氨基磺酸乙基纤维素微胶囊的制备及缓释性能
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摘要
以氨基磺酸(SA)为芯材、乙基纤维素(EC)为壁材,采用油相相分离法制备了EC/SA微胶囊。研究了EC黏度、芯壁质量比及搅拌速率等因素对微胶囊包封率的影响。利用红外光谱(FT-IR)、扫描电镜(SEM)对所得微胶囊进行表征,并测试其在不同温度下的缓释性。最佳工艺条件为:EC黏度为180～220 m Pa·s、芯壁比为10∶3、搅拌速率为500 r/min。红外光谱和扫描电镜结果表明,氨基磺酸被成功包覆于乙基纤维素内。释放实验结果表明,在80℃时释放率为78. 13%;随着释放环境温度的升高,微胶囊释放速率和累积释放率均增加,缓释时间可达80 min,满足现场施工需求,可实现地层深部酸化;对微胶囊释放效果进行数学拟合,结果表明,释放模型符合一级动力学模型,释放行为主要受囊芯从囊壁中延缓扩散控制。
EC/SA microcapsules are prepared through oil phase separation method using sulfamic acid( SA) as core material and ethyl cellulose( EC) as wall material.The effects of EC viscosity,core/wall ratio and stirring rate on the encapsulation efficiency of microcapsules are studied. The obtained microcapsules are characterized by FT-IR and SEM,and tested at different temperatures. The optimum process conditions are gained as follows: EC viscosity is in the range of 180-220 MPa·s,the ratio of core to wall is 10 ∶3 and stirring rate is 500 r·min-1.Results from FT-IR and SEM indicate that sulfamic acid is successfully coated into ethyl cellulose. The release test results show that the release rate reaches 78. 13% at 80℃; the release rate and cumulative release rate of microcapsules both increase with the release of ambient temperature,and the sustained release time can reach up to 80 min,which can meet the on-site construction requirements and realize deep acidification. Through mathematically fitting the microcapsule release effect,the results show that the release model conforms to the first-order kinetic model,indicating that the release behavior is controlled mainly by the slow diffusion of core from capsule wall.
EC/SA microcapsules are prepared through oil phase separation method using sulfamic acid( SA) as core material and ethyl cellulose( EC) as wall material.The effects of EC viscosity,core/wall ratio and stirring rate on the encapsulation efficiency of microcapsules are studied. The obtained microcapsules are characterized by FT-IR and SEM,and tested at different temperatures. The optimum process conditions are gained as follows: EC viscosity is in the range of 180-220 MPa·s,the ratio of core to wall is 10 ∶3 and stirring rate is 500 r·min-1.Results from FT-IR and SEM indicate that sulfamic acid is successfully coated into ethyl cellulose. The release test results show that the release rate reaches 78. 13% at 80℃; the release rate and cumulative release rate of microcapsules both increase with the release of ambient temperature,and the sustained release time can reach up to 80 min,which can meet the on-site construction requirements and realize deep acidification. Through mathematically fitting the microcapsule release effect,the results show that the release model conforms to the first-order kinetic model,indicating that the release behavior is controlled mainly by the slow diffusion of core from capsule wall.
引文
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[15]Jucelio Kilinski Tavares,Ant8nio Augusto Ulson de Souza,JoséVladimir de Oliveira,et al.Modeling of the controlled release of betacarotene into anhydrous ethanol from microcapsules[J]. Opaen Nano,2016,5(1):25-35.
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[17]Paulo Costa,Jose Manuel Sousa Lobo.Modeling and comparison of dissolution profiles[J]. EuropeanJournal of Pharmaceutical Sciences,2001,13(2):123-133.
[2]刘有权,王琳,熊颖,等.高温碳酸盐岩缓速酸酸液体系研究[J].石油与天然气化工,2011,(4):367-369.
[3]Wang Bo.Sulfamic acid:A very useful catalyst[J].Synlett,2005,(8):1342.
[4]Latnikova A,Jobmann M.Towards microcapsules with improved barrier properties[J].Top Curr Chem,2017,375(3):64-66.
[5]张可达,徐冬梅,王平.微胶囊化方法[J].功能高分子学报,2011,14(14):474-480.
[6]Benita S. Microencapsulation:Methods and industrial applications[M].USA:CRC Press,2006.
[7]Dowding P J,Atkin R,Vincent B,et al.Oil core/polymer shell microcapsules by internal phase separayion from emulsion droplets[J].Langmuir,2005,21(12):5278-5284.
[8]Sirpa Tirkkonen,Perreri Paronen.Enhancement of drug release from ethylcellulos microcapsules using solid sodium chloride in the wall[J].International Journal of Pharmaceutics,1992,(88):39-51.
[9]冯俊婷,贺艳,邹微,等.HG/T 2527—2011.工业氨基磺酸[S].北京:化学工业出版社,2011.
[10]Wang Xiuli,Deng Xiaofang.Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug[J]. Journal of Pharmaceutical Practice,2014,32(2):114-117.
[11]Omran M F,Suwayeh S A,Helw A M.Taste masking of diclofenac sodium using microencapsulation[J].Journal of Microencapsulation,2002,19(1):45-52.
[12]True L Rogers,Dave Wallick.Reviewing the use of ethylcellulose,methylcellulose and hypromellose in microencapsulation[J]. Drug Development and Industrial Pharmacy,2012,38(2):129-157.
[13]李书国,薛文通,李雪梅,等.乙基纤维素微胶囊化VC工艺参数及其活性保护的研究[J].食品添加剂,2005,26(5):143-148.
[14]许时婴,张晓鸣,夏书芹.微胶囊化技术原理与应用[M].北京:化学工业出版社,2006:65-70.
[15]Jucelio Kilinski Tavares,Ant8nio Augusto Ulson de Souza,JoséVladimir de Oliveira,et al.Modeling of the controlled release of betacarotene into anhydrous ethanol from microcapsules[J]. Opaen Nano,2016,5(1):25-35.
[16]Hadi Mohammadi,Walter Herzog.A novel model for diffusion based release kinetics using an inverse numerical method[J].Medical Engineering&Physics,2011,33(8):893-899.
[17]Paulo Costa,Jose Manuel Sousa Lobo.Modeling and comparison of dissolution profiles[J]. EuropeanJournal of Pharmaceutical Sciences,2001,13(2):123-133.