藻酸衍生物在生物医药领域的研究进展
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摘要
海藻酸衍生物作为1种性能优异的高分子生物材料被广泛应用于生物医药领域。本文描述了藻酸衍生物材料的特征优势、结构和性质之间的比较。着重从伤口敷料、组织工程、药物缓释和细胞微囊化4个方面对近几年藻酸衍生物材料在生物医药领域的研发与应用进行综述。
As a kind of environment-friendly polymer biomaterials,aglinic acid and its derivatives have been widely used in biomedicine due to their good hygroscopicity,gelling obstruction,oxygen permeability,biocompatibility,biodegradability and low toxicity.In this paper,the characteristics,advantages,comparison between structure and property and potential applications of alginate biomaterials were described,the modification of alginate biomaterials was discussed.The development and application of alginic acid biomaterials in the field of biological medicine in recent years were reviewed from four aspects:wound dressing,tissue engineering materials,drug delivery carrier and cellular microencapsulation technology,The aim was to provide some reference information for the research of polymer field.
As a kind of environment-friendly polymer biomaterials,aglinic acid and its derivatives have been widely used in biomedicine due to their good hygroscopicity,gelling obstruction,oxygen permeability,biocompatibility,biodegradability and low toxicity.In this paper,the characteristics,advantages,comparison between structure and property and potential applications of alginate biomaterials were described,the modification of alginate biomaterials was discussed.The development and application of alginic acid biomaterials in the field of biological medicine in recent years were reviewed from four aspects:wound dressing,tissue engineering materials,drug delivery carrier and cellular microencapsulation technology,The aim was to provide some reference information for the research of polymer field.
引文
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[2]钱树本,刘东艳,孙军.海藻学[M].青岛:中国海洋大学出版社,2005:53-85.
[3]秦益民.海藻酸盐纤维的开发和应用[J].成都纺织高等专科学校学报,2016,33(1):19-23.
[4]Geddie J L,Sutherland I W.The effect of acetylation on cation binding by algal and bacterial alginates[J].Biotechnol Appl Biochem,1994,20(8):117-129.
[5]Pacheco-Leyva I,Pezoa F G,Díaz-Barrera A.Alginate biosynthesis in azotobacter vinelandii:overview of molecular mechanisms in connection with the oxygen availability[J].Int J Polym Sci,2016,4:1-12.
[6]张苹,卢凌彬,曹阳.海藻酸盐水凝胶在组织工程中的研究[J].功能材料,2007,38(5):1954-1956.
[7]De V P,De H B,Van S R.Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules[J].Biomaterials,1997,18(3):273-278.
[8]Li D,Lv C,Liu L,et al.Egg-Box structure in cobalt alginate:a new approach to multifunctional hierarchical mesoporous N-Doped carbon nanofibers for efficient catalysis and energy storage[J].Acs Central Sci,2015,1(5):261-269.
[9]Lee K Y,Rowley J A,Eiselt P,et al.Controlling mechanical and swelling properties of alginate hydrogels independently by cross-linker type and cross-linking density[J].Macromolecules,2000,33(11):4291-4294.
[10]苏晓樱.海藻酸及其衍生物的应用进展[J].科技创新与应用,2017(10):50.
[11]Chhatbar M U,Meena R,Prasad K,et al.Microwave-induced facile synthesis of water-soluble fluorogenic alginic acid derivatives[J].Carbohyd Res,2011,346(5):527-533.
[12]Lee K Y,Mooney D J.Alginate:properties and biomedical applications[J].Prog Polym Sci,2012,37(1):106-126.
[13]张珠,易继凌,殷义霞,等.新型海藻酸盐湿性敷料的制备及其生物相容性[J].武汉大学学报(理学版),2015,61(3):208-212.
[14]王琰,陈长平,梁君荣,等.海藻酸盐医用敷料的研究进展[J].中国海洋药物,2015,34(4):109-114.
[15]王清华,钟文菲,何盟.藻酸盐敷料的临床应用:与传统材料特征的比较[J].中国组织工程研究与临床康复,2010,14(3):533-536.
[16]秦益民.海藻酸盐医用敷料的临床应用[J].纺织学报,2014,35(4):148-153.
[17]Winter G D.Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig[J].J Wound Care,1995,193(8):366-367.
[18]秦益民,朱长俊,冯德明,等.海藻酸钙医用敷料与普通棉纱布的性能比较[J].纺织学报,2007,28(3):45-48.
[19]Sood A,Granick M S,Tomaselli N L.Wound dressings and comparative effectiveness data[J].Adv Wound Care,2014,3(8):511-529.
[20]李晓明,刘苹,张波.创面敷料的研究现状[J].重庆医学,2017,46(20):2851-2853.
[21]王超,李普旺,李思东,等.壳聚糖/海藻酸盐作为新型止血材料的研究进展[J].高分子通报,2016,7:30-36.
[22]初晓夏.海藻酸盐纤维医用止血敷料的评价研究[D].青岛:青岛大学,2016.
[23]许冠哲.改性海藻酸钠水凝胶的制备及其在止血剂与医用敷料中的应用[D].上海:华东理工大学,2017.
[24]Khanna P K,Subbarao V.Nanosized silver powder via reduction of silver nitrate by sodium formaldehydesulfoxy late in acidic pH medium[J].Mater Lett,2003,57(15):2242-2245.
