CD30阴性淋巴瘤样丘疹病2例及文献复习
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摘要
目的探讨中国人淋巴瘤样丘疹病的临床特点。方法对本院确诊的2例CD30阴性淋巴瘤样丘疹病患者的临床表型进行详细报告,并将结果与自1993年以来国内发表的35例中国人淋巴瘤样丘疹病患者临床资料进行综合对比分析,总结中国人淋巴瘤样丘疹病的临床特点。结果 37例患者中,男23例,女14例;发病年龄9~80岁,平均(42.44±16.51)岁;发病到就诊平均时间为(64.91±96.76)个月,多中年发病,病程呈慢性经过。病因不详,无明显相关的伴发疾病,大部分患者无不适症状,少数患者有瘙痒,皮疹可表现为局限性和泛发性,呈现丘疹、坏死、溃疡、结痂和萎缩等多形性改变,一般不侵犯指甲、掌趾、口腔和外阴等黏膜部位;组织病理学特征为真皮浅层至深层血管周围异质性T淋巴细胞增生,病理表型多样,治疗方法多种。结论淋巴瘤样丘疹病多发生于中年人群,男性发病例数较女性多,首发皮疹多分布于躯干或四肢,可呈现为局限型或泛发型,组织病理呈谱系性改变,该病总体预后较好。
Objective To analyze the clinical features of lymphomatoid papulosis( Ly P).Methods Two cases of Ly P from our hospital and 35 cases which were reported in domestic documents from 1993 to present were reviewed retrospectively. Results There were 23 males and 14 females among 37 Ly P patients,the range of age onset was 9 to 80 years old,the mean age of onset was( 42. 44 ± 16. 51) years old. The process of this disease was chronic disease and middle aged people were more prone to this disease. Major patients had no symptoms,a small number of patients with itching. The rash can be expressed as limitations or generalized and generally did not involve the nail,palm,mouth,vulva and other mucosal parts. Histopathological features of Ly P was the T lymphocyte infiltration from superficial dermis to deep vascular around and pathological phenotype was diversity,various therapies have been reported to be used to treat Ly P. Conclusion There were significant differences between males and females in incidence rate,the first skin eruption mainly located in trunk orlimbs and can be expressed as limitations or generalized,histopathology features of Ly P showed the spectrum change,the overall survival of the patient was well.
Objective To analyze the clinical features of lymphomatoid papulosis( Ly P).Methods Two cases of Ly P from our hospital and 35 cases which were reported in domestic documents from 1993 to present were reviewed retrospectively. Results There were 23 males and 14 females among 37 Ly P patients,the range of age onset was 9 to 80 years old,the mean age of onset was( 42. 44 ± 16. 51) years old. The process of this disease was chronic disease and middle aged people were more prone to this disease. Major patients had no symptoms,a small number of patients with itching. The rash can be expressed as limitations or generalized and generally did not involve the nail,palm,mouth,vulva and other mucosal parts. Histopathological features of Ly P was the T lymphocyte infiltration from superficial dermis to deep vascular around and pathological phenotype was diversity,various therapies have been reported to be used to treat Ly P. Conclusion There were significant differences between males and females in incidence rate,the first skin eruption mainly located in trunk orlimbs and can be expressed as limitations or generalized,histopathology features of Ly P showed the spectrum change,the overall survival of the patient was well.
引文
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[10]吴磊,黄琼.湿疹样表现的淋巴瘤样丘疹病[J].临床皮肤科杂志,2012,41(12):732-733.
[11]惠云,郑冰洁,陈浩,等.儿童淋巴瘤样丘疹病(C型)一例[J].国际皮肤性病学杂志,2013,39(1):9-11.
[12]石翠萍.局限性淋巴瘤样丘疹病[J].实用皮肤病学杂志,2011,4(2):126.
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[14]韩世新,高明阳,张振颖,等.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2011,27(1):48-49.
[15]沈小雁,李可嘉,施若非,等.CD8+的淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2010,24(6):553-555.
