女性宫颈病变患者HPV感染分布特点meta分析
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摘要
目的分析女性宫颈病变患者HPV感染分布特点,了解高危HPV型别,以便有针对性进行预防和诊治。方法通过知网、万方、维普等查询期刊和论文,并参考相关宫颈病变mate分析文献,对全国范围内宫颈病变患者HPV感染分布进行统计分析,对不同型别的HPV在不同组织类别中的感染率进行比较,筛选高危型别进行进一步的差异分析。结果慢性宫颈炎患者HPV感染率为26. 99%,宫颈上皮内瘤样变患者HPV感染率为86. 94%,宫颈癌患者HPV感染率为94. 09%,三者差异有统计学意义(P <0. 05)。12种高危HPV型别中,综合感染率前五的HPV型别依次是HPV16> HPV18> HPV58> HPV52> HPV31,感染率分别为58. 75%、6. 04%、4. 33%、2. 97%、2. 28%;对比分析前三位高危型HPV16、18、58在慢性宫颈炎组和宫颈病变组的感染率差异,HPV16、HPV18在慢性宫颈炎组和宫颈病变组感染率差异有统计学意义(P <0. 05),HPV58在慢性宫颈炎组和宫颈病变组感染率差异无统计学意义(P> 0. 05)。结论不同型别的HPV在不同组织类别中的分布有差异,这种差异可以用来有针对性地研制疫苗,达到对宫颈癌更好的预防和治疗。
Objective To analyze the distribution of HPV infection in women with cervical lesions. Know the type of high-risk HPV,in order to facilitate targeted prevention and treatment. Methods By means of journals,essays and other related journals and papers,and referring to the relevant mate analysis of cervical lesions,the statistical analysis of the distribution of HPV infection in patients with cervical lesions across the country was carried out. In different types of HPV,Infection rate comparison,screening for high-risk type for further analysis of differences. Results HPV infection rate was 26. 99% in patients with chronic cervicitis,HPV infection rate in cervical intraepithelial neoplasia was 86. 94%,HPV infection rate in cervical cancer was94. 09%,the difference was statistically significant( P < 0. 05). Among the 12 high-risk HPV types,the HPV types with the highest comprehensive infection rates were HPV16 > HPV18 > HPV58 > HPV52 > HPV31 in succession,and the infection rates were 58. 75%,6. 04%,4. 33%,2. 97% and 2. 28% The infection rates of HPV16,HPV18 and HPV18 in patients with chronic cervicitis and cervical lesions were significantly different( P < 0. 05). The infection rate of HPV58 in patients with chronic cervicitis and cervical lesions was significantly different Cervicitis group and cervical lesions group infection rate difference was not statistically significant( P > 0. 05). Conclusion There are differences in the distribution of different types of HPV in different tissue types. This difference can be used to develop targeted vaccines to achieve better prevention and treatment of cervical cancer.
Objective To analyze the distribution of HPV infection in women with cervical lesions. Know the type of high-risk HPV,in order to facilitate targeted prevention and treatment. Methods By means of journals,essays and other related journals and papers,and referring to the relevant mate analysis of cervical lesions,the statistical analysis of the distribution of HPV infection in patients with cervical lesions across the country was carried out. In different types of HPV,Infection rate comparison,screening for high-risk type for further analysis of differences. Results HPV infection rate was 26. 99% in patients with chronic cervicitis,HPV infection rate in cervical intraepithelial neoplasia was 86. 94%,HPV infection rate in cervical cancer was94. 09%,the difference was statistically significant( P < 0. 05). Among the 12 high-risk HPV types,the HPV types with the highest comprehensive infection rates were HPV16 > HPV18 > HPV58 > HPV52 > HPV31 in succession,and the infection rates were 58. 75%,6. 04%,4. 33%,2. 97% and 2. 28% The infection rates of HPV16,HPV18 and HPV18 in patients with chronic cervicitis and cervical lesions were significantly different( P < 0. 05). The infection rate of HPV58 in patients with chronic cervicitis and cervical lesions was significantly different Cervicitis group and cervical lesions group infection rate difference was not statistically significant( P > 0. 05). Conclusion There are differences in the distribution of different types of HPV in different tissue types. This difference can be used to develop targeted vaccines to achieve better prevention and treatment of cervical cancer.
引文
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[25]万晓春,杨慧娟,周晓燕,等.高危型HPV亚型及亚型组合检测宫颈癌及高级别宫颈上皮内瘤变的比较研究[J].中国癌症杂志,2014,24(5):342-348.
[26]强萍,陈丽娟,陈萍.宫颈液基细胞学联合阴道镜下活检对子宫颈病变的诊断价值[J].中国妇幼保健,2013,28(1):172-173.
[27]庄晴晴,王常玉.新辅助化疗与单纯手术在局部晚期宫颈癌患者中的疗效对比分析[J].现代妇产科进展,2016,25(7):7-10.
[28]Wang N,Wei H,Yin D,et al.MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.[J].Tumor Biology,2016,37(4):1-10.
[29]李萱,刘颖群,方兆武.P16、Ki67和cyclin D1在宫颈癌中的表达及TCT与HPV-DNA检查在宫颈癌早期诊断中的研究[J].中国妇幼保健,2016,31(4):829-831.
[30]Iwata T,Miyauchi A,Suga Y,et al.Neoadjuvant chemotherapy for locally advanced cervical cancer[J].中国癌症研究(英文版),2016,51(2):235-240.
[31]Turkistanli EC,Sogukpinar N,Saydam BK,et al.Cervical cancer prevention and early detection--the role of nurses and midwives[J].AAPJCP,2016,4(1):15-21.
