丹酚酸B的化学成分及药理作用的研究进展
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摘要
丹酚酸B(salvianolic acid B,Sal B)为丹参中含量最高、活性最强的一种成分,具有多种药理活性,包括对心脏、脑、肝脏的保护作用,抗肿瘤等等。本文就其药理作用做一综述。
Salvianolic acid B(Sal B) is a water-soluble active ingredient of Salvia miltiorrhiza.It is the most abundant and active component of Salvia miltiorrhiza. Salvianolic acid B has a variety of pharmacological activities,including protection of the heart,brain,liver,resist neoplasia and so on.This article reviews its pharmacological effects.
Salvianolic acid B(Sal B) is a water-soluble active ingredient of Salvia miltiorrhiza.It is the most abundant and active component of Salvia miltiorrhiza. Salvianolic acid B has a variety of pharmacological activities,including protection of the heart,brain,liver,resist neoplasia and so on.This article reviews its pharmacological effects.
引文
[1]Liang W,Chen W,Wu L,et al.Quality evaluation and chemical markers screening of Salvia miltiorrhiza Bge (Danshen) based on HPLC fingerprints and HPL C-MS coupled with chemometrics[J].Molecules (Basel,Switzerland),2017,22(3):478-482.
[2]Liu A H,Li L,Xu M,et al.Simultaneous quantification of six major phenolic acids in the roots of Salvia miltiorrhiza and four related traditional Chinese medicinal preparations by HPLC-DAD method[J].Journal of pharmaceutical and biomedical analysis,2006,41(1):48-56.
[3]Zeng H,Su S,Xiang X,et al.Comparative analysis of the major chemical constituents in salvia miltiorrhiza roots,stems,leaves and flowers during different growth periods by UPLC-TQ-MS/MS and HPLC-ELSD methods[J].Molecules (Basel,Switzer land),2017,22(5):771-787.
[4]Cao J,Wei Y J,Qi L W,et al.Determination of fifteen bioactive components in Radix et Rhizoma Salviae Miltiorrhizae by high-performance liquid chromatography with ultraviolet and mass spectrometric detection[J].Biomedical chromatography:BMC,2008,22(2):164-172.
[5]朱静,陈慧清,白鹏,等.丹酚酸B水溶液分解反应的动力学研究[J].中成药,2009,31(4):541-544.
[6]林青,黄琳,肖晓丽,等.丹参水提液中丹酚酸B湿热降解动力学研究[J].中国现代中药,2008(8):29-31.
[7]刘生生,韩飞,许卉,等.丹酚酸B热解产物化学成分的分离与鉴定[J].中草药,2011,42(2):247-250.
[8]Wang J,Zhang Y,Guo L L,et al.Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopoly-saccharide[J].Chinese Journal of Integrative Medicine,2011,17(10):775-779.
[9]柴丽娟,张萌,王虹,等.Sal B/PNS配伍对心肌梗死后炎症因子表达的影响[J].河南中医,2008(8):28-30.
[10]杨宇杰,程晓亮,吕英超,等.双氢丹酚酸B对大鼠急性心肌缺血的治疗作用[J].中草药,2010,41(3):447-449.
[11]刘晓龙,崔子林,李阳,等.丹酚酸B对脓毒症大鼠心肌损伤的保护作用[J].中国实验方剂学杂志,2019(4):1-7.
[12]Zhao W,Lu L,Chen S S.Temporal and spatial characteristics of apoptosis in the infarcted rat heart[J].Biochemical and biophysical research communications,2004,325(2):605-611.
[13]张萌,王怡,王虹,等.丹酚酸B对心肌梗死大鼠心肌细胞凋亡的影响[J].天津中医药,2008(4):318-321.
[14]Chen R C,Sun G B,Ye J X,et al.Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca overload in rat cardiomyocytes[J].Toxicology Letters,2017,276(3):21-30.
[15]卫永鲲,郭晓华,王波平,等.丹参酚酸B通过Nrf2/HO-1对脑缺血/再灌注损伤的保护作用研究[J].现代生物医学进展,2016(35):6817-6821.
