前S1抗原在乙型肝炎病毒诊断和治疗中的研究进展
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摘要
前S1抗原是位于乙型肝炎病毒(HBV)颗粒表面的一种膜蛋白。近些年有临床研究显示,前S1抗原在乙肝感染的早期就能出现在血清中,可用于乙肝病毒感染的早期诊断。前S1抗原与HBV-DNA、HBe Ag检测高度符合,是HBV-DNA、HBe Ag检测指标的补充和对照;前S1抗原的转阴时间及持续阳性提示了乙肝病毒感染后的疾病转归。因此,前S1抗原可作为HBV诊断和治疗的重要依据。本文就前S1抗原的结构和功能,其在HBV感染有关的肝脏疾病中的临床应用进行综述。
Pre-S1 antigen is a membrane protein which is located at the surface of hepatitis B virus(HBV) particle.Recently,a lot of studies suggested Pre-S1 antigen could be detected in blood and used as a marker of the early infection of HBV. The detection of Pre-S1 antigen is highly consistent with the detection of HBV-DNA and HBe Ag to be the supplement and reference. The clearance time and continuing positive of Pre-S1 antigen could respectively indicate the prognosis of the infection of HBV. Therefore, Pre-S1 antigen could be used as an important tool for the diagnosis and therapy of hepatitis B virus infection. In this study, we will summarize the structure and function of Pre-S1 antigen and it clinical use in liver diseases associated with hepatitis B virus infection.
Pre-S1 antigen is a membrane protein which is located at the surface of hepatitis B virus(HBV) particle.Recently,a lot of studies suggested Pre-S1 antigen could be detected in blood and used as a marker of the early infection of HBV. The detection of Pre-S1 antigen is highly consistent with the detection of HBV-DNA and HBe Ag to be the supplement and reference. The clearance time and continuing positive of Pre-S1 antigen could respectively indicate the prognosis of the infection of HBV. Therefore, Pre-S1 antigen could be used as an important tool for the diagnosis and therapy of hepatitis B virus infection. In this study, we will summarize the structure and function of Pre-S1 antigen and it clinical use in liver diseases associated with hepatitis B virus infection.
引文
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[2]中华医学会肝病分会,中华医学会感染学分会.慢性乙型肝炎防治指南[J].临床肝脏病杂志,2015,31(12):1941-1954.
[3]刘佩,赵旭鸿.乙肝五项、HBV-DNA定量及乙肝前S1抗原联合检测用于诊断乙肝的临床价值分析[J].标记免疫分析与临床,2016,23(11):1275-1278.
[4]陈华宏,陈谋,洪洁华,等.乙肝前S1抗原在乙肝诊疗中的临床价值以及与HBV-DNA相关性研究[J].实验与检验医学,2017,35(1):102-109.
[5]谭磊,韩愈,石庆芬.乙型肝炎病毒前S1抗原阳性检验价值分析[J].中外医疗,2017,36(3):69-71.
[6]于海滨,翟云,孙亚男,等.HBe Ag阴性及HBe Ag阳性慢性乙型肝炎患者的临床特征比较[J].中国临床医生杂志,2017,45(2):35-38.
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[8]Deng JJ,Kong KE,Gao WW,et al.Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription[J].Biochim Biophys Acta,2017,1860(4):491-501.
[9]纪冬,成军,韩萍,等.噬菌体展示技术在HBV前-S1蛋白反式激活基因1启动子DNA的结合蛋白筛选中的应用[J].中华实验和临床感染病杂志,2012,6(4):263-267.
[10]冷俊,周晔,郁森,等.前S1抗原与HBV血清标志物的相关性及临床意义[J].临床和实验医学杂志,2013,12(7):509-510.
[11]熊格,乔斌,李艳.乙型肝炎患者前S1抗原与HBVDNA和HBe Ag的相关性研究[J].海南医学,2016,27(8):1225-1227.
[12]Castelain S,Descamps V,Brochot E.High association of T1858-G1896 precore mutations with impaired base pairing and high hepatitis B virus DNA levels in HBe Ag-negativechronically infected patients[J].Arch Virol,2017,162(7):1913-1920.
[13]王小杰,于宏亮.乙肝患者前S1抗原与乙肝五项及ALT联合检测的意义[J].中国实用医药,2015,10(10):56-57.
[14]林凤金,梁雅.282例乙肝感染无症状表面抗原阳性者血清ALT与乙肝前S1抗原的检测[J].热带医学杂志,2012,12(1):73-74.
