清痰宁神方联合奥沙西泮治疗失眠痰热扰心证60例疗效观察
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摘要
目的:观察自拟清痰宁神方联合奥沙西泮治疗失眠痰热扰心证的临床疗效。方法:将120例失眠痰热扰心证患者按随机数字表法分为治疗组和对照组,每组60例。对照组采用奥沙西泮片治疗,治疗组在对照组的基础上加用自拟清痰宁神方治疗。4周为1个疗程,共治疗2个疗程。观察两组患者的临床疗效、匹兹堡睡眠质量指数量表、中医证候积分和不良反应等情况。结果:治疗组有效率为91.67%,对照组有效率为68.33%,两组比较,差异有统计学意义(P<0.05)。两组患者匹兹堡睡眠质量指数量表、焦虑自评量表、中医证候积分比较,差异均有统计学意义(P<0.05)。结论:清痰宁神方联合奥沙西泮治疗失眠痰热扰心证疗效显著,且不良反应少。
Objective: To observe the clinical effect of Qingtan Ningshen prescription combined with oxazepam in the treatment of insomnia caused by phlegm heat disturbing heart type. Methods: A total of 120 patients were randomly divided into the treatment group( 60 cases) and the control group( 60 cases). The control group was given oxazepam tablets. The treatment group was treated with Qingtan Ningshen prescription on the basis of the control group,4 weeks for a course of treatment. After 2 courses of treatment,the clinical efficacy,Pittsburgh Sleep quality Index( PSQI),TCM syndromes score and adverse reactions were observed. Results: The effective rate was 91. 67% in the treatment group and 68. 33% in the control group,the difference was statistically significant( P < 0. 05). The differences of PSQI,self-rating anxiety scale and TCM syndromes between the two groups were statistically significant( P < 0. 05). Conclusion: Qingtan Ningshen prescription combined with oxazepam in the treatment of insomnia caused by phlegm heat disturbing heart type has significant effect,and less adverse reaction.
Objective: To observe the clinical effect of Qingtan Ningshen prescription combined with oxazepam in the treatment of insomnia caused by phlegm heat disturbing heart type. Methods: A total of 120 patients were randomly divided into the treatment group( 60 cases) and the control group( 60 cases). The control group was given oxazepam tablets. The treatment group was treated with Qingtan Ningshen prescription on the basis of the control group,4 weeks for a course of treatment. After 2 courses of treatment,the clinical efficacy,Pittsburgh Sleep quality Index( PSQI),TCM syndromes score and adverse reactions were observed. Results: The effective rate was 91. 67% in the treatment group and 68. 33% in the control group,the difference was statistically significant( P < 0. 05). The differences of PSQI,self-rating anxiety scale and TCM syndromes between the two groups were statistically significant( P < 0. 05). Conclusion: Qingtan Ningshen prescription combined with oxazepam in the treatment of insomnia caused by phlegm heat disturbing heart type has significant effect,and less adverse reaction.
引文
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[19]魏珍珍,白明,苗明三.安神药物的现代研究[J].中医学报,2014,29(11):167.
[2]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:19-20.
[3]周仲瑛.中医内科学[M].2版.北京:中国中医药出版社,2007.
[4]何金彩,寿晓夏,刘文,等.中医失眠量表的初步编制[C].北京:第十一届全国心理学学术会议文摘要集,2007.
[5]BUYSSE D J,REYNOLDS C,MONK T H,et al.Pittsburgh Sleep Quality Index:a new insrument for psychiatricpractice and reseh[J].Psychiatry Res,1989,28(2):193-213.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[7]罗辉,廖星,王茜.中医证候积分在疗效评价中的应用:基于240项随机对照试验的比较研究[J].中国中西医结合杂志,2015,35(10):1261-1266.
[8]瞿萍,陈贵海.失眠的药物治疗[J].临床药物治疗杂志,2012,10(2):50-54.
[9]王泽民.失眠症治疗药物现状调查[J].现代中西医结合杂志,2003,12(6):1796-1797.
[10]罗涛,郝伟.奥沙西泮的研究进展[J].国际精神病学杂志,2010,37(4):244-247.
[11]BOUDINOT F D,HOMON C,JUSKO W,et al.Proteinbindingof oxazepam and its glucuronide conjugates to human albu-min[J].Biochemical Pharmacology,1985,34(12):2115-2121.
[12]顾之光.失眠症的药物治疗[J].中国新药与临床杂志,2005,24(5):405-408.
[13]周静媛,王全涛.疏肝解郁、养血活血法治疗失眠症体会[J].中国中医药信息杂志,2002,9(8):60.
[14]孙静均,李瞬贤.中国矿物药研究[M].济南:山东科学技术出版社,1992.
[15]刘胜金,吴德康.青礞石的药理作用及临床研究进展[J].中国中医药信息杂志,2010,17(10):109-112.
[16]梁华龙.大黄黄连即泻心,气机滞塞生痞证—痞证的辨证论治[J].中医学报,2014,29(3):190.
[17]李梦頔,黄世敬.补益药及其复方制剂抗抑郁作用研究进展[J].中医学报,2017,32(5):818.
[18]吴涛,张程亮.牛黄及体外培育牛黄的研究进展[J].中医药师,2014,8(5):86.
[19]魏珍珍,白明,苗明三.安神药物的现代研究[J].中医学报,2014,29(11):167.