天然药物诱导和抑制细胞色素P450酶的研究进展
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摘要
目的查阅近几年国内外相关文献,从天然药物诱导和抑制P450等方面,总结天然药物对药物代谢功能的影响。天然药物能通过孕烷X受体、组成型雄甾烷受体等途径诱导细胞色素P450酶,也能抑制主要的细胞色素P450酶亚型,从而影响药物代谢,并引发药物-药物相互作用。
引文
[1]段金廒,宿树兰,范欣生,等.基于药物相互作用探讨中药七情合和/相反/相恶/相畏配伍禁忌作用模式与机制[J].世界科学技术:中医药现代化,2012,14(3):1547-1552.
[2]毛凤斐,朱家璧.药物相互作用[J].中国医院药学杂志,1981,1(1):39-52.
[3]Sun H,Veith H,Xia M,et al.Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data[J].J Chem Inf Model,2011,51(10):2474-2481.
[4]Lin J H.CYP induction-mediated drug interactions:in vitro assessment and clinical implications[J].Pharm Res,2006,23(6):1089-1116.
[5]艾常虹,孙汉雄,李桦,等.中药有效成分对细胞色素P450酶的抑制活性评价[J].中国药理学通报,2011,27(4):519-523.
[6]Sasaki H,Suzuki N,Alshwaimi E,et al.18Beta-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-kappa B inactivation in interleukin-10-deficient mice[J].J Periodontal Res,2010,45(6):757-763.
[7]Wang Y G,Zhou J M,Ma Z C,et al.Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin:a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury[J].Chem Biol Interact,2012,200(1):11-20.
[8]刘冬英,杨敏,祝慧娟,等.几种植物化学物对人孕烷X受体介导的细胞色素P450 3A4转录调节作用[J].浙江大学学报:医学版,2006,35(1):8-13.
[9]Li Y,Wang Q,Yao X,et al.Induction of CYP3A4 and MDR1 gene expression by baicalin,baicalein,chlorogenic acid,and ginsenoside Rf through constitutive androstane receptor-and pregnane X receptor-mediated pathways[J].Eur J Pharmacol,2010,640(1-3):46-54.
[10]蔡丽萍,习志刚,杨红.丹参酮的药理作用和临床研究进展[J].广东药学院学报,2008,24(3):321-324.
[11]Yu C,Ye S,Sun H,et al.PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinoneⅡA[J].Chem Biol Interact,2009,177(1):58-64.
[12]Huang L,Huang M,Li Y H,et al.Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn[J].J Ethnopharmacol,2013,148(2):596-602.
[13]岚崔,祝德秋,安富荣.吴茱萸碱药理作用研究进展[J].中国中医药信息杂志,2005,12(6):108-110.
[14]黄凌,邝少轶,张丽.吴茱萸碱与吴茱萸次碱经PXR,CAR核受体通路影响CYP3A4表达的研究[J].中国药房,2013,24(35):3274-3279.
[15]周涛,王宇光,马增春,等.银杏内酯B通过激活孕烷X受体诱导CYP3A4的表达[J].中国药理学通报,2014,30(7):926-931.
[16]Kobayashi K,Urashima K,Shimada N,et al.Substrate specificity for rat cytochrome P450(CYP)isoforms:screening with c DNA-expressed systems of the rat[J].Biochem Pharmacol,2002,63(5):889-896.
[17]黄伟锋.大黄素的药理作用研究进展[J].柳州医学,2013,26(4):241-244.
[18]王青秀,雷荣辉,吴纯启,等.大黄素对大鼠肝脏CYP450酶的诱导研究[J].药物评价研究,2015,38(2):147-150.
[19]白燕,冯素香,周悌强,等.探针药物评价大黄苷元对P450酶CYP1A2活性的影响[J].中国实验方剂学杂志,2015,21(5):143-146.
[20]田丽婷,马龙,堵年生.齐墩果酸的药理作用研究概况[J].中国中药杂志,2002,24(3):92-94.
