从中药复方配伍减毒的物质基础探讨“异类相制”理论的研究思路
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摘要
"异类相制"理论源于临床,是传统中医药理论传承基础上的创新,对有毒中药的临床应用起着重要的指导作用。在异类相制理论的指导下,对中药复方配伍减毒的物质基础进行深入分析,方能阐明配伍减毒效应的内在机制。在物质基础的层面探讨中药复方配伍减毒的作用机制,应从毒性的化学成分、毒性成分的代谢、毒性物质与效应的相关性三个途径入手,充分借鉴现代科学领域的最新技术和研究方法,加强多学科协作,进行研究探索。
引文
[1]李春庆,孙伟,邵家德,等.雷公藤减毒研究述评[J].中国实验方剂学杂志,2011(10):263-265.Li CQ,Sun W,Shao JD,et al.Review research on attenuating toxicity of Chinese herb tripterygium wilfordii[J].Chin J Exper Tradit Med Form,2011(10):263-265.
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[3]张静,江莹,王芳,等.基于“异类相制”理论探讨雷公藤肝毒性配伍减毒的作用[J].中草药,2014(18):2711-2715.Zhang J,Jiang Y,Wang F,et al.Detoxicity effect of hepatotoxicity of Tripterygium wilfordii by compatibility mechanism based on"diversity restriction"theory[J].Chin Tradit Herb Drug,2014(18):2711-2715.
[4]张新龙,郭立玮,周学平,等.清络通痹汤药效物质“组合筛选”库的制备[J].中草药,2012(1):60-64.Zhang XL,Guo LW,Zhou XP,et al.Establishment of"combinatorial screening"library of efficacy substances for Qingluo Tongbi Decoction[J].Chin Tradit Herb Drug,2012(1):60-64.
[5]刘蒙竹,张新龙,潘林梅,等.清络通痹方中雷公藤配伍减毒的化学基础研究[J].中国实验方剂学杂志,2014(7):107-112.Liu MZ,Zhang XL,Pan LM,et al.Chemical basis of tripterygium Qingluo wilfordii compatibility for attenuation in Tongbi decoction[J].Chin J Exper Tradit Med Form,2014(7):107-112.
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[7]周聪,周玲玲,柳璋璞,等.基于肝毒性的雷公藤复方配伍减毒作用及机制研究[J].中药药理与临床,2013(5):106-109.Zhou C,Zhou LL,Liu ZP,et al.Study on attenuation effect of the compatibility of Compound Tripterygium wilfordii[J].Pharmacol Clin Chin Mater Med,2013(5):106-109.
[8]周昕欣.基于雷公藤毒性配伍组方对肾病雌性大鼠生殖系统影响的实验研究[D].沈阳:辽宁中医药大学,2007.Zhou XX.Experimental study on compatibility of Compound Tripterygium wilfordii on the reproductive system of female rat nephropathy[D].Shenyang:Liaoning University of Chinese Medicine,2007.
[9]王小娟.川楝子毒性及配伍减毒的代谢组学研究[D].合肥:安徽医科大学,2011.Wang XJ.The study on the metabolism of Melia toosendan Sieb's toxic and compatibility of drugs[D].HeFei:Anhui University of Medicine,2011.
[10]刘建群,王雪梅,刘一文,等.基于影响药物代谢的中药配伍研究进展[J].中国实验方剂学杂志,2014,19:221-224.Liu JQ,Wang XM,Liu YW,et al.Progress in compatibility of traditional Chinese medicine based on effect of drug metabolism[J].Chin J Exper Tradit Med Form,2014(19):221-224.
[11]陶长戈.附子干姜组分配伍的胃肠吸收动力学研究[D].成都中医药大学,2011.Tao CG.Gastrointestinal absorption kinetics of composition compatibilities from Radix Aconiti Lateralis and Rhizoma Zingiberis.[D].Chengdu:Chengdu University of Chinese Medicine,2011.
