验的诊断价值[J].中华儿科杂志,2011,49(5):329-332.
[10] 韩煦,景晔,陆光生,等.血清食物不耐受特异性IgG检测方法的研究[J].中国实验诊断学,2015,19(6):951-954.
[11] 拉母卓嘎,皮装,吕欣桐,等.开放性食物激发试验在牛奶蛋白过敏诊治中的应用价值[J].中国免疫学杂志,2016,32(4):567-569.
[12] 唐鲁静,赵泓,陈洁.牛奶蛋白激发试验在消化道牛奶蛋白过敏症中的临床意义[J].中华儿科杂志,2015,53(4):285-289.
[13] 许朝晖,杨敏,耿岚岚,等.饮食回避对6个月以下婴儿儿乳糖不耐受和(或)牛奶蛋白过敏致迁延性慢性腹泻病的效果[J].广东医学,2015,36(19):2990-2991.
[14] SKYPALA I,VLIEG-BOERSTRA B.Food intolerance and allergy:increased incidence or contemporary inadequate diets [J].Curr Opin Clin Nutr Metab Care,2014,17(5):442-447.
[15] 孙灿,娄岩,赵睛,等.260例婴幼儿牛奶蛋白过敏的临床分析[J].国际儿科学杂志,2016,43(4):421-424.
[16] 闫俊梅,陈静,黎海芪,等.三种低敏配方治疗牛奶蛋白过敏效果评价[J].中华儿科杂志,2011,49(7):501-505.
[17] MAVROUDI A,XINIAS I.Dietary interventions for primary allergy prevention in infants[J].Hippokratia,2011,15(3):216-222.
[18] SHOICHI,KANAKO,TETSUYA,et al.Prophylactic probiotics reduce cow′s milk protein intolerance in neonates after small intestine surgery and antibiotic treatment presenting symptoms that mimics postoperative infection[J].Allergology International,2012,61(1):107-113.
[19] WANG JL.Hugh A Sampson,Food allergy:recent advances in pathophysiology and treatment[J].Allergy Asthma Immunol Res,2009,1(1):19-29.
[20] GREER FR,SICHERER SH,BURKS AW.Effects off early nutritional interventions on the development of atopic disease in infants and children:the role of maternal dietary restriction,breastfeeding,timing of complementary foods,and hydrolyzed formulas [J].Pediatrics,2008,121(1):183-191.