甲羟孕酮与去氧孕烯炔雌醇片治疗青春期功能失调性子宫出血的临床疗效
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摘要
目的分析青春期功能失调性子宫出血患者行甲羟孕酮和去氧孕烯炔雌醇片治疗的临床效果。方法选入该院于2015年5月—2016年5月期间前来就诊的青春期功能失调性子宫出血患者共52例,采用随机数字表法的形式将其平均分为观察组和参照组,每组各为26例。观察组行去氧孕烯炔雌醇片治疗,参照组行甲羟孕酮治疗,对比两组患者治疗后的出血时间、临床总有效率以及不良反应发生率等指标。结果观察组治疗后控制出血时间为(22.73±7.47)h,完全止血时间为(45.27±18.26)h,参照组上述指标为(30.17±10.55)h,(63.10±20.51)h,组间对比差异有统计学意义(t=2.934 7、3.310 7,P<0.05);临床总有效率分析,观察组总有效率92.3%优于参照组65.3%,临床对比差异有统计学意义(χ~2=5.649 7,P<0.05);不良反应分析中,观察组总不良反应发生率为23.0%,参照组为53.8%,两组比较差异有统计学意义(χ~2=5.200 0,P<0.05)。结论甲羟孕酮以及去氧孕烯炔雌醇片均能起到治疗青春期功能失调性子宫出血的效果,两种药物相比较,去氧孕烯炔雌醇片的临床治疗效果最优,治疗有效率得以提升,这一方法值得临床进一步推广和应用。
Objective To analyze the clinical effect of medroxyprogesterone and desogestrel and ethinylestradiol tablets in treatment of adolescent dysfunctional uterine bleeding. Methods 52 cases of patients with adolescent dysfunctional uterine bleeding diagnosed in our hospital from May 2015 to May 2016 were selected and randomly divided into two groups with 26 cases in each, the observation group and the control group were respectively treated with desogestrel and ethinylestradiol tablets and medroxyprogesterone, and the bleeding time, total clinical treatment effective rate and incidence rate of adverse reactions after treatment were compared between the two groups. Results The bleeding control time after treatment and total hemostasis time in the observation group and in the control group were respectively(22.73±7.47) h,( 45.27±18.26) h and( 30.17±10.55) h,( 63.10±20.51) h, and the differences were statistically significant(t=2.934 7,3.310 7, P<0.05), and the total clinical effective rate in the observation group was better than that in the control group(92.3% vs 65.3%), and the difference was statistically significant(χ~2=5.649 7, P<0.05); and the incidence rate of total adverse reactions in the observation group and in the control group was respectively 23.0% and53.8%, and the differences were statistically significant(χ~2=5.200 0, P<0.05). Conclusion Both the medroxyprogesterone and desogestrel and ethinylestradiol tablets can treat the adolescent dysfunctional uterine bleeding, and the clinical treatment effect of desogestrel and ethinylestradiol tablets is better, thus improving the treatment effective rate, and it is worth further promotion and application in clinic.
Objective To analyze the clinical effect of medroxyprogesterone and desogestrel and ethinylestradiol tablets in treatment of adolescent dysfunctional uterine bleeding. Methods 52 cases of patients with adolescent dysfunctional uterine bleeding diagnosed in our hospital from May 2015 to May 2016 were selected and randomly divided into two groups with 26 cases in each, the observation group and the control group were respectively treated with desogestrel and ethinylestradiol tablets and medroxyprogesterone, and the bleeding time, total clinical treatment effective rate and incidence rate of adverse reactions after treatment were compared between the two groups. Results The bleeding control time after treatment and total hemostasis time in the observation group and in the control group were respectively(22.73±7.47) h,( 45.27±18.26) h and( 30.17±10.55) h,( 63.10±20.51) h, and the differences were statistically significant(t=2.934 7,3.310 7, P<0.05), and the total clinical effective rate in the observation group was better than that in the control group(92.3% vs 65.3%), and the difference was statistically significant(χ~2=5.649 7, P<0.05); and the incidence rate of total adverse reactions in the observation group and in the control group was respectively 23.0% and53.8%, and the differences were statistically significant(χ~2=5.200 0, P<0.05). Conclusion Both the medroxyprogesterone and desogestrel and ethinylestradiol tablets can treat the adolescent dysfunctional uterine bleeding, and the clinical treatment effect of desogestrel and ethinylestradiol tablets is better, thus improving the treatment effective rate, and it is worth further promotion and application in clinic.
