瞬时受体电位通道和消化系肿瘤的关系研究进展
|
摘要
瞬时受体电位通道(transient receptor potential channels,TRPC)是位于细胞膜上的一类重要的阳离子通道,在呼吸道、消化道、肝脏和心脏等组织器官都有表达。近来的研究表明TRPC参与了肿瘤的发生发展。本文综述了TRPC在消化系统肿瘤发生发展及治疗中的作用,希望进一步了解消化系统肿瘤发生发展的机制,为消化系统肿瘤的治疗提供另一个方向进行探讨。.
Transient receptor potential( TRP) channels,which are important selective cation channels located in the cell membrane,are widely expressed in the human respiratory tract,digestive tract,liver,and heart. Many studies have demonstrated the involvement of TRP channels in the development and progression of malignant tumors. Herein,we review the roles of TRP channels in the development,progression,and treatment of digestive tumors. We hope to provide further understanding of the mechanisms of pathogenesis and progression of digestive cancers,as well as an alternative direction for their treatment.
Transient receptor potential( TRP) channels,which are important selective cation channels located in the cell membrane,are widely expressed in the human respiratory tract,digestive tract,liver,and heart. Many studies have demonstrated the involvement of TRP channels in the development and progression of malignant tumors. Herein,we review the roles of TRP channels in the development,progression,and treatment of digestive tumors. We hope to provide further understanding of the mechanisms of pathogenesis and progression of digestive cancers,as well as an alternative direction for their treatment.
引文
[1] Samanta A,Hughes TET,Moiseenkova-Bell VY. Transient receptor potential(TRP)channels[J]. Subcell Biochem,2018,87:141-165.
[2]孙宏伟,沈锋,王以政,等.原发性肝细胞癌与癌旁组织中TRPC6表达的研究[J].解放军医学杂志, 2008, 33(1):115.
[3]王淑贞,尹红,钟耀艺,等.敲除TRPC6对MPTP诱导小鼠神经炎性损伤的影响[J].中国比较医学,2017,27(12):1-7.
[4]朱科,张军平,李萌. TRPV1通道在动脉粥样硬化中的作用[J].生理科学进展,2018,49(4):305-307。
[5]李佳,刘霞,白占涛. TRPV1的药物靶点及多肽类毒素调制剂[J].延安大学学报(自然科学版),2016,35(2):50-54.
[6]闫凤娜,刘素晓,崔琳,等. TRPV4受体对血管紧张素II诱导的小鼠肾损害的影响[J].中国比较医学,2018,28(2):1-6.
[7]刘强,刘国兴,方雨,等. TRPV4通道蛋白在肿瘤发生发展中的研究进展[J].中国普通外科杂志,2016,25(1):132-137.
[8]林长明,梁朝朝. TRPM7的肿瘤研究进展[J].现代泌尿生殖肿瘤,2017,9(4):248-252.
[9]李富春,谷贵山,孙大辉,等.新型钙离子通道TRPV5和TRPV6与成骨细胞信号传递的关系[J].吉林大学学报(医学版),2007,33(3):600-603.
[10]秦冬梅,李晶,欧阳颖,等.TRPM8离子通道在偏头痛发生中的作用[J].实用疼痛医学杂志,2012,8(6):456-459.
[11]温自强,王洪成,黄新余.TRPM8与肿瘤的研究进展[J].国际外科学,2014,41(1):42-46.
[12] Holzer P. Transient receptor potential(TRP)channels as drug targets for diseases of the digestive system[J]. Pharmacol Ther,2011,131(1):142-170.
[13] Kim BJ. Involvement of transient receptor potential melastatin 7channels in ophorae radix-induced apoptosis in cancer cells sophorae radix and TRPM7[J]. J Pharmacopuncture,2012,15(3):31-38.
[14] Lim B,Lee HJ,Kim MC,et al. Effects of ulmipumilae cortex on AGS gastric cancer cells[J]. J Pharmacopuncture,2013,16(2):55-61.
[15] Lee HJ,Kim MC,Lim B,et al. Buxus microphylla var. Koreana nakai extract for the treatment of gastric cancer[J]. J Pharmacopuncture,2013,16(3):39-45.
[16] Kim BJ,Nam JH,Kwon YK,et al. The role of waixenicin a as transient receptor potential melastatin 7 blocker[J]. Basic Clin Pharmacol Toxicol,2013,112(2):83-89.
[17]郑云华,刘伟.果蝇TRP离子通道C端一个新钙调蛋白的结合位点的鉴定和分析[J].中国生物化学与分子生物学报,2016,32(7):790-797.
[18] Xie R,Xu JY,Xiao YF,et al. Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel[J]. Cancer Res,2017,77(23):6499-6512.