[25]Mokhena T C,Luyt A S.Electrospun alginate nanofibres impregnated with silver nanoparticles:Preparation,morphology and antibacterial properties[J].Carbohyd Polym,2017,165:304-312.
[26]李小军,顾其胜,王庆生,等.含银海藻酸盐敷料理化性质及其抗菌性能的研究[J].军事医学,2016,40(7):564-568.
[27]刘龙清,高培军,王红梅,等.一种含复合银锌抗菌剂的藻酸盐敷料及其制备方法:中国,104940980A[P].2015-9-30.
[28]葛芸伶.生物材料在新型医用敷料中的应用[J].明胶科学与技术,2016,2:65-69.
[29]徐文.纤维级海藻酸钠原料及纺丝效果分析[D].青岛:青岛大学,2013.
[30]朱平,王柳,张传杰,等.海藻酸钙纤维的结构与性能[J].合成纤维工业,2009,32(6):1-4.
[31]张正男,韩立涛,敖宁建.一种治疗褥疮的海藻酸盐敷料及其制备方法:中国,104758977A[P].2015-9-30.
[32]卢亢,陈锦涛,熊亮.一种高效吸液止血的复合型敷料及其制备方法:中国,107115555A[P].2017-9-01.
[33]Rafiq M,Hussain T,Abid S,et al.Development of sodium alginate/PVA antibacterial nanofibers by the incorporation of essential oils[J].Mater Res Express,2018,5(3):1-34.
[34]Zhang R,Guo J,Liu Y,et al.Effects of sodium salt types on the intermolecular interaction of sodium alginate/antarctic krill protein composite fibers[J].Carbohyd Polym,2018,189:72-78.
[35]罗淳译.天然高分子材料在组织工程中的应用[J].广东化工,2018,1:139-140.
[36]Ahn S,Lee H,Bonassar L J,et al.Cells(MC3T3-E1)-laden alginate scaffolds fabricated by a modified solid-freeform fabrication process supplemented with an aerosol spraying[J].Biomacromolecules,2012,13(9):2997-3003.
[37]Peak C W,Wilker J J,Schmidt G.A review on tough and sticky hydrogels[J].Colloid Polym Sci,2013,291(9):2031-2047.
[38]Hoffman A S.Hydrogels for biomedical applications[J].Adv Drug Deliver Rev,2012,64:18-23.
[39]Giri T K,Thakur D,Alexander A,et al.Alginate basedhydrogel as a potential biopolymeric carrier for drug delivery and cell delivery systems:present status and applications[J].Curr Drug Deliv,2012,9(6):539-555.
[40]颜慧琼,陈秀琼,李嘉诚,等.海藻酸盐水凝胶作为组织工程支架材料改性与应用研究进展[J].化工新型材料,2017(3):28-30.
[41]Pawar S N,Edgar K J.Alginate derivatization:a review of chemistry,properties and applications[J].Biomaterials,2012,33(11):3279-3305.
[42]Luo Y,Li Y,Qin X,et al.3Dprinting of concentrated alginate/gelatin scaffolds with homogeneous nano apatite coating for bone tissue engineering[J].Mater Design,2018,146:12-19.
[43]Yan H,Chen X,Feng M,et al.Layer-by-layer assembly of3Dalginate-chitosan-gelatin composite scaffold incorporating bacterial cellulose nanocrystals for bone tissue engineering[J].Mater Lett,2017,209:492-496.
[44]阮长顺,罗桂林,吴明明,等.改性海藻酸或其盐及制备方法、生物修复材料及支架:中国,106589161A[P].2017-4-26.
[45]Vignesh S,Gopalakrishnan A,Poorna M R,et al.Fabrication of micropatterned alginate-gelatin and k-carrageenan hydrogels of defined shapes using simple wax mould method as a platform for stem cell/induced Pluripotent Stem Cells(iPSC)culture[J].Int J Biol Macromol,2018,112:737-744.
[46]Marrella A,Lagazzo A,Barberis F,et al.Enhanced mechanical performances and bioactivity of cell laden-graphene oxide/alginate hydrogels open new scenario for articular tissue engineering applications[J].Carbon,2017,115:608-616.
[47]杜高来.高强韧功能水凝胶的制备及其应用[D].宁波:中国科学院宁波材料技术与工程研究所,2016.
[48]王勇,解玉冰,马小军.壳聚糖/海藻酸钠生物微胶囊的研究进展[J].中国生物工程杂志,1999,19(2):13-20.
[49]徐一驰,赵楚翘,刘志辉.海藻酸钠/壳聚糖微载体的研究进展[J].中国生物制品学杂志,2018,3:332-335.
[50]Mcclements D J.Designing biopolymer microgels to encapsulate,protect and deliver bioactive components:Physicochemical aspects[J].Adv Colloid Interfac,2016,240:31-59.
[51]Andhariya J V,Burgess D J.Recent advances in testing of microsphere drug delivery systems[J].Expert Opin Drug Del,2016,13(4):593-608.
[52]Mujtaba A,Ali M,Kohli K.Formulation of extended release cefpodoxime proxetil chitosan-alginate beads using quality by design approach[J].Int J Biol Macromol,2014,69(8):420-429.
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