[16]Durante W.Targeting Heme Oxygenase-1 in Vascular Disease[J].Current Drug Targets,2010,11(12):1504-1516.
[17]李琴,韩力培,李泽慧,等.丹酚酸b通过抑制mapk通路减轻大鼠脑缺血再灌注引起的血脑屏障损伤[J].药学学报,2010(12):1485-1490.
[18]Li M,Lu Y,Hu Y,et al.Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats[J].Toxicology Letters,2014,228(2):67-74.
[19]马滢,方萌,伍超,等.丹酚酸B调控pSmad3C/pSmad3L发挥抗肝纤维化-肝细胞癌作用[J].中国药理学通报,2018,34(1):44-50.
[20]Yan X F,Zhao P,Ma D Y,et al.Salvianolic acid B protects hepatocytes from HO injury by stabilizing the lysosomal membrane[J].World Journal of Gastroenterology,2017,23(29):5333-5344.
[21]黄秀兰,崔国辉,周克元.PI3K-Akt信号通路与肿瘤细胞凋亡关系的研究进展[J].癌症,2008(3):331-336.
[22]向元俤,刘卫红,吴娟,等.丹酚酸B对人鼻咽癌裸鼠移植瘤模型的放疗增敏效应[J].华中科技大学学报(医学版),2016,45(5):535-538,550.
[23]Liu X A.Effects of salvianolic acid B on in vitro growth inhibition and apoptosis induction of retinoblastoma cells[J].International Journal of Ophthalmology,2012,5(3):272-276.
[24]赵敏,张瑜,张岚,等.丹酚酸B通过mTOR/Ulk1信号通路诱导胶质瘤细胞C6自噬性死亡[J].中国免疫学杂志,2018,34(4):549-552.
[25]Zhou Z T,Yang Y,Ge J P.The preventive effect of salvianolic acid B on the malignant transformation of DMBA-induced oral premalignant lesions in hamster[J].Carcinogenesis,2006,27(4):826-832.
[26]Hao Y,Xie T,Korotcov A,et al.Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways[J].International Journal of Cancer,2009,124(9):2200-2209.
[27]徐艺丹.丹酚酸B对H2O2诱导的HaCaT细胞衰老作用的影响及机制研究[J].齐齐哈尔医学院学报,2018,39(10):1117-1120.
[28]林劲,刘碧好,欧阳辉,等.丹酚酸B对慢性血清病肾炎大鼠肾脏保护作用的研究[J].中药新药与临床药理,2016,27(3):338-342.
[29]陶善珺,任尤楠,赵梦秋,等.丹酚酸B对糖尿病血糖波动模型大鼠胰岛细胞的保护作用[J].中草药,2016,47(17):3058-3063.
[2]Liu A H,Li L,Xu M,et al.Simultaneous quantification of six major phenolic acids in the roots of Salvia miltiorrhiza and four related traditional Chinese medicinal preparations by HPLC-DAD method[J].Journal of pharmaceutical and biomedical analysis,2006,41(1):48-56.
[3]Zeng H,Su S,Xiang X,et al.Comparative analysis of the major chemical constituents in salvia miltiorrhiza roots,stems,leaves and flowers during different growth periods by UPLC-TQ-MS/MS and HPLC-ELSD methods[J].Molecules (Basel,Switzer land),2017,22(5):771-787.
[4]Cao J,Wei Y J,Qi L W,et al.Determination of fifteen bioactive components in Radix et Rhizoma Salviae Miltiorrhizae by high-performance liquid chromatography with ultraviolet and mass spectrometric detection[J].Biomedical chromatography:BMC,2008,22(2):164-172.
[5]朱静,陈慧清,白鹏,等.丹酚酸B水溶液分解反应的动力学研究[J].中成药,2009,31(4):541-544.
[6]林青,黄琳,肖晓丽,等.丹参水提液中丹酚酸B湿热降解动力学研究[J].中国现代中药,2008(8):29-31.
[7]刘生生,韩飞,许卉,等.丹酚酸B热解产物化学成分的分离与鉴定[J].中草药,2011,42(2):247-250.
