肺癌恶性胸腔积液置管引流患者生活质量调查及影响因素分析
|
摘要
目的调查肺癌恶性胸腔积液置管引流患者的生活质量并探讨影响其生活质量的主要因素。方法选择2017年1~10月解放军总医院呼吸科收治的64例肺癌恶性胸腔积液置管引流患者为观察组,同时选择66例晚期肺癌未出现恶性胸腔积液患者为对照组。采用肺癌生活质量量表(FACT-L 4.0)评估患者生活质量,采用多因素分析对可能影响肺癌恶性胸腔积液置管引流患者生活质量的因素进行分析。结果观察组患者FACT-L量表生理状况、功能状况、肺癌特异模块及生活质量总分低于对照组,差异有统计学意义(P<0.05)。病理分型、体力活动状态(PS)评分、胸腔置管引流次数、文化程度、收入来源、知情状态是肺癌恶性胸腔积液置管引流患者生活质量的影响因素(P<0.05)。PS评分、知情状态、胸腔置管引流次数是肺癌恶性胸腔积液置管引流患者生活质量的独立影响因素(P<0.05)。结论肺癌恶性胸腔积液置管引流患者生活质量差,PS评分、知情状态、胸腔置管引流次数是其独立影响因素。
Objective To investigate the quality of life(QOL) of lung cancer malignant pleural effusion patients with catheter drainage and explore the main factors affecting their quality of life. Methods From January to October in2017, in Department of Respiratory Medicine, Chinese PLA General Hospital, 64 cases of lung cancer with malignant pleural effusion were selected as observation group, and at the same time, 66 cases of advanced lung cancer without malignant pleural effusion were selected as control group, the quality of life of patients were evaluated by using lung cancer quality of life scale(Fact-l 4.0). Multivariate analysis was used to analyze the factors that may affect the life quality of patients with malignant pleural effusion and drainage of lung cancer. Results The Physical well-being, functional well-being, lung cancer subscale and FACT-L total score in the observation group were significantly lower than those in the control group, the differences were statistically significant(P < 0.05). Pathologic typing, PS score, number of indwelling pleural catheters, education level, source of income, informed status were the factors of quality of life in lung cancer malignant pleural effusion patients with catheter drainage(P < 0.05). PS score, informed status, and number of indwelling pleural catheters were independent factors affecting the quality of life of lung cancer malignant pleural effusion patients with catheter drainage(P < 0.05). Conclusion The quality of life of lung cancer malignant pleural effusion patients with catheter drainage is poor, PS score, informed state and number of indwelling pleural catheters are independent influencing factors.
Objective To investigate the quality of life(QOL) of lung cancer malignant pleural effusion patients with catheter drainage and explore the main factors affecting their quality of life. Methods From January to October in2017, in Department of Respiratory Medicine, Chinese PLA General Hospital, 64 cases of lung cancer with malignant pleural effusion were selected as observation group, and at the same time, 66 cases of advanced lung cancer without malignant pleural effusion were selected as control group, the quality of life of patients were evaluated by using lung cancer quality of life scale(Fact-l 4.0). Multivariate analysis was used to analyze the factors that may affect the life quality of patients with malignant pleural effusion and drainage of lung cancer. Results The Physical well-being, functional well-being, lung cancer subscale and FACT-L total score in the observation group were significantly lower than those in the control group, the differences were statistically significant(P < 0.05). Pathologic typing, PS score, number of indwelling pleural catheters, education level, source of income, informed status were the factors of quality of life in lung cancer malignant pleural effusion patients with catheter drainage(P < 0.05). PS score, informed status, and number of indwelling pleural catheters were independent factors affecting the quality of life of lung cancer malignant pleural effusion patients with catheter drainage(P < 0.05). Conclusion The quality of life of lung cancer malignant pleural effusion patients with catheter drainage is poor, PS score, informed state and number of indwelling pleural catheters are independent influencing factors.
引文
[1]Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[2]Dixit R,Agarwal KC,Gokhroo A,et al.Diagnosis and management options in malignant pleural effusions[J].Lung India,2017,34(2):160-166.
[3]Nam HS.Malignant pleural effusion:medical approaches for diagnosis and management[J].Tuberc Respir Dis(Seoul),2014,76(5):211-217.
[4]游捷,施志明,张娴静.两种国际肺癌患者生活质量量表EORTC QLQ-LC43与FACT-L的比较[J].中国癌症杂志,2009,19(5):364-370.
[5]王瑞.延续性护理干预对老年冠心病患者不停跳冠脉搭桥术后生活质量的影响[D].郑州:郑州大学,2017.
[6]Yeh HH,Chang WT,Lu KC,et al.Upregulation of tissue factor by activated Stat3 contributes to malignant pleural effusion generation via enhancing tumor metastasis and vascular permeability in lung adenocarcinoma[J].PLo S One,2013,8(9):e75 287.
[7]De Camp MM,Mentzer SJ,Swanson SJ,et al.Malignant effusive disease of the pleura and pericardium[J].Chest,1997,112(4 Suppl):291S-295S.
[8]田野,王园,刘思洋,等.肺癌伴恶性胸腔积液中EGFR突变检测及其临床意义[J].中国医科大学学报,2016,45(2):150-153.
[9]Lorenzo MJ,Modesto M,Pérez J,et al.Quality-of-Life assessment in malignant pleural effusion treated with indwelling pleural catheter:a prospective study[J].Palliat Med,2014,28(4):326-334.
[10]Ran J,Wang J,Bi N,et al.Health-related quality of life in long-term survivors of unresectable locally advanced non-small cell lung cancer[J].Radiat Oncol,2017,12(1):195.