[19] Cai R,Ding X,Zhou KC,et al. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells[J]. Int J Cancer,2009,125(10):2281-2287.
[20]葛蓬勃,张明凯,王凯.瞬时受体电位通道蛋白6(TRPC6)在SGC-7901细胞增殖中的作用[J].滨州医学院学报,2018,4:247-250.
[21] Kim BJ,Park EJ,Lee JH,et al. Suppression of transient receptor potenti lastatin 7 channel induces cell death in gastric cancer[J]. Cancer Sci,2008,99(12):2502-2509.
[22] Zhang Y,Zhang Y,Fan H,et al. Study on the role of transient receptor potential C6 channels in esophageal squamous cell carcinoma radiosensitivity[J]. J Thorac Dis,2017,9(10):3802-3809.
[23] Zhou K,Zhang SS,Yan Y,et al. Overexpression of transient receptor potential vanilloid 2 is associated with poor prognosis in patients with esophageal squamous cell carcinoma[J]. Med Oncol,2014,31(7):17.
[24] Zhang SS,Wen J,Yang F,et al. High expression of transient potential receptor C6 correlated with poor prognosis in patients with esophageal squamous cell carcinoma[J]. Med Oncol,2013,30(3):607.
[25] EI Boustany C,Bidaux G,Enfissi A,et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation[J]. Hepatology,2008,47(6):2068-2077.
[26] Cheung JY,Miller BA. Transient receptor potential-melastatin channel family member 2:friend or foe[J]. Trans Am Clin Climatol Assoc,2017,128:308-329.
[27] Wen L,Liang C,Chen E,et al. Regulation of multi-drug resistance in hepatocellular carcinoma cells is TRPC6/calcium dependent[J].Sci Rep,2016,6:23269.
[28]孙宏伟,沈锋,王以政,等. TRPC6对肝癌细胞增殖的介导[J].中华肝胆外科杂志,2009,15(9):697-699.
[29]韩璐,狄翠霞,毛爱红,等.Capsazepine诱导人肝癌HepG2细胞凋亡机制研究[J].中华肿瘤防治杂志,2015,22(10):764-769
[30]王梅;宋波;王波,等..氯离子通道1过表达对小鼠肝癌细胞株Hca-P生物学行为的影响[J].中国癌症杂志,2012,22(7):486-493.
[31]吴珏堃;熊志勇;林良奕,等.SCNM1在乙肝相关性肝癌中的表达及临床意义[J].中国病理生理杂志,2019,35(1):188-192.
[32]金成,朱茂群,顾元龙,等.酸敏感离子通道1a介导的激活蛋白-1在肝细胞肝癌中的表达及其与临床特征的关系[J].中华肝胆外科杂志,2018,24(6):376-380.
[33]胡啸;王艳杰;陈德.过表达钾离子通道调节蛋白抑制肝癌细胞增殖、迁移及侵袭[J].肿瘤,2018,38(6):535-543.
[34] Rybarczyk P,Vanlaeys A,Brassart B,et al. The transient receptor potential melastatin 7 channel regulates pancreatic cancer cell invasion through the Hsp90α/uPA/MMP-2 pathway[J]. Neoplasia,2017,19(4):288-300.
[35] Rybarczyk P,Gautier M,Dhennin-Duthille I,et al. Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration[J]. Int J Cancer,2012,131(6):E851-E861.
[36] Uchida K,Demirkhanyan L,Asuthka S,et al. Stimulationdependent gating of TRPM3 channel in planar lipid bilayers[J].FASEB J,2016,30(3):1306-1316.
[37] Yee NS,Kazi AA,Li Q,et al. Aberrant over-expression of TRPM7 ion channels in pancreatic cancer:Required for cancer cell invasion and implicated in tumor growth and metastasis[J].Biol Open,2015,4(4):507-514.
[38] Yee NS,Li Q,Kazi AA,et al. Aberrantly over-expressed TRPM8 channels in pancreatic adenocarcinoma:Correlation with tumor size/stage and requirement for cancer cells invasion[J].Cells,2014,3(2):500-516.
[39] Yee NS,Zhou WQ,Lee M. Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma[J]. Cancer Lett,2010,297(1):49-55.
[40] Yee NS,Brown RD,Lee MS,et al. TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma[J]. Cancer Biol Ther,2012,13(8):592-599.
[41] Yee NS,Brown RD,Lee MS,et al. TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma[J]. Cancer Biol Ther,2012,13(8):592-599.
[42]熊成成,陈艳芳.瞬时受体通道TRPM8的研究进展[J].今日药学,2017,27(03):209-213.