[15]Xia F,Xu YH,Zheng MJ,et al.Comparative analysis of hepatitis B virus large protein,hepatitis B virus-DNA and Pre-S1 antigen in evaluating serum hepatitis B virus replication[J].Zhonghua Yu Fang Yi Xue,2017,51(6):501-505.
[16]罗慧琴,王志刚,李玲,等.乙肝患者血清标志物与前S1抗原及HBV-DNA相关性分析[J].国际检验医学杂志,2013,34(24):3337-3338.
[17]王书华,张立平,陈六生.乙型肝炎病毒前S1抗原阳性在乙型肝炎病情诊断及预后判断中的应用[J].国际检验医学杂志,2016,37(1):101-102.
[18]王碧玉,黄燕妮.乙肝两对半定量、乙肝DNA定量与乙肝前S1抗原联合检测的临床意义[J].海南医学,2016,27(7):1182-1184.
[19]蒋姣姣,孟伟,李萍.HBV前S1抗原、HBV血清标志物和HBV-DNA的检测结果分析[J].泰山医学院学报,2016,37(9):1036-1037.
[20]王凤敏,李志.乙肝不同血清模式及乙肝DNA定量与前S1抗原联合检测的临床意义[J].国际病毒学杂志,2016,23(2):105-107.
[21]徐新蓉,龚国富,马萍.HBV前S1抗原与乙型肝炎五项及HBV-DNA水平关系分析[J].国际检验医学杂志,2013,34(8):1029-1031.
[22]张静秋.急性乙型肝炎患者前S1抗原与前S1抗体检测的临床意义[J].中国医药指南,2015,13(32):129.
[23]张小丹,任珊,于海滨,等.急性乙型肝炎患者前S1抗原与前S1抗体检测的临床意义[J].传染病信息,2012,25(4):229-231.
[24]王晓霖,黄少军,杨京.前S1抗原在慢性乙型肝炎病毒复制中的作用[J].肝脏,2011,16(6):510-511.
[25]邱冰峰,徐骐,徐汤舟,等.富马酸替诺福韦二吡呋酯单药治疗拉米夫定耐药慢性乙型肝炎的疗效观察[J].中华肝脏病杂志,2016,24(4):307-309.
[26]陈洁,郑瑞丹,徐成润,等.拉米夫定治疗慢性乙型肝炎患者的疗效与前S1抗原变化的关系[J].肝脏,2011,16(2):100-102.
[27]邓益斌,温旺荣.反基因锁核酸体外抑制乙肝病毒前S1基因表达[J].基础医学与临床,2013,33(6):722-725.
[28]王元海,周琼.聚乙二醇干扰素α-2a对乙肝病毒复制以及慢性乙型肝炎患者抗原指标转阴的影响[J].实用预防医学,2012,19(5):735-737.
[29]卓传尚,柳丽娟,谢海花,等.乙型肝炎病毒包膜蛋白诱导肝癌细胞系内质网应激的研究[J].中华实验和临床感染病杂志,2016,10(3):375-379.
[30]Sinn DH,Choi MS,Gwak GY,et al.Pre-S mutation is a significant risk factor for hepatocellular carcinoma development:a long-term retrospective cohort study[J].Dig Dis Sci,2013,58(3):751-758.
[2]中华医学会肝病分会,中华医学会感染学分会.慢性乙型肝炎防治指南[J].临床肝脏病杂志,2015,31(12):1941-1954.
[3]刘佩,赵旭鸿.乙肝五项、HBV-DNA定量及乙肝前S1抗原联合检测用于诊断乙肝的临床价值分析[J].标记免疫分析与临床,2016,23(11):1275-1278.
[4]陈华宏,陈谋,洪洁华,等.乙肝前S1抗原在乙肝诊疗中的临床价值以及与HBV-DNA相关性研究[J].实验与检验医学,2017,35(1):102-109.
[5]谭磊,韩愈,石庆芬.乙型肝炎病毒前S1抗原阳性检验价值分析[J].中外医疗,2017,36(3):69-71.
[6]于海滨,翟云,孙亚男,等.HBe Ag阴性及HBe Ag阳性慢性乙型肝炎患者的临床特征比较[J].中国临床医生杂志,2017,45(2):35-38.
[7]Wang LP,Han FZ,Yan XP,et al.Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients.[J].Cell Mol Biol,2016,62(12):18-23.
[8]Deng JJ,Kong KE,Gao WW,et al.Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription[J].Biochim Biophys Acta,2017,1860(4):491-501.
