不同年龄段前庭诱发肌源性电位参数的正常值
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摘要
目的:测量健康成年人前庭诱发肌源性电位(VEMP)的正常值,如反应阈值、潜伏期、波间期、振幅等,用于指导临床工作。方法:选取天津医科大学总医院眩晕诊疗中心的75例(男39例,女36例)健康志愿者,按年龄段分为组1(21~30岁)、组2(>30~50岁)、组3(>50~70岁),分别进行眼性前庭诱发肌源性电位(oVEMP)和颈性前庭诱发肌源性电位(cVEMP)检查,得到正常值。以SPSS 19.0统计软件进行分析。结果:oVEMP和cVEMP总的引出率分别为77.3%和85.3%。oVEMP正常值:组1引出率为100%,振幅为(8.29±1.25)μV,阈值为(83.65±4.10)dBnHL;组2引出率为85.4%,振幅为(6.32±1.21)μV,阈值为(89.24±4.18)dBnHL;组3引出率为46.0%,振幅为(4.26±1.20)μV,阈值为(95.13±4.21)dBnHL。cVEMP正常值:组1引出率为100%,振幅为(108.87±19.10)μV,阈值为(84.54±4.35)dBnHL;组2引出率为83.3%,振幅为(84.10±20.02)μV,阈值为(90.33±4.29)dBnHL;组3引出率为72.0%,振幅为(64.18±19.22)μV,阈值为(95.19±4.30)dBnHL。经统计分析,3组间oVEMP及cVEMP引出率、阈值、振幅比较均差异有统计学意义(均P<0.05),N1、P1潜伏期、N1-P1波间期比较差异无统计学意义(P>0.05)。结论:该研究得到了天津医科大学总医院健康成年人VEMP参数的正常值,为其应用于临床相关疾病的诊断提供了依据。
Objective:To obtain the normative values of vestibular evoked myogenic potential(VEMP),i.e.the threshold,latency,latency-interval,amplitude of healthy population in Tianjin medical university General hospital.These values will help clinical diagnosis.Method:Seventy-five healthy individuals(39males and 36 females,age from 21 to 70years)were enrolled in this study.They were divided into 3groups according to age:group 1(21-30years),group 2(>30-50years),group 3(>50-70years).oVEMP and cVEMP were performed and the normative values were obtained.SPSS 19.0was used to analyze the data.Result:The response rate was 77.3%and 85.3% of oVEMP and cVEMP respectively in all subjects.The values of oVEMP:in group 1response rate was 100%,amplitude was(8.29±1.25)μV and threshold value was(83.65±4.10)dBnHL.In group 2response rate was 85.4%,amplitude was(6.32±1.21)μV and threshold value was(89.24±4.18)dBnHL.In group 3response rate was 46%,amplitude was(4.26±1.20)μV,threshold value was(95.13±4.21)dBnHL.The values of cVEMP:in group 1response rate was 100%,amplitude was(108.87±19.10)μV and threshold value was(84.54±4.35)dBnHL.In group 2response rate was 83.3%,amplitude was(84.10±20.02)μV and threshold value was(90.33±4.29)dBnHL.In group 3response rate was 72.0%,amplitude was(64.18±19.22)μV and threshold value was(95.19±4.30)dBnHL.The statistical analysis show significant difference in oVEMP/cVEMP response rate,threshold and amplitude among different age-groups(P<0.05).No significant difference was found in N1,P1 latency and latency-interval among different age-groups(P>0.05).Conclusion:The normative values of VEMP of healthy population in Tianjin medical university General hospital were obtained in this research.These VEMP data were used for the diagnosis of related diseases.
Objective:To obtain the normative values of vestibular evoked myogenic potential(VEMP),i.e.the threshold,latency,latency-interval,amplitude of healthy population in Tianjin medical university General hospital.These values will help clinical diagnosis.Method:Seventy-five healthy individuals(39males and 36 females,age from 21 to 70years)were enrolled in this study.They were divided into 3groups according to age:group 1(21-30years),group 2(>30-50years),group 3(>50-70years).oVEMP and cVEMP were performed and the normative values were obtained.SPSS 19.0was used to analyze the data.Result:The response rate was 77.3%and 85.3% of oVEMP and cVEMP respectively in all subjects.The values of oVEMP:in group 1response rate was 100%,amplitude was(8.29±1.25)μV and threshold value was(83.65±4.10)dBnHL.In group 2response rate was 85.4%,amplitude was(6.32±1.21)μV and threshold value was(89.24±4.18)dBnHL.In group 3response rate was 46%,amplitude was(4.26±1.20)μV,threshold value was(95.13±4.21)dBnHL.The values of cVEMP:in group 1response rate was 100%,amplitude was(108.87±19.10)μV and threshold value was(84.54±4.35)dBnHL.In group 2response rate was 83.3%,amplitude was(84.10±20.02)μV and threshold value was(90.33±4.29)dBnHL.In group 3response rate was 72.0%,amplitude was(64.18±19.22)μV and threshold value was(95.19±4.30)dBnHL.The statistical analysis show significant difference in oVEMP/cVEMP response rate,threshold and amplitude among different age-groups(P<0.05).No significant difference was found in N1,P1 latency and latency-interval among different age-groups(P>0.05).Conclusion:The normative values of VEMP of healthy population in Tianjin medical university General hospital were obtained in this research.These VEMP data were used for the diagnosis of related diseases.
