强散射介质中0π脉冲的受激拉曼光谱
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摘要
拉曼光谱由于具有响应速度快,灵敏度高,不侵入待测物质等特点,近年来在生物和医学检测及成像领域的应用受到了较多的关注.然而,生物活组织往往具有较强的散射特性,影响受激拉曼光谱的成像质量.为了提高受激拉曼光谱的成像质量,引入脉冲波形技术,采用对拉曼散射具有较高敏感性的0π脉冲为斯托克斯脉冲,利用离散偶极矩近似方法,对强散射介质中的脉冲传输进行数值模拟.研究发现:在多次散射的作用下,尽管激光脉冲强度随着其在介质中的传输距离增大而衰减,但受益于0π脉冲的特性,输出信号在双光子共振时的强度将增强2倍左右,为提高强散射介质中的受激拉曼光谱质量提供了一个新的可能.
Due to its fast response,high sensitivity,and non-intrusion into the sample,the application of Raman spectroscopy in the biological and medical detection and imaging fields has received much attention in recent years.However,biological living tissues usually exhibit high scattering characteristics,which greatly limit the imaging quality of stimulated Raman spectroscopy.To improve the imaging quality,we study the propagation of pulses and stimulated Raman spectroscopy process in strong scattering media by using the pulse shaping technique and discrete dipole moment approximation method,in which a 0-pi pulse with high sensitivity to Raman scattering is adopted as Stokes pulse.It is found that under the influence of multiple scattering,the pulse intensity decreases with the increase of its propagation distance in the media.Benefiting from these characteristics of 0πpulse,the intensity of output signal in two-photon resonance increases by approximately three times,providing apossible way to improve the imaging quality of stimulated Raman spectroscopy in strong scattering media.
Due to its fast response,high sensitivity,and non-intrusion into the sample,the application of Raman spectroscopy in the biological and medical detection and imaging fields has received much attention in recent years.However,biological living tissues usually exhibit high scattering characteristics,which greatly limit the imaging quality of stimulated Raman spectroscopy.To improve the imaging quality,we study the propagation of pulses and stimulated Raman spectroscopy process in strong scattering media by using the pulse shaping technique and discrete dipole moment approximation method,in which a 0-pi pulse with high sensitivity to Raman scattering is adopted as Stokes pulse.It is found that under the influence of multiple scattering,the pulse intensity decreases with the increase of its propagation distance in the media.Benefiting from these characteristics of 0πpulse,the intensity of output signal in two-photon resonance increases by approximately three times,providing apossible way to improve the imaging quality of stimulated Raman spectroscopy in strong scattering media.
引文
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[17] DING Y,BRUBAKER R M,NOLTE D D,et al.Femtosecond pulse shaping by dynamic holograms in photorefractive multiple quantum wells[J].Optics Letters,1997,22(10):718-720.
[2] SCULLY M O,KATTAWAR G W,LUCHT B P,et al.FAST CARS:engineering a laser spectroscopic technique for rapid identification of bacterial spores[J].Proc Nat Acad Sci USA,2002,99(17):10994-11001.
[3] PESTOV D,ZHI M C,SARIYANNI Z E,et al.Visible and UV coherent Raman spectroscopy of dipicolinic acid[J].Proc Nat Acad Sci USA,2005,102(42):14976-14981.
[4] PESTOV D,MURAWSKI R K,ARIUNBOLD G O,et al.Optimizing the laser pulse configuration for coherent Raman spectroscopy[J].Science,2007,316(5822):265-268.
[5] PANDEY R,PAIDI S,VALDEZ T,et al.Noninvasive monitoring of blood glucose with Raman spectroscopy[J].Acc Chem Res,2017,50(2):264-272.
[6] OSELEDCHYK A,ANDREOU C,WALL M A,et al.Folate-targetedsurface-enhancedresonanceRaman scattering nanoprobe ratiometry for detection of microscopic ovarian cancer[J].ACS Nano,2017,11(2):1488-1497.
[7] SCHULZE G,JIRASEK A,YU M,et al.Investigation of selected baseline removal techniques as candidates for automated implementation[J].Appl Spectrosc,2005,59(5):545-574.
[8] LIAO C S,SLIPCHNKO M N,WANG P,et al.Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy[J].Light:Sci Appl,2015,4:e265.
[9] SUHALIM J L,CHUNG C Y,LILLEDAHL M B,et al.Characterization of cholesterol crystals in atherosclerotic plaques using stimulated Raman scattering and secondharmonic generation microscopy[J].Biophysical Journal,2012,102(8):1988-1995.
[10] DUNCAN M D,Mahon R,TANKERSLEY L L,et al.Time-gated imaging through scattering media using stimulated Raman amplification[J].Optics Letters,1991,16(23):1868-1870.
[11] MONMAYRANT A,WEBER S,CHATEL B.Anewcomer’s guide to ultra-short pulse shaping and characterization[J].Political Science Quarterly,2010,43(10):759-775.
[12]WEINER A M.Femto-second pulse shaping using spatial light modulators[J].Rev Scient Instru,2000,71(5):1929-1960.
[13] DRAINE B T,FLATAU P J.Discrete-dipole approximation for scattering calculations[J].J Opt Soc Am A,1994,11(4):1491-1499.
[14] ALLEN L,EBERLY J H.Optical resonance and two level atoms[M].New York:Dover,1987:72.
[15] SUN D,SARIYANNI Z E,DAS S,et al.Propagation of0πpulses in a gas of three-level atoms[J].Phys Rev A,2011,83(6):063815.
[16] SARIYANNI Z E,SUN D,ROSTOVTSEV Y V.Stimulated Raman spectroscopy with 0πpulses[J].Opt Lett,2014,39(4):766-768.
[17] DING Y,BRUBAKER R M,NOLTE D D,et al.Femtosecond pulse shaping by dynamic holograms in photorefractive multiple quantum wells[J].Optics Letters,1997,22(10):718-720.