红核妇洁洗液联合硝呋太尔制霉菌素阴道软胶囊治疗外阴阴道假丝酵母菌病的疗效观察
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摘要
目的观察红核妇洁洗液联合硝呋太尔制霉菌素阴道软胶囊治疗外阴阴道假丝酵母菌病的临床疗效。方法选取2016年11月至2017年5月于武汉市妇幼保健院就诊的外阴阴道假丝酵母菌病(VVC)病人90例,按随机数字表法分为研究组与对照组,每组45例。研究组采用红核妇洁洗液雾化联合硝呋太尔制霉菌素阴道软胶囊治疗,对照组采用红核妇洁洗液治疗,记录一个疗程结束后7～14 d及治疗后1个月月经干净3～7 d的常规妇科检查及分泌物检查结果,将治疗结果按照治愈、显效、好转、无效进行分析。结果研究组和对照组治疗后7～14 d常规行妇科检查及分泌物检查结果显示,痊愈率分别为34.15%和11.63%(χ~2=6.081,P=0.014);研究组总有效率(51.22%)明显高于对照组(25.58%),差异有统计学意义(χ~2=5.850,P<0.016)。研究组与对照组治疗后1个月月经干净3～7 d常规行妇科检查及分泌物检查结果显示,痊愈率分别为39.02%、13.95%,差异有统计学意义(χ~2=6.824,P=0.009);研究组总有效率(56.10%)明显高于对照组(32.56%),差异有统计学意义(χ~2=4.719,P=0.030)。结论红核妇洁洗液联合硝呋太尔制霉菌素阴道软胶囊治疗VVC疗程短,疗效显著,是治疗VVC安全有效的方案,可在临床上推广使用。
Objective To observe the clinical efficacy of the treatment with Honghefujie lotion combined with Nifuratel nysfungin vaginal soft capsules on vulvovaginal candidiasis.Methods Ninety cases of patients who underwent the treatment of vulvovaginal candidiasis(VVC) in Wuhan Maternal and Child Health Hospital from November 2016 to May 2017 were selected and assigned into control group and experimental group using random number table method,with 45 cases in each group.Experimental group was treated by Honghefujie lotioncombined with Nifuratel nysfungin vaginal soft capsules,while control group adopted Honghefujie lotion in the treatment of VVC;7 to 14 days after completion of a course and 1 month after treatment routine gynaecological examination and secretion examination on 3 to 7 days after menstruation were recorded,and the treatment outcomes were analyzed according to cure,development,improvement,and invalidation.Results Routine gynaecological examination and secretion examination results of experimental group and control group 7 to 14 days after treatment showed that the recovery rates were 34.15%,11.63%,respectively(χ~2=6.081,P=0.014);total effective rate(51.22%) in experimental group was significantly higher than 25.58% of the control group(χ~2=5.850,P<0.016).One month after treatment routine gynaecological examination and secretion examination results of experimental group and control group showed that recovery rates were 39.02%,13.95% respectively(χ~2=6.824,P=0.009);total effective rate(56.10%) of experimental group was significantly higher than 32.56% of the control group(χ~2=4.719,P=0.030).Conclusions Honghefujie lotion combined with Nifuratel nysfungin vaginal soft capsules in the treatment of VVC had short course of treatment and significant curative effect,which was an effective and safe treatment of VVC in clinic and is worthy of promotion.