[21]刘昌辉,郑侠,王宁生,等.齐墩果酸对大鼠体内细胞色素P450酶活性的影响[J].中国民族民间医药杂志,2012,21(9):37-39.
[22]Carrasco O F,Vidrio H.Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta[J].Vascul Pharmacol,2007,47(1):68-73.
[23]Huang Y,Zheng S,Zhu H Y,et al.Effects of aescin on cytochrome P450 enzymes in rats[J].J.Ethnopharmacol,2014,151(1):83-90.
[24]Xu R A,Xu Z S,Ge R S.Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats[J].J Ethnopharmacol,2014,151(3):1141-1146.
[25]Zhao Y L.Development in pharmacological application of puerarin[J].Anhui Med Pharm,2010,34(2):383-392.
[26]孙紫阳.葛根素对鼠肝微粒体细胞色素P450的影响[J].河北医学,2007,13(9):1057-1060.
[27]Jiang Y,Fan X,Wang Y,et al.Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation[J].Chem Biol Interact,2015,231:83-89.
[28]刘耕陶,包天桐,魏怀玲,等.五味子乙素对小鼠肝细胞微粒体细胞色素P-450的诱导作用[J].药学学报,1980,15(4):206-206.
[29]Jiang Y,Fan X,Wang Y,et al.Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration[J].Toxicol Sci,2015,143(1):107-115.
[30]Liu L,Xiao J,Peng Z H,et al.In vitro metabolism of glycyrrhetic acid by human cytochrome P450[J].Acta pharm Sin,2011,46(1):81-87.
[31]段立军,孙博航.黄芪甲苷的研究进展[J].沈阳药科大学学报,2011,28(9):410-415.
[32]单文雅,张玉峰,朱捷强,等.黄芪甲苷对大鼠肝微粒体酶活性影响[J].中国中药杂志,2012,37(1):85-88.
[33]Choi J G,Kang S Y,Kim J M,et al.Antinociceptive effect of Cyperi rhizoma and Corydalis tuber extracts on neuropathic pain in rats[J].Korean J Physiol Pharmacol,2012,16(6):387-392.
[34]颜晶晶,俸珊,何丽娜,等.延胡索乙素对映体对人肝微粒体细胞色素P450酶抑制作用机制研究[J].中草药,2015,46(4):534-540.
[35]谢丹红,盛志新,孔红娟,等.银杏叶的临床应用[J].中国医院药学杂志,2007,27(8):1111-1112.
[36]Rastogi H S,Jana S.Evaluation of inhibitory effects of caffeic acid and quercetin on human liver cytochrome p450 activities[J].Phytother Res,2014,28(12):1873-1878.
[37]姚骥如,孙莹,罗顺葵,等.雷公藤多苷的临床应用进展[J].中国新药与临床杂志,2010,29(3):179-182.
[38]夏军,夏宗玲.雷公藤多苷对大鼠与人肝微粒体CYP3A酶活性的体外抑制作用[J].中国药房,2015,26(4):473-476.
[39]Wang Y,Jiang Y,Fan X,et al.Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways[J].Toxicol lett,2015,236(2):82-89.
[40]刘海培,孟繁华,郭继芬,等.淫羊藿素在大鼠体内的药动学研究[J].中国药学杂志,2010,45(7):539-543.
[41]Liang D L,Zheng S L.Effects of icaritin on cytochrome P450enzymes in rats[J].Pharmazie,2014,69(4):301-305.
[42]Voskresensky O N,Levitsky A P.QSAR aspects of flavonoids as a plentiful source of new drugs[J].Curr Med Chem,2002,9(14):1367-1383.
[43]Guo Y J,Zheng S L.Effect of myricetin on cytochrome P450isoforms CYP1A2,CYP2C9 and CYP3A4 in rats[J].Pharmazie,2014,69(4):306-310.
