恶性腹水源性腹腔间隔室综合征肝脏损伤的研究进展
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摘要
恶性腹水源性腹腔间隔室综合征(malignant ascites-induced abdominal compartment syndrome,MAACS)继发肝脏损伤,临床症状隐匿,受到的关注较少.探索MAACS继发肝脏损害具有重要的临床意义.近年来,随着临床对腹腔间隔室综合征的发病机制及病理生理研究逐步深入,肝脏的继发改变成为研究的新热点.本文对MAACS继发肝脏损害中的病理生理过程、病理改变及治疗进行述评.
Liver injury in malignant ascites-induced abdominal compartment syndrome(MAACS) has received little attention. In recent years, due to the gradual clarification of pathogenesis and pathological physiology of abdominal interval syndrome, liver injury in MAACS has become a hot research topic. In this paper, we will review the pathophysiological process, pathological changes, and treatment of liver injury in MAACS.
Liver injury in malignant ascites-induced abdominal compartment syndrome(MAACS) has received little attention. In recent years, due to the gradual clarification of pathogenesis and pathological physiology of abdominal interval syndrome, liver injury in MAACS has become a hot research topic. In this paper, we will review the pathophysiological process, pathological changes, and treatment of liver injury in MAACS.
引文
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3 Stagnitti F,Calderale SM,Priore F,Ribaldi S,Tiberi R,De Pascalis M,Corona F,Schillaci F,Costantini A,Salvi PF.Abdominal compartment syndrome:patophysiologic and clinic remarks.G Chir 2004;25:335-342[PMID:15756955]
4王宏业,安峰,杨秀义,杨秀峰,冉祥根.腹腔置管减压治疗恶性腹水源性腹腔间隔室综合征29例临床观察.中华胃肠外科杂志2010;13:273-275
5 Sugrue M.Intra-abdominal pressure:time for clinical practice guidelines?Intensive Care Med2002;28:389-391[PMID:11967590 DOI:10.1007/S00134-002-1253-2]
6 Cheatham ML,Malbrain ML,Kirkpatrick A,Sugrue M,Parr M,De Waele J,Balogh Z,Leppaniemi A,Olvera C,Ivatury R,D'Amours S,Wendon J,Hillman K,Wilmer A.Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome.Ⅱ.Recommendations.Intensive Care Med 2007;33:951-962[PMID:17377769 DOI:10.1007/s00134-007-0592-4]
7 Sanchez NC,Tenofsky PL,Dort JM,Shen LY,Helmer SD,Smith RS.What is normal intraabdominal pressure?Am Surg 2001;67:243-248[PMID:11270882]
8刘丽蕾,王湘英.重症急性胰腺炎合并腹腔间隔室综合征诊治现状.中华胰腺病杂志2014;14:139-143
9乐冬友,张阳德,王志英,郑翼德,乐园,赵志坚.腹部创伤后24h晶体液量与腹腔间隔室综合征的关系分析.中国医学工程2006;14:58-60
10袁璐.无痛胃肠镜致不完全性肠梗阻合并腹腔间隔室综合征1例.现代中西医结合杂志2011;20:1125-1126
11戴毅敏,凌静娴,王志群,李荣,顾宁,郑明明.胡娅莉大量产后出血致腹腔间隔室综合征一例.中华围产医学杂志2014;17:286-287
12张建平,倪家连,刘晓明.肝移植术后腹腔高压致腹腔间隔室综合征2例.世界华人消化杂志2011;19:758-760
