纳米炭在乳腺癌治疗中的临床应用进展
|
摘要
随着乳腺癌前哨淋巴结活检术在临床的广泛开展,纳米炭因在前哨淋巴结示踪方面展现了特异性淋巴结染色、显影迅速、检出率高等独特优势而在乳腺癌临床治疗方面广泛应用。研究表明纳米炭可吸附化疗药物进行靶向化疗,提高化疗疗效同时减少全身副反应,展现了其在药物治疗方面的应用前景。全文就纳米炭在乳腺癌临床治疗中的应用情况予以综述。
The sentinel lymph node biopsy is widely used in surgical treatment of breast cancer.The nano-carbon,as the third generation tracer for sentinel lymph node has advantages of specific lymph node staining,rapid tracing and high detection rate. In addition,nano-carbon conjugating chemotherapeutic drugs used in target therapy can improve the efficacy of chemotherapy and reduce the systemic side effects. This article reviews the clinical application and the prospects of nano-carbon in treatment of breast cancer.
The sentinel lymph node biopsy is widely used in surgical treatment of breast cancer.The nano-carbon,as the third generation tracer for sentinel lymph node has advantages of specific lymph node staining,rapid tracing and high detection rate. In addition,nano-carbon conjugating chemotherapeutic drugs used in target therapy can improve the efficacy of chemotherapy and reduce the systemic side effects. This article reviews the clinical application and the prospects of nano-carbon in treatment of breast cancer.
引文
[1]Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[2]Hagiwara A,Takahashi T,Sawai K,et al.Lymph nodal vital staining with newer carbon particle suspensions compared with India ink:experimental and clinical observations[J].Lymphology,1992,25(2):84-89.
[3]Yang F,Jin C,Yang D,et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].Eur J Cancer,2011,47(12):1873-1882.
[4]Ge J,Yan B,Cao XC.Comparison of sentinel lymph node detection by methylene blue and carbon nanoparticle suspensioninjection in early breast cancer[J].Chin J Oncol,2011,33(3):226-228.[葛洁,颜博,曹旭晨,等.纳米炭混悬注射液与亚甲蓝注射液在早中期乳腺癌前哨淋巴结活检中的应用[J].中华肿瘤杂志,2011,33(3):226-228.]
[5]Xue FQ,Chen HY,Xu C,et al.Application of carbon nanoparticles on the detection of lymph nodes in radical resection for colorectal cancer[J].Chinese Journal of Medical Physics,2015,32(4):490~492,502.[薛芳沁,陈鸿源,许超,等.纳米炭示踪在结直肠癌根治术淋巴结检出中的应用[J].中国医学物理学杂志,2015,32(4):490-492,502.]
[6]Fan LJ,Zhong L,Guo DY,et al.Effect and safety of carbon nanoparticles dyeing in axillary lymph node dissection of breast cancer[J].Chin J Breast Dis(Electronic Edition),2010,4(3):313-321.[范林军,钟玲,郭德玉,等.纳米炭对乳腺癌腋窝淋巴结示踪效果及其安全性的初步研究[J].中华乳腺病杂志(电子版),2010,4(3):313-321.]
[7]Cabanas RM.An approach for the treatment of penile carcinoma[J].Cancer,1977,39(2):456-466.
[8]Niebling MG,Pleijhuis RG,Bastiaannet E,et al.A systematic review and meta-analyses of sentinel lymph node identification in breast cancer and melanoma,a plea for tracer mapping[J].European Journal of Surgical Oncology(EJSO),2016,42(4):466-473.
[9]Wu X,Lin Q,Chen G,et al.Sentinel lymph node detection using carbon nanoparticles in patients with early breast cancer[J].PLoS One,2015,10(8):e0135714.
[10]Tu JH,Zhang H,Lu YH,et al.Feasibility of nanogate carbon as agent for sentinel lymph node biospy in early breast cancer patients[J].Chin J ExpSurg,2015,32(12):3147-3150.[屠俊浩,张浩,陆奕含,等.纳米碳悬浊液在乳腺癌前哨淋巴结活检中的应用[J].中华实验外科杂志,2015,32(12):3147-3150.]
[11]Radovanovic Z,Golubovic A,Plzak A,et al.Blue dye versus combined blue dye-radioactive tracer technique in detection of sentinel lymph node in breast cancer[J].European Journal of Surgical Oncology(EJSO),2004,30(9):913-917.
