福建药用植物金线莲研究进展
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摘要
福建药用植物金线莲具有丰富的营养物质,为高效安全的天然药物。本文对金线莲的化学成分、提取分析、生物活性等方面的最新研究进展进行综述,并讨论金线莲药用植物的研究与开发。
Medical herb Anoectochilus Roxburghii in Fujian province, China, has been widely used as a safe natural medicine due to its rich nutrients and bioactive components. We reviewed the recent research on the extraction and identification of its major bioactive compounds as well as its respective biological activities, focusing on the research and development of its potential as natural medicine.
Medical herb Anoectochilus Roxburghii in Fujian province, China, has been widely used as a safe natural medicine due to its rich nutrients and bioactive components. We reviewed the recent research on the extraction and identification of its major bioactive compounds as well as its respective biological activities, focusing on the research and development of its potential as natural medicine.
引文
1刘江枫,胡明芳,黎维英,等.福州市野生兰科植物资源调查及其保育与可持续利用的探讨.中国野生植物资源,2009,28(4):420-24.
2 Sut S,Maggi F,Dall.Acqua S.Bioactive secondary metabolites from orchids(orchidaceae).Chem Biodivers,2017,14(11).
3王晋成.金线莲化学成分研究进展.东南园艺,2014,2(6):68-74.
4 Steed,A L,et al.The microbial metabolite desaminotyrosine protects from influenza through type I interferon.Science,2017,357(6350):498-502.
5 Ye S,Shao Q,Zhang A.Anoectochilus roxburghii:a review of its phytochemistry,pharmacology,and clinical applications.J Ethnopharmacol,2017,209:184-202.
6杨振国,张晓辉,余杰.金线莲多糖结构的初步分析.中国药物经济学,2015,12(S1):36-37.
7陈焰,陈新峰,阙万才,等.金线莲挥发油成分的提取及其体外抗肿瘤作用研究.中国药业,2012,21(6):21-22.
8吴萍萍,黄丽英.金线莲HPLC指纹图谱研究.中草药,2015,46(3):1975-1979.
9朱善岚.金线莲活性成分的分析.福州:福建医科大学硕士研究生学位论文,2010.
10梅榆,邱道寿.金线莲活性成分和分子鉴定的研究进展.安徽农业科学,2018,46(9):29-33.
11 Xu M,et al.Simultaneous extraction and identification of phenolic compounds in anoectochilus roxburghii using microwave-assisted extraction combined with UPLC-Q-TOF-MS/MS and their antioxidant activities.Front Plant Sci,2017,8:1474.
12李仲达.金线莲多糖的提取及其性质研究.广州:仲恺农业工程学院硕士研究生学位论文,2014.
13王晓雪.福建金线莲粗提物多粗分的快速质谱分析方法及NMR/RRLC-MS相关谱分析方法方法研究.北京:中国医学科学院博士研究生学位论文,2011.
14王勇,陈硕,卢端萍,等.金线莲化学成分的研究.中草药,2017,48(13):2619-2624.
15唐楠楠,陶佳青,陈常理,等.台湾金线莲与浙江金线莲多糖含量及抗氧化活性比较研究.西北植物学报,2016,36(3):521-526.
16邹金美,王兵丽,赵晓丹,等.福建金线莲组培苗和移栽苗主要活性成分及抗氧化的研究.食品工业科技,2014,35(23):136-139.
17陈强威,张莉莉,王秋新,等.金线莲乙醇提取物抗氧化作用的研究.广东药科大学学报,2017,33(3):352-356.
18 Martinez R M,Pinhoribeiro F A,Steffen V S,et al.Trans-chalcone,a flavonoid precursor,inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production.Photochem Photobiol Sci,2017,16(7):1162-1173.
19 Zeng B,Su M,Chen Q,et al.Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice.J Ethnopharmacol,2017,200:124-135.
20 Hsiao H B,Hsieh C C,Wu J B,et al.Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses.BMC Complement Altern Med,2016,16(1):80.