[11]邹华,单锦露,李梦侠,等.438例肺癌恶性胸腔积液的诊治及预后因素分析[J].重庆医学,2015,44(27):3794-3797,3802.
[12]Desai NR,Lee HJ.Diagnosis and management of malignant pleural effusions:state of the art in 2017[J].J Thorac Dis,2017,9(Suppl 10):S1111-S1122.
[13]Chang O,Choi EK,Kim IR,et al.Association between socioeconomic status and altered appearance distress,body image,and quality of life among breast cancer patients[J].Asian Pac J Cancer Prev,2014,15(20):8607-8612.
[14]Penson DF,Stoddard ML,Pasta DJ,et al.The association between socioeconomic status,health insurance coverage,and quality of life in men with prostate cancer[J].J Clin Epidemiol,2001,54(4):350-358.
[15]潘雁,徐云华,王韡旻,等.非小细胞肺癌患者生命质量的影响因素分析[J].上海交通大学学报:医学版,2011,31(3):339-342.
[16]黎银焕,周燕斌,黄琬玲,等.肺癌患者睡眠与生活质量影响因素的回归分析[J].中华肿瘤防治杂志,2011,18(23):1874-1877.
[17]Penz E,Watt KN,Hergott CA,et al.Management of malignant pleural effusion:challenges and solutions[J].Cancer Manag Res,2017,9:229-241.
[18]马鑫.癌症患者的知情程度对身心健康的影响及护理干预[J].锦州医科大学学报,2017,38(5):102-103.
[19]沈超,沈伟.50例晚期肿瘤患者对病情告知需求分析[J].医学与哲学(B),2014,35(5):44-46.
[20]沈慧敏.肺癌患者癌因性疲乏与生命质量相关性研究及其护理对策[J].中国医药导报,2016,13(23):106-109.
[21]赵欣欣,刘祖望,郭静波,等.病情告知对肿瘤晚期患者抑郁焦虑情绪影响的分析[J].现代肿瘤医学,2013,21(12):2815-2817.
[2]Dixit R,Agarwal KC,Gokhroo A,et al.Diagnosis and management options in malignant pleural effusions[J].Lung India,2017,34(2):160-166.
[3]Nam HS.Malignant pleural effusion:medical approaches for diagnosis and management[J].Tuberc Respir Dis(Seoul),2014,76(5):211-217.
[4]游捷,施志明,张娴静.两种国际肺癌患者生活质量量表EORTC QLQ-LC43与FACT-L的比较[J].中国癌症杂志,2009,19(5):364-370.
[5]王瑞.延续性护理干预对老年冠心病患者不停跳冠脉搭桥术后生活质量的影响[D].郑州:郑州大学,2017.
[6]Yeh HH,Chang WT,Lu KC,et al.Upregulation of tissue factor by activated Stat3 contributes to malignant pleural effusion generation via enhancing tumor metastasis and vascular permeability in lung adenocarcinoma[J].PLo S One,2013,8(9):e75 287.
[7]De Camp MM,Mentzer SJ,Swanson SJ,et al.Malignant effusive disease of the pleura and pericardium[J].Chest,1997,112(4 Suppl):291S-295S.
[8]田野,王园,刘思洋,等.肺癌伴恶性胸腔积液中EGFR突变检测及其临床意义[J].中国医科大学学报,2016,45(2):150-153.
[9]Lorenzo MJ,Modesto M,Pérez J,et al.Quality-of-Life assessment in malignant pleural effusion treated with indwelling pleural catheter:a prospective study[J].Palliat Med,2014,28(4):326-334.
[10]Ran J,Wang J,Bi N,et al.Health-related quality of life in long-term survivors of unresectable locally advanced non-small cell lung cancer[J].Radiat Oncol,2017,12(1):195.
[11]邹华,单锦露,李梦侠,等.438例肺癌恶性胸腔积液的诊治及预后因素分析[J].重庆医学,2015,44(27):3794-3797,3802.
[12]Desai NR,Lee HJ.Diagnosis and management of malignant pleural effusions:state of the art in 2017[J].J Thorac Dis,2017,9(Suppl 10):S1111-S1122.
[13]Chang O,Choi EK,Kim IR,et al.Association between socioeconomic status and altered appearance distress,body image,and quality of life among breast cancer patients[J].Asian Pac J Cancer Prev,2014,15(20):8607-8612.
[14]Penson DF,Stoddard ML,Pasta DJ,et al.The association between socioeconomic status,health insurance coverage,and quality of life in men with prostate cancer[J].J Clin Epidemiol,2001,54(4):350-358.
[15]潘雁,徐云华,王韡旻,等.非小细胞肺癌患者生命质量的影响因素分析[J].上海交通大学学报:医学版,2011,31(3):339-342.
[16]黎银焕,周燕斌,黄琬玲,等.肺癌患者睡眠与生活质量影响因素的回归分析[J].中华肿瘤防治杂志,2011,18(23):1874-1877.
[17]Penz E,Watt KN,Hergott CA,et al.Management of malignant pleural effusion:challenges and solutions[J].Cancer Manag Res,2017,9:229-241.
[18]马鑫.癌症患者的知情程度对身心健康的影响及护理干预[J].锦州医科大学学报,2017,38(5):102-103.
[19]沈超,沈伟.50例晚期肿瘤患者对病情告知需求分析[J].医学与哲学(B),2014,35(5):44-46.
[20]沈慧敏.肺癌患者癌因性疲乏与生命质量相关性研究及其护理对策[J].中国医药导报,2016,13(23):106-109.
[21]赵欣欣,刘祖望,郭静波,等.病情告知对肿瘤晚期患者抑郁焦虑情绪影响的分析[J].现代肿瘤医学,2013,21(12):2815-2817.