[12]Bakhtiar N,Jaleel F,Moosa FA,et al.Sentinel lymph node identification by blue dye in patients with breast carcinoma[J].Pak J Med Sci,2016,32(2):448-451.
[13]Varghese P,Mostafa A,Abdel-Rahman AT,et al.Methylene blue dye versus combined dye-radioactive tracer technique for sentinel lymph node localisation in early breast cancer[J].European Journal of Surgical Oncology(EJSO),2007,33(2):147-152.
[14]Shao ZM,Fan JJ.Interpretation of“guideline and standard for the diagnosis and treatment of breast cancer by Chinese Anti-Cancer Association(2015 edition)”:surgical section[J].Chin J Breast Dis(Electronic Edition),2016,10(1):1-5.[邵志敏,李俊杰.2015版《中国抗癌协会乳腺癌诊治指南与规范》:外科部分解读[J].中华乳腺病杂志(电子版),2016,10(1):1-5.]
[15]Zhang YS,Liang QK,Zhong L,et al.Evaluation of the tracing effect of carbon nanoparticles and methylene blue combined with 99Tcm-sulfurcolloid in endoscopic sentinel lymph node biopsy for breast cancer[J].Chin J Breast Dis(Electronic Edition),2015,9(4):231-235.[张永松,梁全琨,钟玲,等.纳米炭和亚甲蓝联合核素示踪法在腔镜乳腺癌前哨淋巴结活组织检查中的对照研究[J].中华乳腺病杂志(电子版),2015,9(4):231-235.]
[16]Chen Z,Qin QH,Lian B,et al.Clinical research of carbon nanoparticles suspension and methylene blue in sentinel lymph node biopsy for breast cancer[J].The Practical Journal of Cancer,2015,30(9):1320-1323.[陈智,覃庆洪,练斌,等.纳米炭混悬液与美蓝在乳腺癌前哨淋巴结活检中的应用研究[J].实用癌症杂志,2015,30(9):1320-1323.]
[17]Wu Y,Zhou Y,Yang GS,et al.Application analysis of carbon nanoparticles suspension in sentinel lymph node biopsy for breastcancer[J].J ClinSurg,2015,23(7):511-513.[吴燕,周毅,杨贵森,等.纳米炭混悬液在乳腺癌前哨淋巴结活检中的应用分析[J].临床外科杂志,2015,23(7):511-513.]
[18]Wang L,Chen X,Zhao CG,et al.Application of nano-carbon to the sentinel lymph node biopsy for breast cancer[J].Chin J Clin Oncol Rehabil,2017,24(1):49-51.[王雷,陈旭,赵成功,等.纳米碳在乳腺癌前哨淋巴结活检中的应用[J].中国肿瘤临床与康复,2017,24(1):49-51.]
[19]Yagata H,Yamauchi H,Tsugawa K,et al.Sentinel node biopsy after neoadjuvant chemotherapy in cytologically proven node-positive breast cancer[J].Clinical Breast Cancer,2013,13(6):471-477.
[20]El HCH,Headon H,Kasem A,et al.Refining the performance of sentinel lymph node biopsy post-neoadjuvant chemotherapy in patients with pathologically proven pretreatment node-positive breast cancer:an update for clinical practice[J].Anticancer Res,2016,36(4):1461-1471.
[21]Rebollo-Aguirre AC,Gallego-Peinado M,Sanchez-Sanchez R,et al.Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with operable breast cancer and positive axillary nodes at initial diagnosis[J].Rev Esp Med Nucl Imagen Mol,2013,32(4):240-245.
[22]Zhao L,Chen WL,Xu ZN.Clinical significance of axillary sentinel lymph node biopsy in breast cancer patients after neoadjuvant chemotherapy[J].Chin J Clin Oncol Rehabil,2013,20(3):242-244.[赵玲,陈文林,徐忠能.乳腺癌新辅助化疗后前哨淋巴结活检的临床意义[J].中国肿瘤临床与康复,2013.20(3):242-244.]
[23]Liu X,Pang D.Research progress of sentinel lymph node biopsy after neoadjuvant therapy in breast cancer[J].Modern Oncology,2017,25(8):1336-1340.[刘旭,庞达.乳腺癌新辅助治疗后前哨淋巴结活检术应用的研究进展[J].现代肿瘤医学,2017,25(8):1336-1340.]
[24]Choy N,Lipson J,Porter C,et al.Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients[J].Ann Surg Oncol,2015,22(2):377-382.