[12]刘建群,王雪梅,刘一文,等.基于影响药物代谢的中药配伍研究进展[J].中国实验方剂学杂志,2014(19):221-224.Liu JQ,Wang XM,Liu YW,et al.Progress in compatibility of traditional Chinese medicine based on effect of drug metabolism[J].Chin J Exper Tradit Med Form,2014(19):221-224.
[13]陶长戈.附子干姜组分配伍的胃肠吸收动力学研究[D].成都:成都中医药大学,2011.Tao CG.Gastrointestinal absorption kinetics of composition compatibilities fromRadix Aconiti lateralis and Rhizoma Zingiberis[D].Chengdu:Chengdu University of Chinese Medicine,2011.
[14]马婧伟.乌头类有毒中药炮制配伍减毒机制的体外模型研究[D].长春:吉林大学,2014.Ma JW.In vitro study an mechanism of attenuation in aconitum by processing and compatibility[D].Changchun:Jilin University,2014.
[15]王加志.黄药子致肝毒性/配伍当归后减毒的亚细胞机制及毒性成分体外代谢研究[D].哈尔滨:黑龙江中医药大学,2009.Wang JZ.Dioscorea bulbiferal sends the liver toxicity to blend the angelica sinensis to reduce the poisonous subcellular fraction mechanism and the toxic ingredient in vitro metabolism research[D].Haerbin:Heilongjiang University of Chinese Medicine,2009.
[16]陈长勋,徐姗臖.甘草、干姜与附子配伍减毒的物质基础与作用环节研究进展[J].中药新药与临床药理,2006,17(6):472-476.Chen CX,Xu SJ.Progress and research on the material basis and attenuated link among Licorice,ginger and Aconite[J].Tradit Chin Drug Res Clin Pharm,2006,17(6):472-476.
[17]李彦文,李志勇,刘会永,等.中药配伍减毒研究的新思路[J].中国实验方剂学杂志,2012(20):321-324.Li YW,Li ZY,Liu HY,et al.New thought of traditional Chinese medicine in detoxification by compatibility[J].Chin J Exper Tradit Med Form,2012(20):321-324.
[18]冯哲,周学平.复方配伍效应物质基础研究路径的探讨[J].中华中医药杂志,2013(6):1835-1838.Feng Z,Zhou XP.Discussion of the research approach for the material foundation of the compatibility effect of traditional Chinese herbal formula[J].China J Tradit Chin Med Pharm,2013(6):1835-1838.
[19]郭浩,黎巍威,王小莹,等.方剂配伍减毒的现代研究进展[J].中国中药杂志,2012,01:120-123.Guo H,Li WW,Wang XY,et al.Advance of research on toxic of traditional Chinese attenuation by compatibility medicine prescriptions[J].China J Chin Mater Med,2012(1):120-123.
[20]赵佳伟,何家乐,马增春,等.参附配伍减毒作用的尿液代谢组学研究[J].中药药理与临床,2015(1):1-5.Zhao JW,He JL,Ma ZC,et al.Urine metabolomics studies of Shenfu attenuated compatility[J].Pharm Clin Chin Mater Med,2015(1):1-5.
[21]李俊健.基于NMR的代谢组学对甘遂甘草配伍减毒机制的研究[D].广州:广东药学院,2014.Li JJ.NMR-based Metabonomics Study of the Attenuated of Kansui and Licorice Compatibility[D].Guangzhou:Guangdong College of Pharmacy,2014.
[22]梁琦,谢鸣,倪诚,等.广防己配伍黄芪肾毒性的代谢组学研究[J].浙江中医药大学学报,2010(1):42-43,45.Liang Q,Xie M,Ni C,et al.Nephrotoxicity study of Aristolochia Fangchi and it's compatible with Astragali Radixin rats by metabonomics[J].J Zhejiang Univ Chin Med,2010(1):42-43,45.
[23]周学平,周玲玲,王旭.基于“异类相制”理论探讨中药复方的配伍减毒作用[J].中医杂志,2013(4):271-273.Zhou XP,Zhou LL,Wang X.Study on the compatibility of Chinese herbal medicine compound by The"Heterogeneous Restriction"theory[J].J Tradit Chin Med,2013(4):271-273.