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14 Kendrick JE,Leath CA,Melton SM,Straughn JM.Use of a fascial prosthesis for management of abdominal compartment syndrome secondary to obstetric hemorrhage.Obstet Gynecol 2006;107:493-496[PMID:16449161 DOI:10.1097/01.AOG.0000168445.41145.7b]
15王丽,谢镒鞠,唐小唪,王正刚,刘道城,张连阳,葛衡江.创伤失血性休克后腹腔高压对心肺基础监测指标的影响.第三军医大学学报2013;35:2159-2163
16余剑,付晓娟,张连阳.腹内高压症对机体病理生理影响的研究进展.解放军医药杂志2013;25:23-27
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18 De Waele JJ,Cheatham ML,Malbrain ML,Kirkpatrick AW,Sugrue M,Balogh Z,Ivatury R,De Keulenaer B,Kimball EJ.Recommendations for research from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome.Acta Clin Belg 2009;64:203-209[PMID:19670559 DOI:10.1179/acb.2009.036]
19江利冰,张茂,马岳峰.腹腔高压和腹腔间隔室综合征诊疗指南(2013版).中华急诊医学杂志2013;22:839-841
20徐伟,Pierre M.ICU患者腹内压和腹腔灌注压影响因素分析.中国医药2007;2:605-607
21张志红.恶性腹水的研究进展.中国肿瘤临床与康复2008;15:380-381
22陈庆仁,贺赐平,李湖潮.血性腹水45例临床分析.中国医师杂志2003;5:1050-1051
23杨显文,姜海行,卢威顺,陈梅,卢东红,黄小丽,王家旭,覃山羽.Th22细胞在肝癌恶性腹水中的发病机制.世界华人消化杂志2014;22:5069-5078
24 Saif MW,Siddiqui IA,Sohail MA.Management of ascites due to gastrointestinal malignancy.Ann Saudi Med 2009;29:369-377[PMID:19700895 DOI:10.4103/0256-4947.55167]
25 Becker G.Medical and palliative management of malignant ascites.Cancer Treat Res 2007;134:459-467[PMID:17633074 DOI:10.1007/978-0-387-48993-3_31]
26 Hu L,Ferrara N,Jaffe RB.Paracrine VEGF/VEcadherin action on ovarian cancer permeability.Exp Biol Med(Maywood)2006;231:1646-1652[PMID:17060686]
27米登海,陈学鹏.腹腔内化疗治疗恶性腹水.国际肿瘤学杂志2006;33:854-867
28 Schafer M,Sagesser H,Reichen J,Kr(a|")henb(u|")hl L.Alterations in hemodynamics and hepatic and splanchnic circulation during laparoscopy in rats.Surg Endosc 2001;15:1197-1201[PMID:11443454DOI:10.1007/S004640080159]
29吴伟,朱维铭,李宁.腹内高压对门静脉压、中心静脉压影响的实验研究.消化外科2006;5:266-268
30 Varela JE,Cohn SM,Giannotti GD,Dolich MO,Ramon H,Wiseberg JA,McKenney M.Near-infrared spectroscopy reflects changes in mesenteric and systemic perfusion during abdominal compartment syndrome.Surgery 2001;129:363-370[PMID:11231465 DOI:10.1067/msy.2001.111695]
31 Cheatham ML,Malbrain ML.Cardiovascular implications of abdominal compartment syndrome.Acta Clin Belg 2007;62 Suppl 1:98-112[PMID:24881706 DOI:10.1179/acb.2007.62.s1.013]
32 Berger P,Nijsten MW,Paling JC,Zwaveling JH.The abdominal compartment syndrome:a complication with many faces.Neth J Med 2001;58:197-203[PMID:11334680 DOI:10.1016/S0300-2977(01)00104-8]
33 Kopelman T,Harris C,Miller R,Arrillaga A.Abdominal compartment syndrome in patients with isolated extraperi to neal injuries.J Trauma2000;49:744-747;discussion 747-749[PMID:11038095 DOI:10.1097/00005373-200010000-00025]