[25]Zhang Z,Zhang XH,Zhao LJ,et al.Effect of carbon nanoparticles dyeing on axillary lymph node dissection in modified radical mastectomy for breast cancer[J].Chin JBases Clin General Surg,2014,21(9):1130-1133.[张珍,张晓红,赵丽娟,等.纳米炭在乳腺癌改良根治术中淋巴示踪效果的临床研究[J].中国普外基础与临床杂志,2014,21(9):1130-1133.]
[26]Wu Y,Zhou Y,Yang GS,et al.Application analysis of carbon nanoparticles suspension in sentinel lymph node biopsy for breast cancer[J].J Clin Surg,2015,23(7):511-513.[吴燕,周毅,杨贵森,等.纳米炭混悬液在乳腺癌前哨淋巴结活检中的应用分析[J].临床外科杂志,2015,23(7):511-513.]
[27]Gao W,Guo WB.Application of carbon nanoparticle suspension injection into the mammary gland in the sentinel lymph node biopsy for breast cancer[J].Practical Pharmacy And Clinical Remedies,2013,16(3):187-189.[高伟,郭文斌.纳米碳示踪剂在乳腺癌腋窝前哨淋巴结活检中的应用[J].实用药物与临床,2013,16(3):187-189.]
[28]Zou WW,Bai Y,Wang XL,et al.Comparison between indocyanine green fluorescence imaging plus methylene blue and plus carbonnanoparticles suspension injection for sentinel lymph node biopsy in breast cancer patients[J].The Journal of Practical Medicine,2017,33(11):1857-1860.[邹伟伟,白玉,王希龙,等.吲哚菁绿荧光成像联合亚甲蓝与纳米炭在乳腺癌前哨淋巴结活检中的对比[J].实用医学杂志,2017,33(11):1857-1860.]
[29]Zhao LJ,Zhang XH,Zhang Z,et al.A comparative study of the timing of carbon injection before modified radical mastectomy for breast cancer[J].Sichuan Medical Journal,2016,37(6):609-612.[赵丽娟,张晓红,张珍,等.乳癌改良根治术前纳米炭注射时机的对比研究[J].四川医学,2016,37(6):609-612.]
[30]Wang CX,Wu L,Zheng YQ,et al.Research progress of nanomedicine for lung cancer[J].Medical Recapitulate,2017,23(2):311-317.[王彩霞,乌兰,郑源强,等.纳米药物在肺癌治疗中的研究进展[J].医学综述,2017,23(2):311-317.]
[31]Zhou X,Han J,Wu YF,et al.Research progress on the application of nanotechnology in tumor targeting diagnosis and treatment[J].E-J Transl Med,2017,4(2):10-15.[周雪,韩俊,吴一凡,等.纳米技术在肿瘤靶向诊疗中的应用研究进展[J].转化医学电子杂志,2017,4(2):10-15.]
[32]Yang F,Jin C,Yang D,et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].European Journal of Cancer,2011,47(12):1873-1882.
[33]Ji S,Liu C,Zhang B,et al.Carbon nanotubes in cancer diagnosis and therapy[J].Biochimica et Biophysica Acta(BBA)-Reviews on Cancer,2010,1806(1):29-35.
[34]Yao ZW,Tai KY,Wang YC,et al.The present situation and prospect of nano-paclitaxel in the treatment of breast cancer[J].Progress in Modern Biomedicine,2016,16(21):4177-4180.[姚志伟,泰科宇,王宇翀,等.纳米紫杉类药物在乳腺癌治疗中的研究现状[J].现代生物医学进展,2016,16(21):4177-4180.]
[35]Cao X,Deng W,Fu M,et al.Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles:in vitro release kinetics and in vitro/in vivo correlations in beagle dogs[J].Eur J Pharm Sci,2013,48(1-2):64-71.
[36]Ghaffarian R,Bhowmick T,Muro S.Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1[J].J Control Release,2012,163(1):25-33.
[37]Nie S.Understanding and overcoming major barriers in cancer nanomedicine[J].Nanomedicine(Lond),2010,5(4):523-528.
[38]Lee JJ,Saiful YL,Che ACA.A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment[J].2017,12:2373-2384.
[39]Xu T,Fan YL,Huang JW,et al.Influencing factors of sentinel lymph node biopsy in upper quadrant breast cancer by blue dye method[J].Guizhou Medical Journal,2016,40(7):767-768.[徐泰,范苑林,黄杰文,等.外上象限乳腺癌蓝染法前哨淋巴结活检术的影响因素分析[J].贵州医药,2016,40(7):767-768.]