[44]魏宝红,叶静,薛宝娟,等.环黄芪醇连续灌胃对大鼠肝脏P450酶活性的影响[J].中国新药杂志,2014,23(4):476-479.
[45]Li W L,Xin H W,Yu A R,et al.In vivo effect of schisandrin B on cytochrome P450 enzyme activity[J].Phytomedicine,2013,20(8-9):760-765.
[2]毛凤斐,朱家璧.药物相互作用[J].中国医院药学杂志,1981,1(1):39-52.
[3]Sun H,Veith H,Xia M,et al.Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data[J].J Chem Inf Model,2011,51(10):2474-2481.
[4]Lin J H.CYP induction-mediated drug interactions:in vitro assessment and clinical implications[J].Pharm Res,2006,23(6):1089-1116.
[5]艾常虹,孙汉雄,李桦,等.中药有效成分对细胞色素P450酶的抑制活性评价[J].中国药理学通报,2011,27(4):519-523.
[6]Sasaki H,Suzuki N,Alshwaimi E,et al.18Beta-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-kappa B inactivation in interleukin-10-deficient mice[J].J Periodontal Res,2010,45(6):757-763.
[7]Wang Y G,Zhou J M,Ma Z C,et al.Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin:a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury[J].Chem Biol Interact,2012,200(1):11-20.
[8]刘冬英,杨敏,祝慧娟,等.几种植物化学物对人孕烷X受体介导的细胞色素P450 3A4转录调节作用[J].浙江大学学报:医学版,2006,35(1):8-13.
[9]Li Y,Wang Q,Yao X,et al.Induction of CYP3A4 and MDR1 gene expression by baicalin,baicalein,chlorogenic acid,and ginsenoside Rf through constitutive androstane receptor-and pregnane X receptor-mediated pathways[J].Eur J Pharmacol,2010,640(1-3):46-54.
[10]蔡丽萍,习志刚,杨红.丹参酮的药理作用和临床研究进展[J].广东药学院学报,2008,24(3):321-324.
[11]Yu C,Ye S,Sun H,et al.PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinoneⅡA[J].Chem Biol Interact,2009,177(1):58-64.
[12]Huang L,Huang M,Li Y H,et al.Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn[J].J Ethnopharmacol,2013,148(2):596-602.
[13]岚崔,祝德秋,安富荣.吴茱萸碱药理作用研究进展[J].中国中医药信息杂志,2005,12(6):108-110.
[14]黄凌,邝少轶,张丽.吴茱萸碱与吴茱萸次碱经PXR,CAR核受体通路影响CYP3A4表达的研究[J].中国药房,2013,24(35):3274-3279.
[15]周涛,王宇光,马增春,等.银杏内酯B通过激活孕烷X受体诱导CYP3A4的表达[J].中国药理学通报,2014,30(7):926-931.
[16]Kobayashi K,Urashima K,Shimada N,et al.Substrate specificity for rat cytochrome P450(CYP)isoforms:screening with c DNA-expressed systems of the rat[J].Biochem Pharmacol,2002,63(5):889-896.
[17]黄伟锋.大黄素的药理作用研究进展[J].柳州医学,2013,26(4):241-244.
[18]王青秀,雷荣辉,吴纯启,等.大黄素对大鼠肝脏CYP450酶的诱导研究[J].药物评价研究,2015,38(2):147-150.
[19]白燕,冯素香,周悌强,等.探针药物评价大黄苷元对P450酶CYP1A2活性的影响[J].中国实验方剂学杂志,2015,21(5):143-146.
[20]田丽婷,马龙,堵年生.齐墩果酸的药理作用研究概况[J].中国中药杂志,2002,24(3):92-94.
[21]刘昌辉,郑侠,王宁生,等.齐墩果酸对大鼠体内细胞色素P450酶活性的影响[J].中国民族民间医药杂志,2012,21(9):37-39.
[22]Carrasco O F,Vidrio H.Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta[J].Vascul Pharmacol,2007,47(1):68-73.