34 Pelosi P,Quintel M,Malbrain ML.Effect of intraabdominal pressure on respiratory mechanics.Acta Clin Belg 2007;62 Suppl 1:78-88[PMID:24881704 DOI:10.1179/acb.2007.62.sl.011]
35 Quintel M,Pelosi P,Caironi P,Meinhardt JP,Luecke T,Herrmann P,Taccone P,Rylander C,Valenza F,Carlesso E,Gattinoni L.An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury.Am J Respir Crit Care Med 2004;169:534-541[PMID:14670801DOI:10.1164/rccm.200209-1060OC]
36 van Minnen LP,Blom M,Timmerman HM,Visser MR,Gooszen HG,Akkermans LM.The use of animal models to study bacterial translocation during acute pancreatitis.J Gastrointest Surg2007;11:682-689[PMID:17468930 DOI:10.1007/s11605-007-0088-0]
37程君涛,肖光夏,夏培元,袁建成,秦孝建.腹内高压对兔肠道通透性及内毒素细菌移位的影响.中华烧伤杂志2003;19:229-232
38赵晓琴,秦志丹,邝晓聪,陈英,莫非,陈强,吴英林,覃桦,蒙永毅,叶永康.SD大鼠腹腔高压动物模型建立及肝损伤的实验研究.中华急诊医学杂志2013;22:1127-1131
39王宏业,尉继伟.腹腔高压动物模型肝脏的继发改变.世界华人消化杂志2016;24:1393-1397
40巩鹏,许海波,张嘉宁,王忠裕.PPARs/NF-Kb及SOD在梗阻性黄疸大鼠肝脏损害中的作用.中华肝胆外科杂志2010;16:620-623
41 Ganeshanantham G,Walsh SR,Varty K.Abdominal compartment syndrome in vascular surgery-A review.Int J Surg 2010;8:181-185[PMID:20074677 DOI:10.1016/j.ijsu.2010.01.001]
42 Schachtrupp A,Toens Ch,Hoer J,Klosterhalfen B,Lawong AG,Schumpelick V.A 24-h pneumoperitoneum leads to multiple organ impairment in a porcine model.J Surg Res 2002;106:37-45[PMID:12127806 DOI:10.1006/jsre.2002.6421]
43王宏业,尉继伟,杨靖.改良腹腔高压水嚢动物模型肝、肾病理改变.中国实用医刊2015;42:62-65
44莫非,赵晓琴,黄宗海,韦宇宁,曾湖,黄明权.腔高压对大鼠肝功能的独立影响.蛇志2013;25:6-8
45王正刚,王丽,孙士锦,刘道城,张连阳.腹腔扩容术治疗猪失血性休克复苏后腹腔高压对肝脏的影响.解放军医学杂志2012;37:104-108
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2 Lerner SM.Review article:the abdominal compartment syndrome.Aliment Pharmacol Ther2008;28:377-384[PMID:18513379 DOI:10.1111/j.1365-2036.2008.03747.x]
3 Stagnitti F,Calderale SM,Priore F,Ribaldi S,Tiberi R,De Pascalis M,Corona F,Schillaci F,Costantini A,Salvi PF.Abdominal compartment syndrome:patophysiologic and clinic remarks.G Chir 2004;25:335-342[PMID:15756955]
4王宏业,安峰,杨秀义,杨秀峰,冉祥根.腹腔置管减压治疗恶性腹水源性腹腔间隔室综合征29例临床观察.中华胃肠外科杂志2010;13:273-275
5 Sugrue M.Intra-abdominal pressure:time for clinical practice guidelines?Intensive Care Med2002;28:389-391[PMID:11967590 DOI:10.1007/S00134-002-1253-2]
6 Cheatham ML,Malbrain ML,Kirkpatrick A,Sugrue M,Parr M,De Waele J,Balogh Z,Leppaniemi A,Olvera C,Ivatury R,D'Amours S,Wendon J,Hillman K,Wilmer A.Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome.Ⅱ.Recommendations.Intensive Care Med 2007;33:951-962[PMID:17377769 DOI:10.1007/s00134-007-0592-4]