[40]Cong BB,Sun X,Song XR,et al.Preparation study of indocyanine green-rituximab:a new receptor-targeted tracer for sentinel lymph node in breast cancer[J].Oncotarget,2016,7(30):47526-47535.
[41]Park YM,Quan YH,Kwon KH,et al.Endoscopic sentinel lymph node biopsy using indocyanine green-neomannosyl human serum albumin[J].Laryngoscope,2018,128(4):135-140.
[42]Kim HK,Quan YH,Oh Y,et al.Macrophage-targeted indocyanine green-neomannosyl human serum albumin for intraoperative sentinel lymph node mapping in porcine esophagus[J].Ann Thorac Surg,2016,102(4):1149-1155.
[2]Hagiwara A,Takahashi T,Sawai K,et al.Lymph nodal vital staining with newer carbon particle suspensions compared with India ink:experimental and clinical observations[J].Lymphology,1992,25(2):84-89.
[3]Yang F,Jin C,Yang D,et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].Eur J Cancer,2011,47(12):1873-1882.
[4]Ge J,Yan B,Cao XC.Comparison of sentinel lymph node detection by methylene blue and carbon nanoparticle suspensioninjection in early breast cancer[J].Chin J Oncol,2011,33(3):226-228.[葛洁,颜博,曹旭晨,等.纳米炭混悬注射液与亚甲蓝注射液在早中期乳腺癌前哨淋巴结活检中的应用[J].中华肿瘤杂志,2011,33(3):226-228.]
[5]Xue FQ,Chen HY,Xu C,et al.Application of carbon nanoparticles on the detection of lymph nodes in radical resection for colorectal cancer[J].Chinese Journal of Medical Physics,2015,32(4):490~492,502.[薛芳沁,陈鸿源,许超,等.纳米炭示踪在结直肠癌根治术淋巴结检出中的应用[J].中国医学物理学杂志,2015,32(4):490-492,502.]
[6]Fan LJ,Zhong L,Guo DY,et al.Effect and safety of carbon nanoparticles dyeing in axillary lymph node dissection of breast cancer[J].Chin J Breast Dis(Electronic Edition),2010,4(3):313-321.[范林军,钟玲,郭德玉,等.纳米炭对乳腺癌腋窝淋巴结示踪效果及其安全性的初步研究[J].中华乳腺病杂志(电子版),2010,4(3):313-321.]
[7]Cabanas RM.An approach for the treatment of penile carcinoma[J].Cancer,1977,39(2):456-466.
[8]Niebling MG,Pleijhuis RG,Bastiaannet E,et al.A systematic review and meta-analyses of sentinel lymph node identification in breast cancer and melanoma,a plea for tracer mapping[J].European Journal of Surgical Oncology(EJSO),2016,42(4):466-473.
[9]Wu X,Lin Q,Chen G,et al.Sentinel lymph node detection using carbon nanoparticles in patients with early breast cancer[J].PLoS One,2015,10(8):e0135714.
[10]Tu JH,Zhang H,Lu YH,et al.Feasibility of nanogate carbon as agent for sentinel lymph node biospy in early breast cancer patients[J].Chin J ExpSurg,2015,32(12):3147-3150.[屠俊浩,张浩,陆奕含,等.纳米碳悬浊液在乳腺癌前哨淋巴结活检中的应用[J].中华实验外科杂志,2015,32(12):3147-3150.]
[11]Radovanovic Z,Golubovic A,Plzak A,et al.Blue dye versus combined blue dye-radioactive tracer technique in detection of sentinel lymph node in breast cancer[J].European Journal of Surgical Oncology(EJSO),2004,30(9):913-917.
[12]Bakhtiar N,Jaleel F,Moosa FA,et al.Sentinel lymph node identification by blue dye in patients with breast carcinoma[J].Pak J Med Sci,2016,32(2):448-451.
[13]Varghese P,Mostafa A,Abdel-Rahman AT,et al.Methylene blue dye versus combined dye-radioactive tracer technique for sentinel lymph node localisation in early breast cancer[J].European Journal of Surgical Oncology(EJSO),2007,33(2):147-152.
[14]Shao ZM,Fan JJ.Interpretation of“guideline and standard for the diagnosis and treatment of breast cancer by Chinese Anti-Cancer Association(2015 edition)”:surgical section[J].Chin J Breast Dis(Electronic Edition),2016,10(1):1-5.[邵志敏,李俊杰.2015版《中国抗癌协会乳腺癌诊治指南与规范》:外科部分解读[J].中华乳腺病杂志(电子版),2016,10(1):1-5.]