Objective To observe the clinical efficacy of the treatment with Honghefujie lotion combined with Nifuratel nysfungin vaginal soft capsules on vulvovaginal candidiasis.Methods Ninety cases of patients who underwent the treatment of vulvovaginal candidiasis(VVC) in Wuhan Maternal and Child Health Hospital from November 2016 to May 2017 were selected and assigned into control group and experimental group using random number table method,with 45 cases in each group.Experimental group was treated by Honghefujie lotioncombined with Nifuratel nysfungin vaginal soft capsules,while control group adopted Honghefujie lotion in the treatment of VVC;7 to 14 days after completion of a course and 1 month after treatment routine gynaecological examination and secretion examination on 3 to 7 days after menstruation were recorded,and the treatment outcomes were analyzed according to cure,development,improvement,and invalidation.Results Routine gynaecological examination and secretion examination results of experimental group and control group 7 to 14 days after treatment showed that the recovery rates were 34.15%,11.63%,respectively(χ~2=6.081,P=0.014);total effective rate(51.22%) in experimental group was significantly higher than 25.58% of the control group(χ~2=5.850,P<0.016).One month after treatment routine gynaecological examination and secretion examination results of experimental group and control group showed that recovery rates were 39.02%,13.95% respectively(χ~2=6.824,P=0.009);total effective rate(56.10%) of experimental group was significantly higher than 32.56% of the control group(χ~2=4.719,P=0.030).Conclusions Honghefujie lotion combined with Nifuratel nysfungin vaginal soft capsules in the treatment of VVC had short course of treatment and significant curative effect,which was an effective and safe treatment of VVC in clinic and is worthy of promotion.
引文
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[8] 付晓敏,何社红,席朝阳.硝呋太尔制霉素阴道软胶囊治疗霉菌性阴道炎临床观察[J].中国实用医药,2015,10(7):162-163.
[9] 耿力,宋学红,郝增平,等.国产硝呋太尔制霉素阴道软胶囊治疗阴道炎的临床研究[J].中国妇产科临床杂志,2007,8(1):26-29.
[10] 孙海芹.红核妇洁洗液治疗孕期外阴阴道念珠菌病86例疗效观察[J].中外医学研究,2010,8(14):94-95.
[11] 罗艳玲.保妇康栓联合红核妇洁洗液治疗外阴阴道假丝酵母菌病临床效果研究[J].临床医药实践,2016,25(9):657-659.
[12] 黄锦惠.硝呋太尔制霉菌素栓治疗霉菌性阴道炎的效果研究[J].当代医药论丛,2017,15(3):18-19.
[2] VICARIOTTO F,DEL PIANO M,MOGNA L,et al.Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product,in women affected by vulvovaginal candidiasis:a pilot study[J].J Clin Gastroenterol,2012,46(Suppl):S73-S80.
[3] 孟惠娟,王琳,陈友国,等.红核妇洁洗液联合硝呋太尔制霉素阴道软胶囊及康妇炎胶囊治疗VVC的疗效观察[J].母婴世界,2016(10):15-16.
[4] 高静.顽固性霉菌性阴道炎128例临床分析[J].中国现代药物应用,2011,5(9):39-40.
[5] 秦俊.新编实用药物手册[M].南宁:广西民族出版社,2001.
[6] 张凯.中西医结合治疗霉菌性阴道炎的临床疗效分析[J].中国现代药物应用,2014,8(11):148-149.
[7] 陈莉君,杨静.硝呋太尔制霉素阴道软胶囊治疗孕妇霉菌性阴道炎的临床观察[J].国外医药(抗生素分册),2015,36(1):7-8.
[8] 付晓敏,何社红,席朝阳.硝呋太尔制霉素阴道软胶囊治疗霉菌性阴道炎临床观察[J].中国实用医药,2015,10(7):162-163.
[9] 耿力,宋学红,郝增平,等.国产硝呋太尔制霉素阴道软胶囊治疗阴道炎的临床研究[J].中国妇产科临床杂志,2007,8(1):26-29.
[10] 孙海芹.红核妇洁洗液治疗孕期外阴阴道念珠菌病86例疗效观察[J].中外医学研究,2010,8(14):94-95.
[11] 罗艳玲.保妇康栓联合红核妇洁洗液治疗外阴阴道假丝酵母菌病临床效果研究[J].临床医药实践,2016,25(9):657-659.
[12] 黄锦惠.硝呋太尔制霉菌素栓治疗霉菌性阴道炎的效果研究[J].当代医药论丛,2017,15(3):18-19.