[9]纪冬,成军,韩萍,等.噬菌体展示技术在HBV前-S1蛋白反式激活基因1启动子DNA的结合蛋白筛选中的应用[J].中华实验和临床感染病杂志,2012,6(4):263-267.
[10]冷俊,周晔,郁森,等.前S1抗原与HBV血清标志物的相关性及临床意义[J].临床和实验医学杂志,2013,12(7):509-510.
[11]熊格,乔斌,李艳.乙型肝炎患者前S1抗原与HBVDNA和HBe Ag的相关性研究[J].海南医学,2016,27(8):1225-1227.
[12]Castelain S,Descamps V,Brochot E.High association of T1858-G1896 precore mutations with impaired base pairing and high hepatitis B virus DNA levels in HBe Ag-negativechronically infected patients[J].Arch Virol,2017,162(7):1913-1920.
[13]王小杰,于宏亮.乙肝患者前S1抗原与乙肝五项及ALT联合检测的意义[J].中国实用医药,2015,10(10):56-57.
[14]林凤金,梁雅.282例乙肝感染无症状表面抗原阳性者血清ALT与乙肝前S1抗原的检测[J].热带医学杂志,2012,12(1):73-74.
[15]Xia F,Xu YH,Zheng MJ,et al.Comparative analysis of hepatitis B virus large protein,hepatitis B virus-DNA and Pre-S1 antigen in evaluating serum hepatitis B virus replication[J].Zhonghua Yu Fang Yi Xue,2017,51(6):501-505.
[16]罗慧琴,王志刚,李玲,等.乙肝患者血清标志物与前S1抗原及HBV-DNA相关性分析[J].国际检验医学杂志,2013,34(24):3337-3338.
[17]王书华,张立平,陈六生.乙型肝炎病毒前S1抗原阳性在乙型肝炎病情诊断及预后判断中的应用[J].国际检验医学杂志,2016,37(1):101-102.
[18]王碧玉,黄燕妮.乙肝两对半定量、乙肝DNA定量与乙肝前S1抗原联合检测的临床意义[J].海南医学,2016,27(7):1182-1184.
[19]蒋姣姣,孟伟,李萍.HBV前S1抗原、HBV血清标志物和HBV-DNA的检测结果分析[J].泰山医学院学报,2016,37(9):1036-1037.
[20]王凤敏,李志.乙肝不同血清模式及乙肝DNA定量与前S1抗原联合检测的临床意义[J].国际病毒学杂志,2016,23(2):105-107.
[21]徐新蓉,龚国富,马萍.HBV前S1抗原与乙型肝炎五项及HBV-DNA水平关系分析[J].国际检验医学杂志,2013,34(8):1029-1031.
[22]张静秋.急性乙型肝炎患者前S1抗原与前S1抗体检测的临床意义[J].中国医药指南,2015,13(32):129.
[23]张小丹,任珊,于海滨,等.急性乙型肝炎患者前S1抗原与前S1抗体检测的临床意义[J].传染病信息,2012,25(4):229-231.
[24]王晓霖,黄少军,杨京.前S1抗原在慢性乙型肝炎病毒复制中的作用[J].肝脏,2011,16(6):510-511.
[25]邱冰峰,徐骐,徐汤舟,等.富马酸替诺福韦二吡呋酯单药治疗拉米夫定耐药慢性乙型肝炎的疗效观察[J].中华肝脏病杂志,2016,24(4):307-309.
[26]陈洁,郑瑞丹,徐成润,等.拉米夫定治疗慢性乙型肝炎患者的疗效与前S1抗原变化的关系[J].肝脏,2011,16(2):100-102.
[27]邓益斌,温旺荣.反基因锁核酸体外抑制乙肝病毒前S1基因表达[J].基础医学与临床,2013,33(6):722-725.
[28]王元海,周琼.聚乙二醇干扰素α-2a对乙肝病毒复制以及慢性乙型肝炎患者抗原指标转阴的影响[J].实用预防医学,2012,19(5):735-737.
[29]卓传尚,柳丽娟,谢海花,等.乙型肝炎病毒包膜蛋白诱导肝癌细胞系内质网应激的研究[J].中华实验和临床感染病杂志,2016,10(3):375-379.
[30]Sinn DH,Choi MS,Gwak GY,et al.Pre-S mutation is a significant risk factor for hepatocellular carcinoma development:a long-term retrospective cohort study[J].Dig Dis Sci,2013,58(3):751-758.