21邓燕群,李伟,张晓辉,等.金线莲多糖对α-葡萄糖苷酶活性及糖尿病小鼠血糖的影响.汕头大学学报,2014,29(3):41-45.
22王建栋,王红珍,张爱莲,等.金线莲苷研究进展.中国医院药学杂志,2015,35(19):1795-1798.
23 Liu Z L,Liu Q,Xiao B,et al.The vascular protective properties of kinsenoside isolated from Anoectochilus roxburghii under high glucose condition.Fitoterapia,2013,86:163-70.
24 Vernarelli J A,Lambert J D.Flavonoid intake is inversely associated with obesity and C-reactive protein,a marker for inflammation,in USadults.Nutr Diabetes,2017,7(5):e276.
25王慧群,杨博,罗增伟,等.金线莲甲醇提取物降脂作用研究.中南药学,2014,12(1):14-17.
26张赛男.金线莲多糖降血脂功能的实验研究.云南中医中药杂志,2014,35(12):64-66.
27 Cheng K T,Wang Y S,Chou H C,et al.Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes:Roles of AMPK and PPARalpha in the lipolytic effect of kinsenoside.Phytomedicine,2015.22(6):641-7.
28刘政芳,李芳.复方金线莲口服液联合恩替卡韦治疗慢性乙型肝炎30例临床观察.福建中医药,2008,39(5):3-4.
29 Xiang M,Liu T,Tan W,et al.Effects of kinsenoside,a potential immunosuppressive drug for autoimmune hepatitis,on dendritic cells/CD8(+)T cells communication in mice.Hepatology,2016,64(6):2135-2150.
30 Li L,Li Y M,Liu Z L,et al.The renal protective effects of Anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin.J Ethnopharmacol,2016,178:58-65.
31 Yu X,Lin S,Zhang J,et al.Purification of polysaccharide from artificially cultivated Anoectochilus roxburghii(wall.)Lindl.by highspeed counter current chromatography and its antitumor activity.J Sep Sci,2017,40(22):4338-4346.
32 Chomicki G,et al.The velamen protects photosynthetic orchid roots against UV-B damage,and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic.New Phytol,2015,205(3):1330-41.
33 Xu J J,Zhang W J,Wang J Y,et al.The active component screening of Anoectochilus roxburghii and the functional study on inhibition of melanogenesis in zebrafish.Hereditas,2017,39(12):1178-1187.
2 Sut S,Maggi F,Dall.Acqua S.Bioactive secondary metabolites from orchids(orchidaceae).Chem Biodivers,2017,14(11).
3王晋成.金线莲化学成分研究进展.东南园艺,2014,2(6):68-74.
4 Steed,A L,et al.The microbial metabolite desaminotyrosine protects from influenza through type I interferon.Science,2017,357(6350):498-502.
5 Ye S,Shao Q,Zhang A.Anoectochilus roxburghii:a review of its phytochemistry,pharmacology,and clinical applications.J Ethnopharmacol,2017,209:184-202.
6杨振国,张晓辉,余杰.金线莲多糖结构的初步分析.中国药物经济学,2015,12(S1):36-37.
7陈焰,陈新峰,阙万才,等.金线莲挥发油成分的提取及其体外抗肿瘤作用研究.中国药业,2012,21(6):21-22.
8吴萍萍,黄丽英.金线莲HPLC指纹图谱研究.中草药,2015,46(3):1975-1979.
9朱善岚.金线莲活性成分的分析.福州:福建医科大学硕士研究生学位论文,2010.
10梅榆,邱道寿.金线莲活性成分和分子鉴定的研究进展.安徽农业科学,2018,46(9):29-33.
11 Xu M,et al.Simultaneous extraction and identification of phenolic compounds in anoectochilus roxburghii using microwave-assisted extraction combined with UPLC-Q-TOF-MS/MS and their antioxidant activities.Front Plant Sci,2017,8:1474.