[16]李保强,陆洁,申兴斌,等.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2010,26(1):60-61.
[17]郝进,刘文,邓娅.C型淋巴瘤样丘疹病[J].临床皮肤科杂志,2010,39(2):99-101.
[18]张瑞麟,罗金石,唐志强,等.淋巴瘤样丘疹病1例[J].中国实用外科杂志,2009,29(11):963.
[19]杜尊国,唐峰,王虹,等.淋巴瘤样丘疹病C型一例报道及文献复习[J].中国癌症杂志,2008,18(9):689-692.
[20]关杨,肖尹,孙建方.限局型淋巴瘤样丘疹病二例[J].中华皮肤科杂志,2008,41(2):135-136.
[21]苏明,沈斌,陈健.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2007,21(12):754-755.
[22]刘明章,吴原,平金良,等.头面部淋巴瘤样丘疹病一例[J].中华皮肤科杂志,2008,41(3):199-200.
[23]陈柳青,王玮蓁,姜一化,等.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2007,21(12):754-755.
[24]邢有兰,关杨,肖尹,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2006,35(2):106.
[25]周少娜,王俊民,耿松梅,等.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2006,20(10):623-624.
[26]吴晓琦,张荷香,王铁生.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2006,22(5):416-417.
[27]刘杨英,陈金,谢震,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2005,34(3):176-177.
[28]顾小平,吴瑞斌,陈玉新,等.皮肤淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2004,20(5):473.
[29]归冰,李锋.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2004,18(11):688-689.
[30]林玫,侯胜金,林萱,等.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2004,20(3):268.
[31]黎静宜,李薇,谢英,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2004,33(6):367-368.
[32]佟春光,张秀英,兰东,等.皮肤淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2003,32(9):536.
[33]王平,邱丙森,高红阳,等.淋巴瘤样丘疹病继发蕈样肉芽肿:共同T细胞克隆增生一例报告[J].中华皮肤科杂志,2003,36(6):303-305.
[34]刘晖,王冬云,潘敏,等.阿维A联合得宝松治愈淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2002,16(6):394-395.
[35]惠云,郑冰洁,陈浩,等.儿童淋巴瘤样丘疹病(C型)一例[J].国际皮肤性病学杂志,2013,39(1):9-11.
[36]Macaulay WL.Lymphomatoid papulosis.A continuing selfhealing eruption,clinically benign-histologically malignant[J].Arch Dermatol,1968,97(1):23-30.
[37]Swerdlow SH,Campo E,Pileri SA,et al.The 2016 revision of the world health organization classification of lymphoid neoplasms[J].Blood,2016,127(20):2375-2390.
[38]Kempf W,Mitteldorf C,Karai LJ,et al.Lymphomatoid papulosis-making sense of the alphabet soup:a proposal to simplify terminology[J].J Dtsch Dermatol Ges,2017,15(4):390-394.
[2]乔丽,李新技,刘延,等.淋巴瘤样丘疹病1例并文献复习[J].空军医学杂志,2016,32(3):201-203.
[3]张芳,田歆,陈霄霄,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2016,45(1):52-53.
[4]张谦,樊俊威,多兰·达力汗.C型淋巴瘤样丘疹病1例并文献复习[J].中国皮肤性病学杂志,2016,30(10):1054-1056.
[5]李蕾,邹先彪,陈虹霞,等.淋巴瘤样丘疹病一例[J].实用皮肤病学杂志,2015,8(3):229-231.
[6]冯立文,谢建兰,黄文勇,等.淋巴瘤样丘疹病C型伴TCRγ弱阳性表达一例[J].中华病理学杂志,2015,44(8):608-609.
[7]辛甜甜,彭洁雯,易江华,等.皮损酷似麻风病的淋巴瘤样丘疹病一例[J].中华皮肤科杂志,2015,48(9):659.
[8]吴飞,殷芳,陈佳,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2014,43(8):497-498.