7 Sanchez NC,Tenofsky PL,Dort JM,Shen LY,Helmer SD,Smith RS.What is normal intraabdominal pressure?Am Surg 2001;67:243-248[PMID:11270882]
8刘丽蕾,王湘英.重症急性胰腺炎合并腹腔间隔室综合征诊治现状.中华胰腺病杂志2014;14:139-143
9乐冬友,张阳德,王志英,郑翼德,乐园,赵志坚.腹部创伤后24h晶体液量与腹腔间隔室综合征的关系分析.中国医学工程2006;14:58-60
10袁璐.无痛胃肠镜致不完全性肠梗阻合并腹腔间隔室综合征1例.现代中西医结合杂志2011;20:1125-1126
11戴毅敏,凌静娴,王志群,李荣,顾宁,郑明明.胡娅莉大量产后出血致腹腔间隔室综合征一例.中华围产医学杂志2014;17:286-287
12张建平,倪家连,刘晓明.肝移植术后腹腔高压致腹腔间隔室综合征2例.世界华人消化杂志2011;19:758-760
13卢秀波,许雅娟,马秀现,许培钦.布-加综合征继发腹腔间隔室综合征的处理.中国普通外科杂志2001;10:166-168
14 Kendrick JE,Leath CA,Melton SM,Straughn JM.Use of a fascial prosthesis for management of abdominal compartment syndrome secondary to obstetric hemorrhage.Obstet Gynecol 2006;107:493-496[PMID:16449161 DOI:10.1097/01.AOG.0000168445.41145.7b]
15王丽,谢镒鞠,唐小唪,王正刚,刘道城,张连阳,葛衡江.创伤失血性休克后腹腔高压对心肺基础监测指标的影响.第三军医大学学报2013;35:2159-2163
16余剑,付晓娟,张连阳.腹内高压症对机体病理生理影响的研究进展.解放军医药杂志2013;25:23-27
17 Malbrain ML,Cheatham ML,Kirkpatrick A,Sugrue M,Parr M,De Waele J,Balogh Z,Leppaniemi A,Olvera C,Ivatury R,D'Amours S,Wendon J,Hillman K,Johansson K,Kolkman K,Wilmer A.Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome.Ⅰ.Definitions.Intensive Care Med 2006;32:1722-1732[PMID:16967294 DOI:10.1007/s00134-006-0349-5]
18 De Waele JJ,Cheatham ML,Malbrain ML,Kirkpatrick AW,Sugrue M,Balogh Z,Ivatury R,De Keulenaer B,Kimball EJ.Recommendations for research from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome.Acta Clin Belg 2009;64:203-209[PMID:19670559 DOI:10.1179/acb.2009.036]
19江利冰,张茂,马岳峰.腹腔高压和腹腔间隔室综合征诊疗指南(2013版).中华急诊医学杂志2013;22:839-841
20徐伟,Pierre M.ICU患者腹内压和腹腔灌注压影响因素分析.中国医药2007;2:605-607
21张志红.恶性腹水的研究进展.中国肿瘤临床与康复2008;15:380-381
22陈庆仁,贺赐平,李湖潮.血性腹水45例临床分析.中国医师杂志2003;5:1050-1051
23杨显文,姜海行,卢威顺,陈梅,卢东红,黄小丽,王家旭,覃山羽.Th22细胞在肝癌恶性腹水中的发病机制.世界华人消化杂志2014;22:5069-5078
24 Saif MW,Siddiqui IA,Sohail MA.Management of ascites due to gastrointestinal malignancy.Ann Saudi Med 2009;29:369-377[PMID:19700895 DOI:10.4103/0256-4947.55167]
25 Becker G.Medical and palliative management of malignant ascites.Cancer Treat Res 2007;134:459-467[PMID:17633074 DOI:10.1007/978-0-387-48993-3_31]
26 Hu L,Ferrara N,Jaffe RB.Paracrine VEGF/VEcadherin action on ovarian cancer permeability.Exp Biol Med(Maywood)2006;231:1646-1652[PMID:17060686]
27米登海,陈学鹏.腹腔内化疗治疗恶性腹水.国际肿瘤学杂志2006;33:854-867
28 Schafer M,Sagesser H,Reichen J,Kr(a|")henb(u|")hl L.Alterations in hemodynamics and hepatic and splanchnic circulation during laparoscopy in rats.Surg Endosc 2001;15:1197-1201[PMID:11443454DOI:10.1007/S004640080159]