12李仲达.金线莲多糖的提取及其性质研究.广州:仲恺农业工程学院硕士研究生学位论文,2014.
13王晓雪.福建金线莲粗提物多粗分的快速质谱分析方法及NMR/RRLC-MS相关谱分析方法方法研究.北京:中国医学科学院博士研究生学位论文,2011.
14王勇,陈硕,卢端萍,等.金线莲化学成分的研究.中草药,2017,48(13):2619-2624.
15唐楠楠,陶佳青,陈常理,等.台湾金线莲与浙江金线莲多糖含量及抗氧化活性比较研究.西北植物学报,2016,36(3):521-526.
16邹金美,王兵丽,赵晓丹,等.福建金线莲组培苗和移栽苗主要活性成分及抗氧化的研究.食品工业科技,2014,35(23):136-139.
17陈强威,张莉莉,王秋新,等.金线莲乙醇提取物抗氧化作用的研究.广东药科大学学报,2017,33(3):352-356.
18 Martinez R M,Pinhoribeiro F A,Steffen V S,et al.Trans-chalcone,a flavonoid precursor,inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production.Photochem Photobiol Sci,2017,16(7):1162-1173.
19 Zeng B,Su M,Chen Q,et al.Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice.J Ethnopharmacol,2017,200:124-135.
20 Hsiao H B,Hsieh C C,Wu J B,et al.Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses.BMC Complement Altern Med,2016,16(1):80.
21邓燕群,李伟,张晓辉,等.金线莲多糖对α-葡萄糖苷酶活性及糖尿病小鼠血糖的影响.汕头大学学报,2014,29(3):41-45.
22王建栋,王红珍,张爱莲,等.金线莲苷研究进展.中国医院药学杂志,2015,35(19):1795-1798.
23 Liu Z L,Liu Q,Xiao B,et al.The vascular protective properties of kinsenoside isolated from Anoectochilus roxburghii under high glucose condition.Fitoterapia,2013,86:163-70.
24 Vernarelli J A,Lambert J D.Flavonoid intake is inversely associated with obesity and C-reactive protein,a marker for inflammation,in USadults.Nutr Diabetes,2017,7(5):e276.
25王慧群,杨博,罗增伟,等.金线莲甲醇提取物降脂作用研究.中南药学,2014,12(1):14-17.
26张赛男.金线莲多糖降血脂功能的实验研究.云南中医中药杂志,2014,35(12):64-66.
27 Cheng K T,Wang Y S,Chou H C,et al.Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes:Roles of AMPK and PPARalpha in the lipolytic effect of kinsenoside.Phytomedicine,2015.22(6):641-7.
28刘政芳,李芳.复方金线莲口服液联合恩替卡韦治疗慢性乙型肝炎30例临床观察.福建中医药,2008,39(5):3-4.
29 Xiang M,Liu T,Tan W,et al.Effects of kinsenoside,a potential immunosuppressive drug for autoimmune hepatitis,on dendritic cells/CD8(+)T cells communication in mice.Hepatology,2016,64(6):2135-2150.
30 Li L,Li Y M,Liu Z L,et al.The renal protective effects of Anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin.J Ethnopharmacol,2016,178:58-65.
31 Yu X,Lin S,Zhang J,et al.Purification of polysaccharide from artificially cultivated Anoectochilus roxburghii(wall.)Lindl.by highspeed counter current chromatography and its antitumor activity.J Sep Sci,2017,40(22):4338-4346.
32 Chomicki G,et al.The velamen protects photosynthetic orchid roots against UV-B damage,and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic.New Phytol,2015,205(3):1330-41.
33 Xu J J,Zhang W J,Wang J Y,et al.The active component screening of Anoectochilus roxburghii and the functional study on inhibition of melanogenesis in zebrafish.Hereditas,2017,39(12):1178-1187.