[2]李桓,周学平,陆艳.雷公藤“异类相制”配伍减毒作用探讨[J].中医杂志,2015(1):10-13.Li H,Zhou XP,Lu Y.Discussion on Detoxicity effect of Leigongteng in"diversity restriction”compatibility[J].J Tradit Chin Med,2015(1):10-13.
[3]张静,江莹,王芳,等.基于“异类相制”理论探讨雷公藤肝毒性配伍减毒的作用[J].中草药,2014(18):2711-2715.Zhang J,Jiang Y,Wang F,et al.Detoxicity effect of hepatotoxicity of Tripterygium wilfordii by compatibility mechanism based on"diversity restriction"theory[J].Chin Tradit Herb Drug,2014(18):2711-2715.
[4]张新龙,郭立玮,周学平,等.清络通痹汤药效物质“组合筛选”库的制备[J].中草药,2012(1):60-64.Zhang XL,Guo LW,Zhou XP,et al.Establishment of"combinatorial screening"library of efficacy substances for Qingluo Tongbi Decoction[J].Chin Tradit Herb Drug,2012(1):60-64.
[5]刘蒙竹,张新龙,潘林梅,等.清络通痹方中雷公藤配伍减毒的化学基础研究[J].中国实验方剂学杂志,2014(7):107-112.Liu MZ,Zhang XL,Pan LM,et al.Chemical basis of tripterygium Qingluo wilfordii compatibility for attenuation in Tongbi decoction[J].Chin J Exper Tradit Med Form,2014(7):107-112.
[6]黄家卫,严云良,戴晓燕.配伍对桃核承气汤中苦杏仁苷代谢分解的影响研究[J].中华中医药杂志,2012(6):1688-1692.Huang JW,Yan YL,Dai XY.Influence of compatibility difference on the content change of amarogentin in Taohe Chengqi Decoction[J].China J Tradit Chin Med Pharm,2012(6):1688-1692.
[7]周聪,周玲玲,柳璋璞,等.基于肝毒性的雷公藤复方配伍减毒作用及机制研究[J].中药药理与临床,2013(5):106-109.Zhou C,Zhou LL,Liu ZP,et al.Study on attenuation effect of the compatibility of Compound Tripterygium wilfordii[J].Pharmacol Clin Chin Mater Med,2013(5):106-109.
[8]周昕欣.基于雷公藤毒性配伍组方对肾病雌性大鼠生殖系统影响的实验研究[D].沈阳:辽宁中医药大学,2007.Zhou XX.Experimental study on compatibility of Compound Tripterygium wilfordii on the reproductive system of female rat nephropathy[D].Shenyang:Liaoning University of Chinese Medicine,2007.
[9]王小娟.川楝子毒性及配伍减毒的代谢组学研究[D].合肥:安徽医科大学,2011.Wang XJ.The study on the metabolism of Melia toosendan Sieb's toxic and compatibility of drugs[D].HeFei:Anhui University of Medicine,2011.
[10]刘建群,王雪梅,刘一文,等.基于影响药物代谢的中药配伍研究进展[J].中国实验方剂学杂志,2014,19:221-224.Liu JQ,Wang XM,Liu YW,et al.Progress in compatibility of traditional Chinese medicine based on effect of drug metabolism[J].Chin J Exper Tradit Med Form,2014(19):221-224.
[11]陶长戈.附子干姜组分配伍的胃肠吸收动力学研究[D].成都中医药大学,2011.Tao CG.Gastrointestinal absorption kinetics of composition compatibilities from Radix Aconiti Lateralis and Rhizoma Zingiberis.[D].Chengdu:Chengdu University of Chinese Medicine,2011.
[12]刘建群,王雪梅,刘一文,等.基于影响药物代谢的中药配伍研究进展[J].中国实验方剂学杂志,2014(19):221-224.Liu JQ,Wang XM,Liu YW,et al.Progress in compatibility of traditional Chinese medicine based on effect of drug metabolism[J].Chin J Exper Tradit Med Form,2014(19):221-224.
