二甲双胍对脂质代谢影响的研究新进展
摘要
肥胖与糖尿病、心血管疾病及其他代谢并发症的发生和发展相关,世界范围内肥胖的流行已造成相关疾病发病率的持续增长。二甲双胍是目前治疗2型糖尿病的一线用药,其对脂质代谢的影响可改善心血管疾病的结局及治疗其他脂质代谢异常的疾病。本文综述二甲双胍对脂质代谢影响的研究进展,探讨可能的作用机制。
引文
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[3]Zhang Y,Takemori H,Wang C,et al.Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in Hep G2 cells and metformin intervention[J].Life Sci,2017,15(173):107-115.
[4]Meng X,Guo J,Fang W,et al.Liver Micro RNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulatio of Adenosine5’-Monophosphate(AMP)-activated Protein Kinaseα1[J].J Biol Chem,2016,291(20):10625-10634.
[5]Schommers P,Thurau A,Bultmann-Mellin I,et al.Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state[J].Mol Metab,2017,6(7):737-747.
[6]Meng XM,Ma XX,Tian YL,et al.Metformin improves the glucose and lipid metabolism via influencing the level of serum total bile acids in rats with streptozotocin-induced type 2 diabetes mellitus[J].Eur Rev Med Pharmacol Sci,2017,21(9):2232-2237.
[7]Tokubuchi I,Tajiri Y,Iwata S,et al.Beneficial effects of metformin on energy metabolism and visceral fat volume through a possible mechanism of fatty acid oxidation in human subjects and rats[J].PLo S One,2017,12(2):171293.
[8]Sato D,Morino K,Nakagawa F,et al.Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying[J].Int J Mol Sci,2017,18(6):1282.
[9]Geerling JJ,Boon MR,Gc VDZ,et al.Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice.[J].Diabetes,2014,63(3):880-891.
[10]Lima-Martínez MM,Paoli M,Rodney M,et al.Effect of sitagliptin on epicardial fat thickness in subjects with type 2 diabetes and obesity:a pilot study[J].Endocrine,2016,51(3):448.
[11]Liu F,Wang C,Zhang L,et al.Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein[J].Int J Mol Med,2014,33(1):51-58.
[12]Delitala AP,Capobianco G,Delitala G,et al.Polycystic ovary syndrome,adipose tissue and metabolic syndrome[J].Archives of Gynecology&Obstetrics,2017,296(3):1-15.
[13]Macut D,Bo?i?anti?I,Bjeki?macut J,et al.Management of endocrine disease:Polycystic ovary syndrome and nonalcoholic fatty liver disease[J].European Journal of Endocrinology,2017,177(3):145.
[14]Liu Y,Ding Z.Obesity,a serious etiologic factor for male subfertility in modern society[J].Reproduction,2017,154(4):123-131.
[15]Louden ED,Luzzo KM,Jimenez PT,et al.Tally HO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism which is reversed by metformin[J].Reprod Fertil Dev,2014,27(1):31-39.
[16]Stefan N,Schick F,H?ring HU.Causes,Characteristics,and Consequences of Metabolically Unhealthy Normal Weight in Humans[J].Cell Metab,2017,26(2):292-300.