实时二维定量剪切波弹性成像对肝纤维化程度的评估价值研究
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摘要
目的:探讨实时二维定量剪切波弹性成像(E-成像)对肝纤维化程度的评估价值。方法:纳入由临床确诊为肝纤维化的患者共153例,对所有患者进行E-成像检查。按照肝脏穿刺病理结果,将所有患者分为4组:肝纤维化1期组(S1组)、肝纤维化2期组(S2组)、肝纤维化3期组(S3组)和肝纤维化4期组(S4组),另选取同期80例正常者为对照组。比较各组弹性杨氏模量值的差异。结果:病例组与对照组比较:对照组显著低于肝纤维化组(P<0.05),病例组各亚组与对照组组间比较:弹性杨氏模量值正常对照组 Objective:To explore the value of real-time two-dimensional quantitative shear wave elastography(E-imaging) in evaluating the degree of liver fibrosis.Method:A total of 153 patients with clinically confirmed hepatic fibrosis were enrolled.All patients were examined by E-imaging.According to the pathological results of liver puncture,all patients were divided into four groups:hepatic fibrosis stage 1 group(S1 group),hepatic fibrosis stage 2 group(S2 group),hepatic fibrosis stage 3 group(S3 group) and hepatic fibrosis stage 4 group(S4 group),and 80 normal persons in the same period were selected as control group.The difference of Young's modulus of elasticity between groups was compared.Results:The case group was compared with the control group.The control group was significantly lower than that of hepatic fibrosis group(P<0.05).The Young's modulus of elasticity in case group was significantly higher than that in control group< S1 group< S2 group< S3 group< S4 group(P <0.05).Conclusion:Real-time two-dimensional quantitative shear wave elastography(E-imaging) can provide objective criteria for evaluating the grading of liver fibrosis.
引文
[1]张文东,王瑞范,吴会敏,等.抗肝纤维化药物研发进展[J].药学学报,2018,53(5):667~675.
[2]梁萍,郑荣琴.二维剪切波弹性成像评估慢性乙型肝炎肝纤维化临床应用指南[J].临床肝胆病杂志,2018,34(2):255~261.
[3]方群,晋军,贾学明.超声实时组织弹性成像评估慢性乙型肝炎肝纤维化的临床应用价值[J].河北医学,2014,20(3):473~476.
[4]姚希贤,徐克成.肝纤维化的基础与临床[M].上海科技教育出版社,2003.64~73.
[5]刘昱含,谢青.肝纤维化的临床评估[J].肝脏,2013,18(6):414~417.
[6]Masuzaki R,Tateishi R,Yoshida H,et al.Comparison of liver biopsy and transient elastography based on clinical relevance[J].Can Gastroenterol 2016,22(9):753~757.
[7]M.Zemanova.New diagnostic imaging technique-shear wave elastography[J].Cesk Slov Oftalmol,2016;72(4):103~110.
[8]杨道玲,韦嘉,张勇,等.实时剪切波超声弹性成像对健康成人肝组织硬度定量分析研究[J].中国超声医学杂志,2014,30(5):411~414.
[9]穆晓洁,孟繁坤.实时剪切波弹性成像在乙型肝病诊断中的应用研究[J].医学影像学杂志,2017,27(11):2131~2134.
[10]马苏亚,李国军,喻一奇,等.实时剪切波弹性成像检测慢性乙型肝炎患者肝硬度与病理分级分期的相关性[J].中华传染病杂志,2015,33(9):513~517.
[11]马苏亚,朱玲斐,李国军,等.实时剪切波弹性成像检测肝脏硬度与肝脏病理的相关性研究[J].中国超声医学工程学会成立30周年暨全国超声医学学术大会,2014.
[2]梁萍,郑荣琴.二维剪切波弹性成像评估慢性乙型肝炎肝纤维化临床应用指南[J].临床肝胆病杂志,2018,34(2):255~261.
[3]方群,晋军,贾学明.超声实时组织弹性成像评估慢性乙型肝炎肝纤维化的临床应用价值[J].河北医学,2014,20(3):473~476.
[4]姚希贤,徐克成.肝纤维化的基础与临床[M].上海科技教育出版社,2003.64~73.
[5]刘昱含,谢青.肝纤维化的临床评估[J].肝脏,2013,18(6):414~417.
[6]Masuzaki R,Tateishi R,Yoshida H,et al.Comparison of liver biopsy and transient elastography based on clinical relevance[J].Can Gastroenterol 2016,22(9):753~757.
[7]M.Zemanova.New diagnostic imaging technique-shear wave elastography[J].Cesk Slov Oftalmol,2016;72(4):103~110.
[8]杨道玲,韦嘉,张勇,等.实时剪切波超声弹性成像对健康成人肝组织硬度定量分析研究[J].中国超声医学杂志,2014,30(5):411~414.
[9]穆晓洁,孟繁坤.实时剪切波弹性成像在乙型肝病诊断中的应用研究[J].医学影像学杂志,2017,27(11):2131~2134.
[10]马苏亚,李国军,喻一奇,等.实时剪切波弹性成像检测慢性乙型肝炎患者肝硬度与病理分级分期的相关性[J].中华传染病杂志,2015,33(9):513~517.
[11]马苏亚,朱玲斐,李国军,等.实时剪切波弹性成像检测肝脏硬度与肝脏病理的相关性研究[J].中国超声医学工程学会成立30周年暨全国超声医学学术大会,2014.