[43] Huang J,Furuya H,Faouzi M,et al. Inhibition of TRPM7suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane induced early colon cancer in mice[J]. Cell Commun Signal,2017,15(1):30.
[44] Sobradillo D, Herna'ndez-Morales M, Ubierna D, et al. A reciprocal shift in transient receptor potential channel 1(TRPC1)and stromal interaction molecule 2(STIM2)contributes to Ca2+remodeling and cancer hallmarks in colorectal carcinoma cells[J]. J Biol Chem,2014,289(42):28765-28782.
[45] Vinuesa AG,Sancho R,García-Limones C,et al. Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer[J]. Cancer Res,2012,72(7):1705-1716.
[46]张慧,刘模荣,董辉,等.TRPV5 TRPV6对结肠癌SW480细胞生物学行为的影响[J].中国肿瘤临床,2017,44(12):577-582.
[2]孙宏伟,沈锋,王以政,等.原发性肝细胞癌与癌旁组织中TRPC6表达的研究[J].解放军医学杂志, 2008, 33(1):115.
[3]王淑贞,尹红,钟耀艺,等.敲除TRPC6对MPTP诱导小鼠神经炎性损伤的影响[J].中国比较医学,2017,27(12):1-7.
[4]朱科,张军平,李萌. TRPV1通道在动脉粥样硬化中的作用[J].生理科学进展,2018,49(4):305-307。
[5]李佳,刘霞,白占涛. TRPV1的药物靶点及多肽类毒素调制剂[J].延安大学学报(自然科学版),2016,35(2):50-54.
[6]闫凤娜,刘素晓,崔琳,等. TRPV4受体对血管紧张素II诱导的小鼠肾损害的影响[J].中国比较医学,2018,28(2):1-6.
[7]刘强,刘国兴,方雨,等. TRPV4通道蛋白在肿瘤发生发展中的研究进展[J].中国普通外科杂志,2016,25(1):132-137.
[8]林长明,梁朝朝. TRPM7的肿瘤研究进展[J].现代泌尿生殖肿瘤,2017,9(4):248-252.
[9]李富春,谷贵山,孙大辉,等.新型钙离子通道TRPV5和TRPV6与成骨细胞信号传递的关系[J].吉林大学学报(医学版),2007,33(3):600-603.
[10]秦冬梅,李晶,欧阳颖,等.TRPM8离子通道在偏头痛发生中的作用[J].实用疼痛医学杂志,2012,8(6):456-459.
[11]温自强,王洪成,黄新余.TRPM8与肿瘤的研究进展[J].国际外科学,2014,41(1):42-46.
[12] Holzer P. Transient receptor potential(TRP)channels as drug targets for diseases of the digestive system[J]. Pharmacol Ther,2011,131(1):142-170.
[13] Kim BJ. Involvement of transient receptor potential melastatin 7channels in ophorae radix-induced apoptosis in cancer cells sophorae radix and TRPM7[J]. J Pharmacopuncture,2012,15(3):31-38.
[14] Lim B,Lee HJ,Kim MC,et al. Effects of ulmipumilae cortex on AGS gastric cancer cells[J]. J Pharmacopuncture,2013,16(2):55-61.
[15] Lee HJ,Kim MC,Lim B,et al. Buxus microphylla var. Koreana nakai extract for the treatment of gastric cancer[J]. J Pharmacopuncture,2013,16(3):39-45.
[16] Kim BJ,Nam JH,Kwon YK,et al. The role of waixenicin a as transient receptor potential melastatin 7 blocker[J]. Basic Clin Pharmacol Toxicol,2013,112(2):83-89.
[17]郑云华,刘伟.果蝇TRP离子通道C端一个新钙调蛋白的结合位点的鉴定和分析[J].中国生物化学与分子生物学报,2016,32(7):790-797.
[18] Xie R,Xu JY,Xiao YF,et al. Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel[J]. Cancer Res,2017,77(23):6499-6512.
[19] Cai R,Ding X,Zhou KC,et al. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells[J]. Int J Cancer,2009,125(10):2281-2287.
[20]葛蓬勃,张明凯,王凯.瞬时受体电位通道蛋白6(TRPC6)在SGC-7901细胞增殖中的作用[J].滨州医学院学报,2018,4:247-250.
[21] Kim BJ,Park EJ,Lee JH,et al. Suppression of transient receptor potenti lastatin 7 channel induces cell death in gastric cancer[J]. Cancer Sci,2008,99(12):2502-2509.
[22] Zhang Y,Zhang Y,Fan H,et al. Study on the role of transient receptor potential C6 channels in esophageal squamous cell carcinoma radiosensitivity[J]. J Thorac Dis,2017,9(10):3802-3809.