[23]Huang Y,Zheng S,Zhu H Y,et al.Effects of aescin on cytochrome P450 enzymes in rats[J].J.Ethnopharmacol,2014,151(1):83-90.
[24]Xu R A,Xu Z S,Ge R S.Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats[J].J Ethnopharmacol,2014,151(3):1141-1146.
[25]Zhao Y L.Development in pharmacological application of puerarin[J].Anhui Med Pharm,2010,34(2):383-392.
[26]孙紫阳.葛根素对鼠肝微粒体细胞色素P450的影响[J].河北医学,2007,13(9):1057-1060.
[27]Jiang Y,Fan X,Wang Y,et al.Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation[J].Chem Biol Interact,2015,231:83-89.
[28]刘耕陶,包天桐,魏怀玲,等.五味子乙素对小鼠肝细胞微粒体细胞色素P-450的诱导作用[J].药学学报,1980,15(4):206-206.
[29]Jiang Y,Fan X,Wang Y,et al.Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration[J].Toxicol Sci,2015,143(1):107-115.
[30]Liu L,Xiao J,Peng Z H,et al.In vitro metabolism of glycyrrhetic acid by human cytochrome P450[J].Acta pharm Sin,2011,46(1):81-87.
[31]段立军,孙博航.黄芪甲苷的研究进展[J].沈阳药科大学学报,2011,28(9):410-415.
[32]单文雅,张玉峰,朱捷强,等.黄芪甲苷对大鼠肝微粒体酶活性影响[J].中国中药杂志,2012,37(1):85-88.
[33]Choi J G,Kang S Y,Kim J M,et al.Antinociceptive effect of Cyperi rhizoma and Corydalis tuber extracts on neuropathic pain in rats[J].Korean J Physiol Pharmacol,2012,16(6):387-392.
[34]颜晶晶,俸珊,何丽娜,等.延胡索乙素对映体对人肝微粒体细胞色素P450酶抑制作用机制研究[J].中草药,2015,46(4):534-540.
[35]谢丹红,盛志新,孔红娟,等.银杏叶的临床应用[J].中国医院药学杂志,2007,27(8):1111-1112.
[36]Rastogi H S,Jana S.Evaluation of inhibitory effects of caffeic acid and quercetin on human liver cytochrome p450 activities[J].Phytother Res,2014,28(12):1873-1878.
[37]姚骥如,孙莹,罗顺葵,等.雷公藤多苷的临床应用进展[J].中国新药与临床杂志,2010,29(3):179-182.
[38]夏军,夏宗玲.雷公藤多苷对大鼠与人肝微粒体CYP3A酶活性的体外抑制作用[J].中国药房,2015,26(4):473-476.
[39]Wang Y,Jiang Y,Fan X,et al.Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways[J].Toxicol lett,2015,236(2):82-89.
[40]刘海培,孟繁华,郭继芬,等.淫羊藿素在大鼠体内的药动学研究[J].中国药学杂志,2010,45(7):539-543.
[41]Liang D L,Zheng S L.Effects of icaritin on cytochrome P450enzymes in rats[J].Pharmazie,2014,69(4):301-305.
[42]Voskresensky O N,Levitsky A P.QSAR aspects of flavonoids as a plentiful source of new drugs[J].Curr Med Chem,2002,9(14):1367-1383.
[43]Guo Y J,Zheng S L.Effect of myricetin on cytochrome P450isoforms CYP1A2,CYP2C9 and CYP3A4 in rats[J].Pharmazie,2014,69(4):306-310.
[44]魏宝红,叶静,薛宝娟,等.环黄芪醇连续灌胃对大鼠肝脏P450酶活性的影响[J].中国新药杂志,2014,23(4):476-479.
[45]Li W L,Xin H W,Yu A R,et al.In vivo effect of schisandrin B on cytochrome P450 enzyme activity[J].Phytomedicine,2013,20(8-9):760-765.