[15]Zhang YS,Liang QK,Zhong L,et al.Evaluation of the tracing effect of carbon nanoparticles and methylene blue combined with 99Tcm-sulfurcolloid in endoscopic sentinel lymph node biopsy for breast cancer[J].Chin J Breast Dis(Electronic Edition),2015,9(4):231-235.[张永松,梁全琨,钟玲,等.纳米炭和亚甲蓝联合核素示踪法在腔镜乳腺癌前哨淋巴结活组织检查中的对照研究[J].中华乳腺病杂志(电子版),2015,9(4):231-235.]
[16]Chen Z,Qin QH,Lian B,et al.Clinical research of carbon nanoparticles suspension and methylene blue in sentinel lymph node biopsy for breast cancer[J].The Practical Journal of Cancer,2015,30(9):1320-1323.[陈智,覃庆洪,练斌,等.纳米炭混悬液与美蓝在乳腺癌前哨淋巴结活检中的应用研究[J].实用癌症杂志,2015,30(9):1320-1323.]
[17]Wu Y,Zhou Y,Yang GS,et al.Application analysis of carbon nanoparticles suspension in sentinel lymph node biopsy for breastcancer[J].J ClinSurg,2015,23(7):511-513.[吴燕,周毅,杨贵森,等.纳米炭混悬液在乳腺癌前哨淋巴结活检中的应用分析[J].临床外科杂志,2015,23(7):511-513.]
[18]Wang L,Chen X,Zhao CG,et al.Application of nano-carbon to the sentinel lymph node biopsy for breast cancer[J].Chin J Clin Oncol Rehabil,2017,24(1):49-51.[王雷,陈旭,赵成功,等.纳米碳在乳腺癌前哨淋巴结活检中的应用[J].中国肿瘤临床与康复,2017,24(1):49-51.]
[19]Yagata H,Yamauchi H,Tsugawa K,et al.Sentinel node biopsy after neoadjuvant chemotherapy in cytologically proven node-positive breast cancer[J].Clinical Breast Cancer,2013,13(6):471-477.
[20]El HCH,Headon H,Kasem A,et al.Refining the performance of sentinel lymph node biopsy post-neoadjuvant chemotherapy in patients with pathologically proven pretreatment node-positive breast cancer:an update for clinical practice[J].Anticancer Res,2016,36(4):1461-1471.
[21]Rebollo-Aguirre AC,Gallego-Peinado M,Sanchez-Sanchez R,et al.Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with operable breast cancer and positive axillary nodes at initial diagnosis[J].Rev Esp Med Nucl Imagen Mol,2013,32(4):240-245.
[22]Zhao L,Chen WL,Xu ZN.Clinical significance of axillary sentinel lymph node biopsy in breast cancer patients after neoadjuvant chemotherapy[J].Chin J Clin Oncol Rehabil,2013,20(3):242-244.[赵玲,陈文林,徐忠能.乳腺癌新辅助化疗后前哨淋巴结活检的临床意义[J].中国肿瘤临床与康复,2013.20(3):242-244.]
[23]Liu X,Pang D.Research progress of sentinel lymph node biopsy after neoadjuvant therapy in breast cancer[J].Modern Oncology,2017,25(8):1336-1340.[刘旭,庞达.乳腺癌新辅助治疗后前哨淋巴结活检术应用的研究进展[J].现代肿瘤医学,2017,25(8):1336-1340.]
[24]Choy N,Lipson J,Porter C,et al.Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients[J].Ann Surg Oncol,2015,22(2):377-382.
[25]Zhang Z,Zhang XH,Zhao LJ,et al.Effect of carbon nanoparticles dyeing on axillary lymph node dissection in modified radical mastectomy for breast cancer[J].Chin JBases Clin General Surg,2014,21(9):1130-1133.[张珍,张晓红,赵丽娟,等.纳米炭在乳腺癌改良根治术中淋巴示踪效果的临床研究[J].中国普外基础与临床杂志,2014,21(9):1130-1133.]
[26]Wu Y,Zhou Y,Yang GS,et al.Application analysis of carbon nanoparticles suspension in sentinel lymph node biopsy for breast cancer[J].J Clin Surg,2015,23(7):511-513.[吴燕,周毅,杨贵森,等.纳米炭混悬液在乳腺癌前哨淋巴结活检中的应用分析[J].临床外科杂志,2015,23(7):511-513.]
