体检人群幽门螺杆菌感染与高同型半胱氨酸血症和脂代谢相关指标的关系
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摘要
目的分析幽门螺杆菌(Hp)与血清高同型半胱氨酸血症(HHcy)、脂代谢相关指标的关系。方法选取2016年1—12月解放军白求恩国际和平医院进行健康体检同时进行Hp、同型半胱氨酸(Hcy)、血脂、血糖及腰高比(WHtR)和体重指数(BMI)的检测者1613例,根据碳13(~(13)C)和碳14(~(14)C)呼气试验结果分为Hp感染组和Hp未感染组,比较两组一般资料、代谢指标及高同型半胱氨酸血症(HHcy)检出率,对危险因素进行多因素Logistic回归分析。结果 1613例受检者中有861例(53.4%)发生Hp感染。Hp感染组血清Hcy浓度高于Hp未感染组,HHcy检出率高于Hp未感染组(P<0.05)。HHcy为Hp感染的危险因素(P<0.05)。结论 Hp感染与HHcy的发生密切相关。
Objective To investigate relationship between helicobacter pylori( Hp) with hyperhomocysteinemia( HHcy) and related indexes of lipid metabolism in healthy people taking medical examinations. Methods A total of1613 healthy people,who underwent Hp,homocysteine( Hcy),blood fat,blood glucose,waist-to-stature ratio( WSR)and body mass index( BMI) tests from January to December 2016,were recruited in this study,and the people were divided into Hp infection group and Hp non-infection group according to results of13 C and14 C breath tests. General conditions,metabolic indexes and hyperhomocysteinaemia( HHcy) detection rate were compared,and multiple logistic regression analysis was performed to analyze related factors in two groups. Results A total of 861 subjects( 53. 4%) had Hp infection among the 1613 subjects,Values of Hp concentration and HHcy detection rate in Hp infection group were significantly higher than those in Hp non-infection group( P < 0. 05). HHcy was the risk factor of Hp infection( P < 0. 05).Conclusion Hp infection is closely associated with HHcy pathogenesy.
Objective To investigate relationship between helicobacter pylori( Hp) with hyperhomocysteinemia( HHcy) and related indexes of lipid metabolism in healthy people taking medical examinations. Methods A total of1613 healthy people,who underwent Hp,homocysteine( Hcy),blood fat,blood glucose,waist-to-stature ratio( WSR)and body mass index( BMI) tests from January to December 2016,were recruited in this study,and the people were divided into Hp infection group and Hp non-infection group according to results of13 C and14 C breath tests. General conditions,metabolic indexes and hyperhomocysteinaemia( HHcy) detection rate were compared,and multiple logistic regression analysis was performed to analyze related factors in two groups. Results A total of 861 subjects( 53. 4%) had Hp infection among the 1613 subjects,Values of Hp concentration and HHcy detection rate in Hp infection group were significantly higher than those in Hp non-infection group( P < 0. 05). HHcy was the risk factor of Hp infection( P < 0. 05).Conclusion Hp infection is closely associated with HHcy pathogenesy.
引文
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[17]张吉,张晨莉,蔡凯愉,等.幽门螺杆菌感染对健康人群血脂和颈动脉内膜中层厚度的影响[J].内科理论与实践,2013,8(1):20-22.
[18]刘志军,杨秀蓉,张丹,等.体检人群幽门螺杆菌感染与血脂异常的相关性分析[J].华南国防医学杂志,2017,32(1):23-25.
[19]谢桃,杨璋斌,李文华,等.幽门螺杆菌感染与血浆中同型半胱氨酸的关系探讨[J].重庆医学,2015,44(31):4343-4344,4348.
[2]Mc Cully K S.Vascular pathology of homocy-steinemia:implications for the pathogenesis of arteries-erosis[J].Am J Pathol,1969,56(1):111-128.
[3]赵燕颖,程海涛,王志军,等.冠状动脉粥样硬化性心脏病与幽门螺杆菌感染的相关性[J].世界华人消化杂志,2016,24(10):1613-1617.
[4]朱华伟,任保仙,齐进兴,等.脑梗死与幽门螺杆菌感染相关性研究[J].中华医院感染学杂志,2015,25(16):3669-3671.
[5]孙艺菡,杨星林,李峰,等.幽门螺杆菌感染与糖尿病血管病变[J].国际内分泌代谢杂志,2015,35(1):38-40.
[6]雷鸣,白驹,吴建华,等.幽门螺杆菌感染对颈动脉粥样硬化患者血清同型半胱氨酸水平的影响[J].检验医学,2015,30(9):894-897.
[7]吴琴琴,洋韩伟,李乔,等.幽门螺旋杆菌感染与同型半胱氨酸增高的关系研究[J].四川医学,2015,36(10):1381-1384.
[8]邝建,杨华章,王声涌.腰围/身高比值:预测糖尿病和高血压的有效的腹型肥胖指标[J].中华内分泌代谢杂志,2004,20(3):272-275.
[9]刘莉,平智广,李琳琳,等.腰围身高比对代谢综合征的筛查能力分析及界值确定[J].卫生研究,2012,41(6):992-996.
[10]中国肥胖问题工作组.中国成人超重和肥胖症预防与控制指南(节录)[J].营养学报,2004,26(1):1-4.
[11]邢渊.我国超重肥胖的诊断标准探讨[J].青岛医药卫生,2007,39(1):60-61.
[12]陈烨.幽门螺杆菌胃炎是一种感染性疾病[J].中华消化杂志,2016(1):8-10.
[13]Eusebi L H,Zagari R M,Bazzoli F.Epidemiology of Helicobacter pylori infection[J].Helicobacter,2014,19(Suppl 1):1-5.
[14]宋珏,冉利梅,刘玉屏,等.幽门螺杆菌感染与血脂水平的关系[J].贵州医药,2015,39(11):973-975.
[15]于汶,宗力群,胡荣,等.幽门螺杆菌感染与颈动脉斑块及心血管病危险因素的关系[J].中国医药,2016,11(10):1442-1446.
[16]程丹丹,何丛,吕农华.幽门螺杆菌与代谢综合征的研究进展[J].中华消化杂志,2016,36(1):68-70.
[17]张吉,张晨莉,蔡凯愉,等.幽门螺杆菌感染对健康人群血脂和颈动脉内膜中层厚度的影响[J].内科理论与实践,2013,8(1):20-22.
[18]刘志军,杨秀蓉,张丹,等.体检人群幽门螺杆菌感染与血脂异常的相关性分析[J].华南国防医学杂志,2017,32(1):23-25.
[19]谢桃,杨璋斌,李文华,等.幽门螺杆菌感染与血浆中同型半胱氨酸的关系探讨[J].重庆医学,2015,44(31):4343-4344,4348.