锶掺杂纳米羟基磷灰石的制备
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摘要
骨缺损的治疗是临床研究中的一项重大挑战,在天然骨骼中发现的各种人体必需元素中,锶是一种非常特殊的元素。在人体中,锶具有很强的亲骨性。锶掺杂后的纳米羟基磷灰石,与未掺杂的羟基磷灰石相比表现出增强的促成骨细胞分化活性。
The treatment of bone defects is a major challenge in clinical research. Strontium is a very special element among various essential elements found in natural bones. It has a great affinity for bone in human body. Strontium-doped hydroxyapatite showed enhanced osteoblast activity compared with undoped hydroxyapatite.
The treatment of bone defects is a major challenge in clinical research. Strontium is a very special element among various essential elements found in natural bones. It has a great affinity for bone in human body. Strontium-doped hydroxyapatite showed enhanced osteoblast activity compared with undoped hydroxyapatite.
引文
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[2]Zilm M E, Chen L, Sharma V, et al. Hydroxyapatite substituted by transition metals:experiment and theory[J]. Physical Chemistry Chemical Physics, 2016, 18(24):16457-16465.
[3]López E O, Rossi A L, Archanjo B S, et al. Crystalline nanocoatings of fluorine-substituted hydroxyapatite produced by magnetron sputtering with high plasma confinement[J]. Surface&Coatings Technology, 2015, 264:163-174.
[4]Cameron K, Travers P, Chander C, et al. Directed osteogenic differentiation of human mesenchymal stem/precursor cells on silicate substituted calcium phosphate[J]. Journal of Biomedical Materials Research Part A, 2013, 101(1):13-22.
[5]Mostafa N Y, Hassan H M, Abd Elkader O H. Preparation and Characterization of Na+, SiO4-4, and CO2-3Co-Substituted Hydroxyapatite[J]. Journal of the American Ceramic Society, 2011, 94(5):1584-1590.
[6]Stani? V, Dimitrijevi? S, Anti?-Stankovi? J, et al. Synthesis,characterization and antimicrobial activity of copper and zincdoped hydroxyapatite nanopowders[J]. Applied Surface Science,2010, 256(20):6083-6089.
[7]Lin Y, Yang Z, Cheng J. Preparation, characterization and antibacterial property of cerium substituted hydroxyapatite nanoparticles[J]. Journal of Rare Earths, 2007, 25(4):452-456.
[8]Bigi A, Boanini E, Capuccini C, et al. Strontium-substituted hydroxyapatite nanocrystals[J]. Inorganica Chimica Acta, 2007, 360(3):1009-1016.
[9]Yang H, Qu X, Lin W, et al. In vitro and in vivo studies on zinchydroxyapatite composites as novel biodegradable metal matrix composite for orthopedic applications[J]. Acta biomaterialia,2018, 71:200-214.