29吴伟,朱维铭,李宁.腹内高压对门静脉压、中心静脉压影响的实验研究.消化外科2006;5:266-268
30 Varela JE,Cohn SM,Giannotti GD,Dolich MO,Ramon H,Wiseberg JA,McKenney M.Near-infrared spectroscopy reflects changes in mesenteric and systemic perfusion during abdominal compartment syndrome.Surgery 2001;129:363-370[PMID:11231465 DOI:10.1067/msy.2001.111695]
31 Cheatham ML,Malbrain ML.Cardiovascular implications of abdominal compartment syndrome.Acta Clin Belg 2007;62 Suppl 1:98-112[PMID:24881706 DOI:10.1179/acb.2007.62.s1.013]
32 Berger P,Nijsten MW,Paling JC,Zwaveling JH.The abdominal compartment syndrome:a complication with many faces.Neth J Med 2001;58:197-203[PMID:11334680 DOI:10.1016/S0300-2977(01)00104-8]
33 Kopelman T,Harris C,Miller R,Arrillaga A.Abdominal compartment syndrome in patients with isolated extraperi to neal injuries.J Trauma2000;49:744-747;discussion 747-749[PMID:11038095 DOI:10.1097/00005373-200010000-00025]
34 Pelosi P,Quintel M,Malbrain ML.Effect of intraabdominal pressure on respiratory mechanics.Acta Clin Belg 2007;62 Suppl 1:78-88[PMID:24881704 DOI:10.1179/acb.2007.62.sl.011]
35 Quintel M,Pelosi P,Caironi P,Meinhardt JP,Luecke T,Herrmann P,Taccone P,Rylander C,Valenza F,Carlesso E,Gattinoni L.An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury.Am J Respir Crit Care Med 2004;169:534-541[PMID:14670801DOI:10.1164/rccm.200209-1060OC]
36 van Minnen LP,Blom M,Timmerman HM,Visser MR,Gooszen HG,Akkermans LM.The use of animal models to study bacterial translocation during acute pancreatitis.J Gastrointest Surg2007;11:682-689[PMID:17468930 DOI:10.1007/s11605-007-0088-0]
37程君涛,肖光夏,夏培元,袁建成,秦孝建.腹内高压对兔肠道通透性及内毒素细菌移位的影响.中华烧伤杂志2003;19:229-232
38赵晓琴,秦志丹,邝晓聪,陈英,莫非,陈强,吴英林,覃桦,蒙永毅,叶永康.SD大鼠腹腔高压动物模型建立及肝损伤的实验研究.中华急诊医学杂志2013;22:1127-1131
39王宏业,尉继伟.腹腔高压动物模型肝脏的继发改变.世界华人消化杂志2016;24:1393-1397
40巩鹏,许海波,张嘉宁,王忠裕.PPARs/NF-Kb及SOD在梗阻性黄疸大鼠肝脏损害中的作用.中华肝胆外科杂志2010;16:620-623
41 Ganeshanantham G,Walsh SR,Varty K.Abdominal compartment syndrome in vascular surgery-A review.Int J Surg 2010;8:181-185[PMID:20074677 DOI:10.1016/j.ijsu.2010.01.001]
42 Schachtrupp A,Toens Ch,Hoer J,Klosterhalfen B,Lawong AG,Schumpelick V.A 24-h pneumoperitoneum leads to multiple organ impairment in a porcine model.J Surg Res 2002;106:37-45[PMID:12127806 DOI:10.1006/jsre.2002.6421]
43王宏业,尉继伟,杨靖.改良腹腔高压水嚢动物模型肝、肾病理改变.中国实用医刊2015;42:62-65
44莫非,赵晓琴,黄宗海,韦宇宁,曾湖,黄明权.腔高压对大鼠肝功能的独立影响.蛇志2013;25:6-8
45王正刚,王丽,孙士锦,刘道城,张连阳.腹腔扩容术治疗猪失血性休克复苏后腹腔高压对肝脏的影响.解放军医学杂志2012;37:104-108
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