[23] Zhou K,Zhang SS,Yan Y,et al. Overexpression of transient receptor potential vanilloid 2 is associated with poor prognosis in patients with esophageal squamous cell carcinoma[J]. Med Oncol,2014,31(7):17.
[24] Zhang SS,Wen J,Yang F,et al. High expression of transient potential receptor C6 correlated with poor prognosis in patients with esophageal squamous cell carcinoma[J]. Med Oncol,2013,30(3):607.
[25] EI Boustany C,Bidaux G,Enfissi A,et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation[J]. Hepatology,2008,47(6):2068-2077.
[26] Cheung JY,Miller BA. Transient receptor potential-melastatin channel family member 2:friend or foe[J]. Trans Am Clin Climatol Assoc,2017,128:308-329.
[27] Wen L,Liang C,Chen E,et al. Regulation of multi-drug resistance in hepatocellular carcinoma cells is TRPC6/calcium dependent[J].Sci Rep,2016,6:23269.
[28]孙宏伟,沈锋,王以政,等. TRPC6对肝癌细胞增殖的介导[J].中华肝胆外科杂志,2009,15(9):697-699.
[29]韩璐,狄翠霞,毛爱红,等.Capsazepine诱导人肝癌HepG2细胞凋亡机制研究[J].中华肿瘤防治杂志,2015,22(10):764-769
[30]王梅;宋波;王波,等..氯离子通道1过表达对小鼠肝癌细胞株Hca-P生物学行为的影响[J].中国癌症杂志,2012,22(7):486-493.
[31]吴珏堃;熊志勇;林良奕,等.SCNM1在乙肝相关性肝癌中的表达及临床意义[J].中国病理生理杂志,2019,35(1):188-192.
[32]金成,朱茂群,顾元龙,等.酸敏感离子通道1a介导的激活蛋白-1在肝细胞肝癌中的表达及其与临床特征的关系[J].中华肝胆外科杂志,2018,24(6):376-380.
[33]胡啸;王艳杰;陈德.过表达钾离子通道调节蛋白抑制肝癌细胞增殖、迁移及侵袭[J].肿瘤,2018,38(6):535-543.
[34] Rybarczyk P,Vanlaeys A,Brassart B,et al. The transient receptor potential melastatin 7 channel regulates pancreatic cancer cell invasion through the Hsp90α/uPA/MMP-2 pathway[J]. Neoplasia,2017,19(4):288-300.
[35] Rybarczyk P,Gautier M,Dhennin-Duthille I,et al. Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration[J]. Int J Cancer,2012,131(6):E851-E861.
[36] Uchida K,Demirkhanyan L,Asuthka S,et al. Stimulationdependent gating of TRPM3 channel in planar lipid bilayers[J].FASEB J,2016,30(3):1306-1316.
[37] Yee NS,Kazi AA,Li Q,et al. Aberrant over-expression of TRPM7 ion channels in pancreatic cancer:Required for cancer cell invasion and implicated in tumor growth and metastasis[J].Biol Open,2015,4(4):507-514.
[38] Yee NS,Li Q,Kazi AA,et al. Aberrantly over-expressed TRPM8 channels in pancreatic adenocarcinoma:Correlation with tumor size/stage and requirement for cancer cells invasion[J].Cells,2014,3(2):500-516.
[39] Yee NS,Zhou WQ,Lee M. Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma[J]. Cancer Lett,2010,297(1):49-55.
[40] Yee NS,Brown RD,Lee MS,et al. TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma[J]. Cancer Biol Ther,2012,13(8):592-599.
[41] Yee NS,Brown RD,Lee MS,et al. TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma[J]. Cancer Biol Ther,2012,13(8):592-599.
[42]熊成成,陈艳芳.瞬时受体通道TRPM8的研究进展[J].今日药学,2017,27(03):209-213.
[43] Huang J,Furuya H,Faouzi M,et al. Inhibition of TRPM7suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane induced early colon cancer in mice[J]. Cell Commun Signal,2017,15(1):30.
[44] Sobradillo D, Herna'ndez-Morales M, Ubierna D, et al. A reciprocal shift in transient receptor potential channel 1(TRPC1)and stromal interaction molecule 2(STIM2)contributes to Ca2+remodeling and cancer hallmarks in colorectal carcinoma cells[J]. J Biol Chem,2014,289(42):28765-28782.
[45] Vinuesa AG,Sancho R,García-Limones C,et al. Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer[J]. Cancer Res,2012,72(7):1705-1716.
[46]张慧,刘模荣,董辉,等.TRPV5 TRPV6对结肠癌SW480细胞生物学行为的影响[J].中国肿瘤临床,2017,44(12):577-582.