[27]Gao W,Guo WB.Application of carbon nanoparticle suspension injection into the mammary gland in the sentinel lymph node biopsy for breast cancer[J].Practical Pharmacy And Clinical Remedies,2013,16(3):187-189.[高伟,郭文斌.纳米碳示踪剂在乳腺癌腋窝前哨淋巴结活检中的应用[J].实用药物与临床,2013,16(3):187-189.]
[28]Zou WW,Bai Y,Wang XL,et al.Comparison between indocyanine green fluorescence imaging plus methylene blue and plus carbonnanoparticles suspension injection for sentinel lymph node biopsy in breast cancer patients[J].The Journal of Practical Medicine,2017,33(11):1857-1860.[邹伟伟,白玉,王希龙,等.吲哚菁绿荧光成像联合亚甲蓝与纳米炭在乳腺癌前哨淋巴结活检中的对比[J].实用医学杂志,2017,33(11):1857-1860.]
[29]Zhao LJ,Zhang XH,Zhang Z,et al.A comparative study of the timing of carbon injection before modified radical mastectomy for breast cancer[J].Sichuan Medical Journal,2016,37(6):609-612.[赵丽娟,张晓红,张珍,等.乳癌改良根治术前纳米炭注射时机的对比研究[J].四川医学,2016,37(6):609-612.]
[30]Wang CX,Wu L,Zheng YQ,et al.Research progress of nanomedicine for lung cancer[J].Medical Recapitulate,2017,23(2):311-317.[王彩霞,乌兰,郑源强,等.纳米药物在肺癌治疗中的研究进展[J].医学综述,2017,23(2):311-317.]
[31]Zhou X,Han J,Wu YF,et al.Research progress on the application of nanotechnology in tumor targeting diagnosis and treatment[J].E-J Transl Med,2017,4(2):10-15.[周雪,韩俊,吴一凡,等.纳米技术在肿瘤靶向诊疗中的应用研究进展[J].转化医学电子杂志,2017,4(2):10-15.]
[32]Yang F,Jin C,Yang D,et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].European Journal of Cancer,2011,47(12):1873-1882.
[33]Ji S,Liu C,Zhang B,et al.Carbon nanotubes in cancer diagnosis and therapy[J].Biochimica et Biophysica Acta(BBA)-Reviews on Cancer,2010,1806(1):29-35.
[34]Yao ZW,Tai KY,Wang YC,et al.The present situation and prospect of nano-paclitaxel in the treatment of breast cancer[J].Progress in Modern Biomedicine,2016,16(21):4177-4180.[姚志伟,泰科宇,王宇翀,等.纳米紫杉类药物在乳腺癌治疗中的研究现状[J].现代生物医学进展,2016,16(21):4177-4180.]
[35]Cao X,Deng W,Fu M,et al.Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles:in vitro release kinetics and in vitro/in vivo correlations in beagle dogs[J].Eur J Pharm Sci,2013,48(1-2):64-71.
[36]Ghaffarian R,Bhowmick T,Muro S.Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1[J].J Control Release,2012,163(1):25-33.
[37]Nie S.Understanding and overcoming major barriers in cancer nanomedicine[J].Nanomedicine(Lond),2010,5(4):523-528.
[38]Lee JJ,Saiful YL,Che ACA.A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment[J].2017,12:2373-2384.
[39]Xu T,Fan YL,Huang JW,et al.Influencing factors of sentinel lymph node biopsy in upper quadrant breast cancer by blue dye method[J].Guizhou Medical Journal,2016,40(7):767-768.[徐泰,范苑林,黄杰文,等.外上象限乳腺癌蓝染法前哨淋巴结活检术的影响因素分析[J].贵州医药,2016,40(7):767-768.]
[40]Cong BB,Sun X,Song XR,et al.Preparation study of indocyanine green-rituximab:a new receptor-targeted tracer for sentinel lymph node in breast cancer[J].Oncotarget,2016,7(30):47526-47535.
[41]Park YM,Quan YH,Kwon KH,et al.Endoscopic sentinel lymph node biopsy using indocyanine green-neomannosyl human serum albumin[J].Laryngoscope,2018,128(4):135-140.
[42]Kim HK,Quan YH,Oh Y,et al.Macrophage-targeted indocyanine green-neomannosyl human serum albumin for intraoperative sentinel lymph node mapping in porcine esophagus[J].Ann Thorac Surg,2016,102(4):1149-1155.