[13]陶长戈.附子干姜组分配伍的胃肠吸收动力学研究[D].成都:成都中医药大学,2011.Tao CG.Gastrointestinal absorption kinetics of composition compatibilities fromRadix Aconiti lateralis and Rhizoma Zingiberis[D].Chengdu:Chengdu University of Chinese Medicine,2011.
[14]马婧伟.乌头类有毒中药炮制配伍减毒机制的体外模型研究[D].长春:吉林大学,2014.Ma JW.In vitro study an mechanism of attenuation in aconitum by processing and compatibility[D].Changchun:Jilin University,2014.
[15]王加志.黄药子致肝毒性/配伍当归后减毒的亚细胞机制及毒性成分体外代谢研究[D].哈尔滨:黑龙江中医药大学,2009.Wang JZ.Dioscorea bulbiferal sends the liver toxicity to blend the angelica sinensis to reduce the poisonous subcellular fraction mechanism and the toxic ingredient in vitro metabolism research[D].Haerbin:Heilongjiang University of Chinese Medicine,2009.
[16]陈长勋,徐姗臖.甘草、干姜与附子配伍减毒的物质基础与作用环节研究进展[J].中药新药与临床药理,2006,17(6):472-476.Chen CX,Xu SJ.Progress and research on the material basis and attenuated link among Licorice,ginger and Aconite[J].Tradit Chin Drug Res Clin Pharm,2006,17(6):472-476.
[17]李彦文,李志勇,刘会永,等.中药配伍减毒研究的新思路[J].中国实验方剂学杂志,2012(20):321-324.Li YW,Li ZY,Liu HY,et al.New thought of traditional Chinese medicine in detoxification by compatibility[J].Chin J Exper Tradit Med Form,2012(20):321-324.
[18]冯哲,周学平.复方配伍效应物质基础研究路径的探讨[J].中华中医药杂志,2013(6):1835-1838.Feng Z,Zhou XP.Discussion of the research approach for the material foundation of the compatibility effect of traditional Chinese herbal formula[J].China J Tradit Chin Med Pharm,2013(6):1835-1838.
[19]郭浩,黎巍威,王小莹,等.方剂配伍减毒的现代研究进展[J].中国中药杂志,2012,01:120-123.Guo H,Li WW,Wang XY,et al.Advance of research on toxic of traditional Chinese attenuation by compatibility medicine prescriptions[J].China J Chin Mater Med,2012(1):120-123.
[20]赵佳伟,何家乐,马增春,等.参附配伍减毒作用的尿液代谢组学研究[J].中药药理与临床,2015(1):1-5.Zhao JW,He JL,Ma ZC,et al.Urine metabolomics studies of Shenfu attenuated compatility[J].Pharm Clin Chin Mater Med,2015(1):1-5.
[21]李俊健.基于NMR的代谢组学对甘遂甘草配伍减毒机制的研究[D].广州:广东药学院,2014.Li JJ.NMR-based Metabonomics Study of the Attenuated of Kansui and Licorice Compatibility[D].Guangzhou:Guangdong College of Pharmacy,2014.
[22]梁琦,谢鸣,倪诚,等.广防己配伍黄芪肾毒性的代谢组学研究[J].浙江中医药大学学报,2010(1):42-43,45.Liang Q,Xie M,Ni C,et al.Nephrotoxicity study of Aristolochia Fangchi and it's compatible with Astragali Radixin rats by metabonomics[J].J Zhejiang Univ Chin Med,2010(1):42-43,45.
[23]周学平,周玲玲,王旭.基于“异类相制”理论探讨中药复方的配伍减毒作用[J].中医杂志,2013(4):271-273.Zhou XP,Zhou LL,Wang X.Study on the compatibility of Chinese herbal medicine compound by The"Heterogeneous Restriction"theory[J].J Tradit Chin Med,2013(4):271-273.