引文
[1]张青,宋辉,胡娟,等.气导短纯音诱发的眼肌前庭诱发肌源性电位在健康青年人群中的波形特征[J].中华耳鼻咽喉头颈外科杂志,2012,47(1):15-18.
[2]胡娟,许珉,张青,等.眼肌前庭诱发肌源性电位的研究现状及展望[J].临床耳鼻咽喉头颈外科杂志,2013,27(7):388-392.
[3]谢溯江,郑颖鹃,张琳,等.眼性前庭诱发肌电位研究进展[J].中华临床医师杂志,2013,7(9):3980-3983.
[4]DERIU F,ORTU E,CAPOBIANCO S,et al.Origin of sound-evoked EMG responses in human masseter muscles[J].J Physiol,2007,580:195-209.
[5]CURTHOYS I S.A critical review of the neurophysiological evidence underlying clinical vestibular testing using sound vibration and galvanic stimuli[J].Clin Neurophysiol,2010,121:132-144.
[6]SHIN B S,OH S Y,KIM J S,et al.Cervical and ocular vestibular-evoked myogenic potentials in acute vestibular neuritis[J].Clin Neurophysiol,2012,123:369-375.
[7]ZUNIGA M G,JANKY K L,SCHUBERT M C,et al.Can vestibular-evoked myogenic potentials help differentiate meniere disease from vestibular migraine[J].Otolaryngol Head Neck Surg,2012,146:788-796.
[8]MUROFUSHI T,WAKAYAMA K,CHIHARA Y.oVEMP to air-conducted tones reflects functions of different vestibular population from cVEMP[J]?Eur Arch Otorhinolaryngol,2010,267:995-996.
[9]NGUYN K D,WELAAMPOLA M S,CAREY J P.Test-retest reliability and age-related characteristics of the ocular and cervical vestibular-evoked myogenic potential tests[J].Otol Neurotol,2010,31:793-802.
[10]林细康,李晓璐.眼性前庭诱发肌源电位对眩晕定位诊断的价值探讨[J].中华临床医师杂志,2014,8(3):411-414.
[11]BAYRAM A,DOGAN M,KOC A,et al.Cervical and ocular vestibular evoked myogenic potentials in Behcet's disease[J].Am J Otolaryngol Head Neck Med Surg,2015,36:503-508.
[12]刘海红,张华,莫玲燕,等.听力相关疾病成人患者的年龄因素分析[J].听力学及言语疾病杂志,2011,19(4):328-330.
[13]李婧,杨旭,吴子明,等.眼源性前庭诱发肌源性电位[J].中华耳科学杂志,2014,12(2):231-234.
[14]SHEYKHOLESLAMI K,MUREFUSHI T,KAGA K.The effect of sternocleidomastoid electrode location on vestibular evoked myogenic potential[J].Auris Nasus Larynx,2001,28:41-43.
[15]ROENGREN S M,GOVENDER S,COLEBATCH J G.Ocular and cervical vestibular evoked myogenic potentials produced by air-and bone-conducted stimuli:comparative properties and effects of age[J].Clin Neurophysiol,2011,122:2282-2289.
[16]OCHI K,OHASHI T.Age-related changes in the vestibular evoked myogenic potentials[J].Otolaryngol Head Neck Surg,2003,129:655-659.
[17]韩朝,田亮,王璟,等.颈性前庭诱发肌源性电位正常值及影响因素的探讨[J].中国眼耳鼻喉科杂志,2015,15(2):101-104.
[18]MCNERNEY K M,BURKARD R F.The vestibular evoked myogenic potential(VEMP):air-versus boneconducted stimuli[J].Ear Hear,2011,32:e6-e15.
[19]XIE S J,XU Y,BI H Z,et al.Ocular vestibular-evoked myogenic potentials in healthy pilots and student pilots[J].Aviation Space Environmental Med,2011,7:729-733.
