火焰原子吸收法测定复方利血平片中的泛酸钙

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英文篇名：Determination of calcium pantothenate in Compound reserpine tablets by Flame atomic absorption spectrometry 作者：张晓栋 ; 范婷婷 英文作者：ZHANG Xiaodong;FAN Tingting;Changzhou Food and Drug Supervision and Inspection Center; 关键词：火焰原子吸收测定法 ; 含量测定 ; 泛酸钙 ; 钙 ; 复方利血平片 ; 微波消解 ; 氯化锶 ; 掩蔽剂 英文关键词：Flame atomic absorption spectrometry;;Content determination;;Calcium pantothenate;;Calcium;;Compound reserpine tablets;;Microwave digestion;;Strontium chloride;;Masking agent 中文刊名：HXYO 英文刊名：West China Journal of Pharmaceutical Sciences 机构：常州市食品药品监督检验中心; 出版日期：2019-01-22 14:33 出版单位：华西药学杂志 年：2019 期：v.34 语种：中文; 页：HXYO201901019 页数：2 CN：01 ISSN：51-1218/R 分类号：83-84

摘要

目的采用火焰原子吸收法测定复方利血平片中泛酸钙的含量。方法以微波消化法消解样品,以氯化锶作为掩蔽剂,采用火焰原子吸收法测定复方利血平片中泛酸钙的含量。结果 5. 37～42. 96μg·mL~(-1)泛酸钙与吸光度的线性关系良好(r=0. 9999),平均回收率为97. 3%,RSD=2. 1%(n=9)。结论所用方法准确、可靠、方便,可用于复方利血平片中泛酸钙的含量测定及质量控制,同时也为同类产品的测定提供了参考依据。
        OBJECTIVE To determine calcium pantothenate in Compound reserpine tablets( CRT) by Flame atomicabsorption spectrometry( FAAS). METHODS The samples were digested by microwave digestion,and strontium chloride wasused as a masking agent. Calcium pantothenate in CRT was determined by FAAS. RESULTS There was a good linearrelationship of calcium pantothenate within the range of 5. 37-42. 96 μg·mL~(-1)(r = 0. 9999). The average recovery of calciumpantothenate was 97. 3% with the RSD of 2. 1%( n = 9). CONCLUSION The method is accurate,reliable and convenient,hence can be used for the determination of calcium pantothenate in CRT and the quality control. It also provides reference for thedetermination of similar products.

引文

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