中医病机干预视角下的中药物质基础研究思路
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摘要
病机是病变本质的反映,指导中医临床立法组方。中药物质基础是中药起效、中医实现疾病防治以及病后康复的关键所在。病机能将中医理论与临床用药紧密联系,文章从中医病机干预的视角,探讨中药物质基础研究的思路,以求中医病机思维与中药研究紧密结合,相互融通,协同发展。
Pathogenesis is the reflection of the nature of the lesion, guiding clinical prescription of traditional Chinese medicine(TCM). Material basis of Chinese medicine is the key to efficacy, disease prevention and treatment by TCM and disease rehabilitation. The theory of TCM is closely connected with clinical medication under the application of pathogenesis. From the perspective of intervention using pathogenesis of TCM, the study on material basis of Chinese medicine was discussed in this article. So that the pathogenesis of TCM and the research of Chinese materia medica will be tightly integrated, developing in coordination and approaching to a point of merger.
Pathogenesis is the reflection of the nature of the lesion, guiding clinical prescription of traditional Chinese medicine(TCM). Material basis of Chinese medicine is the key to efficacy, disease prevention and treatment by TCM and disease rehabilitation. The theory of TCM is closely connected with clinical medication under the application of pathogenesis. From the perspective of intervention using pathogenesis of TCM, the study on material basis of Chinese medicine was discussed in this article. So that the pathogenesis of TCM and the research of Chinese materia medica will be tightly integrated, developing in coordination and approaching to a point of merger.
引文
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[31]程海波,沈卫星,吴勉华,等.中医药转化医学研究现状与发展述评.南京中医药大学学报,2016,32(5):401-404
[32]王君,戴丽,李鹏跃,等.芍药与甘草配伍协同增效作用的物质基础研究.中国实验方剂学杂志,2014,20(11):83-86
[33]刘蒙竹,张新龙,潘林梅,等.清络通痹方中雷公藤配伍减毒的化学基础研究.中国实验方剂学杂志,2014,20(7):107-112
[34]吴国琳,余国友,卢雯雯.中药复方对肠道微生态的调节作用研究现状.中国中药杂志,2015,40(18):3534-3537
[2]周学平,叶放,郭立中,等.中医病机辨证新体系的构建.南京中医药大学学报,2016,32(4):301-304
[3]程海波,李柳,周学平,等.中医内科学病机辨证思路探析.中华中医药杂志, 2016,31(12):5339-5341
[4]查鸯岚,程海波.程海波运用癌毒病机理论辨治肿瘤转移经验.浙江中医药大学学报,2017,41(5):381-384
[5]王维广,陈子杰,王慧如,等.当代中医病机概念的演变.中医杂志,2017,58(17):1441-1443
[6]赵凯维,于智敏.中医“病机”研究现状述评.中华中医药杂志,2010,25(1):10-13
[7]刘晓艳,王乙,吕明.中医病机理论的研究现状.时珍国医国药,2016,27(2):437-438
[8]Joshi K, Ghodke Y,Shintre P.Traditional medicine and genomics.Journal of Ayurveda&Integrative Medicine,2010,1(1):26-32
[9]Wang P,Chen Z.Traditional Chinese medicine ZHENG and Omics convergence:a systems approach to post-genomics medicine in a global world.Omics A Journal of Integrative Biology,2013,17(9):451-459
[10]Suo T C,Wang H X,Zheng L.Application of proteomics in research on traditional Chinese medicine.Expert Rev Proteomics,2016,13(9):873-881
[11]Liu X, Guo D A.Application of proteomics in the mechanistic study of traditional Chinese medicine.Biochemical Society Transactions,2011,39(5):1348-1352
[12]Zhang A H,Sun H,Wang Z G,et al.Metabolomics:Towards understanding traditional Chinese medicine.Planta Medica,2010,76(17):2026-2035
[13]Zhang A H,Sun H,Qiu S,et al.Recent Highlights of Metabolomics in Chinese Medicine Syndrome Research.Evidence-based Complementary and Alternative Medicine,2013,Article ID 402159,4pages
[14]徐舒,蔡红兵,孙学刚,等.中医证候现代研究的“组学”发展之路.医学与哲学, 2011,32(1):71-72
[15]黄燕如,万毅刚,孙伟,等.雷公藤多苷调节肾组织p38MAPK信号通路改善糖尿病肾病肾小球炎症性损伤的作用和机制.中国中药杂志,2014,39(21):4102-4109
[16]唐斌,张金国,谭洪勇,等.黄芪甲苷对慢性心衰大鼠心肌纤维化及能量代谢的影响.中国病理生理杂志,2017,33(3):411-416
[17]廖月霞.半枝莲黄酮活性成分双向调节肿瘤免疫作用及机制.扬州:扬州大学,2014
[18]李晓娟,白晓晖,陈家旭,等.中医动物模型研制方法及展望.中华中医药杂志,2014,29(7):2263-2266
[19]张晓龙.肝郁证动物模型实验研究评述.中医学报,2016,31(3):398-401
[20]孙晓倩,孙蓉.大鼠脂肪肝肝郁脾虚证的模型.中国实验方剂学杂志,2017,23(10):92-98
[21]朱闽,何清湖,荀建宁,等.中医“湿热证”病证结合动物模型研究进展.中华中医药杂志,2017,32(2):656-658
[22]周红光,陈海彬,周学平,等.蛋白质组学是中医病机研究的重要技术平台.中国中西医结合杂志,2012,32(7):990-993
[23]王玄,欧阳罗丹,代春美,等.动物类中药质量控制的生物评价研究.中国中药杂志,2017,42(12):2228-2235
[24]程海波,沈政洁,孙东东,等.抗肿瘤中药对肿瘤微环境的干预作用评述.中医杂志,2014,55(15):1343-1350
[25]秦雪梅,李爱平,刘月涛,等.多效中药定向药效成分研究策略.中草药,2017,48(5):847-852
[26]孙东东,程海波,沈卫星,等.补肾活血方中5种黄酮类成分的体外抗炎活性.中国实验方剂学杂志,2015,21(7):137-141
[27]Zhang Y Q,Guo X D,Wang D H,et al.A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma.Scientific Reports,2014,4(2):4154
[28]Xiang Z,Sun H,Cai X J, et al.The study on the material basis and the mechanism for anti-renal interstitial fibrosis efficacy of rhubarb through integration of metabonomics and network pharmacology.Molecular Biosystems,2015,11(4):1067-1078
[29]牛明,章从恩,伍珊娜,等.基于生物靶标网络的中药“一药多效”评价与精准用药.世界科学技术-中医药现代化,2017,19(1):44-49
[30]方樑,叶放,周学平,等.关于中医病机辨证体系中若干问题的探讨.南京中医药大学学报,2017,33(5):440-442
[31]程海波,沈卫星,吴勉华,等.中医药转化医学研究现状与发展述评.南京中医药大学学报,2016,32(5):401-404
[32]王君,戴丽,李鹏跃,等.芍药与甘草配伍协同增效作用的物质基础研究.中国实验方剂学杂志,2014,20(11):83-86
[33]刘蒙竹,张新龙,潘林梅,等.清络通痹方中雷公藤配伍减毒的化学基础研究.中国实验方剂学杂志,2014,20(7):107-112
[34]吴国琳,余国友,卢雯雯.中药复方对肠道微生态的调节作用研究现状.中国中药杂志,2015,40(18):3534-3537