[2]Sukumar P,Gnanamurthy RK.Computer aided detection of cervical cancer using pap smear images based on adaptive neuro fuzzy inference system classifier[J].JMIH,2016,6(2):312-319.
[3]Liu S,Song L,Zeng S,et al.MALAT1-miR-124-RBG2 axis is involved in growth and invasion of HR-HPV-positive cervical cancer cells[J].Tumor Bio,2016,37(1):633-640.
[4]Cao Y,Liu Y,Lu X,et al.Upregulation of long noncoding RNA SPRY4-IT1 correlates with tumor progression and poor prognosis in cervical cancer[J].Febs Open Bio,2016,6(9):954.
[5]熊洋,司民真,高飞,等.基于NIR-SERS光谱技术分析宫颈癌氧合血红蛋白[J].中国激光,2015,42(1):332-341.
[6]刘少晓,程晓燕,郑红枫,等.紫杉醇联合顺铂新辅助治疗局部晚期宫颈癌的临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(6):432-434.
[7]李萱,张莉,刘颖群.盐酸伊立替康联合顺铂方案对宫颈癌患者宫颈上皮组织Bcl-2及MACC1蛋白表达的影响[J].中国生化药物杂志,2015,35(11):86-88.
[8]杨丽娟,姚宇峰,严志凌,等.HPV16型E6、E7变异与宫颈癌发生发展的研究进展[J].现代肿瘤医学,2016,24(11):1829-1832.
[9]马春华,玛依努尔.宫颈锥切术在诊治宫颈上皮内瘤变的临床分析[J].新疆医学,2013,43(10):18-20.
[10]蒋晓芳,林山,卢航超,等.宫颈癌应用放化疗联合复方苦参注射液治疗对细胞免疫功能影响分析[J].中国医院药学杂志,2016,36(2):119-121.
[11]张琴,孙青.TCT、HPV检测在宫颈病变筛查中的应用价值[J].皖南医学院学报,2015,14(5):455-458.
[12]揭伟霞,薛武进,史志华,等.宫颈上皮内瘤变与宫颈癌患者人乳头状瘤病毒感染的临床分析[J].中华医院感染学杂志,2016,26(6):1380-1381.
[13]常凯凯,杨慧丽,周文洁,等.缺氧通过刺激胸腺基质淋巴细胞生成素分泌促进宫颈癌细胞体外侵袭[J].中国临床医学,2017,24(2):161-165.
[14]熊洋,司民真,高飞,等.基于NIR-SERS光谱技术分析宫颈癌氧合血红蛋白[J].中国激光,2015,42(1):332-341.
[15]罗招云,杨立业,林敏,等.潮州地区高危型HR-HPV感染与子宫颈病变的关系[J].临床与实验病理学杂志,2011,27(9):962-965.
[16]刘慧强.231例宫颈病变中人乳头瘤病毒感染情况分析[J].临床医药实践,2011,20(3):178-182.
[17]段蒙.HPV16 E6变异在天津市筛查人群和宫颈病变患者中的研究[D].天津医科大学,2015.
[18]陈志芳,杜蓉,韩英,等.维吾尔族宫颈癌人乳头瘤病毒感染与CD4+CD25+CD127-调节性T细胞的相关性研究[J].实用妇产科杂志,2011,27(6):439-443.
[19]杨丹.MRI对宫颈癌的诊断运用分析[J].中国性科学,2013,22(6):12-14.
[20]王芹,许海燕,孙辉.拓扑替康治疗宫颈癌的实验研究[J].医学信息,2011,24(20):6781-6782.
[21]李雁青.河南384例宫颈上皮内病变HPV感染型别及危险因素调查[D].郑州大学,2012.
[22]田玉旺,刘光,周建,等.细胞DNA定量分析技术在宫颈癌及癌前病变早期筛查中的应用价值[C].北方四战区病理学术会议,2014.
[23]周爱芬.武汉市农村户籍妇女宫颈癌筛查及影响因素研究[D].华中科技大学,2014.
[24]杜晓辉.CIN患者HPV感染亚型特点及宫颈锥切术后HPV感染转阴相关因素的研究[D].大连医科大学,2013.
[25]万晓春,杨慧娟,周晓燕,等.高危型HPV亚型及亚型组合检测宫颈癌及高级别宫颈上皮内瘤变的比较研究[J].中国癌症杂志,2014,24(5):342-348.
[26]强萍,陈丽娟,陈萍.宫颈液基细胞学联合阴道镜下活检对子宫颈病变的诊断价值[J].中国妇幼保健,2013,28(1):172-173.
[27]庄晴晴,王常玉.新辅助化疗与单纯手术在局部晚期宫颈癌患者中的疗效对比分析[J].现代妇产科进展,2016,25(7):7-10.
[28]Wang N,Wei H,Yin D,et al.MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.[J].Tumor Biology,2016,37(4):1-10.
[29]李萱,刘颖群,方兆武.P16、Ki67和cyclin D1在宫颈癌中的表达及TCT与HPV-DNA检查在宫颈癌早期诊断中的研究[J].中国妇幼保健,2016,31(4):829-831.
[30]Iwata T,Miyauchi A,Suga Y,et al.Neoadjuvant chemotherapy for locally advanced cervical cancer[J].中国癌症研究(英文版),2016,51(2):235-240.
[31]Turkistanli EC,Sogukpinar N,Saydam BK,et al.Cervical cancer prevention and early detection--the role of nurses and midwives[J].AAPJCP,2016,4(1):15-21.