[9]陈琳,张江安,于建斌,等.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2013,27(1):64-65.
[10]吴磊,黄琼.湿疹样表现的淋巴瘤样丘疹病[J].临床皮肤科杂志,2012,41(12):732-733.
[11]惠云,郑冰洁,陈浩,等.儿童淋巴瘤样丘疹病(C型)一例[J].国际皮肤性病学杂志,2013,39(1):9-11.
[12]石翠萍.局限性淋巴瘤样丘疹病[J].实用皮肤病学杂志,2011,4(2):126.
[13]赵艳霞,邢有兰.淋巴瘤样丘疹病1例及文献复习[J].中国中西医结合皮肤性病学杂志,2011,10(1):49-50.
[14]韩世新,高明阳,张振颖,等.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2011,27(1):48-49.
[15]沈小雁,李可嘉,施若非,等.CD8+的淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2010,24(6):553-555.
[16]李保强,陆洁,申兴斌,等.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2010,26(1):60-61.
[17]郝进,刘文,邓娅.C型淋巴瘤样丘疹病[J].临床皮肤科杂志,2010,39(2):99-101.
[18]张瑞麟,罗金石,唐志强,等.淋巴瘤样丘疹病1例[J].中国实用外科杂志,2009,29(11):963.
[19]杜尊国,唐峰,王虹,等.淋巴瘤样丘疹病C型一例报道及文献复习[J].中国癌症杂志,2008,18(9):689-692.
[20]关杨,肖尹,孙建方.限局型淋巴瘤样丘疹病二例[J].中华皮肤科杂志,2008,41(2):135-136.
[21]苏明,沈斌,陈健.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2007,21(12):754-755.
[22]刘明章,吴原,平金良,等.头面部淋巴瘤样丘疹病一例[J].中华皮肤科杂志,2008,41(3):199-200.
[23]陈柳青,王玮蓁,姜一化,等.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2007,21(12):754-755.
[24]邢有兰,关杨,肖尹,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2006,35(2):106.
[25]周少娜,王俊民,耿松梅,等.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2006,20(10):623-624.
[26]吴晓琦,张荷香,王铁生.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2006,22(5):416-417.
[27]刘杨英,陈金,谢震,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2005,34(3):176-177.
[28]顾小平,吴瑞斌,陈玉新,等.皮肤淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2004,20(5):473.
[29]归冰,李锋.淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2004,18(11):688-689.
[30]林玫,侯胜金,林萱,等.淋巴瘤样丘疹病1例[J].中国麻风皮肤病杂志,2004,20(3):268.
[31]黎静宜,李薇,谢英,等.淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2004,33(6):367-368.
[32]佟春光,张秀英,兰东,等.皮肤淋巴瘤样丘疹病1例[J].临床皮肤科杂志,2003,32(9):536.
[33]王平,邱丙森,高红阳,等.淋巴瘤样丘疹病继发蕈样肉芽肿:共同T细胞克隆增生一例报告[J].中华皮肤科杂志,2003,36(6):303-305.
[34]刘晖,王冬云,潘敏,等.阿维A联合得宝松治愈淋巴瘤样丘疹病1例[J].中国皮肤性病学杂志,2002,16(6):394-395.
[35]惠云,郑冰洁,陈浩,等.儿童淋巴瘤样丘疹病(C型)一例[J].国际皮肤性病学杂志,2013,39(1):9-11.
[36]Macaulay WL.Lymphomatoid papulosis.A continuing selfhealing eruption,clinically benign-histologically malignant[J].Arch Dermatol,1968,97(1):23-30.
[37]Swerdlow SH,Campo E,Pileri SA,et al.The 2016 revision of the world health organization classification of lymphoid neoplasms[J].Blood,2016,127(20):2375-2390.
[38]Kempf W,Mitteldorf C,Karai LJ,et al.Lymphomatoid papulosis-making sense of the alphabet soup:a proposal to simplify terminology[J].J Dtsch Dermatol Ges,2017,15(4):390-394.