引文
[1]陈忠兰,梁小洁.宫血宁胶囊联合醋酸甲羟孕酮和戊酸雌二醇治疗青春期功能失调性子宫出血的疗效观察[J].现代药物与临床, 2016, 31(7):1063-1066.
[2]柳先廉,刘燕燕,袁秀英,等.复方益母草胶囊联合屈螺酮炔雌醇片治疗青春期功能失调性子宫出血的效果[J].广东医学, 2016, 37(1):238-240.
[3]李艳.第三代口服避孕药与天然孕激素治疗青春期功能失调性子宫出血临床疗效探讨[J].中国药物与临床,2015(1):98-100.
[4]岳明明,克比努尔·艾则孜,沙塔娜提·穆罕默德.宫血宁胶囊联合去氧孕烯炔雌醇片治疗无排卵性功能失调性子宫出血的临床研究[J].山西医药杂志, 2017, 46(13):1527-1529.
[5]杨晓辉.葆宫止血颗粒联合去氧孕烯炔雌醇治疗功能失调性子宫出血的疗效观察[J].现代药物与临床, 2017,32(1):109-112.
[6]李雪萍,罗菊玉.去氧孕烯炔雌醇联合米非司酮治疗围绝经期无排卵型功能失调性子宫出血的临床观察[J].中国药房, 2016(14):1981-1983.
[7]麻翠玲.米非司酮与去氧孕烯炔雌醇片治疗围绝经期功能性子宫出血患者效果及对子宫内膜厚度影响的对比研究[J].中国妇幼保健, 2015, 30(5):698-699.
[8]楼颖素,陈文波.去氧孕烯炔雌醇片联合米非司酮对围绝经期功能性子宫出血患者子宫内膜的影响观察[J].中国性科学, 2015(12):73-75.
[9]吕翠芬,陈晓辉.去氧孕烯炔雌醇片、米非司酮联合归脾丸治疗围绝经期功能性子宫出血疗效观察[J].现代中西医结合杂志, 2017, 26(35):3937-3939.
[10]岳明明,孙炜星,沙塔娜提·穆罕默德.中西医结合治疗对气虚血瘀型无排卵性功能失调性子宫出血患者子宫内膜厚度、生殖激素及炎性因子水平的影响[J].中国卫生检验杂志, 2017(14):1987-1989.
[2]柳先廉,刘燕燕,袁秀英,等.复方益母草胶囊联合屈螺酮炔雌醇片治疗青春期功能失调性子宫出血的效果[J].广东医学, 2016, 37(1):238-240.
[3]李艳.第三代口服避孕药与天然孕激素治疗青春期功能失调性子宫出血临床疗效探讨[J].中国药物与临床,2015(1):98-100.
[4]岳明明,克比努尔·艾则孜,沙塔娜提·穆罕默德.宫血宁胶囊联合去氧孕烯炔雌醇片治疗无排卵性功能失调性子宫出血的临床研究[J].山西医药杂志, 2017, 46(13):1527-1529.
[5]杨晓辉.葆宫止血颗粒联合去氧孕烯炔雌醇治疗功能失调性子宫出血的疗效观察[J].现代药物与临床, 2017,32(1):109-112.
[6]李雪萍,罗菊玉.去氧孕烯炔雌醇联合米非司酮治疗围绝经期无排卵型功能失调性子宫出血的临床观察[J].中国药房, 2016(14):1981-1983.
[7]麻翠玲.米非司酮与去氧孕烯炔雌醇片治疗围绝经期功能性子宫出血患者效果及对子宫内膜厚度影响的对比研究[J].中国妇幼保健, 2015, 30(5):698-699.
[8]楼颖素,陈文波.去氧孕烯炔雌醇片联合米非司酮对围绝经期功能性子宫出血患者子宫内膜的影响观察[J].中国性科学, 2015(12):73-75.
[9]吕翠芬,陈晓辉.去氧孕烯炔雌醇片、米非司酮联合归脾丸治疗围绝经期功能性子宫出血疗效观察[J].现代中西医结合杂志, 2017, 26(35):3937-3939.
[10]岳明明,孙炜星,沙塔娜提·穆罕默德.中西医结合治疗对气虚血瘀型无排卵性功能失调性子宫出血患者子宫内膜厚度、生殖激素及炎性因子水平的影响[J].中国卫生检验杂志, 2017(14):1987-1989.