前S1蛋白与HBV血清标志物检测结果对比研究
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摘要
目的探讨前S1蛋白与乙肝(HBV)血清标志物检测在HBV感染中的临床意义。方法采用酶联免疫吸附试验(ELISA)同时进行乙肝病毒前S1蛋白和HBV血清标志物检测,对比2种检测方法在乙肝检验和治疗中的价值。结果不同HBV感染模式下HBV-DNA检测总阳性率为66.71%,与前S1蛋白检测总阳性59.27%比较,差异有统计学意义(P<0.05);前S1蛋白检测敏感性为81.9%明显高于HBeAg的55.03%(P<0.05),前S1蛋白检测准确性为83.54%高于HBeAg的66.83%(P<0.05)。结论前S1蛋白与HBV血清标志物的检测均能较好的反映乙肝病毒复制情况,前S1蛋白检测敏感性和准确性较高,两者联合测定能为HBV患者提供更为客观的诊断和治疗依据。
Objective To discuss the clinical significance of pre- S1 protein and HBV serum marker in detecting HBV infection. Methods Using the enzyme linked immunosorbent assay( ELISA) and detecting the pre- S1 protein and HBV serum marker at the same time. Values of the 2 kinds of detection methods in inspection and treatment of HVB were compared. Results Under different HBV infection modes,total positive rate of HBV- DNA detection was 66. 71% obviously higher than pre- S1 protein detection 59. 27%. The difference has statistical significance( P < 0. 05). Sensitivity of pre- S1 protein detection was 81. 9% obviously higher than HBeAg 55. 03%( P < 0. 05). Accuracy of pre- S1 protein detection was 83. 54% obviously higher than HBeAg 66. 83%( P < 0. 05). Conclusion Pre- S1 protein and HBV serum marker detection both can reflect HBV replication,but pre- S1 protein detection has higher sensitivity and accuracy. Combination of the 2 methods can provide more objective diagnostic and treatment evidences for HBV patients.
Objective To discuss the clinical significance of pre- S1 protein and HBV serum marker in detecting HBV infection. Methods Using the enzyme linked immunosorbent assay( ELISA) and detecting the pre- S1 protein and HBV serum marker at the same time. Values of the 2 kinds of detection methods in inspection and treatment of HVB were compared. Results Under different HBV infection modes,total positive rate of HBV- DNA detection was 66. 71% obviously higher than pre- S1 protein detection 59. 27%. The difference has statistical significance( P < 0. 05). Sensitivity of pre- S1 protein detection was 81. 9% obviously higher than HBeAg 55. 03%( P < 0. 05). Accuracy of pre- S1 protein detection was 83. 54% obviously higher than HBeAg 66. 83%( P < 0. 05). Conclusion Pre- S1 protein and HBV serum marker detection both can reflect HBV replication,but pre- S1 protein detection has higher sensitivity and accuracy. Combination of the 2 methods can provide more objective diagnostic and treatment evidences for HBV patients.
引文
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[3]刘波,王君,邱小华.乙型肝炎病毒前S1抗原与其血清标志物及DNA的关系分析[J].国际流行病学传染病学杂志,2011,38(5):308-310.
[4]Faisal BL,Prichard JG.Serum tumor markers[J].The Pro Med J,2006,13(1):31-33.
[5]王丹.乙肝病毒前S1抗原检测在临床检测中的应用价值[J].吉林医药学院学报,2012,33(4):212.
[6]Lin Z,Jia L,Feng L,et al.Serum tumor markers for detection of hepatocellular carcinoma[J].World J Gastro,2011,12(8):1175-1181.
[7]Paola AC,Victoria EV,Sandra RR,et al.Biological Basis and Clinical Application of Serum Tumor Markers[J].Rev Cienc Salud,2008,6(2):51-55.