[20]NGUYEN K D,WELGAMPOLA M S,CAREY J P.Test-retest reliability and age-related characteristics of the ocular and cervical vestibular evoked myogenic potential tests[J].Otol Neurotol,2010,31:793-802.
[21]张青,许信达,牛晓蓉,等.年龄因素对气导声刺激诱发的眼肌和颈肌前庭诱发肌源性电位的影响[J].中华耳鼻咽喉头颈外科杂志,2014,49(11):897-901.
[2]胡娟,许珉,张青,等.眼肌前庭诱发肌源性电位的研究现状及展望[J].临床耳鼻咽喉头颈外科杂志,2013,27(7):388-392.
[3]谢溯江,郑颖鹃,张琳,等.眼性前庭诱发肌电位研究进展[J].中华临床医师杂志,2013,7(9):3980-3983.
[4]DERIU F,ORTU E,CAPOBIANCO S,et al.Origin of sound-evoked EMG responses in human masseter muscles[J].J Physiol,2007,580:195-209.
[5]CURTHOYS I S.A critical review of the neurophysiological evidence underlying clinical vestibular testing using sound vibration and galvanic stimuli[J].Clin Neurophysiol,2010,121:132-144.
[6]SHIN B S,OH S Y,KIM J S,et al.Cervical and ocular vestibular-evoked myogenic potentials in acute vestibular neuritis[J].Clin Neurophysiol,2012,123:369-375.
[7]ZUNIGA M G,JANKY K L,SCHUBERT M C,et al.Can vestibular-evoked myogenic potentials help differentiate meniere disease from vestibular migraine[J].Otolaryngol Head Neck Surg,2012,146:788-796.
[8]MUROFUSHI T,WAKAYAMA K,CHIHARA Y.oVEMP to air-conducted tones reflects functions of different vestibular population from cVEMP[J]?Eur Arch Otorhinolaryngol,2010,267:995-996.
[9]NGUYN K D,WELAAMPOLA M S,CAREY J P.Test-retest reliability and age-related characteristics of the ocular and cervical vestibular-evoked myogenic potential tests[J].Otol Neurotol,2010,31:793-802.
[10]林细康,李晓璐.眼性前庭诱发肌源电位对眩晕定位诊断的价值探讨[J].中华临床医师杂志,2014,8(3):411-414.
[11]BAYRAM A,DOGAN M,KOC A,et al.Cervical and ocular vestibular evoked myogenic potentials in Behcet's disease[J].Am J Otolaryngol Head Neck Med Surg,2015,36:503-508.
[12]刘海红,张华,莫玲燕,等.听力相关疾病成人患者的年龄因素分析[J].听力学及言语疾病杂志,2011,19(4):328-330.
[13]李婧,杨旭,吴子明,等.眼源性前庭诱发肌源性电位[J].中华耳科学杂志,2014,12(2):231-234.
[14]SHEYKHOLESLAMI K,MUREFUSHI T,KAGA K.The effect of sternocleidomastoid electrode location on vestibular evoked myogenic potential[J].Auris Nasus Larynx,2001,28:41-43.
[15]ROENGREN S M,GOVENDER S,COLEBATCH J G.Ocular and cervical vestibular evoked myogenic potentials produced by air-and bone-conducted stimuli:comparative properties and effects of age[J].Clin Neurophysiol,2011,122:2282-2289.
[16]OCHI K,OHASHI T.Age-related changes in the vestibular evoked myogenic potentials[J].Otolaryngol Head Neck Surg,2003,129:655-659.
[17]韩朝,田亮,王璟,等.颈性前庭诱发肌源性电位正常值及影响因素的探讨[J].中国眼耳鼻喉科杂志,2015,15(2):101-104.
[18]MCNERNEY K M,BURKARD R F.The vestibular evoked myogenic potential(VEMP):air-versus boneconducted stimuli[J].Ear Hear,2011,32:e6-e15.
[19]XIE S J,XU Y,BI H Z,et al.Ocular vestibular-evoked myogenic potentials in healthy pilots and student pilots[J].Aviation Space Environmental Med,2011,7:729-733.
[20]NGUYEN K D,WELGAMPOLA M S,CAREY J P.Test-retest reliability and age-related characteristics of the ocular and cervical vestibular evoked myogenic potential tests[J].Otol Neurotol,2010,31:793-802.
[21]张青,许信达,牛晓蓉,等.年龄因素对气导声刺激诱发的眼肌和颈肌前庭诱发肌源性电位的影响[J].中华耳鼻咽喉头颈外科杂志,2014,49(11):897-901.