[8]Wang J,Zhang Y,Guo L L,et al.Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopoly-saccharide[J].Chinese Journal of Integrative Medicine,2011,17(10):775-779.
[9]柴丽娟,张萌,王虹,等.Sal B/PNS配伍对心肌梗死后炎症因子表达的影响[J].河南中医,2008(8):28-30.
[10]杨宇杰,程晓亮,吕英超,等.双氢丹酚酸B对大鼠急性心肌缺血的治疗作用[J].中草药,2010,41(3):447-449.
[11]刘晓龙,崔子林,李阳,等.丹酚酸B对脓毒症大鼠心肌损伤的保护作用[J].中国实验方剂学杂志,2019(4):1-7.
[12]Zhao W,Lu L,Chen S S.Temporal and spatial characteristics of apoptosis in the infarcted rat heart[J].Biochemical and biophysical research communications,2004,325(2):605-611.
[13]张萌,王怡,王虹,等.丹酚酸B对心肌梗死大鼠心肌细胞凋亡的影响[J].天津中医药,2008(4):318-321.
[14]Chen R C,Sun G B,Ye J X,et al.Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca overload in rat cardiomyocytes[J].Toxicology Letters,2017,276(3):21-30.
[15]卫永鲲,郭晓华,王波平,等.丹参酚酸B通过Nrf2/HO-1对脑缺血/再灌注损伤的保护作用研究[J].现代生物医学进展,2016(35):6817-6821.
[16]Durante W.Targeting Heme Oxygenase-1 in Vascular Disease[J].Current Drug Targets,2010,11(12):1504-1516.
[17]李琴,韩力培,李泽慧,等.丹酚酸b通过抑制mapk通路减轻大鼠脑缺血再灌注引起的血脑屏障损伤[J].药学学报,2010(12):1485-1490.
[18]Li M,Lu Y,Hu Y,et al.Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats[J].Toxicology Letters,2014,228(2):67-74.
[19]马滢,方萌,伍超,等.丹酚酸B调控pSmad3C/pSmad3L发挥抗肝纤维化-肝细胞癌作用[J].中国药理学通报,2018,34(1):44-50.
[20]Yan X F,Zhao P,Ma D Y,et al.Salvianolic acid B protects hepatocytes from HO injury by stabilizing the lysosomal membrane[J].World Journal of Gastroenterology,2017,23(29):5333-5344.
[21]黄秀兰,崔国辉,周克元.PI3K-Akt信号通路与肿瘤细胞凋亡关系的研究进展[J].癌症,2008(3):331-336.
[22]向元俤,刘卫红,吴娟,等.丹酚酸B对人鼻咽癌裸鼠移植瘤模型的放疗增敏效应[J].华中科技大学学报(医学版),2016,45(5):535-538,550.
[23]Liu X A.Effects of salvianolic acid B on in vitro growth inhibition and apoptosis induction of retinoblastoma cells[J].International Journal of Ophthalmology,2012,5(3):272-276.
[24]赵敏,张瑜,张岚,等.丹酚酸B通过mTOR/Ulk1信号通路诱导胶质瘤细胞C6自噬性死亡[J].中国免疫学杂志,2018,34(4):549-552.
[25]Zhou Z T,Yang Y,Ge J P.The preventive effect of salvianolic acid B on the malignant transformation of DMBA-induced oral premalignant lesions in hamster[J].Carcinogenesis,2006,27(4):826-832.
[26]Hao Y,Xie T,Korotcov A,et al.Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways[J].International Journal of Cancer,2009,124(9):2200-2209.
[27]徐艺丹.丹酚酸B对H2O2诱导的HaCaT细胞衰老作用的影响及机制研究[J].齐齐哈尔医学院学报,2018,39(10):1117-1120.
[28]林劲,刘碧好,欧阳辉,等.丹酚酸B对慢性血清病肾炎大鼠肾脏保护作用的研究[J].中药新药与临床药理,2016,27(3):338-342.
[29]陶善珺,任尤楠,赵梦秋,等.丹酚酸B对糖尿病血糖波动模型大鼠胰岛细胞的保护作用[J].中草药,2016,47(17):3058-3063.