非小细胞肺癌中GRIM-19的表达及其临床意义
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摘要
目的研究非小细胞肺癌中诱导细胞凋亡相关基因19(gene associated with retinoid/interferon induced mortality 19, GRIM-19)的表达及其与临床各病理学特征间的关系。方法应用免疫组织化学技术检测GRIM-19的表达情况,并分析其与各临床病理特征之间的可能关系。结果 67例非小细胞肺癌组织中,GRIM-19阳性表达率为53.7%,低于在远端正常组织中的表达(P<0.01)。结论 GRIM-19在非小细胞肺癌中有不同程度的表达,可能与非小细胞肺癌发生、发展有关。
Objective To study the expression of gene associated with retinoid/interferon induced mortality 19(GRIM-19) in human non-small cell lung cancer and their relationships with clinical pathological characteristics of the cancer. Methods The S-P immunohistochemical method was used to examine the expression of GRIM-19.The correlations between the expression and the clinicopathological features of the cancer were analyzed. Results The positive expression rate of GRIM-19 in 67 cases of non-small cell lung cancer tissues was53.7%(P<0.01), the expression in non-small cell lung cancer tissue were lower than expression in the distal normal tissues. Conclusions GRIM-19 was expressed in various degrees in non-small cell lung cancer, and may be associated with the primary multidrug resistance of the cancer. The clinical detection of GRIM-19 in human non-small cell lung cancer can help to provide theoretical basis for reasonable individual chemotherapy scheme.
Objective To study the expression of gene associated with retinoid/interferon induced mortality 19(GRIM-19) in human non-small cell lung cancer and their relationships with clinical pathological characteristics of the cancer. Methods The S-P immunohistochemical method was used to examine the expression of GRIM-19.The correlations between the expression and the clinicopathological features of the cancer were analyzed. Results The positive expression rate of GRIM-19 in 67 cases of non-small cell lung cancer tissues was53.7%(P<0.01), the expression in non-small cell lung cancer tissue were lower than expression in the distal normal tissues. Conclusions GRIM-19 was expressed in various degrees in non-small cell lung cancer, and may be associated with the primary multidrug resistance of the cancer. The clinical detection of GRIM-19 in human non-small cell lung cancer can help to provide theoretical basis for reasonable individual chemotherapy scheme.
引文
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[2]Viala M,Brosseau S,Planchard D,et al.Second generation ALK inhibitors in non-small cell lung cancer:Systemic review[J].Bull Cancer,2015,102(4):381-389.
[3]Lin T,Wang H,Li LK.Effect of RNA silencing of HMGN5 gene on proliferation of lung cancer A549 cells and its significance[J].Chongqing Medicine,2016,45(4):457-459.
[4]Weng M,Song F, Chen J, et al. The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells[J]. Tumour Biol,2015,36(2):959-966.
[5]Lufei C,MaJ,Huang G,etal. GRIM-19,adeath-regulatorygene product, suppresses Stat3 activity via functional interaction[J]. EMBO J,2003,22(6):1325-1335.
[6]周爱民,刘荣玉.GRIM-19蛋白在非小细胞肺癌组织中的表达及其临床意义[J].癌症,2009,28(4):431-435.
[7]周涛,王晓.GRIM-19和STAT3在乳腺癌组织中的表达及相关性[J].中国现代普通外科进展,2013,16(6):466-469.